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    April C Deng MD, PhD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPathology
    AddressUniversity of Massachusetts Medical School
    One Innovation Drive, Biotech Three
    Worcester MA 01605
    Phone508-793-6188
        Overview 
        Narrative

        Academic Background

        MD - HenanMedical University, ZhengZhou,China 1978-1983.

        MS - Department of Pathophysiology,HenanMedical University, ZhengZhou, China. 1983-1986.

        PhD - Department of Physiology & Biophysics,University of Arkansas Medical center, Little Rock, AR 1989-1994.

        Postdoctoral Research Fellow - Department of Medicine,University of RochesterMedical Center,Rochester, NY. 1994-1996

        Resident (Anatomic and Clinical Pathology) - Department of Pathology,University Rochester Medical Center,Rochester, NY1996-2001

        Fellowship in Dermatopathology - Department of Pathology,Ohio State University Medical Center, Columbus, OH 2001-2002

        Attending Physician, Assistant Professor, Director of Dermatopathology - Dermatology Department, University of Maryland School of Medicine, Baltimore, MD 2002-2007

        Dr. Deng's pictureResearch Interests:

        As a dermatopathologist, my first and most important task is to provide accurate and timely pathology diagnosis on skin biopsies to assist dermatologists and other clinicians to achieve high quality patient care for cutaneous diseases. I have been an academician during my entire career and enjoy providing a high standard educational experience for medical students, pathology and dermatology residents, and dermatopathology fellows. With a MS in pathophysiology and PhD in molecular biology, I am interested in the pathogenesis of skin malignancies such as melanoma, non-melanocytic tumors, and lymphoma. I strive to advance medical knowledge through basic and clinical research, and the translation of advances from the laboratory to clinical practice.



