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    Last Name
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    Francis A Ennis MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North, S6-860
    Worcester MA 01655
    Phone508-856-4182
      Other Positions
      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentCenter for AIDS Research

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentCenter for Infectious Disease and Vaccine Research

        Overview 
        Narrative

        Immune response of host to virus infections, emphasizing cellular responses

        Overall themes:

        • Human Immune Responses
        • Immunopathology to Virus Infections and
        • Failure to Eliminate Virus in Persistent Infection

        A. T cell triggered and cytokine mediated immunopathology.

        Photo: Francis A. EnnisWe hypothesize that certain virus infections e.g. Dengue HemorrhagicFever (DHF), or the Hantavirus Pulmonary Syndrome (HPS) may be due to"over"responses of dengue or hantavirus specific T cells incertain high-responders, due to immune responses genes. These T cellresponses are needed for clearance of virus-infected cells but markedinflammatory responses probably mediated by cytokines, cause endothelialcell leakness and shock (DHF) or pulmonary edema (HPS). We are definingCD4+ and CD8+ T cell epitopes, determining the Th1 and Th2 cytokineresponses at the protein and m-RNA levels and by immunocytochemistry. TCRusage is determined, and correlations with disease phenotypes arestudied.

        Immunopathogenesis of DHF

        Immunopathogenesis of DHF/DSS

        B. Failure to Eliminate Virus in HCV Infection

        Failure of immune response to eliminate HCV infection is very commonand chronic progression liver disease frequently results. Is this due toa poor CD8+ T cell response in those individuals? We are also developingCD8+ T cell clones from the liver tissues and blood cells of patients withHCV infections. We will determine whether interferon therapy which is theonly known treatment, alters the HCV+ CD8+ CTL responses in the patientswho respond to therapy or those that do not. We are also defining Th1,Th2 cytokine patterns in liver tissues by immunocytochemistry.



