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    Last Name

    Jeffrey A Bailey MD, PhD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
      Other Positions
      InstitutionUMMS - School of Medicine

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBioinformatics and Computational Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentImmunology and Virology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentBioinformatics and Integrative Biology


        Jeffrey Bailey graduated from Saint Olaf College (Northfield Minnesota) in 1989 with a B.A. in Biology Suma Cum Laude. He then pursued volunteer work as a science and math teacher in Liberia and Botswana with the United States Peace Corps. He returned to the United States and entered the Medical Scientist Training Program at Case Western Reserve University. He received his PhD in Genetics characterizing and studying segmental duplications within the human genome in the laboratory of Dr. Evan Eichler. His postdoctoral research has focused on the detection and analysis of copy number variation—particularly in relationship to segmental duplications. After receiving his MD in 2005, he completed a residency in Clinical Pathology at Case Medical Center in Cleveland and the Cleveland City-wide Transfusion Medicine Fellowship. In August of 2009, Dr. Bailey joined the faculty as a tenure-track assistant professor in the Program in Bioinformatics and Integrative Biology. He continues to pursue clinical medicine in the Division of Transfusion Medicine. He is Board certified in Clinical Pathology.

        Our overall research focus involves understanding the role of segmental duplication and copy number variation in human disease susceptibility and pathogenesis. Segmental duplications, blocks of transposed genomic DNA within or between chromosomes, have long been recognized as an important substrate for the evolution of novel genes. As a result of the human genome project, they are now generally recognized as a significant source of copy number variation (variation between normal individuals) that can impact human disease. We are optimizing both experimental and computational approaches for the assessment of copy number variation within the context of several specific diseases. Utilizing technologies such as array comparative genomic hybridization and massively-parallel sequencing we hope to gain novel insight into etiologic and pathogenic mechanisms.

        One focus of the lab is directed towards dissecting the role of copy number variation in the pathogenesis of malaria. Malaria has been one of the strongest selective forces affecting the human population and still accounts for an estimated two to three million deaths per year. Another focus of the lab isexamining the role of copy number variation in amyotrophic lateral sclerosis (ALS) or Lou Gehrig disease. We are collaborating with Dr. Robert Brown here at UMass to identify copy number variants affecting susceptibility and/or disease progression.

        Rotation Projects

        Rotation projects are available related to the evolution of segmental duplications and copy number variation and/or examination of the role of copy number variation in disease