        Bibliographic 
        selected publications
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        1. Cornejo KM, Hutchinson L, Deng A, Tomaszewicz K, Welch M, Lyle S, Dresser K, Cosar EF. BRAF/KRAS gene sequencing of sebaceous neoplasms after mismatch repair protein analysis. Hum Pathol. 2014 Jun; 45(6):1213-20.
          View in: PubMed
        2. Rashighi M, Agarwal P, Richmond JM, Harris TH, Dresser K, Su MW, Zhou Y, Deng A, Hunter CA, Luster AD, Harris JE. CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo. Sci Transl Med. 2014 Feb 12; 6(223):223ra23.
          View in: PubMed
        3. Snadecki H, Criscione V, Jaquith A, Hay B, Deng A, Wiss K. Dystrophic epidermolysis bullosa associated with amniotic band syndrome. Pediatr Dermatol. 2014 Mar; 31(2):212-6.
          View in: PubMed
        4. Cornejo KM, Hutchinson L, Cosar EF, Smith T, Tomaszewicz K, Dresser K, Deng A. Is it a primary or metastatic melanocytic neoplasm of the central nervous system?: A molecular based approach. Pathol Int. 2013 Nov; 63(11):559-64.
          View in: PubMed
        5. Cornejo KM, Deng A. Pilomatrix carcinoma: a case report and review of the literature. Am J Dermatopathol. 2013 May; 35(3):389-94.
          View in: PubMed
        6. Cornejo KM, Deng AC. Malignant melanoma within squamous cell carcinoma and basal cell carcinoma: is it a combined or collision tumor?--a case report and review of the literature. Am J Dermatopathol. 2013 Apr; 35(2):226-34.
          View in: PubMed
        7. Sagransky MJ, Deng AC, Magro CM. Primary cutaneous langerhans cell sarcoma: a report of four cases and review of the literature. Am J Dermatopathol. 2013 Apr; 35(2):196-204.
          View in: PubMed
        8. Le LP, Dias-Santagata D, Pawlak AC, Cosper AK, Nguyen AT, Selim MA, Deng A, Horick NK, Iafrate AJ, Mihm MC, Hoang MP. Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses. PLoS One. 2012; 7(10):e47290.
          View in: PubMed
        9. Janko M, Ontiveros F, Fitzgerald TJ, Deng A, DeCicco M, Rock KL. IL-1 generated subsequent to radiation-induced tissue injury contributes to the pathogenesis of radiodermatitis. Radiat Res. 2012 Sep; 178(3):166-72.
          View in: PubMed
        10. Summe HS, Greenlaw SM, Deng A, Magro C, Wiss K. Generalized spinous follicular lichen nitidus with perifollicular granulomas. Pediatr Dermatol. 2013 May-Jun; 30(3):e20-1.
          View in: PubMed
        11. Deng A, Lowitt M. Acute generalized erythematous pustulosis occurring with Hailey-Hailey disease. Skinmed. 2012 Jul-Aug; 10(4):251-3.
          View in: PubMed
        12. Corey K, Levin NA, Hure M, Deng A, Mailhot J. Eruption of bullae within psoriatic plaques: a rare adverse effect of narrow-band ultraviolet B (NB-UVB) phototherapy. Dermatol Online J. 2012 Jun; 18(6):3.
          View in: PubMed
        13. Walls AC, Deng A, Geist DE. Mohs micrographic surgery for recurrent chondroid syringoma of the eyebrow. Dermatol Surg. 2012 May; 38(5):800-2.
          View in: PubMed
        14. Miller DD, Emley A, Yang S, Richards JE, Lee JE, Deng A, Hoang MP, Mahalingam M. Mixed versus pure variants of desmoplastic melanoma: a genetic and immunohistochemical appraisal. Mod Pathol. 2012 Apr; 25(4):505-15.
          View in: PubMed
        15. McEnery-Stonelake M, Deng A, Case C, Levin NA. Asymptomatic vesicular eruption on the chest in a breast cancer survivor. Diagnosis: Benign lymphangiomatous papules (BLAP) of the skin following radiotherapy. Arch Dermatol. 2011 Dec; 147(12):1443, 1448.
          View in: PubMed
        16. Foley E, Greenlaw SM, Givan J, Deng A, Maloney M, Geist DE. Dermal melanoma in a transplant patient. J Drugs Dermatol. 2011 Jul; 10(7):808-9.
          View in: PubMed
        17. Tam CC, Dare DM, DiGiovanni JJ, Harrington AC, Deng AC. Recurrent and metastatic primary cutaneous mucinous carcinoma after excision and Mohs micrographic surgery. Cutis. 2011 May; 87(5):245-8.
          View in: PubMed
        18. Alisjahbana B, Dinata R, Sutedja E, Suryahudaya I, Soedjana H, Hidajat NN, Soetikno RD, Oktaliansah E, Deng A, Rady P, Tyring S, Gaspari AA. Disfiguring generalized verrucosis in an indonesian man with idiopathic CD4 lymphopenia. Arch Dermatol. 2010 Jan; 146(1):69-73.
          View in: PubMed
        19. Bremmer M, Deng A, Gaspari AA. A mechanism-based classification of dermatologic reactions to biologic agents used in the treatment of cutaneous disease: Part 2. Dermatitis. 2009 Sep-Oct; 20(5):243-56.
          View in: PubMed
        20. Bremmer M, Deng A, Gaspari AA. A mechanism-based classification of dermatologic reactions to biologic agents used in the treatment of cutaneous disease: Part 1. Dermatitis. 2009 Jul-Aug; 20(4):182-92.
          View in: PubMed
        21. Sina B, Kao GF, Deng AC, Gaspari AA. Skin biopsy for inflammatory and common neoplastic skin diseases: optimum time, best location and preferred techniques. A critical review. J Cutan Pathol. 2009 May; 36(5):505-10.
          View in: PubMed
        22. Bremmer M, Deng A, Martin DB. Spontaneous eruptive keloid-like cutaneous lesions in a renal transplant patient: a form of nephrogenic systemic fibrosis? J Dermatolog Treat. 2009; 20(1):63-6.
          View in: PubMed