        Rotation Projects

        Potential Rotation Projects

        Project #1: Establish novel human T cell clones to viruses

        Project #2: Develop quantitative PCR to viruses



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Terajima M, Babon JA, Co MD, Ennis FA. Cross-reactive human B cell and T cell epitopes between influenza A and B viruses. Virol J. 2013; 10:244.
          View in: PubMed
        2. Yin L, Calvo-Calle JM, Cruz J, Newman FK, Frey SE, Ennis FA, Stern LJ. CD4+ T Cells Provide Intermolecular Help To Generate Robust Antibody Responses in Vaccinia Virus-Vaccinated Humans. J Immunol. 2013 Jun 15; 190(12):6023-33.
          View in: PubMed
        3. Srikiatkhachorn A, Wichit S, Gibbons RV, Green S, Libraty DH, Endy TP, Ennis FA, Kalayanarooj S, Rothman AL. Dengue viral RNA levels in peripheral blood mononuclear cells are associated with disease severity and preexisting dengue immune status. PLoS One. 2012; 7(12):e51335.
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        4. Terajima M, Ennis FA. Nuclear Export Signal and Immunodominant CD8+ T Cell Epitope in Influenza A Virus Matrix Protein 1. J Virol. 2012 Sep; 86(18):10258.
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        5. Dawn Co M, Cruz J, Takeda A, Ennis F, Terajima M. Comparison of complement dependent lytic, hemagglutination inhibition and microneutralization antibody responses in influenza vaccinated individuals. Hum Vaccin Immunother. 2012 Sep 1; 8(9):1218-22.
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        6. Terajima M, Babon JA, Ennis FA. Epidemiology of the Influenza A Virus H5N1 Subtype and Memory of Immunity to the H2N2 Subtype. MBio. 2012; 3(4).
          View in: PubMed
        7. Babon JA, Cruz J, Ennis FA, Yin L, Terajima M. A Human CD4+ T Cell Epitope in the Influenza Hemagglutinin Is Cross-Reactive to Influenza A Virus Subtypes and to Influenza B Virus. J Virol. 2012 Sep; 86(17):9233-43.
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        8. Libraty DH, Mäkelä S, Vlk J, Hurme M, Vaheri A, Ennis FA, Mustonen J. The Degree of Leukocytosis and Urine GATA-3 mRNA Levels Are Risk Factors for Severe Acute Kidney Injury in Puumala Virus Nephropathia Epidemica. PLoS One. 2012; 7(4):e35402.
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        9. Kurane I, Matsutani T, Suzuki R, Takasaki T, Kalayanarooj S, Green S, Rothman AL, Ennis FA. T-cell responses to dengue virus in humans. Trop Med Health. 2011 Dec; 39(4 Suppl):45-51.
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        10. Terajima M, Cruz J, Co MD, Lee JH, Kaur K, Wilson PC, Ennis FA. Complement-dependent lysis of influenza a virus-infected cells by broadly cross-reactive human monoclonal antibodies. J Virol. 2011 Dec; 85(24):13463-7.
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        11. Srikiatkhachorn A, Rothman AL, Gibbons RV, Sittisombut N, Malasit P, Ennis FA, Nimmannitya S, Kalayanarooj S. Dengue--how best to classify it. Clin Infect Dis. 2011 Sep; 53(6):563-7.
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        12. Terajima M, Ennis FA. T cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic Fever with renal syndrome. Viruses. 2011 Jul; 3(7):1059-73.
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        13. Simon SL, Inneh IA, Lee MS, Sullivan S, Ennis F. Tenosynovial giant cell tumor of the thigh: positron emission tomography findings. Am J Orthop (Belle Mead NJ). 2011 Jun; 40(6):E115-7.
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        14. Smith HL, Monath TP, Pazoles P, Rothman AL, Casey DM, Terajima M, Ennis FA, Guirakhoo F, Green S. Development of Antigen-Specific Memory CD8+ T Cells Following Live-Attenuated Chimeric West Nile Virus Vaccination. J Infect Dis. 2011 Feb; 203(4):513-22.
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        15. Green S, Ennis FA, Mathew A. Long term recall of memory CD8 T cells in mice to first and third generation smallpox vaccines. Vaccine. 2011 Feb 11; 29(8):1666-76.
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        16. Singh R, Rothman AL, Potts J, Guirakhoo F, Ennis FA, Green S. Sequential immunization with heterologous chimeric flaviviruses induces broad-spectrum cross-reactive CD8+ T cell responses. J Infect Dis. 2010 Jul 15; 202(2):223-33.
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        17. Augustine AD, Cassetti MC, Ennis FA, Harris E, Hildebrand WH, Repik PM. NIAID workshop on Flavivirus immunity. Viral Immunol. 2010 Jun; 23(3):235-40.
          View in: PubMed
        18. Jameson JM, Cruz J, Costanzo A, Terajima M, Ennis FA. A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes. Cell Immunol. 2010; 264(1):71-7.
          View in: PubMed
        19. Trobaugh DW, Yang L, Ennis FA, Green S. Altered effector functions of virus-specific and virus cross-reactive CD8+ T cells in mice immunized with related flaviviruses. Eur J Immunol. 2010 May; 40(5):1315-27.
          View in: PubMed
        20. Srikiatkhachorn A, Gibbons RV, Green S, Libraty DH, Thomas SJ, Endy TP, Vaughn DW, Nisalak A, Ennis FA, Rothman AL, Nimmannitaya S, Kalayanarooj S. Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005. Clin Infect Dis. 2010 Apr 15; 50(8):1135-43.
          View in: PubMed
        21. Moutaftsi M, Tscharke DC, Vaughan K, Koelle DM, Stern L, Calvo-Calle M, Ennis F, Terajima M, Sutter G, Crotty S, Drexler I, Franchini G, Yewdell JW, Head SR, Blum J, Peters B, Sette A. Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens. Future Microbiol. 2010 Feb; 5(2):221-39.
