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    Peter Novak PhD, MD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentNeurology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-2527
        Overview 
        Narrative

        1) Autonomic neuropathy in Parkinson’s disease and multiple system atrophy and dysautonomia in general. We are exploring a variety of approaches to the dynamic analysis of the autonomic nervous system and cerebral blood flow in dysautonomia. Another research interest includes evaluation of dermal innervation in autonomic neuropathy using markers of neurodegeneration. We also designed a single-center open label pilot study to evaluate the effect of IVIg in multiple system atrophy. The study is ongoing.

        2) Mechanisms of deep brain stimulation (DBS) in Parkinson disease. The purpose of this project is to clarify how the deep brain stimulation of the subthalamic nucleus (STN) interacts with underlying neuronal activity and how these changes affect the function of basal ganglia. This project utilizes computer modeling, and direct recordings of the neuronal activity during DBS to clarify the proposed mechanisms of DBS - inhibition, excitation or modulation of the STH activity.



        Bibliographic 
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        1. Ramirez-Zamora A, Levine D, Sommer DB, Dalfino J, Novak P, Pilitsis JG. Intraparenchymal cyst development after deep brain stimulator placement. Stereotact Funct Neurosurg. 2013; 91(5):338-41.
          View in: PubMed
        2. Novak P, Williams A, Ravin P, Zurkiya O, Abduljalil A, Novak V. Treatment of multiple system atrophy using intravenous immunoglobulin. BMC Neurol. 2012; 12:131.
          View in: PubMed
        3. Burrows AM, Ravin PD, Novak P, Peters ML, Dessureau B, Swearer J, Pilitsis JG. Limbic and motor function comparison of deep brain stimulation of the zona incerta and subthalamic nucleus. Neurosurgery. 2012 Mar; 70 Suppl Operative:ons125-31.
          View in: PubMed
        4. Novak P, Przybyszewski AW, Barborica A, Ravin P, Margolin L, Pilitsis JG. Localization of the subthalamic nucleus in Parkinson disease using multiunit activity. J Neurol Sci. 2011 Nov 15; 310(1-2):44-9.
          View in: PubMed
        5. Novak V, Zhao P, Manor B, Sejdic E, Alsop D, Abduljalil A, Roberson PK, Munshi M, Novak P. Adhesion molecules, altered vasoreactivity, and brain atrophy in type 2 diabetes. Diabetes Care. 2011 Nov; 34(11):2438-41.
          View in: PubMed
        6. Novak P. Quantitative autonomic testing. J Vis Exp. 2011; (53).
          View in: PubMed
        7. Rissanen SM, Kankaanpää M, Tarvainen MP, Novak V, Novak P, Hu K, Manor B, Airaksinen O, Karjalainen PA. Analysis of EMG and acceleration signals for quantifying the effects of deep brain stimulation in Parkinson's disease. IEEE Trans Biomed Eng. 2011 Sep; 58(9):2545-53.
          View in: PubMed
        8. Novak P. Assessment of sympathetic index from the Valsalva maneuver. Neurology. 2011 Jun 7; 76(23):2010-6.
          View in: PubMed
        9. Daniluk S, G Davies K, Ellias SA, Novak P, Nazzaro JM. Assessment of the variability in the anatomical position and size of the subthalamic nucleus among patients with advanced Parkinson's disease using magnetic resonance imaging. Acta Neurochir (Wien). 2010 Feb; 152(2):201-10; discussion 210.
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        10. Hajjar I, Zhao P, Alsop D, Abduljalil A, Selim M, Novak P, Novak V. Association of blood pressure elevation and nocturnal dipping with brain atrophy, perfusion and functional measures in stroke and nonstroke individuals. Am J Hypertens. 2010 Jan; 23(1):17-23.
          View in: PubMed
        11. Novak P, Klemp JA, Ridings LW, Lyons KE, Pahwa R, Nazzaro JM. Effect of deep brain stimulation of the subthalamic nucleus upon the contralateral subthalamic nucleus in Parkinson disease. Neurosci Lett. 2009 Sep 29; 463(1):12-6.
          View in: PubMed
        12. Daniluk S, Davies KG, Novak P, Vu T, Nazzaro JM, Ellias SA. Isolation of the brain-related factor of the error between intended and achieved position of deep brain stimulation electrodes implanted into the subthalamic nucleus for the treatment of Parkinson's disease. Neurosurgery. 2009 May; 64(5 Suppl 2):374-82; discussion 382-4.
          View in: PubMed
        13. Novak V, Haertle M, Zhao P, Hu K, Munshi M, Novak P, Abduljalil A, Alsop D. White matter hyperintensities and dynamics of postural control. Magn Reson Imaging. 2009 Jul; 27(6):752-9.
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        14. Novak P, Marya NB, Whren K, Bhawan J. Dermal sheet preparations in the evaluation of dermal innervation in Parkinson's disease and multiple system atrophy. J Cutan Pathol. 2009 Mar; 36(3):296-301.
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        15. Selim M, Jones R, Novak P, Zhao P, Novak V. The effects of body mass index on cerebral blood flow velocity. Clin Auton Res. 2008 Dec; 18(6):331-8.
          View in: PubMed
        16. Novak P, Daniluk S, Ellias SA, Nazzaro JM. Detection of the subthalamic nucleus in microelectrographic recordings in Parkinson disease using the high-frequency (> 500 hz) neuronal background. Technical note. J Neurosurg. 2007 Jan; 106(1):175-9.
          View in: PubMed
        17. Novak P, Novak V. Effect of step-synchronized vibration stimulation of soles on gait in Parkinson's disease: a pilot study. J Neuroeng Rehabil. 2006; 3:9.
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        18. Novak V, Chowdhary A, Abduljalil A, Novak P, Chakeres D. Venous cavernoma at 8 Tesla MRI. Magn Reson Imaging. 2003 Nov; 21(9):1087-9.
          View in: PubMed
        19. Chakeres DW, Abduljalil AM, Novak P, Novak V. Comparison of 1.5 and 8 tesla high-resolution magnetic resonance imaging of lacunar infarcts. J Comput Assist Tomogr. 2002 Jul-Aug; 26(4):628-32.
          View in: PubMed
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