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    Jaishree T Narayanan MD, PhD

    TitleClinical Associate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentNeurology
    AddressUMass Memorial Medical Center
    119 Belmont Street
    Worcester MA 01605
    Phone508-334-3023
        Overview 
        Narrative

        1) Modification of anti-epileptic medication binding to P-glycoprotein

        Computational modeling of P-GP, molecular dynamics and study of binding mechanisms to anti-epileptic medications as well as inhibition techniques

        2) Frequency flow analysis of EEG to detect and suppress seizures

        Frequency flow analysis of EEG for seizure prediction and design of a suppression sequence

        3) Effect of treatment of PLEDS on patient outcome

        Study the risk-benefits of treating patients with non-anoxic PLEDS on their EEG

        4) Efficacy of verapamil in medically refractory epilepsy

        Determine if low dose verapamil, a P-glycoprotein inhibitor can improve seizure control in patients with medically refractory epilepsy

        5) Treatment of patients with post-hypothermia PEDS

        Study the risk-benefits of aggressively treating patients with PEDS on their EEG, after hypothermia for cardiac arrest

        6) A randomized clinical trial for treatment of refractory status epilepticus.

        Determine if Propofol or pentobarbital is better for treatment of refractory status epilepticus.



        Bibliographic 
        selected publications
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        1. Williamson JR, Bliss DW, Browne DW, Narayanan JT. Seizure prediction using EEG spatiotemporal correlation structure. Epilepsy Behav. 2012 Oct; 25(2):230-8.
          View in: PubMed
        2. Indic P, Narayanan J. Dynamics of frequency flow in epileptic brain during extra-temporal partial and idiopathic generalized epilepsy. Epilepsy Res. 2012 Mar; 99(1-2):176-9.
          View in: PubMed
        3. Indic P, Narayanan J. Wavelet based algorithm for the estimation of frequency flow from electroencephalogram data during epileptic seizure. Clin Neurophysiol. 2011 Apr; 122(4):680-6.
          View in: PubMed
        4. Indic P, Narayanan J. Frequency flow dynamics of epileptic brain. Int J Neurosci. 2010 Mar; 120(3):222-5.
          View in: PubMed
        5. Narayanan JT, Labar DR, Schaul N. Latency to first spike in the EEG of epilepsy patients. Seizure. 2008 Jan; 17(1):34-41.
          View in: PubMed
        6. Narayanan JT, Murthy JM. Nonconvulsive status epilepticus in a neurological intensive care unit: profile in a developing country. Epilepsia. 2007 May; 48(5):900-6.
          View in: PubMed
        7. Narayanan JT, Murthy JM. New-onset acute symptomatic seizure in a neurological intensive care unit. Neurol India. 2007 Apr-Jun; 55(2):136-40.
          View in: PubMed
        8. Narayanan JT, Watts R, Haddad N, Labar DR, Li PM, Filippi CG. Cerebral activation during vagus nerve stimulation: a functional MR study. Epilepsia. 2002 Dec; 43(12):1509-14.
          View in: PubMed
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