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        22. Liu P, Woda M, Ennis FA, Libraty DH. Dengue virus infection differentially regulates endothelial barrier function over time through type I interferon effects. J Infect Dis. 2009 Jul 15; 200(2):191-201.
          View in: PubMed
        23. Babon JA, Cruz J, Orphin L, Pazoles P, Co MD, Ennis FA, Terajima M. Genome-wide screening of human T-cell epitopes in influenza A virus reveals a broad spectrum of CD4(+) T-cell responses to internal proteins, hemagglutinins, and neuraminidases. Hum Immunol. 2009 Sep; 70(9):711-21.
          View in: PubMed
        24. Vejbaesya S, Luangtrakool P, Luangtrakool K, Kalayanarooj S, Vaughn DW, Endy TP, Mammen MP, Green S, Libraty DH, Ennis FA, Rothman AL, Stephens HA. TNF and LTA gene, allele, and extended HLA haplotype associations with severe dengue virus infection in ethnic Thais. J Infect Dis. 2009 May 15; 199(10):1442-8.
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        25. Frey SE, Newman FK, Kennedy JS, Ennis F, Abate G, Hoft DF, Monath TP. Comparison of the safety and immunogenicity of ACAM1000, ACAM2000 and Dryvax in healthy vaccinia-naive adults. Vaccine. 2009 Mar 4; 27(10):1637-44.
          View in: PubMed
        26. Co MD, Orphin L, Cruz J, Pazoles P, Green KM, Potts J, Leporati AM, Babon JA, Evans JE, Ennis FA, Terajima M. In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses. Vaccine. 2009 Jan 7; 27(2):319-27.
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        27. Terajima M, Orphin L, Leporati AM, Pazoles P, Cruz J, Rothman AL, Ennis FA. Vaccinia virus-specific CD8(+) T-cell responses target a group of epitopes without a strong immunodominance hierarchy in humans. Hum Immunol. 2008 Dec; 69(12):815-25.
          View in: PubMed
        28. Mathew A, O'Bryan J, Marshall W, Kotwal GJ, Terajima M, Green S, Rothman AL, Ennis FA. Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus. PLoS One. 2008; 3(10):e3323.
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        29. Pavlin JA, Hickey AC, Ulbrandt N, Chan YP, Endy TP, Boukhvalova MS, Chunsuttiwat S, Nisalak A, Libraty DH, Green S, Rothman AL, Ennis FA, Jarman R, Gibbons RV, Broder CC. Human metapneumovirus reinfection among children in Thailand determined by ELISA using purified soluble fusion protein. J Infect Dis. 2008 Sep 15; 198(6):836-42.
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        30. Wang S, Kennedy JS, West K, Montefiori DC, Coley S, Lawrence J, Shen S, Green S, Rothman AL, Ennis FA, Arthos J, Pal R, Markham P, Lu S. Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers. Vaccine. 2008 Jul 23; 26(31):3947-57.
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        31. Terajima M, Cruz J, Leporati AM, Orphin L, Babon JA, Co MD, Pazoles P, Jameson J, Ennis FA. Influenza A virus matrix protein 1-specific human CD8+ T-cell response induced in trivalent inactivated vaccine recipients. J Virol. 2008 Sep; 82(18):9283-7.
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        32. Strug I, Calvo-Calle JM, Green KM, Cruz J, Ennis FA, Evans JE, Stern LJ. Vaccinia peptides eluted from HLA-DR1 isolated from virus-infected cells are recognized by CD4+ T cells from a vaccinated donor. J Proteome Res. 2008 Jul; 7(7):2703-11.
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        33. Jarman RG, Holmes EC, Rodpradit P, Klungthong C, Gibbons RV, Nisalak A, Rothman AL, Libraty DH, Ennis FA, Mammen MP, Endy TP. Microevolution of Dengue viruses circulating among primary school children in Kamphaeng Phet, Thailand. J Virol. 2008 Jun; 82(11):5494-500.
          View in: PubMed
        34. Co MD, Orphin L, Cruz J, Pazoles P, Rothman AL, Ennis FA, Terajima M. Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine. Vaccine. 2008 Apr 7; 26(16):1990-8.
          View in: PubMed
        35. Wang S, Kennedy JS, West K, Montefiori DC, Coley S, Lawrence J, Shen S, Green S, Rothman AL, Ennis FA, Arthos J, Pal R, Markham P, Lu S. Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers. Vaccine. 2008 Feb 20; 26(8):1098-110.
          View in: PubMed
        36. Libraty DH, Myint KS, Murray CK, Gibbons RV, Mammen MP, Endy TP, Li W, Vaughn DW, Nisalak A, Kalayanarooj S, Hospenthal DR, Green S, Rothman AL, Ennis FA. A comparative study of leptospirosis and dengue in Thai children. PLoS Negl Trop Dis. 2007; 1(3):e111.
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        37. Frey SE, Newman FK, Kennedy JS, Sobek V, Ennis FA, Hill H, Yan LK, Chaplin P, Vollmar J, Chaitman BR, Belshe RB. Clinical and immunologic responses to multiple doses of IMVAMUNE (Modified Vaccinia Ankara) followed by Dryvax challenge. Vaccine. 2007 Dec 12; 25(51):8562-73.
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        38. Terajima M, Hayasaka D, Maeda K, Ennis FA. Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: Do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers? Immunol Lett. 2007 Nov 15; 113(2):117-20.
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        39. Tuuminen T, Kekäläinen E, Mäkelä S, Ala-Houhala I, Ennis FA, Hedman K, Mustonen J, Vaheri A, Arstila TP. Human CD8+ T cell memory generation in Puumala hantavirus infection occurs after the acute phase and is associated with boosting of EBV-specific CD8+ memory T cells. J Immunol. 2007 Aug 1; 179(3):1988-95.
