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    Ellen M Gravallese MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB
    Worcester MA 01605
    Phone508-856-8730
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentCell and Developmental Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCell Biology

        Bibliographic 
        selected publications
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        1. Walsh NC, Alexander KA, Manning CA, Karmakar S, Wang JF, Weyand CM, Pettit AR, Gravallese EM. Activated human T cells express alternative mRNA transcripts encoding a secreted form of RANKL. Genes Immun. 2013 Sep; 14(6):407.
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        2. Walsh NC, Alexander KA, Manning CA, Karmakar SK, Wang JF, Weyand CM, Pettit AR, Gravallese EM. Activated human T cells express alternative mRNA transcripts encoding a secreted form of RANKL. Genes Immun. 2013 Jul; 14(5):336-45.
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        3. Kay J, Gravallese EM. Rheumatoid arthritis: Erosion defined: back to basics. Nat Rev Rheumatol. 2013 Jun; 9(6):323-4.
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        4. Schett G, Gravallese E. Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nat Rev Rheumatol. 2012 Nov; 8(11):656-64.
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        5. Matzelle MM, Gallant MA, Condon KW, Walsh NC, Manning CA, Stein GS, Lian JB, Burr DB, Gravallese EM. Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway. Arthritis Rheum. 2012 May; 64(5):1540-50.
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        6. Gravallese EM, Walsh NC. Rheumatoid arthritis: Repair of erosion in RA--shifting the balance to formation. Nat Rev Rheumatol. 2011 Nov; 7(11):626-8.
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        7. Salomon-Escoto KI, Gravallese EM, Kay J. Assessment of control of rheumatoid arthritis disease activity. Best Pract Res Clin Rheumatol. 2011 Aug; 25(4):497-507.
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        8. Karmakar S, Kay J, Gravallese EM. Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention. Rheum Dis Clin North Am. 2010 May; 36(2):385-404.
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        9. Walsh NC, Gravallese EM. Bone remodeling in rheumatic disease: a question of balance. Immunol Rev. 2010 Jan; 233(1):301-12.
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        10. Desai SP, Gravallese EM, Shadick NA, Glass R, Cui J, Frits M, Chibnik LB, Maher N, Weinblatt ME, Solomon DH. Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA. Rheumatology (Oxford). 2010 Mar; 49(3):513-9.
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        11. Walsh NC, Reinwald S, Manning CA, Condon KW, Iwata K, Burr DB, Gravallese EM. Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis. J Bone Miner Res. 2009 Sep; 24(9):1572-85.
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        12. Colbert RA, Deodhar AA, Fox D, Gravallese EM, Khan MA, McGonagle D, Reveille JD, Schett G, Weisman M, Clegg DO. Entheses and bones in spondyloarthritis: 2008 Annual Research and Education Meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN). J Rheumatol. 2009 Jul; 36(7):1527-31.
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        13. Solomon DH, Finkelstein JS, Shadick N, LeBoff MS, Winalski CS, Stedman M, Glass R, Brookhart MA, Weinblatt ME, Gravallese EM. The relationship between focal erosions and generalized osteoporosis in postmenopausal women with rheumatoid arthritis. Arthritis Rheum. 2009 Jun; 60(6):1624-31.
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        14. Shen Z, Crotti TN, McHugh KP, Matsuzaki K, Gravallese EM, Bierbaum BE, Goldring SR. The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis. Arthritis Res Ther. 2006; 8(3):R70.
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        15. Pettit AR, Walsh NC, Manning C, Goldring SR, Gravallese EM. RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritis. Rheumatology (Oxford). 2006 Sep; 45(9):1068-76.
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        16. Walsh NC, Crotti TN, Goldring SR, Gravallese EM. Rheumatic diseases: the effects of inflammation on bone. Immunol Rev. 2005 Dec; 208:228-51.
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        17. Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, Zhao Y, Taniguchi N, Huang XL, Otu H, Wang H, Wang JF, Komiya S, Ducy P, Rahman MU, Flavell RA, Gravallese EM, Oettgen P, Libermann TA, Goldring MB. A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem. 2005 Nov 18; 280(46):38544-55.
