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    Andrew B Leiter MD, PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB
    Worcester MA 01605
    Phone508-856-8101
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

        Bibliographic 
        selected publications
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        1. Li HJ, Johnston B, Aiello D, Caffrey DR, Giel-Moloney M, Rindi G, Leiter AB. Distinct Cellular Origins for Serotonin-Expressing and Enterochromaffin-like Cells in the Gastric Corpus. Gastroenterology. 2014 Mar; 146(3):754-764.e3.
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        2. Li HJ, Kapoor A, Giel-Moloney M, Rindi G, Leiter AB. Notch signaling differentially regulates the cell fate of early endocrine precursor cells and their maturing descendants in the mouse pancreas and intestine. Dev Biol. 2012 Nov 15; 371(2):156-69.
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        3. Gelegen C, Chandarana K, Choudhury AI, Al-Qassab H, Evans IM, Irvine EE, Hyde CB, Claret M, Andreelli F, Sloan SE, Leiter AB, Withers DJ, Batterham RL. Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice. Am J Physiol Endocrinol Metab. 2012 Sep 1; 303(5):E659-68.
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        4. Packard A, Giel-Moloney M, Leiter A, Schwob JE. Progenitor cell capacity of NeuroD1-expressing globose basal cells in the mouse olfactory epithelium. J Comp Neurol. 2011 Dec 1; 519(17):3580-96.
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        5. Li HJ, Ray SK, Singh NK, Johnston B, Leiter AB. Basic helix-loop-helix transcription factors and enteroendocrine cell differentiation. Diabetes Obes Metab. 2011 Oct; 13 Suppl 1:5-12.
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        6. Pelling M, Anthwal N, McNay D, Gradwohl G, Leiter AB, Guillemot F, Ang SL. Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus. Dev Biol. 2011 Jan 15; 349(2):406-16.
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        7. Thoennissen NH, O'Kelly J, Lu D, Iwanski GB, La DT, Abbassi S, Leiter A, Karlan B, Mehta R, Koeffler HP. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene. 2010 Jan 14; 29(2):285-96.
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        8. Danilova OV, Tai AK, Mele DA, Beinborn M, Leiter AB, Greenberg AS, Perfield JW, Defuria J, Singru PS, Lechan RM, Huber BT. Neurogenin 3-specific dipeptidyl peptidase-2 deficiency causes impaired glucose tolerance, insulin resistance, and visceral obesity. Endocrinology. 2009 Dec; 150(12):5240-8.
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        9. Zhang H, Ables ET, Pope CF, Washington MK, Hipkens S, Means AL, Path G, Seufert J, Costa RH, Leiter AB, Magnuson MA, Gannon M. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev. 2009 Dec; 126(11-12):958-73.
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        10. Choi MY, Romer AI, Wang Y, Wu MP, Ito S, Leiter AB, Shivdasani RA. Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum. Mol Cell Biol. 2008 May; 28(10):3208-18.
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        11. Fujiki Y, Tao K, Bianchi DW, Giel-Moloney M, Leiter AB, Johnson KL. Quantification of green fluorescent protein by in vivo imaging, PCR, and flow cytometry: comparison of transgenic strains and relevance for fetal cell microchimerism. Cytometry A. 2008 Feb; 73(2):11-118.
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        12. Ray SK, Leiter AB. The basic helix-loop-helix transcription factor NeuroD1 facilitates interaction of Sp1 with the secretin gene enhancer. Mol Cell Biol. 2007 Nov; 27(22):7839-47.
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        13. Wang Y, Ray SK, Hinds PW, Leiter AB. The retinoblastoma protein, RB, is required for gastrointestinal endocrine cells to exit the cell cycle, but not for hormone expression. Dev Biol. 2007 Nov 15; 311(2):478-86.
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        14. Kapoor A, Li HJ, Leiter AB. Intestinal development: the many faces of Wnt signaling. Gastroenterology. 2007 Aug; 133(2):710-2.
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        15. Wang Y, Giel-Moloney M, Rindi G, Leiter AB. Enteroendocrine precursors differentiate independently of Wnt and form serotonin expressing adenomas in response to active beta-catenin. Proc Natl Acad Sci U S A. 2007 Jul 3; 104(27):11328-33.