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        40. Mitra-Kaushik S, Cruz J, Stern LJ, Ennis FA, Terajima M. Human cytotoxic CD4+ T cells recognize HLA-DR1-restricted epitopes on vaccinia virus proteins A24R and D1R conserved among poxviruses. J Immunol. 2007 Jul 15; 179(2):1303-12.
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        41. Anderson KB, Chunsuttiwat S, Nisalak A, Mammen MP, Libraty DH, Rothman AL, Green S, Vaughn DW, Ennis FA, Endy TP. Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study. Lancet. 2007 Apr 28; 369(9571):1452-9.
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        42. Srikiatkhachorn A, Krautrachue A, Ratanaprakarn W, Wongtapradit L, Nithipanya N, Kalayanarooj S, Nisalak A, Thomas SJ, Gibbons RV, Mammen MP, Libraty DH, Ennis FA, Rothman AL, Green S. Natural history of plasma leakage in dengue hemorrhagic fever: a serial ultrasonographic study. Pediatr Infect Dis J. 2007 Apr; 26(4):283-90; discussion 291-2.
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        43. Laoprasopwattana K, Libraty DH, Endy TP, Nisalak A, Chunsuttiwat S, Ennis FA, Rothman AL, Green S. Antibody-dependent cellular cytotoxicity mediated by plasma obtained before secondary dengue virus infections: potential involvement in early control of viral replication. J Infect Dis. 2007 Apr 15; 195(8):1108-16.
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        44. Sivapalasingam S, Kennedy JS, Borkowsky W, Valentine F, Zhan MX, Pazoles P, Paolino A, Ennis FA, Steigbigel NH. Immunological memory after exposure to variola virus, monkeypox virus, and vaccinia virus. J Infect Dis. 2007 Apr 15; 195(8):1151-9.
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        45. Hayasaka D, Ennis FA, Terajima M. Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses. Virol J. 2007; 4:22.
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        46. Srikiatkhachorn A, Ajariyakhajorn C, Endy TP, Kalayanarooj S, Libraty DH, Green S, Ennis FA, Rothman AL. Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic Fever. J Virol. 2007 Feb; 81(4):1592-600.
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        47. Hayasaka D, Maeda K, Ennis FA, Terajima M. Increased permeability of human endothelial cell line EA.hy926 induced by hantavirus-specific cytotoxic T lymphocytes. Virus Res. 2007 Feb; 123(2):120-7.
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        48. Myint KS, Endy TP, Mongkolsirichaikul D, Manomuth C, Kalayanarooj S, Vaughn DW, Nisalak A, Green S, Rothman AL, Ennis FA, Libraty DH. Cellular immune activation in children with acute dengue virus infections is modulated by apoptosis. J Infect Dis. 2006 Sep 1; 194(5):600-7.
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        49. Terajima M, Cruz J, Leporati AM, Demkowicz WE, Kennedy JS, Ennis FA. Identification of vaccinia CD8+ T-cell epitopes conserved among vaccinia and variola viruses restricted by common MHC class I molecules, HLA-A2 or HLA-B7. Hum Immunol. 2006 Jul; 67(7):512-20.
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        50. Monath TP, Liu J, Kanesa-Thasan N, Myers GA, Nichols R, Deary A, McCarthy K, Johnson C, Ermak T, Shin S, Arroyo J, Guirakhoo F, Kennedy JS, Ennis FA, Green S, Bedford P. A live, attenuated recombinant West Nile virus vaccine. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6694-9.
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        51. Terajima M, Ennis FA. Using HLA-transgenic mice to identify immunodominant human CD8+ T cell epitopes--does (genome) size matter? Immunol Lett. 2006 May 15; 105(1):97-8.
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        52. Rothman AL, Green S, Libraty DH, Ennis FA. Dengue: translating scientific progress into workable solutions. Expert Rev Anti Infect Ther. 2005 Oct; 3(5):689-92.
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        53. Laoprasopwattana K, Libraty DH, Endy TP, Nisalak A, Chunsuttiwat S, Vaughn DW, Reed G, Ennis FA, Rothman AL, Green S. Dengue Virus (DV) enhancing antibody activity in preillness plasma does not predict subsequent disease severity or viremia in secondary DV infection. J Infect Dis. 2005 Aug 1; 192(3):510-9.
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        54. Mathew A, Terajima M, West K, Green S, Rothman AL, Ennis FA, Kennedy JS. Identification of murine poxvirus-specific CD8+ CTL epitopes with distinct functional profiles. J Immunol. 2005 Feb 15; 174(4):2212-9.
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        55. Greenberg RN, Kennedy JS, Clanton DJ, Plummer EA, Hague L, Cruz J, Ennis FA, Blackwelder WC, Hopkins RJ. Safety and immunogenicity of new cell-cultured smallpox vaccine compared with calf-lymph derived vaccine: a blind, single-centre, randomised controlled trial. Lancet. 2005 Jan 29-Feb 4; 365(9457):398-409.
          View in: PubMed
        56. Maeda K, West K, Hayasaka D, Ennis FA, Terajima M. Recombinant adenovirus vector vaccine induces stronger cytotoxic T-cell responses than recombinant vaccinia virus vector, plasmid DNA, or a combination of these. Viral Immunol. 2005; 18(4):657-67.
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        57. Kennedy JS, Frey SE, Yan L, Rothman AL, Cruz J, Newman FK, Orphin L, Belshe RB, Ennis FA. Induction of human T cell-mediated immune responses after primary and secondary smallpox vaccination. J Infect Dis. 2004 Oct 1; 190(7):1286-94.
