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    L Michael Snyder MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPathology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone774-442-9280
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentMedicine

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentCancer Center

        Overview 
        Narrative

        Academic Background

        MD, 1962, Chicago Medical School

        Chief, Department of Hospital Laboratories and Clinical Pathology

        Cytoskeletal alterations during normal aging process

        Altering physician behavior towards more appropriate use of clinical laboratory services

        My involvement in cytoskeletal alterations which occur during the normal aging process remains a majorMichael Snyder focus for my research career. However, since arriving on the scene at UMASS, I have also become interested in mechanisms to alter physician behavior with a final result of more appropriate utilization of clinical laboratory services.

        Clinical:

        Application of Quality Management in Hospital Laboratories
        Appropriateness of Laboratory Testing and Cost Efficiency

        Research:

        Red cell defects, red cell metabolism, membrane function and how they relate in normal and abnormal conditions and how it effects membrane function. Secondary area would be monocytes and red cells in normal and hemolytic disease.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Kiefer CR, Stock RE, Flanagan SS, Darling CE, Smith CS, Snyder LM. Early verification of myocardial ischemia with a novel biomarker of acute tissue damage: C-reactive protein fractional forms. Clin Chim Acta. 2012 Oct 9; 413(19-20):1536-41.
          View in: PubMed
        2. Yu H, Ok CY, Hesse A, Nordell P, Connor D, Sjostedt E, Pechet L, Snyder LM. Evaluation of an automated digital imaging system, Nextslide Digital Review Network, for examination of peripheral blood smears. Arch Pathol Lab Med. 2012 Jun; 136(6):660-7.
          View in: PubMed
        3. Contois JH, Hartigan C, Rao LV, Snyder LM, Thompson MJ. Analytical validation of an HPLC assay for urinary albumin. Clin Chim Acta. 2006 May; 367(1-2):150-5.
          View in: PubMed
        4. Kiefer CR, McKenney JB, Trainor JF, Snyder LM. Pulse-pressure-driven neutral lipid accumulation and correlative proinflammatory markers of accelerated atherogenesis. Atherosclerosis. 2005 Nov; 183(1):17-24.
          View in: PubMed
        5. Kiefer CR, McKenney JB, Trainor JF, Snyder LM. Maturation-dependent acquired coronary structural alterations and atherogenesis in the Dahl sodium-sensitive hypertensive rat. Circulation. 2002 Nov 5; 106(19):2486-90.
          View in: PubMed
        6. Kiefer CR, Snyder LM. Oxidation and erythrocyte senescence. Curr Opin Hematol. 2000 Mar; 7(2):113-6.
          View in: PubMed
        7. Kiefer CR, McKenney JB, Trainor JF, Lambrecht RW, Bonkovsky HL, Lifshitz LM, Valeri CR, Snyder LM. Porphyrin loading of lipofuscin granules in inflamed striated muscle. Am J Pathol. 1998 Sep; 153(3):703-8.
          View in: PubMed
        8. Kuypers FA, Yuan J, Lewis RA, Snyder LM, Kiefer CR, Bunyaratvej A, Fucharoen S, Ma L, Styles L, de Jong K, Schrier SL. Membrane phospholipid asymmetry in human thalassemia. Blood. 1998 Apr 15; 91(8):3044-51.
          View in: PubMed
        9. Waugh RE, McKenney JB, Bauserman RG, Brooks DM, Valeri CR, Snyder LM. Surface area and volume changes during maturation of reticulocytes in the circulation of the baboon. J Lab Clin Med. 1997 May; 129(5):527-35.
          View in: PubMed
        10. Lieberthal W, McKenney JB, Kiefer CR, Snyder LM, Kroshian VM, Sjaastad MD. Beta1 integrin-mediated adhesion between renal tubular cells after anoxic injury. J Am Soc Nephrol. 1997 Feb; 8(2):175-83.
          View in: PubMed
        11. Aljurf M, Ma L, Angelucci E, Lucarelli G, Snyder LM, Kiefer CR, Yuan J, Schrier SL. Abnormal assembly of membrane proteins in erythroid progenitors of patients with beta-thalassemia major. Blood. 1996 Mar 1; 87(5):2049-56.
          View in: PubMed
        12. PatiƱo-Sarcinelli F, Knecht H, Pechet L, Pihan G, Savas L, Snyder LM. Leukemia with megakaryocytic differentiation following essential thrombocythemia and myelofibrosis. Case report and review of the literature. Acta Haematol. 1996; 95(2):122-8.
          View in: PubMed
        13. Kiefer CR, Trainor JF, McKenney JB, Valeri CR, Snyder LM. Hemoglobin-spectrin complexes: interference with spectrin tetramer assembly as a mechanism for compartmentalization of band 1 and band 2 complexes. Blood. 1995 Jul 1; 86(1):366-71.
          View in: PubMed
