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    Last Name

    Valerie M Cairns PHD

    TitleResearch Assistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMicrobiology and Physiological Systems
    AddressUniversity of Massachusetts Medical School
    373 Plantation Street
    Worcester MA 01605
        Academic Background

        2006 -PresentAssistant Professor, Physiology Biomedical Imaging Group, University of MassachusettsMedical School, Worcester, MA, U.S.A.
        2000-2006Postdoctoral Research Associate, Dept. Physiology Biomedical Imaging Group, University of Massachusetts Medical School, Worcester, MA, U.S.A.
        2000Ph.D. in Physiology from Faculté des Sciences de Tours, France
        1996-2000Graduate Student at UMR-CNRS 6542: Physiologie des Cellules Cardiaques et Vasculaires. Tours, France
        1996Bachelors of Science (Maitrise of Physiology, Montpellier, France)

        Research Interest:valerie

        Calcium signaling in neuronal cells.

        More specifically, the study of the regulation of transient localized intracellular calcium signals using high-speed fluorescence imaging techniques. I examine the physiological function and regulation of these calcium signals. Using electrophysiological techniques such as patch-clamp, membrane capacitance measurement and amperometry, I investigate the mechanisms by which these localized calcium signals activate ion transport and neurotransmitter secretion across cell membranes. The simultaneous acquisition of fluorescent images and electrophysiological data facilitates our further understanding of the processes involved in calcium control of cell function. That study is associated with molecular biology techniques involving antibodies such as immunocytochemestry and western blot.

        selected publications
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        1. De Crescenzo V, Fogarty KE, Lefkowitz JJ, Bellve KD, Zvaritch E, MacLennan DH, Walsh JV. Type 1 ryanodine receptor knock-in mutation causing central core disease of skeletal muscle also displays a neuronal phenotype. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):610-5.
          View in: PubMed
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