Nanyin Zhang PhD
|Institution||University of Massachusetts Medical School|
|Address||Penn State University|
201 Old Main Street
University Park PA 16802
|Institution||UMMS - Graduate School of Biomedical Sciences|
2005Ph.D.University of Minnesota, USA (Biomedical Engineering)
2000B.Eng.Zhejiang University, China (Biomedical Engineering)
2009~present Assistant Professor University of Massachusetts
2008~2009Research Assistant ProfessorUniversity of Minnesota
2006~2008Research AssociateUniversity of Minnesota
2005~2006 Postdoctoral AssociateUniversity of Minnesota
Functional Magnetic Resonance Imaging
Functional Magnetic Resonance Imaging (fMRI) is a technique that can noninvasively map brain activation with a very high spatial resolution and a large field of view. This technique, which has been widely used for investigating various brain functions, is based on locally coupled neuronal activity and hemodynamic changes (also called neurovascular coupling). At activated brain regions, cerebral blood flow increases overcompensate oxygen consumption rate increases in response to a higher demand of energy, resulting in a local oxygenation level change which can be detected in MR images. Therefore, the signal source of fMRI is termed the blood-oxygenation-level dependent (BOLD) signal.
The research in our lab encompasses both the mechanism of fMRI and fMRI applications. Specifically, our research is designed to quantitatively bridge the gap between the BOLD signal and the underlying neuronal activity by using simultaneous multi-modal (EEG and fMRI) acquisition. We also study the mechanism and spatiotemporal characteristics of the BOLD signal. We have the ability of obtaining high-resolution fMRI on a submillimeter scale so that we can map elementary functional structures (e.g. columns) in the brain. By designing novel paradigms, we are developing approaches to extract fast temporal information (in tens to hundreds of milliseconds) of neural interaction using the slow BOLD signal.
Resting State and psychiatric disorders
Normal brain consists of numerous neural networks coordinately working together. For the brain to function properly, the activities of these neural networks need to harmonize sequentially or concurrently while electrophysiological signals propagate along different neuronal groups. As a result, investigating the functions of neural networks and their relationships plays a fundamental role in neuroscience. This task is conventionally explored with studies of the brain responses to carefully controlled sensory, cognitive and motor events. Nevertheless, a series of recent studies demonstrate patterned activities exist within various brain networks during resting and passive task states. Distributed brain regions spontaneously increase and decrease their activity together within functional-anatomic networks, even under anesthesia. These studies led to a hypothesis that the human brain is intrinsically organized into dynamic, anti-correlated functional networks.
In our lab, we use fMRI to investigate resting state functional connectivity in several animal models. Our research is designed to examine whether connectivity among various brain regions will change in different psychiatric disease models.
Potential Rotation Projects
Investigate functional connectivity change in different animal models using fMRI. The student will have the opportunity of learn to operate MR scanner, understand the mechanism of fMRI and conduct animal experiments.
Postdoctoral Research Fellow in NeuroImaging
The Center for Comparative NeuroImaging (CCNI) is a neuroimaginginitiative in the Department of Psychiatry at the University of MassachusettsMedical School with a focus on the exploration of neurologic and psychiatricdisorders and co-morbidities. The CCNI houses a 4.7T Bruker animal scanner andhas access to a 3T Phillips human scanner.
The CCNI invites applications for a Post-Doctoral Fellow position.Specifically, the studies in the CCNI utilize fMRI to identify and monitorneuronal mechanism associated with dysfunction in emotional, behavioral andcognitive processes in humans and animal models of mental health disorders.Candidates must have strong research background in MR techniques andtechnology, preferable resting-state fMRI and task-based fMRI.
Applicants should send a CV and application letter to Nanyin Zhang, Ph.D at Nanyin.Zhang@umassmed.edu.
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