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    Sarah H Hughes MD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentObstetrics and Gynecology
    AddressUMass Memorial Medical Center
    119 Belmont Street
    Worcester MA 01605
        Overview 
        Narrative

        Research ExperienceSarah Hughes

        • "Small cell neuroendocrine cervical cancer:" Retrospective review of patients treated at USC. 2007-2008.
        • "Notch inhibition in murine induced cervical cancer models:" Principal Investigator: W. Martin Kast, PhD, Norris Cancer Center, University of Southern California, Keck School of Medicine. 2005-2006.
        • "MRI of the cervix during pregnancy:" Principal Investigator: Michael House, M.D., Department of Obstetrics & Gynecology, Tufts Medical Center. 2004.
        • "Latino beliefs about childhood development and feeding:" Principal Investigator: M. Alex Geertsma, M.D., Department of Pediatrics, Hartford Hospital/Univ. of Connecticut School of Medicine. 1995-1997.
        • "Genetic Linkage Analysis:" Laboratory assistant in molecular genetics. Principal Investigator: Terry Lerner, Ph.D., Molecular Neurogenetics Unit, Massachusetts General Hospital. Summer 1994.
          S.Hughes



        Bibliographic 
        selected publications
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        1. Hughes S, Leary A, Zweizig S, Cain J. Surgery in elderly people: Preoperative, operative and postoperative care to assist healing. Best Pract Res Clin Obstet Gynaecol. 2013 Oct; 27(5):753-65.
          View in: PubMed
        2. Hughes S, Harris J, Flack N, Cuffe RL. The statistician's role in the prevention of missing data. Pharm Stat. 2012 Sep; 11(5):410-6.
          View in: PubMed
        3. Keene ON, Hughes SH, Howitt N. Statistical resource needs to be increased in the European regulatory agencies. Pharm Stat. 2011 Mar-Apr; 10(2):87-8.
          View in: PubMed
        4. Stellbrink HJ, Orkin C, Arribas JR, Compston J, Gerstoft J, Van Wijngaerden E, Lazzarin A, Rizzardini G, Sprenger HG, Lambert J, Sture G, Leather D, Hughes S, Zucchi P, Pearce H. Comparison of changes in bone density and turnover with abacavir-lamivudine versus tenofovir-emtricitabine in HIV-infected adults: 48-week results from the ASSERT study. Clin Infect Dis. 2010 Oct 15; 51(8):963-72.
          View in: PubMed
        5. Carver A, Rafelt S, Gershlick AH, Fairbrother KL, Hughes S, Wilcox R. Longer-term follow-up of patients recruited to the REACT (Rescue Angioplasty Versus Conservative Treatment or Repeat Thrombolysis) trial. J Am Coll Cardiol. 2009 Jul 7; 54(2):118-26.
          View in: PubMed
        6. Brothers CH, Hernandez JE, Cutrell AG, Curtis L, Ait-Khaled M, Bowlin SJ, Hughes SH, Yeo JM, Lapierre DH. Risk of myocardial infarction and abacavir therapy: no increased risk across 52 GlaxoSmithKline-sponsored clinical trials in adult subjects. J Acquir Immune Defic Syndr. 2009 May 1; 51(1):20-8.
          View in: PubMed
        7. Hughes S, Cuffe RL, Lieftucht A, Garrett Nichols W. Informing the selection of futility stopping thresholds: case study from a late-phase clinical trial. Pharm Stat. 2009 Jan-Mar; 8(1):25-37.
          View in: PubMed
        8. Carroll K, Ross HC, Evans D, France L, Hemmings R, Hughes S, Lynn F, Mahoney P, Phillips A. Conditional approval: discussion points from the PSI conditional approval expert group. Pharm Stat. 2008 Oct-Dec; 7(4):263-9; discussion 270-1.
          View in: PubMed
        9. Hughes S, Hughes A, Brothers C, Spreen W, Thorborn D. PREDICT-1 (CNA106030): the first powered, prospective trial of pharmacogenetic screening to reduce drug adverse events. Pharm Stat. 2008 Apr-Jun; 7(2):121-9.
          View in: PubMed
        10. Mallal S, Phillips E, Carosi G, Molina JM, Workman C, Tomazic J, J├Ągel-Guedes E, Rugina S, Kozyrev O, Cid JF, Hay P, Nolan D, Hughes S, Hughes A, Ryan S, Fitch N, Thorborn D, Benbow A. HLA-B*5701 screening for hypersensitivity to abacavir. N Engl J Med. 2008 Feb 7; 358(6):568-79.
          View in: PubMed
        11. Hughes S. European regulatory agencies should employ full time statisticians. BMJ. 2008 Feb 2; 336(7638):250.
          View in: PubMed
        12. Brinkman JA, Hughes SH, Stone P, Caffrey AS, Muderspach LI, Roman LD, Weber JS, Kast WM. Therapeutic vaccination for HPV induced cervical cancers. Dis Markers. 2007; 23(4):337-52.
          View in: PubMed
        13. Hughes S. 30 years of statisticians in the pharmaceutical industry. Pharm Stat. 2007 Jan-Mar; 6(1):1-3.
          View in: PubMed
        14. Hughes SH, Steller MA. Radical gynecologic surgery for cancer. Surg Oncol Clin N Am. 2005 Jul; 14(3):607-31, viii.
          View in: PubMed
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