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        58. Maeda K, West K, Toyosaki-Maeda T, Rothman AL, Ennis FA, Terajima M. Identification and analysis for cross-reactivity among hantaviruses of H-2b-restricted cytotoxic T-lymphocyte epitopes in Sin Nombre virus nucleocapsid protein. J Gen Virol. 2004 Jul; 85(Pt 7):1909-19.
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        59. Endy TP, Nisalak A, Chunsuttitwat S, Vaughn DW, Green S, Ennis FA, Rothman AL, Libraty DH. Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand. J Infect Dis. 2004 Mar 15; 189(6):990-1000.
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        60. Kilpatrick ED, Terajima M, Koster FT, Catalina MD, Cruz J, Ennis FA. Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome. J Immunol. 2004 Mar 1; 172(5):3297-304.
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        61. Terajima M, Vapalahti O, Van Epps HL, Vaheri A, Ennis FA. Immune responses to Puumala virus infection and the pathogenesis of nephropathia epidemica. Microbes Infect. 2004 Feb; 6(2):238-45.
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        62. Mangada MM, Ennis FA, Rothman AL. Quantitation of dengue virus specific CD4+ T cells by intracellular cytokine staining. J Immunol Methods. 2004 Jan; 284(1-2):89-97.
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        63. Pichyangkul S, Endy TP, Kalayanarooj S, Nisalak A, Yongvanitchit K, Green S, Rothman AL, Ennis FA, Libraty DH. A blunted blood plasmacytoid dendritic cell response to an acute systemic viral infection is associated with increased disease severity. J Immunol. 2003 Nov 15; 171(10):5571-8.
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        64. Warke RV, Xhaja K, Martin KJ, Fournier MF, Shaw SK, Brizuela N, de Bosch N, Lapointe D, Ennis FA, Rothman AL, Bosch I. Dengue virus induces novel changes in gene expression of human umbilical vein endothelial cells. J Virol. 2003 Nov; 77(21):11822-32.
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        65. Weltzin R, Liu J, Pugachev KV, Myers GA, Coughlin B, Blum PS, Nichols R, Johnson C, Cruz J, Kennedy JS, Ennis FA, Monath TP. Clonal vaccinia virus grown in cell culture as a new smallpox vaccine. Nat Med. 2003 Sep; 9(9):1125-30.
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        66. Terajima M, Ennis FA. Quantitation of antibody-bound and unbound Sin Nombre virus in the plasma of patient with hantavirus pulmonary syndrome. J Virol Methods. 2003 Jun 30; 110(2):159-62.
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        67. Kurane I, West K, Tuazon CU, Zeng W, Ennis FA. Definition of two new epitopes on human immunodeficiency virus type 1 gag protein recognized by human CD8+ cytotoxic T lymphocyte clones. J Clin Virol. 2003 May; 27(1):38-43.
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        68. Terajima M, Cruz J, Raines G, Kilpatrick ED, Kennedy JS, Rothman AL, Ennis FA. Quantitation of CD8+ T cell responses to newly identified HLA-A*0201-restricted T cell epitopes conserved among vaccinia and variola (smallpox) viruses. J Exp Med. 2003 Apr 7; 197(7):927-32.
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        69. Libraty DH, Young PR, Pickering D, Endy TP, Kalayanarooj S, Green S, Vaughn DW, Nisalak A, Ennis FA, Rothman AL. High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. J Infect Dis. 2002 Oct 15; 186(8):1165-8.
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        70. Van Epps HL, Terajima M, Mustonen J, Arstila TP, Corey EA, Vaheri A, Ennis FA. Long-lived memory T lymphocyte responses after hantavirus infection. J Exp Med. 2002 Sep 2; 196(5):579-88.
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        71. Endy TP, Chunsuttiwat S, Nisalak A, Libraty DH, Green S, Rothman AL, Vaughn DW, Ennis FA. Epidemiology of inapparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand. Am J Epidemiol. 2002 Jul 1; 156(1):40-51.
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        72. Endy TP, Nisalak A, Chunsuttiwat S, Libraty DH, Green S, Rothman AL, Vaughn DW, Ennis FA. Spatial and temporal circulation of dengue virus serotypes: a prospective study of primary school children in Kamphaeng Phet, Thailand. Am J Epidemiol. 2002 Jul 1; 156(1):52-9.
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        73. Zivna I, Green S, Vaughn DW, Kalayanarooj S, Stephens HA, Chandanayingyong D, Nisalak A, Ennis FA, Rothman AL. T cell responses to an HLA-B*07-restricted epitope on the dengue NS3 protein correlate with disease severity. J Immunol. 2002 Jun 1; 168(11):5959-65.
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        74. Bosch I, Xhaja K, Estevez L, Raines G, Melichar H, Warke RV, Fournier MV, Ennis FA, Rothman AL. Increased production of interleukin-8 in primary human monocytes and in human epithelial and endothelial cell lines after dengue virus challenge. J Virol. 2002 Jun; 76(11):5588-97.
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        75. Mangada MM, Endy TP, Nisalak A, Chunsuttiwat S, Vaughn DW, Libraty DH, Green S, Ennis FA, Rothman AL. Dengue-specific T cell responses in peripheral blood mononuclear cells obtained prior to secondary dengue virus infections in Thai schoolchildren. J Infect Dis. 2002 Jun 15; 185(12):1697-703.
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        76. Ennis FA, Cruz J, Demkowicz WE, Rothman AL, McClain DJ. Primary induction of human CD8+ cytotoxic T lymphocytes and interferon-gamma-producing T cells after smallpox vaccination. J Infect Dis. 2002 Jun 1; 185(11):1657-9.