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        18. Grall FT, Prall WC, Wei W, Gu X, Cho JY, Choy BK, Zerbini LF, Inan MS, Goldring SR, Gravallese EM, Goldring MB, Oettgen P, Libermann TA. The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes. FEBS J. 2005 Apr; 272(7):1676-87.
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        19. Jacobs JP, Pettit AR, Shinohara ML, Jansson M, Cantor H, Gravallese EM, Mathis D, Benoist C. Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis. Arthritis Rheum. 2004 Aug; 50(8):2685-94.
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        20. Walsh NC, Gravallese EM. Bone loss in inflammatory arthritis: mechanisms and treatment strategies. Curr Opin Rheumatol. 2004 Jul; 16(4):419-27.
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        21. Goldring SR, Gravallese EM. Bisphosphonates: environmental protection for the joint? Arthritis Rheum. 2004 Jul; 50(7):2044-7.
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        22. Brown C, Gaspar J, Pettit A, Lee R, Gu X, Wang H, Manning C, Voland C, Goldring SR, Goldring MB, Libermann TA, Gravallese EM, Oettgen P. ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. J Biol Chem. 2004 Mar 26; 279(13):12794-803.
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        23. Gravallese EM. Osteopontin: a bridge between bone and the immune system. J Clin Invest. 2003 Jul; 112(2):147-9.
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        24. Grall F, Gu X, Tan L, Cho JY, Inan MS, Pettit AR, Thamrongsak U, Choy BK, Manning C, Akbarali Y, Zerbini L, Rudders S, Goldring SR, Gravallese EM, Oettgen P, Goldring MB, Libermann TA. Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1. Arthritis Rheum. 2003 May; 48(5):1249-60.
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        25. Pisetsky DS, Hunder GG, Gravallese EM. New policy on disclosure of interest for American College of Rheumatology Journals. Arthritis Rheum. 2003 Apr 15; 49(2):149-50.
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        26. Pisetsky DS, Hunder GG, Gravallese EM. New policy on disclosure of interest for American College of Rheumatology journals. Arthritis Rheum. 2003 Apr; 48(4):873-5.
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        27. Gravallese EM, Pettit AR, Lee R, Madore R, Manning C, Tsay A, Gaspar J, Goldring MB, Goldring SR, Oettgen P. Angiopoietin-1 is expressed in the synovium of patients with rheumatoid arthritis and is induced by tumour necrosis factor alpha. Ann Rheum Dis. 2003 Feb; 62(2):100-7.
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        28. Lubberts E, Oppers-Walgreen B, Pettit AR, Van Den Bersselaar L, Joosten LA, Goldring SR, Gravallese EM, Van Den Berg WB. Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis. Arthritis Rheum. 2002 Nov; 46(11):3055-64.
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        29. Gravallese EM. Bone destruction in arthritis. Ann Rheum Dis. 2002 Nov; 61 Suppl 2:ii84-6.
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        30. Ji H, Pettit A, Ohmura K, Ortiz-Lopez A, Duchatelle V, Degott C, Gravallese E, Mathis D, Benoist C. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med. 2002 Jul 1; 196(1):77-85.
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        31. Goldring SR, Gravallese EM. Pathogenesis of bone lesions in rheumatoid arthritis. Curr Rheumatol Rep. 2002 Jun; 4(3):226-31.
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        32. Husni ME, Maier AL, Mease PJ, Overman SS, Fraser P, Gravallese EM, Weinblatt ME. Etanercept in the treatment of adult patients with Still's disease. Arthritis Rheum. 2002 May; 46(5):1171-6.
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        33. Hou WS, Li W, Keyszer G, Weber E, Levy R, Klein MJ, Gravallese EM, Goldring SR, Brömme D. Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum. 2002 Mar; 46(3):663-74.
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        34. Raffel GD, Gravallese EM, Schwab P, Joseph JT, Cannistra SA. Diagnostic dilemmas in oncology: case 2. Dermatomyositis and ovarian cancer. J Clin Oncol. 2001 Dec 1; 19(23):4341-3.
