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    Last Name

    Marcus P Cooper MD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    AddressUniversity of Massachusetts Medical School
    381 Plantation Street
    Worcester MA 01605
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMillennium MD/PhD Program



        Osler Medical Service Department of Medicine (Baltimore, MD)


        Division of Cardiovascular Medicine
        Brigham and Women’s Hospital/Massachusetts General Hospital


        Award for Excellence in Graduate and Undergraduate Medical Education (UMass Medical School) (2012)
        Alpha Omega Alpha (1999)
        Phi Beta Kappa (1999)
        Four Schools Physician-Scientist Program, (1999)
        Magna Cum Laude (1990)
        Who's Who Among American College Students (1990)
        Outstanding Biology Senior Award (1990)
        Alpha Chi Honor Society (1988)
        Freshman Chemistry Award (1987)
        Tri-Beta Biological Honor Society (1987)

        Current Research

        Our mission is to discern and manipulate transcriptional pathways that reduce obesity. Because obesity predisposes to heart disease and diabetes, manipulating pathways that mitigate obesity are anticipated to reduce type 2 diabetes and heart disease. Influencing mitochodnrial transcription in various tissues, including liver, brown fat and muscle, exerts potent control over energy metabolism and fatty acid oxidation. Current projects focus on dicphering underlying mechanisms whereby altered mitochondrial transcription influences insulin senstivity and energy metabolism. Our goal is to activate these pathways and build more efficient mitochondria, enhanced mitocondria poised to handle metaoblic stress imposed by obesity and diabetes.

        Rotation Projects
        (2) Decipher mechanism by which mitochodnrial transcription enhances energy metabolism and fatty acid oxidation: Using mouse and cell based models, this project will determine the pathways downstream of activating mitochondrial transcription. Notably, how do more efficient mitochondria protect against disease?

        (1) Identification of new regulators of mitochondrial transcription: Using a high through screen strategy, this project endeavors to identify new factors that influence mitochodrial transcription. Though discovery driven, the technical aspects of project have already been resolved; hence, this project will likely reach completion in a single rotation.

        The Cooper Lab has rotations available.

        selected publications
        List All   |   Timeline
        1. Akie TE, Cooper MP. Determination of Fatty Acid Oxidation and Lipogenesis in Mouse Primary Hepatocytes. J Vis Exp. 2015; (102).
          View in: PubMed
        2. Nam M, Cooper MP. Role of Energy Metabolism in the Brown Fat Gene Program. Front Endocrinol (Lausanne). 2015; 6:104.
          View in: PubMed
        3. Akie TE, Liu L, Nam M, Lei S, Cooper MP. OXPHOS-Mediated Induction of NAD+ Promotes Complete Oxidation of Fatty Acids and Interdicts Non-Alcoholic Fatty Liver Disease. PLoS One. 2015; 10(5):e0125617.
          View in: PubMed
        4. Liu L, Nam M, Fan W, Akie TE, Hoaglin DC, Gao G, Keaney JF, Cooper MP. Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation. J Clin Invest. 2014 Feb 3; 124(2):768-84.
          View in: PubMed
        5. Jung DY, Chalasani U, Pan N, Friedline RH, Prosdocimo DA, Nam M, Azuma Y, Maganti R, Yu K, Velagapudi A, O'Sullivan-Murphy B, Sartoretto JL, Jain MK, Cooper MP, Urano F, Kim JK, Gray S. KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. PLoS One. 2013; 8(10):e77851.
          View in: PubMed
        6. Shimasaki Y, Pan N, Messina LM, Li C, Chen K, Liu L, Cooper MP, Vita JA, Keaney JF. Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics. Circ Res. 2013 Sep 13; 113(7):891-901.
          View in: PubMed
        7. Cooper MP. Interplay of mitochondrial biogenesis and oxidative stress in heart failure. Circulation. 2013 May 14; 127(19):1932-4.
          View in: PubMed
        8. Pan D, Mao C, Zou T, Yao AY, Cooper MP, Boyartchuk V, Wang YX. The histone demethylase Jhdm1a regulates hepatic gluconeogenesis. PLoS Genet. 2012; 8(6):e1002761.
          View in: PubMed
        9. Zhang Z, Zhang W, Jung DY, Ko HJ, Lee Y, Friedline RH, Lee E, Jun J, Ma Z, Kim F, Tsitsilianos N, Chapman K, Morrison A, Cooper MP, Miller BA, Kim JK. TRPM2 Ca2+ channel regulates energy balance and glucose metabolism. Am J Physiol Endocrinol Metab. 2012 Apr 1; 302(7):E807-16.
          View in: PubMed
        10. Liu L, Sanosaka M, Lei S, Bestwick ML, Frey JH, Surovtseva YV, Shadel GS, Cooper MP. LRP130 protein remodels mitochondria and stimulates fatty acid oxidation. J Biol Chem. 2011 Dec 2; 286(48):41253-64.
          View in: PubMed
        11. Cooper MP, Keaney JF. Epigenetic control of angiogenesis via DNA methylation. Circulation. 2011 Jun 28; 123(25):2916-8.
          View in: PubMed
        12. Xu J, Lai KK, Verlinsky A, Lugea A, French SW, Cooper MP, Ji C, Tsukamoto H. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol. 2011 Sep; 55(3):673-82.
          View in: PubMed
        13. Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM. Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. Diabetes. 2009 Jul; 58(7):1499-508.
          View in: PubMed
        14. Cooper MP, Uldry M, Kajimura S, Arany Z, Spiegelman BM. Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. J Biol Chem. 2008 Nov 14; 283(46):31960-7.
          View in: PubMed
        15. Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008 May 15; 22(10):1397-409.
          View in: PubMed
        16. Cooper MP, Qu L, Rohas LM, Lin J, Yang W, Erdjument-Bromage H, Tempst P, Spiegelman BM. Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes Dev. 2006 Nov 1; 20(21):2996-3009.
          View in: PubMed
        17. Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, J├Ąger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004 Oct 1; 119(1):121-35.
          View in: PubMed
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