        23. Cedeno-Laurent F, Bryant J, Fishelevich R, Jones OD, Deng A, Eng ML, Gaspari AA, Trujillo JR. Inflammatory papillomatous hyperplasia and epidermal necrosis in a transgenic rat for HIV-1. J Dermatol Sci. 2009 Feb; 53(2):112-9.
          View in: PubMed
        24. Paltiel M, Gober LM, Deng A, Mikdashi J, Alexeeva I, Saini SS, Gaspari AA. Immediate type I hypersensitivity response implicated in worsening injection site reactions to adalimumab. Arch Dermatol. 2008 Sep; 144(9):1190-4.
          View in: PubMed
        25. David C, Martin DB, Deng A, Cooper JZ. Disseminated Trichosporon inkin and Histoplasma capsulatum in a patient with newly diagnosed AIDS. J Am Acad Dermatol. 2008 Aug; 59(2 Suppl 1):S13-5.
          View in: PubMed
        26. Deng A, Lee W, Pfau R, Harrington A, DiGiovani J, Prickett KA, Dare DM, Petrali JP. Primary cutaneous Langerhans cell sarcoma without Birbeck granules: indeterminate cell sarcoma? J Cutan Pathol. 2008 Sep; 35(9):849-54.
          View in: PubMed
        27. Zhao Y, Fishelevich R, Petrali JP, Zheng L, Anatolievna MA, Deng A, Eckert RL, Gaspari AA. Activation of keratinocyte protein kinase C zeta in psoriasis plaques. J Invest Dermatol. 2008 Sep; 128(9):2190-7.
          View in: PubMed
        28. Deng AC, Bilu Martin D, Bilu DM, Sina B, Gaspari A. Localized nephrogenic fibrosing dermopathy: Aberrant dermal repairing? J Am Acad Dermatol. 2008 Feb; 58(2):336-9.
          View in: PubMed
        29. Jacobson S, Martin DB, Deng A, Cooper JZ. Pyoderma gangrenosum following tattoo placement in a patient with acute myelogenous leukemia. J Dermatolog Treat. 2008; 19(1):58-60.
          View in: PubMed
        30. Dawn ME, Deng AC, Petrali J, Wessely C, Jaffe D, Gaspari AA. Familial cutaneous collagenoma. Skinmed. 2008 Jan-Feb; 7(1):43-5.
          View in: PubMed
        31. Markowski TR, Martin DB, Kao GF, Lutz L, Deng A, Gaspari AA. Leukemia cutis: a presenting sign in acute promyelocytic leukemia. Arch Dermatol. 2007 Sep; 143(9):1220-1.
          View in: PubMed
        32. Sina B, Deng A. Umbilical metastasis from prostate carcinoma (Sister Mary Joseph's nodule): a case report and review of literature. J Cutan Pathol. 2007 Jul; 34(7):581-3.
          View in: PubMed
        33. Sri JC, Tsai CL, Deng A, Gaspari AA. Osteomyelitis occurring during infliximab treatment of severe psoriasis. J Drugs Dermatol. 2007 Feb; 6(2):207-10.
          View in: PubMed
        34. Sterling JB, Sina B, Gaspari A, Deng A. Acne keloidalis: a novel presentation for tinea capitis. J Am Acad Dermatol. 2007 Apr; 56(4):699-701.
          View in: PubMed
        35. Bilu Martin D, Deng A, Gaspari A, Pearson F. Perinuclear antineutrophil cytoplasmic antibody-associated vasculitis in a patient with Graves' disease treated with methimazole. Skinmed. 2006 Nov-Dec; 5(6):302-5.
          View in: PubMed
        36. Deng A, Gocke CD, Hess J, Heyman M, Paltiel M, Gaspari A. Livedoid vasculopathy associated with plasminogen activator inhibitor-1 promoter homozygosity (4G/4G) treated successfully with tissue plasminogen activator. Arch Dermatol. 2006 Nov; 142(11):1466-9.
          View in: PubMed
        37. Magro CM, Morrison CD, Heerema N, Porcu P, Sroa N, Deng AC. T-cell prolymphocytic leukemia: an aggressive T cell malignancy with frequent cutaneous tropism. J Am Acad Dermatol. 2006 Sep; 55(3):467-77.
          View in: PubMed
        38. Kouba DJ, Dasgeb B, Deng AC, Gaspari AA. Effective treatment of persistent Grover's disease with trichloroacetic acid peeling. Dermatol Surg. 2006 Aug; 32(8):1083-8; discussion 1088.
          View in: PubMed
        39. Stranahan D, Rausch D, Deng A, Gaspari A. The role of intradermal skin testing and patch testing in the diagnosis of autoimmune progesterone dermatitis. Dermatitis. 2006 Mar; 17(1):39-42.
          View in: PubMed
        40. Deng A, Harvey V, Sina B, Strobel D, Badros A, Junkins-Hopkins JM, Samuels A, Oghilikhan M, Gaspari A. Interstitial granulomatous dermatitis associated with the use of tumor necrosis factor alpha inhibitors. Arch Dermatol. 2006 Feb; 142(2):198-202.
          View in: PubMed
        41. Deng A, Petrali J, Jaffe D, Sina B, Gaspari A. Benign cutaneous pseudoglandular schwannoma: a case report. Am J Dermatopathol. 2005 Oct; 27(5):432-5.
          View in: PubMed
        42. Sachdeva M, Frambach GE, Crowson AN, Deng AC, Mihm MC, Magro CM. De novo intraepidermal epithelioid melanocytic dysplasia as a marker of the atypical mole phenotype -- a clinical and pathological study of 75 patients. J Cutan Pathol. 2005 Oct; 32(9):622-8.
          View in: PubMed
        43. Chen M, Deng A, Crowson AN, Srinivasan M, Yearsley KH, Jewell S, Morrison C, Long S, Werling R, Magro C. Assessment of T-cell clonality via T-cell receptor-gamma rearrangements in cutaneous T-cell-dominant infiltrates using polymerase chain reaction and single-stranded DNA conformational polymorphism assay. Appl Immunohistochem Mol Morphol. 2004 Dec; 12(4):373-9.
          View in: PubMed
        44. Magro CM, Deng A, Pope-Harman A, Waldman WJ, Bernard Collins A, Adams PW, Kelsey M, Ross P. Humorally mediated posttransplantation septal capillary injury syndrome as a common form of pulmonary allograft rejection: a hypothesis. Transplantation. 2002 Nov 15; 74(9):1273-80.
          View in: PubMed
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