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        35. Pettit AR, Ji H, von Stechow D, Müller R, Goldring SR, Choi Y, Benoist C, Gravallese EM. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol. 2001 Nov; 159(5):1689-99.
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        36. Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH. Plasma cell differentiation requires the transcription factor XBP-1. Nature. 2001 Jul 19; 412(6844):300-7.
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        37. Gravallese EM, Galson DL, Goldring SR, Auron PE. The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption. Arthritis Res. 2001; 3(1):6-12.
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        38. Gravallese EM, Goldring SR. Cellular mechanisms and the role of cytokines in bone erosions in rheumatoid arthritis. Arthritis Rheum. 2000 Oct; 43(10):2143-51.
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        39. Wexler EJ, Gravallese EM, Czerniak PM, Devenny JJ, Longtine J, Wong MK, Slee AM, Kerr JS. Tumor biology: use of tiled images in conjunction with measurements of cellular proliferation and death in response to drug treatments. Clin Cancer Res. 2000 Aug; 6(8):3361-70.
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        40. Goldring SR, Gravallese EM. Pathogenesis of bone erosions in rheumatoid arthritis. Curr Opin Rheumatol. 2000 May; 12(3):195-9.
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        41. Mandl LA, Folkerth RD, Pick MA, Weinblatt ME, Gravallese EM. Amyloid myopathy masquerading as polymyositis. J Rheumatol. 2000 Apr; 27(4):949-52.
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        42. Gravallese EM, Manning C, Tsay A, Naito A, Pan C, Amento E, Goldring SR. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum. 2000 Feb; 43(2):250-8.
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        43. Ranger AM, Gerstenfeld LC, Wang J, Kon T, Bae H, Gravallese EM, Glimcher MJ, Glimcher LH. The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis. J Exp Med. 2000 Jan 3; 191(1):9-22.
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        44. Goldring SR, Gravallese EM. Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications. Arthritis Res. 2000; 2(1):33-7.
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        45. Gravallese EM, Harada Y, Wang JT, Gorn AH, Thornhill TS, Goldring SR. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol. 1998 Apr; 152(4):943-51.
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        46. Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH. The transcription factor NF-ATc is essential for cardiac valve formation. Nature. 1998 Mar 12; 392(6672):186-90.
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        47. Kelleher Doyle M, Telford SR, Criscione L, Lin SR, Spielman A, Gravallese EM. Cytokines in murine lyme carditis: Th1 cytokine expression follows expression of proinflammatory cytokines in a susceptible mouse strain. J Infect Dis. 1998 Jan; 177(1):242-6.
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        48. Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, Alt FW, de la Brousse FC, Hoey T, Grusby M, Glimcher LH. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity. 1998 Jan; 8(1):125-34.
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        49. Darling JM, Goldring SR, Harada Y, Handel ML, Glowacki J, Gravallese EM. Multinucleated cells in pigmented villonodular synovitis and giant cell tumor of tendon sheath express features of osteoclasts. Am J Pathol. 1997 Apr; 150(4):1383-93.
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        50. Ruderman EM, Crawford JM, Maier A, Liu JJ, Gravallese EM, Weinblatt ME. Histologic liver abnormalities in an autopsy series of patients with rheumatoid arthritis. Br J Rheumatol. 1997 Feb; 36(2):210-3.
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        51. Gravallese EM, Handel ML, Coblyn J, Anderson RJ, Sperling RI, Karlson EW, Maier A, Ruderman EM, Formelli F, Weinblatt ME. N-[4-hydroxyphenyl] retinamide in rheumatoid arthritis: a pilot study. Arthritis Rheum. 1996 Jun; 39(6):1021-6.
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        52. Handel ML, McMorrow LB, Gravallese EM. Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65. Arthritis Rheum. 1995 Dec; 38(12):1762-70.
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        53. Gravallese EM, Weissman BN, Brodsky G, Maguire J. Loosening of a revision total hip replacement in a 60-year-old woman with longstanding rheumatoid arthritis. Arthritis Rheum. 1995 Sep; 38(9):1315-24.