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        77. Libraty DH, Endy TP, Kalayanarooj S, Chansiriwongs W, Nisalak A, Green S, Ennis FA, Rothman AL. Assessment of body fluid compartment volumes by multifrequency bioelectrical impedance spectroscopy in children with dengue. Trans R Soc Trop Med Hyg. 2002 May-Jun; 96(3):295-9.
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        78. Gagnon SJ, Mori M, Kurane I, Green S, Vaughn DW, Kalayanarooj S, Suntayakorn S, Ennis FA, Rothman AL. Cytokine gene expression and protein production in peripheral blood mononuclear cells of children with acute dengue virus infections. J Med Virol. 2002 May; 67(1):41-6.
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        79. Libraty DH, Endy TP, Houng HS, Green S, Kalayanarooj S, Suntayakorn S, Chansiriwongs W, Vaughn DW, Nisalak A, Ennis FA, Rothman AL. Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections. J Infect Dis. 2002 May 1; 185(9):1213-21.
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        80. Frey SE, Newman FK, Cruz J, Shelton WB, Tennant JM, Polach T, Rothman AL, Kennedy JS, Wolff M, Belshe RB, Ennis FA. Dose-related effects of smallpox vaccine. N Engl J Med. 2002 Apr 25; 346(17):1275-80.
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        81. Terajima M, Van Epps HL, Li D, Leporati AM, Juhlin SE, Mustonen J, Vaheri A, Ennis FA. Generation of recombinant vaccinia viruses expressing Puumala virus proteins and use in isolating cytotoxic T cells specific for Puumala virus. Virus Res. 2002 Mar 20; 84(1-2):67-77.
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        82. Co MD, Terajima M, Cruz J, Ennis FA, Rothman AL. Human cytotoxic T lymphocyte responses to live attenuated 17D yellow fever vaccine: identification of HLA-B35-restricted CTL epitopes on nonstructural proteins NS1, NS2b, NS3, and the structural protein E. Virology. 2002 Feb 1; 293(1):151-63.
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        83. Spain-Santana TA, Marglin S, Ennis FA, Rothman AL. MIP-1 alpha and MIP-1 beta induction by dengue virus. J Med Virol. 2001 Oct; 65(2):324-30.
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        84. Rothman AL, Kanesa-thasan N, West K, Janus J, Saluzzo JF, Ennis FA. Induction of T lymphocyte responses to dengue virus by a candidate tetravalent live attenuated dengue virus vaccine. Vaccine. 2001 Sep 14; 19(32):4694-9.
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        85. Waite DC, Jacobson EW, Ennis FA, Edelman R, White B, Kammer R, Anderson C, Kensil CR. Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21. Vaccine. 2001 Jul 16; 19(28-29):3957-67.
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        86. Libraty DH, Pichyangkul S, Ajariyakhajorn C, Endy TP, Ennis FA. Human dendritic cells are activated by dengue virus infection: enhancement by gamma interferon and implications for disease pathogenesis. J Virol. 2001 Apr; 75(8):3501-8.
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        87. Sudiro TM, Zivny J, Ishiko H, Green S, Vaughn DW, Kalayanarooj S, Nisalak A, Norman JE, Ennis FA, Rothman AL. Analysis of plasma viral RNA levels during acute dengue virus infection using quantitative competitor reverse transcription-polymerase chain reaction. J Med Virol. 2001 Jan; 63(1):29-34.
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        88. Gagnon SJ, Leporati A, Green S, Kalayanarooj S, Vaughn DW, Stephens HA, Suntayakorn S, Kurane I, Ennis FA, Rothman AL. T cell receptor Vbeta gene usage in Thai children with dengue virus infection. Am J Trop Med Hyg. 2001 Jan-Feb; 64(1-2):41-8.
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        89. Mathew A, Ennis FA, Rothman AL. Transient decreases in human T cell proliferative responses following vaccinia immunization. Clin Immunol. 2000 Aug; 96(2):100-7.
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        90. Terajima M, Hendershot JD, Kariwa H, Koster FT, Hjelle B, Goade D, DeFronzo MC, Ennis FA. High levels of viremia in patients with the Hantavirus pulmonary syndrome. J Infect Dis. 1999 Dec; 180(6):2030-4.
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        91. Green S, Vaughn DW, Kalayanarooj S, Nimmannitya S, Suntayakorn S, Nisalak A, Rothman AL, Ennis FA. Elevated plasma interleukin-10 levels in acute dengue correlate with disease severity. J Med Virol. 1999 Nov; 59(3):329-34.
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        92. Green S, Pichyangkul S, Vaughn DW, Kalayanarooj S, Nimmannitya S, Nisalak A, Kurane I, Rothman AL, Ennis FA. Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever. J Infect Dis. 1999 Nov; 180(5):1429-35.
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        93. Zivny J, DeFronzo M, Jarry W, Jameson J, Cruz J, Ennis FA, Rothman AL. Partial agonist effect influences the CTL response to a heterologous dengue virus serotype. J Immunol. 1999 Sep 1; 163(5):2754-60.
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        94. Ennis FA, Cruz J, Jameson J, Klein M, Burt D, Thipphawong J. Augmentation of human influenza A virus-specific cytotoxic T lymphocyte memory by influenza vaccine and adjuvanted carriers (ISCOMS). Virology. 1999 Jul 5; 259(2):256-61.
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        95. Van Epps HL, Schmaljohn CS, Ennis FA. Human memory cytotoxic T-lymphocyte (CTL) responses to Hantaan virus infection: identification of virus-specific and cross-reactive CD8(+) CTL epitopes on nucleocapsid protein. J Virol. 1999 Jul; 73(7):5301-8.