        14. Nardella A, Pechet L, Snyder LM. Continuous improvement, quality control, and cost containment in clinical laboratory testing. Effects of establishing and implementing guidelines for preoperative tests. Arch Pathol Lab Med. 1995 Jun; 119(6):518-22.
          View in: PubMed
        15. Griffiths EB, Pechet L, Snyder LM. A laboratory rotation for medical house officers. Bridging the gap. Arch Pathol Lab Med. 1995 May; 119(5):480-2.
          View in: PubMed
        16. Nardella A, Farrell M, Pechet L, Snyder LM. Continuous improvement, quality control, and cost containment in clinical laboratory testing. Enhancement of physicians' laboratory-ordering practices. Arch Pathol Lab Med. 1994 Oct; 118(10):965-8.
          View in: PubMed
        17. Collins K, Quinlan A, Farrell M, Snyder LM. Influencing physician behavior with CQI: a case study. Qual Manag Health Care. 1994; 2(3):27-35.
          View in: PubMed
        18. Yuan J, Angelucci E, Lucarelli G, Aljurf M, Snyder LM, Kiefer CR, Ma L, Schrier SL. Accelerated programmed cell death (apoptosis) in erythroid precursors of patients with severe beta-thalassemia (Cooley's anemia) Blood. 1993 Jul 15; 82(2):374-7.
          View in: PubMed
        19. McKenney J, Valeri CR, Mohandas N, Fortier N, Giorgio A, Snyder LM. Decreased in vivo survival of hydrogen peroxide-damaged baboon red blood cells. Blood. 1990 Jul 1; 76(1):206-11.
          View in: PubMed
        20. Szymanski IO, Araszkiewicz P, Odgren P, Snyder LM. Decreased amount of the Rh antigen D in hereditary spherocytosis (HS). Br J Haematol. 1989 Dec; 73(4):537-40.
          View in: PubMed
        21. Fortier N, Snyder LM, Garver F, Kiefer C, McKenney J, Mohandas N. The relationship between in vivo generated hemoglobin skeletal protein complex and increased red cell membrane rigidity. Blood. 1988 May; 71(5):1427-31.
          View in: PubMed
        22. Snyder LM, Fortier NL, Leb L, McKenney J, Trainor J, Sheerin H, Mohandas N. The role of membrane protein sulfhydryl groups in hydrogen peroxide-mediated membrane damage in human erythrocytes. Biochim Biophys Acta. 1988 Jan 22; 937(2):229-40.
          View in: PubMed
        23. Leb L, Snyder LM, Fortier NL, Andersen M. Antiglobulin serum mediated phagocytosis of normal senescent and oxidized RBC: role of anti-IgM immunoglobulins in phagocytic recognition. Br J Haematol. 1987 Aug; 66(4):565-70.
          View in: PubMed
        24. Snyder LM, Fortier NL, Trainor J, Jacobs J, Leb L, Lubin B, Chiu D, Shohet S, Mohandas N. Effect of hydrogen peroxide exposure on normal human erythrocyte deformability, morphology, surface characteristics, and spectrin-hemoglobin cross-linking. J Clin Invest. 1985 Nov; 76(5):1971-7.
          View in: PubMed
        25. Snyder LM, Garver F, Liu SC, Leb L, Trainor J, Fortier NL. Demonstration of haemoglobin associated with isolated, purified spectrin from senescent human red cells. Br J Haematol. 1985 Nov; 61(3):415-9.
          View in: PubMed
        26. Snyder LM, Fairbanks G, Trainor J, Fortier NL, Jacobs JB, Leb L. Properties and characterization of vesicles released by young and old human red cells. Br J Haematol. 1985 Mar; 59(3):513-22.
          View in: PubMed
        27. Snyder LM, Fortier NL, Sauberman N, Leb L, Trainor J, Fairbanks G. Hemoglobin-spectrin interaction under oxidative conditions. Prog Clin Biol Res. 1984; 159:227-42.
          View in: PubMed
        28. Snyder LM, Leb L, Piotrowski J, Sauberman N, Liu SC, Fortier NL. Irreversible spectrin-haemoglobin crosslinking in vivo: a marker for red cell senescence. Br J Haematol. 1983 Mar; 53(3):379-84.
          View in: PubMed
        29. Snyder LM, Leb L, Jacobs JB, Fortier NL, Reeves D, Neri LL, St John M. Characteristics of peripheral blood monocytes in hereditary xerocytosis and spherocytosis. Acta Haematol. 1982; 67(4):268-74.
          View in: PubMed
        30. Snyder LM, Sauberman N, Condara H, Dolan J, Jacobs J, Szymanski I, Fortier NL. Red cell membrane response to hydrogen peroxide-sensitivity in hereditary xerocytosis and in other abnormal red cells. Br J Haematol. 1981 Jul; 48(3):435-44.
          View in: PubMed
        31. Szymanski IO, Odgren PR, Fortier NL, Snyder LM. Red blood cell associated IgG in normal and pathologic states. Blood. 1980 Jan; 55(1):48-54.
          View in: PubMed
        32. Pechet L, Snyder LM, Chesney C, Colman RW. Hemostatic defect due to acquired circulating inhibitors against lipid procoagulant and factor VIII. Thromb Diath Haemorrh. 1974 Sep 30; 32(1):90-104.
          View in: PubMed
        33. Castro GA, Church A, Pechet L, Snyder LM. Leukemia after chemotherapy of Hodgkin's disease. N Engl J Med. 1973 Jul 12; 289(2):103-4.
          View in: PubMed
        34. Lock JP, Castro GA, Pechet LN, Snyder LM. Hemodialysis in myelomatosis. Ann Intern Med. 1973 Mar; 78(3):454.
          View in: PubMed
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