        selected publications
        List All   |   Timeline
        1. Van Treuren W, Ponnusamy L, Brinkerhoff RJ, Gonzalez A, Parobek CM, Juliano JJ, Andreadis TG, Falco RC, Ziegler LB, Hathaway N, Keeler C, Emch M, Bailey JA, Roe RM, Apperson CS, Knight R, Meshnick SR. Variation in the Microbiota of Ixodes Ticks with Regard to Geography, Species, and Sex. Appl Environ Microbiol. 2015 Sep 15; 81(18):6200-9.
          View in: PubMed
        2. Lin JT, Hathaway NJ, Saunders DL, Lon C, Balasubramanian S, Kharabora O, Gosi P, Sriwichai S, Kartchner L, Chuor CM, Satharath P, Lanteri C, Bailey JA, Juliano JJ. Using Amplicon Deep Sequencing to Detect Genetic Signatures of Plasmodium vivax Relapse. J Infect Dis. 2015 Sep 15; 212(6):999-1008.
          View in: PubMed
        3. Galera P, Martin HC, Welch L, Sulmasy P, Cerny J, Greene M, Vauthrin M, Bailey JA, Weinstein R. Automated red blood cell exchange for acute drug removal in a patient with sirolimus toxicity. J Clin Apher. 2015 Dec; 30(6):367-70.
          View in: PubMed
        4. Weinstein R, Simard A, Ferschke J, Vauthrin M, Bailey JA, Greene M. Prospective surveillance of D- recipients of D+ apheresis platelets: alloimmunization against D is not detected. Transfusion. 2015 Jun; 55(6):1327-30.
          View in: PubMed
        5. Taylor SM, Parobek CM, DeConti DK, Kayentao K, Coulibaly SO, Greenwood BM, Tagbor H, Williams J, Bojang K, Njie F, Desai M, Kariuki S, Gutman J, Mathanga DP, MÃ¥rtensson A, Ngasala B, Conrad MD, Rosenthal PJ, Tshefu AK, Moormann AM, Vulule JM, Doumbo OK, Ter Kuile FO, Meshnick SR, Bailey JA, Juliano JJ. Absence of Putative Artemisinin Resistance Mutations Among Plasmodium falciparum in Sub-Saharan Africa: A Molecular Epidemiologic Study. J Infect Dis. 2015 Mar 1; 211(5):680-8.
          View in: PubMed
        6. Oduor CI, Chelimo K, Ouma C, Mulama DH, Foley J, Vulule J, Bailey JA, Moormann AM. Interleukin-6 and interleukin-10 gene promoter polymorphisms and risk of endemic Burkitt lymphoma. Am J Trop Med Hyg. 2014 Sep; 91(3):649-54.
          View in: PubMed
        7. Parobek CM, Bailey JA, Hathaway NJ, Socheat D, Rogers WO, Juliano JJ. Differing patterns of selection and geospatial genetic diversity within two leading Plasmodium vivax candidate vaccine antigens. PLoS Negl Trop Dis. 2014 Apr; 8(4):e2796.
          View in: PubMed
        8. Simkin AT, Bailey JA, Gao FB, Jensen JD. Inferring the evolutionary history of primate microRNA binding sites: overcoming motif counting biases. Mol Biol Evol. 2014 Jul; 31(7):1894-901.
          View in: PubMed
        9. Bailey JA, Morrison JJ, Rasmussen TE. Military trauma system in Afghanistan: lessons for civil systems? Curr Opin Crit Care. 2013 Dec; 19(6):569-77.
          View in: PubMed
        10. Mulama DH, Bailey JA, Foley J, Chelimo K, Ouma C, Jura WG, Otieno J, Vulule J, Moormann AM. Sickle cell trait is not associated with endemic Burkitt lymphoma: an ethnicity and malaria endemicity-matched case-control study suggests factors controlling EBV may serve as a predictive biomarker for this pediatric cancer. Int J Cancer. 2014 Feb 1; 134(3):645-53.
          View in: PubMed
        11. Mideo N, Kennedy DA, Carlton JM, Bailey JA, Juliano JJ, Read AF. Ahead of the curve: next generation estimators of drug resistance in malaria infections. Trends Parasitol. 2013 Jul; 29(7):321-8.
          View in: PubMed
        12. Aragam NR, Thayer KM, Nge N, Hoffman I, Martinson F, Kamwendo D, Lin FC, Sutherland C, Bailey JA, Juliano JJ. Diversity of T cell epitopes in Plasmodium falciparum circumsporozoite protein likely due to protein-protein interactions. PLoS One. 2013; 8(5):e62427.
          View in: PubMed
        13. Bailey JA, Mvalo T, Aragam N, Weiser M, Congdon S, Kamwendo D, Martinson F, Hoffman I, Meshnick SR, Juliano JJ. Use of massively parallel pyrosequencing to evaluate the diversity of and selection on Plasmodium falciparum csp T-cell epitopes in Lilongwe, Malawi. J Infect Dis. 2012 Aug 15; 206(4):580-7.
          View in: PubMed
        14. Bailey JA, Virgo KS, DiPiro JT, Nathens AB, Sawyer RG, Mazuski JE. Aminoglycosides for intra-abdominal infection: equal to the challenge? Surg Infect (Larchmt). 2002; 3(4):315-35.
          View in: PubMed
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