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        16. Mukhopadhyay NK, Cinar B, Mukhopadhyay L, Lutchman M, Ferdinand AS, Kim J, Chung LW, Adam RM, Ray SK, Leiter AB, Richie JP, Liu BC, Freeman MR. The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. Mol Endocrinol. 2007 Sep; 21(9):2056-70.
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        17. Giel-Moloney M, Krause DS, Chen G, Van Etten RA, Leiter AB. Ubiquitous and uniform in vivo fluorescence in ROSA26-EGFP BAC transgenic mice. Genesis. 2007 Feb; 45(2):83-9.
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        18. Itkin-Ansari P, Marcora E, Geron I, Tyrberg B, Demeterco C, Hao E, Padilla C, Ratineau C, Leiter A, Lee JE, Levine F. NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor. Dev Dyn. 2005 Jul; 233(3):946-53.
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        19. Schonhoff S, Baggio L, Ratineau C, Ray SK, Lindner J, Magnuson MA, Drucker DJ, Leiter AB. Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY. Mol Cell Biol. 2005 May; 25(10):4189-99.
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        20. Lossi L, Bottarelli L, Candusso ME, Leiter AB, Rindi G, Merighi A. Transient expression of secretin in serotoninergic neurons of mouse brain during development. Eur J Neurosci. 2004 Dec; 20(12):3259-69.
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        21. Rindi G, Civallero M, Candusso ME, Marchetti A, Klersy C, Nano R, Leiter AB. Sudden onset of colitis after ablation of secretin-expressing lymphocytes in transgenic mice. Exp Biol Med (Maywood). 2004 Sep; 229(8):826-34.
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        22. Adams SH, Won WB, Schonhoff SE, Leiter AB, Paterniti JR. Effects of peptide YY[3-36] on short-term food intake in mice are not affected by prevailing plasma ghrelin levels. Endocrinology. 2004 Nov; 145(11):4967-75.
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        23. Schonhoff SE, Giel-Moloney M, Leiter AB. Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Dev Biol. 2004 Jun 15; 270(2):443-54.
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        24. Rindi G, Leiter AB, Kopin AS, Bordi C, Solcia E. The "normal" endocrine cell of the gut: changing concepts and new evidences. Ann N Y Acad Sci. 2004 Apr; 1014:1-12.
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        25. Schonhoff SE, Giel-Moloney M, Leiter AB. Minireview: Development and differentiation of gut endocrine cells. Endocrinology. 2004 Jun; 145(6):2639-44.
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        26. Wang G, Leiter AB, Englander EW, Greeley GH. Insulin-like growth factor I increases rat peptide YY promoter activity through Sp1 binding sites. Endocrinology. 2004 Feb; 145(2):659-66.
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        27. Cotta-de-Almeida V, Schonhoff S, Shibata T, Leiter A, Snapper SB. A new method for rapidly generating gene-targeting vectors by engineering BACs through homologous recombination in bacteria. Genome Res. 2003 Sep; 13(9):2190-4.
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        28. Ray SK, Nishitani J, Petry MW, Fessing MY, Leiter AB. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. Mol Cell Biol. 2003 Jan; 23(1):259-71.
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        29. Laforenza U, Gastaldi G, Rindi G, Leiter AB, Cova E, Marchetti A, Candusso ME, Autelli M, Orsenigo MN, Ventura U. PYY-Tag transgenic mice displaying abnormal (H+-K+)ATPase activity and gastric mucosal barrier impairment. Lab Invest. 2003 Jan; 83(1):47-54.
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        30. Ratineau C, Petry MW, Mutoh H, Leiter AB. Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. J Biol Chem. 2002 Mar 15; 277(11):8847-53.
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        31. Shih HH, Xiu M, Berasi SP, Sampson EM, Leiter A, Paulson KE, Yee AS. HMG box transcriptional repressor HBP1 maintains a proliferation barrier in differentiated liver tissue. Mol Cell Biol. 2001 Sep; 21(17):5723-32.
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        32. Ratineau C, Ronco A, Leiter AB. Role of the amino-terminal domain of simian virus 40 early region in inducing tumors in secretin-expressing cells in transgenic mice. Gastroenterology. 2000 Nov; 119(5):1305-11.
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        33. Mutoh H, Ratineau C, Ray S, Leiter AB. Review article: transcriptional events controlling the terminal differentiation of intestinal endocrine cells. Aliment Pharmacol Ther. 2000 Apr; 14 Suppl 1:170-5.
