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    Last Name

    John J Wixted MD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentOrthopedics and Physical Rehabilitation
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
        TitlesAssistant Professor of Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School
        Adult SpecialtiesOrthopedics
        Clinical InterestsAcute orthopedic trauma, deformity correction, fracture management, post-traumatic reconstruction
        Practice LocationUMass Memorial Medical Center - University Campus
        55 Lake Avenue North
        Worcester, MA 01655
        Appointments: 888-244-6094 Fax: 508-334-3408
        Primary HospitalUMass Memorial Medical Center
        Medical SchoolUniversity of Massachusetts Medical School 1997, Worcester, MA
        Board Certification
        Orthopedic Surgery
        ResidencyUMass Memorial Medical Center - UMass Graduate Medical Education
        FellowshipMassachusetts General Hospital (Orthopedic Trauma)

        selected publications
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        1. Dutta A, Li J, Lu H, Akech J, Pratap J, Wang T, Zerlanko BJ, Fitzgerald TJ, Jiang Z, Birbe R, Wixted J, Violette SM, Stein JL, Stein GS, Lian JB, Languino LR. Integrin avß6 Promotes an Osteolytic Program in Cancer Cells by Upregulating MMP2. Cancer Res. 2014 Mar 1; 74(5):1598-608.
          View in: PubMed
        2. Younghein JA, Eskander MS, DeAngelis NA, Wixted JJ. Three-part head-splitting proximal humerus fracture through a unicameral bone cyst. Orthopedics. 2012 Jun; 35(6):e988-90.
          View in: PubMed
        3. Wixted JJ. Patient transfers. J Orthop Trauma. 2011 Jun; 25(6):e60-1.
          View in: PubMed
        4. Pratap J, Akech J, Wixted JJ, Szabo G, Hussain S, McGee-Lawrence ME, Li X, Bedard K, Dhillon RJ, van Wijnen AJ, Stein JL, Stein GS, Westendorf JJ, Lian JB. The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss. Mol Cancer Ther. 2010 Dec; 9(12):3210-20.
          View in: PubMed
        5. Silva JA, McCormick JJ, Reed MA, Morse AS, Heffernan MJ, Lavado RD, Billiar K, Wixted JJ. Biomechanical effects of harvesting bone graft with the Reamer/Irrigator/Aspirator on the adult femur: a cadaver study. Injury. 2010 Nov; 41 Suppl 2:S85-9.
          View in: PubMed
        6. McCormick JJ, Li X, Weiss DR, Billiar KL, Wixted JJ. Biomechanical investigation of a novel ratcheting arthrodesis nail. J Orthop Surg Res. 2010; 5:74.
          View in: PubMed
        7. Wixted JJ, Fanning P, Rothkopf I, Stein G, Lian J. Arachidonic acid, eicosanoids, and fracture repair. J Orthop Trauma. 2010 Sep; 24(9):539-42.
          View in: PubMed
        8. Wixted JJ, Fanning PJ, Gaur T, O'Connell SL, Silva J, Mason-Savas A, Ayers DC, Stein GS, Lian JB. Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor. J Cell Physiol. 2009 Oct; 221(1):31-9.
          View in: PubMed
        9. Gaur T, Wixted JJ, Hussain S, O'Connell SL, Morgan EF, Ayers DC, Komm BS, Bodine PV, Stein GS, Lian JB. Secreted frizzled related protein 1 is a target to improve fracture healing. J Cell Physiol. 2009 Jul; 220(1):174-81.
          View in: PubMed
        10. Anderson SA, Li X, Franklin P, Wixted JJ. Ankle fractures in the elderly: initial and long-term outcomes. Foot Ankle Int. 2008 Dec; 29(12):1184-8.
          View in: PubMed
        11. Pratap J, Wixted JJ, Gaur T, Zaidi SK, Dobson J, Gokul KD, Hussain S, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells. Cancer Res. 2008 Oct 1; 68(19):7795-802.
          View in: PubMed
        12. DeAngelis NA, Wixted JJ, Drew J, Eskander MS, Eskander JP, French BG. Use of the trauma pelvic orthotic device (T-POD) for provisional stabilisation of anterior-posterior compression type pelvic fractures: a cadaveric study. Injury. 2008 Aug; 39(8):903-6.
          View in: PubMed
        13. Marturano JE, Cleveland BC, Byrne MA, O'Connell SL, Wixted JJ, Billiar KL. An improved murine femur fracture device for bone healing studies. J Biomech. 2008; 41(6):1222-8.
          View in: PubMed
        14. Wixted JJ, Reed M, Eskander MS, Millar B, Anderson RC, Bagchi K, Kaur S, Franklin P, Leclair W. The effect of an orthopedic trauma room on after-hours surgery at a level one trauma center. J Orthop Trauma. 2008 Apr; 22(4):234-6.
          View in: PubMed
        15. Weiss DR, Wixted JJ, Anderson RC. Computer-aided surgery: assessing the accuracy of a navigation system. Orthopedics. 2008 Mar; 31(3):247-50.
          View in: PubMed
        16. Bhattacharyya T, McCarty LP, Harris MB, Morrison SM, Wixted JJ, Vrahas MS, Smith RM. The posterior shearing tibial plateau fracture: treatment and results via a posterior approach. J Orthop Trauma. 2005 May-Jun; 19(5):305-10.
          View in: PubMed
        17. Owens BD, Wixted JJ, Cook J, Teebagy AK. Intramedullary transmetatarsal Kirschner wire fixation of Lisfranc fracture-dislocations. Am J Orthop (Belle Mead NJ). 2003 Aug; 32(8):389-91.
          View in: PubMed
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