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        96. Terajima M, Jameson J, Norman JE, Cruz J, Ennis FA. High-yield reassortant influenza vaccine production virus has a mutation at an HLA-A 2.1-restricted CD8+ CTL epitope on the NS1 protein. Virology. 1999 Jun 20; 259(1):135-40.
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        97. Jameson J, Cruz J, Terajima M, Ennis FA. Human CD8+ and CD4+ T lymphocyte memory to influenza A viruses of swine and avian species. J Immunol. 1999 Jun 15; 162(12):7578-83.
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        98. Staats HF, Ennis FA. IL-1 is an effective adjuvant for mucosal and systemic immune responses when coadministered with protein immunogens. J Immunol. 1999 May 15; 162(10):6141-7.
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        99. Mathew A, Kurane I, Green S, Vaughn DW, Kalayanarooj S, Suntayakorn S, Ennis FA, Rothman AL. Impaired T cell proliferation in acute dengue infection. J Immunol. 1999 May 1; 162(9):5609-15.
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        100. Gagnon SJ, Ennis FA, Rothman AL. Bystander target cell lysis and cytokine production by dengue virus-specific human CD4(+) cytotoxic T-lymphocyte clones. J Virol. 1999 May; 73(5):3623-9.
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        101. Rothman AL, Ennis FA. Immunopathogenesis of Dengue hemorrhagic fever. Virology. 1999 Apr 25; 257(1):1-6.
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        102. Green S, Vaughn DW, Kalayanarooj S, Nimmannitya S, Suntayakorn S, Nisalak A, Lew R, Innis BL, Kurane I, Rothman AL, Ennis FA. Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity. J Infect Dis. 1999 Apr; 179(4):755-62.
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        103. Mori M, Rothman AL, Kurane I, Montoya JM, Nolte KB, Norman JE, Waite DC, Koster FT, Ennis FA. High levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome. J Infect Dis. 1999 Feb; 179(2):295-302.
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        104. Spaulding AC, Kurane I, Ennis FA, Rothman AL. Analysis of murine CD8(+) T-cell clones specific for the Dengue virus NS3 protein: flavivirus cross-reactivity and influence of infecting serotype. J Virol. 1999 Jan; 73(1):398-403.
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        105. Jameson J, Cruz J, Ennis FA. Human cytotoxic T-lymphocyte repertoire to influenza A viruses. J Virol. 1998 Nov; 72(11):8682-9.
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        106. Tamura M, Kuwano K, Kurane I, Ennis FA. Definition of amino acid residues on the epitope responsible for recognition by influenza A virus H1-specific, H2-specific, and H1- and H2-cross-reactive murine cytotoxic T-lymphocyte clones. J Virol. 1998 Nov; 72(11):9404-6.
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        107. Sudiro TM, Ishiko H, Rothman AL, Kershaw DE, Green S, Vaughn DW, Nisalak A, Kalayanarooj S, Ennis FA. Microplate-reverse hybridization method to determine dengue virus serotype. J Virol Methods. 1998 Aug; 73(2):229-35.
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        108. Mathew A, Kurane I, Green S, Stephens HA, Vaughn DW, Kalayanarooj S, Suntayakorn S, Chandanayingyong D, Ennis FA, Rothman AL. Predominance of HLA-restricted cytotoxic T-lymphocyte responses to serotype-cross-reactive epitopes on nonstructural proteins following natural secondary dengue virus infection. J Virol. 1998 May; 72(5):3999-4004.
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        109. Okamoto Y, Kurane I, Leporati AM, Ennis FA. Definition of the region on NS3 which contains multiple epitopes recognized by dengue virus serotype-cross-reactive and flavivirus-cross-reactive, HLA-DPw2-restricted CD4+ T cell clones. J Gen Virol. 1998 Apr; 79 ( Pt 4):697-704.
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        110. Kurane I, Zeng L, Brinton MA, Ennis FA. Definition of an epitope on NS3 recognized by human CD4+ cytotoxic T lymphocyte clones cross-reactive for dengue virus types 2, 3, and 4. Virology. 1998 Jan 20; 240(2):169-74.
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        111. Rothman AL, Yamada Y, Jameson J, Cruz J, West K, Green S, Ennis FA. Assessment of human CD4+ and CD8+ T lymphocyte responses in experimental viral vaccine studies. Dev Biol Stand. 1998; 95:95-104.
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        112. Ennis FA, Cruz J, Spiropoulou CF, Waite D, Peters CJ, Nichol ST, Kariwa H, Koster FT. Hantavirus pulmonary syndrome: CD8+ and CD4+ cytotoxic T lymphocytes to epitopes on Sin Nombre virus nucleocapsid protein isolated during acute illness. Virology. 1997 Nov 24; 238(2):380-90.
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        113. Green S, Kurane I, Pincus S, Paoletti E, Ennis FA. Recognition of dengue virus NS1-NS2a proteins by human CD4+ cytotoxic T lymphocyte clones. Virology. 1997 Aug 4; 234(2):383-6.
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        114. Livingston PG, Kurane I, Ennis FA. Use of Epstein-Barr virus-transformed, autologous B-lymphoblastoid cells as antigen-presenting cells for establishment and maintenance of dengue virus-specific, human cytotoxic T lymphocyte clones. J Virol Methods. 1997 Aug; 67(1):77-84.
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        115. Sudiro TM, Ishiko H, Green S, Vaughn DW, Nisalak A, Kalayanarooj S, Rothman AL, Raengsakulrach B, Janus J, Kurane I, Ennis FA. Rapid diagnosis of dengue viremia by reverse transcriptase-polymerase chain reaction using 3'-noncoding region universal primers. Am J Trop Med Hyg. 1997 Apr; 56(4):424-9.