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        34. Rindi G, Ratineau C, Ronco A, Candusso ME, Tsai M, Leiter AB. Targeted ablation of secretin-producing cells in transgenic mice reveals a common differentiation pathway with multiple enteroendocrine cell lineages in the small intestine. Development. 1999 Sep; 126(18):4149-56.
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        35. Mutoh H, Naya FJ, Tsai MJ, Leiter AB. The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 1998 Mar 15; 12(6):820-30.
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        36. Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 1997 Sep 15; 11(18):2323-34.
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        37. Mutoh H, Fung BP, Naya FJ, Tsai MJ, Nishitani J, Leiter AB. The basic helix-loop-helix transcription factor BETA2/NeuroD is expressed in mammalian enteroendocrine cells and activates secretin gene expression. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3560-4.
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        38. Upchurch BH, Fung BP, Rindi G, Ronco A, Leiter AB. Peptide YY expression is an early event in colonic endocrine cell differentiation: evidence from normal and transgenic mice. Development. 1996 Apr; 122(4):1157-63.
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        39. Lopez MJ, Upchurch BH, Rindi G, Leiter AB. Studies in transgenic mice reveal potential relationships between secretin-producing cells and other endocrine cell types. J Biol Chem. 1995 Jan 13; 270(2):885-91.
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        40. Nishitani J, Rindi G, Lopez MJ, Upchurch BH, Leiter AB. Transcriptional regulation of secretin gene expression. J Clin Gastroenterol. 1995; 21 Suppl 1:S50-55.
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        41. Chang CH, Chey WY, Sun Q, Leiter A, Chang TM. Characterization of the release of cholecystokinin from a murine neuroendocrine tumor cell line, STC-1. Biochim Biophys Acta. 1994 Apr 28; 1221(3):339-47.
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        42. Upchurch BH, Aponte GW, Leiter AB. Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor. Development. 1994 Feb; 120(2):245-52.
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        43. Wheeler MB, Nishitani J, Buchan AM, Kopin AS, Chey WY, Chang TM, Leiter AB. Identification of a transcriptional enhancer important for enteroendocrine and pancreatic islet cell-specific expression of the secretin gene. Mol Cell Biol. 1992 Aug; 12(8):3531-9.
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        44. Kopin AS, Wheeler MB, Nishitani J, McBride EW, Chang TM, Chey WY, Leiter AB. The secretin gene: evolutionary history, alternative splicing, and developmental regulation. Proc Natl Acad Sci U S A. 1991 Jun 15; 88(12):5335-9.
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        45. Krasinski SD, Wheeler MB, Leiter AB. Isolation, characterization, and developmental expression of the rat peptide-YY gene. Mol Endocrinol. 1991 Mar; 5(3):433-40.
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        46. Kopin AS, Wheeler MB, Leiter AB. Secretin: structure of the precursor and tissue distribution of the mRNA. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2299-303.
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        47. Krasinski SD, Wheeler MB, Kopin AS, Leiter AB. Pancreatic polypeptide and peptide YY gene expression. Ann N Y Acad Sci. 1990; 611:73-85.
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        48. Kopin AS, Toder AE, Leiter AB. Different splice site utilization generates diversity between the rat and human pancreatic polypeptide precursors. Arch Biochem Biophys. 1988 Dec; 267(2):742-8.
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        49. Leiter AB, Toder A, Wolfe HJ, Taylor IL, Cooperman S, Mandel G, Goodman RH. Peptide YY. Structure of the precursor and expression in exocrine pancreas. J Biol Chem. 1987 Sep 25; 262(27):12984-8.
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        50. Goodman RH, Leiter A, Low MJ, Montminy MR, Tsukada T, Fink JS, Mandel G. Biosynthesis of pancreatic islet hormones. Hepatology. 1987 Jan-Feb; 7(1 Suppl):36S-41S.
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        51. Leiter AB, Montminy MR, Jamieson E, Goodman RH. Exons of the human pancreatic polypeptide gene define functional domains of the precursor. J Biol Chem. 1985 Oct 25; 260(24):13013-7.
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        52. Leiter AB, Keutmann HT, Goodman RH. Structure of a precursor to human pancreatic polypeptide. J Biol Chem. 1984 Dec 10; 259(23):14702-5.
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