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        54. Gravallese EM, Waksmonski C, Winters GL, Simms RW. Fever, arthralgias, skin lesions, and ischemic digits in a 59-year-old man. Arthritis Rheum. 1995 Aug; 38(8):1161-8.
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        55. Ruderman EM, Weinblatt ME, Thurmond LM, Pinkus GS, Gravallese EM. Synovial tissue response to treatment with Campath-1H. Arthritis Rheum. 1995 Feb; 38(2):254-8.
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        56. Ruderman EM, Kerr JS, Telford SR, Spielman A, Glimcher LH, Gravallese EM. Early murine Lyme carditis has a macrophage predominance and is independent of major histocompatibility complex class II-CD4+ T cell interactions. J Infect Dis. 1995 Feb; 171(2):362-70.
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        57. Darling JM, Glimcher LH, Shortkroff S, Albano B, Gravallese EM. Expression of metalloproteinases in pigmented villonodular synovitis. Hum Pathol. 1994 Aug; 25(8):825-30.
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        58. Gravallese EM, Winalski CS, Longtine J, Helfgott SM. Polyarthritis in a 78-year-old woman. Arthritis Rheum. 1994 Jul; 37(7):1087-95.
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        59. Gravallese EM, Weissman BN, Corson JM, Greene JM. Synovitis of the knee in a 42-year-old man. Arthritis Rheum. 1993 Jun; 36(6):860-70.
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        60. Clauss IM, Gravallese EM, Darling JM, Shapiro F, Glimcher MJ, Glimcher LH. In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn. 1993 Jun; 197(2):146-56.
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        61. Gravallese EM, Baker N, Lester S, Kay J, Owen WF. Musculoskeletal manifestations in beta 2-microglobulin amyloidosis. Case discussion. Arthritis Rheum. 1992 May; 35(5):592-602.
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        62. Gravallese EM, Darling JM, Glimcher LH, Boothby M. Role of lipopolysaccharide and IL-4 in control of transcription of the class II A alpha gene. J Immunol. 1991 Oct 1; 147(7):2377-83.
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        63. Gravallese EM, Darling JM, Ladd AL, Katz JN, Glimcher LH. In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium. Arthritis Rheum. 1991 Sep; 34(9):1076-84.
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        64. Boothby M, Liou HC, Finn PW, Gravallese E, Glimcher LH. Control of transcription at the murine A alpha locus. Immunol Res. 1990; 9(2):77-92.
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        65. Gravallese EM, Boothby MR, Smas CM, Glimcher LH. A lipopolysaccharide-induced DNA-binding protein for a class II gene in B cells is distinct from NF-kappa B. Mol Cell Biol. 1989 Aug; 9(8):3184-92.
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        66. Gravallese EM, Corson JM, Coblyn JS, Pinkus GS, Weinblatt ME. Rheumatoid aortitis: a rarely recognized but clinically significant entity. Medicine (Baltimore). 1989 Mar; 68(2):95-106.
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        67. Boothby M, Gravallese E, Liou HC, Glimcher LH. A DNA binding protein regulated by IL-4 and by differentiation in B cells. Science. 1988 Dec 16; 242(4885):1559-62.
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        68. Shmerling RH, Stern SH, Gravallese EM, Kantrowitz FG. Tophaceous deposition in the finger pads without gouty arthritis. Arch Intern Med. 1988 Aug; 148(8):1830-2.
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        69. Gravallese EM, Kantrowitz FG. Arthritic manifestations of inflammatory bowel disease. Am J Gastroenterol. 1988 Jul; 83(7):703-9.
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        70. Merot Y, Gravallese E, Guillén FJ, Murphy GF. Lymphocyte subsets and Langerhans' cells in toxic epidermal necrolysis. Report of a case. Arch Dermatol. 1986 Apr; 122(4):455-8.
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        71. Miller JA, Gravallese E, Bunn HF. Nonenzymatic glycosylation of erythrocyte membrane proteins. Relevance to diabetes. J Clin Invest. 1980 Apr; 65(4):896-901.
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