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    Jeffrey A Bailey MD, PhD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-8034
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBioinformatics and Computational Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentImmunology and Virology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentBioinformatics and Integrative Biology

        Overview 
        Narrative

        Jeffrey Bailey graduated from Saint Olaf College (Northfield Minnesota) in 1989 with a B.A. in Biology Suma Cum Laude. He then pursued volunteer work as a science and math teacher in Liberia and Botswana with the United States Peace Corps. He returned to the United States and entered the Medical Scientist Training Program at Case Western Reserve University. He received his PhD in Genetics characterizing and studying segmental duplications within the human genome in the laboratory of Dr. Evan Eichler. His postdoctoral research has focused on the detection and analysis of copy number variation—particularly in relationship to segmental duplications. After receiving his MD in 2005, he completed a residency in Clinical Pathology at Case Medical Center in Cleveland and the Cleveland City-wide Transfusion Medicine Fellowship. In August of 2009, Dr. Bailey joined the faculty as a tenure-track assistant professor in the Program in Bioinformatics and Integrative Biology. He continues to pursue clinical medicine in the Division of Transfusion Medicine. He is Board certified in Clinical Pathology.

        Our overall research focus involves understanding the role of segmental duplication and copy number variation in human disease susceptibility and pathogenesis. Segmental duplications, blocks of transposed genomic DNA within or between chromosomes, have long been recognized as an important substrate for the evolution of novel genes. As a result of the human genome project, they are now generally recognized as a significant source of copy number variation (variation between normal individuals) that can impact human disease. We are optimizing both experimental and computational approaches for the assessment of copy number variation within the context of several specific diseases. Utilizing technologies such as array comparative genomic hybridization and massively-parallel sequencing we hope to gain novel insight into etiologic and pathogenic mechanisms.

        One focus of the lab is directed towards dissecting the role of copy number variation in the pathogenesis of malaria. Malaria has been one of the strongest selective forces affecting the human population and still accounts for an estimated two to three million deaths per year. Another focus of the lab isexamining the role of copy number variation in amyotrophic lateral sclerosis (ALS) or Lou Gehrig disease. We are collaborating with Dr. Robert Brown here at UMass to identify copy number variants affecting susceptibility and/or disease progression.



        Rotation Projects

        Rotation projects are available related to the evolution of segmental duplications and copy number variation and/or examination of the role of copy number variation in disease



        Bibliographic 
        selected publications
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        1. Parobek CM, Bailey JA, Hathaway NJ, Socheat D, Rogers WO, Juliano JJ. Differing Patterns of Selection and Geospatial Genetic Diversity within Two Leading Plasmodium vivax Candidate Vaccine Antigens. PLoS Negl Trop Dis. 2014 Apr; 8(4):e2796.
          View in: PubMed
        2. Simkin AT, Bailey JA, Gao FB, Jensen JD. Inferring the Evolutionary History of Primate microRNA Binding Sites: Overcoming Motif Counting Biases. Mol Biol Evol. 2014 Jul; 31(7):1894-901.
          View in: PubMed
        3. Mideo N, Kennedy DA, Carlton JM, Bailey JA, Juliano JJ, Read AF. Ahead of the curve: next generation estimators of drug resistance in malaria infections. Trends Parasitol. 2013 Jul; 29(7):321-8.
          View in: PubMed
        4. Aragam NR, Thayer KM, Nge N, Hoffman I, Martinson F, Kamwendo D, Lin FC, Sutherland C, Bailey JA, Juliano JJ. Diversity of T cell epitopes in Plasmodium falciparum circumsporozoite protein likely due to protein-protein interactions. PLoS One. 2013; 8(5):e62427.
          View in: PubMed
        5. Bailey JA, Mvalo T, Aragam N, Weiser M, Congdon S, Kamwendo D, Martinson F, Hoffman I, Meshnick SR, Juliano JJ. Use of massively parallel pyrosequencing to evaluate the diversity of and selection on Plasmodium falciparum csp T-cell epitopes in Lilongwe, Malawi. J Infect Dis. 2012 Aug 15; 206(4):580-7.
          View in: PubMed
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