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        116. Mori M, Kurane I, Janus J, Ennis FA. Cytokine production by dengue virus antigen-responsive human T lymphocytes in vitro examined using a double immunocytochemical technique. J Leukoc Biol. 1997 Mar; 61(3):338-45.
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        117. Rothman AL, Kurane I, Ennis FA. Multiple specificities in the murine CD4+ and CD8+ T-cell response to dengue virus. J Virol. 1996 Oct; 70(10):6540-6.
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        118. Mathew A, Kurane I, Rothman AL, Zeng LL, Brinton MA, Ennis FA. Dominant recognition by human CD8+ cytotoxic T lymphocytes of dengue virus nonstructural proteins NS3 and NS1.2a. J Clin Invest. 1996 Oct 1; 98(7):1684-91.
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        119. Berrios V, Kurane I, Ennis FA. Immunomodulatory effects of IL-7 on dengue virus-specific cytotoxic CD4+ T cell clones. Immunol Invest. 1996 May; 25(3):231-40.
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        120. Demkowicz WE, Littaua RA, Wang J, Ennis FA. Human cytotoxic T-cell memory: long-lived responses to vaccinia virus. J Virol. 1996 Apr; 70(4):2627-31.
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        121. Gagnon SJ, Zeng W, Kurane I, Ennis FA. Identification of two epitopes on the dengue 4 virus capsid protein recognized by a serotype-specific and a panel of serotype-cross-reactive human CD4+ cytotoxic T-lymphocyte clones. J Virol. 1996 Jan; 70(1):141-7.
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        122. Zivny J, Kurane I, Leporati AM, Ibe M, Takiguchi M, Zeng LL, Brinton MA, Ennis FA. A single nine-amino acid peptide induces virus-specific, CD8+ human cytotoxic T lymphocyte clones of heterogeneous serotype specificities. J Exp Med. 1995 Sep 1; 182(3):853-63.
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        123. Kurane I, Okamoto Y, Dai LC, Zeng LL, Brinton MA, Ennis FA. Flavivirus-cross-reactive, HLA-DR15-restricted epitope on NS3 recognized by human CD4+ CD8- cytotoxic T lymphocyte clones. J Gen Virol. 1995 Sep; 76 ( Pt 9):2243-9.
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        124. Livingston PG, Toomey S, Kurane I, Janus J, Ennis FA. Modulation of the functions of dengue virus-specific human CD8+ cytotoxic T cell clone by IL-2, IL-7 and IFN gamma. Immunol Invest. 1995 May; 24(4):619-29.
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        125. Livingston PG, Kurane I, Dai LC, Okamoto Y, Lai CJ, Men R, Karaki S, Takiguchi M, Ennis FA. Dengue virus-specific, HLA-B35-restricted, human CD8+ cytotoxic T lymphocyte (CTL) clones. Recognition of NS3 amino acids 500 to 508 by CTL clones of two different serotype specificities. J Immunol. 1995 Feb 1; 154(3):1287-95.
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        126. Kurane I, Innis BL, Hoke CH, Eckels KH, Meager A, Janus J, Ennis FA. T cell activation in vivo by dengue virus infection. J Clin Lab Immunol. 1995; 46(1):35-40.
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        127. Okamoto Y, Gagnon SJ, Kurane I, Leporati AM, Ennis FA. Preferential usage of T-cell receptor V beta 17 by dengue virus-specific human T lymphocytes in a donor with immunity to dengue virus type 4. J Virol. 1994 Nov; 68(11):7614-9.
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        128. Tamura M, Webster RG, Ennis FA. Subtype cross-reactive, infection-enhancing antibody responses to influenza A viruses. J Virol. 1994 Jun; 68(6):3499-504.
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        129. Livingston PG, Kurane I, Lai CJ, Bray M, Ennis FA. Recognition of envelope protein by dengue virus serotype-specific human CD4+ CD8- cytotoxic T-cell clones. J Virol. 1994 May; 68(5):3283-8.
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        130. Kurane I, Rothman AL, Livingston PG, Green S, Gagnon SJ, Janus J, Innis BL, Nimmannitya S, Nisalak A, Ennis FA. Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock syndrome. Arch Virol Suppl. 1994; 9:59-64.
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        131. Kurane I, Ennis FA. Cytotoxic T lymphocytes in dengue virus infection. Curr Top Microbiol Immunol. 1994; 189:93-108.
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        132. Gotoff R, Tamura M, Janus J, Thompson J, Wright P, Ennis FA. Primary influenza A virus infection induces cross-reactive antibodies that enhance uptake of virus into Fc receptor-bearing cells. J Infect Dis. 1994 Jan; 169(1):200-3.
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        133. Green S, Kurane I, Edelman R, Tacket CO, Eckels KH, Vaughn DW, Hoke CH, Ennis FA. Dengue virus-specific human CD4+ T-lymphocyte responses in a recipient of an experimental live-attenuated dengue virus type 1 vaccine: bulk culture proliferation, clonal analysis, and precursor frequency determination. J Virol. 1993 Oct; 67(10):5962-7.
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        134. Kurane I, Dai LC, Livingston PG, Reed E, Ennis FA. Definition of an HLA-DPw2-restricted epitope on NS3, recognized by a dengue virus serotype-cross-reactive human CD4+ CD8- cytotoxic T-cell clone. J Virol. 1993 Oct; 67(10):6285-8.
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        135. Kobayashi K, Takeda A, Green S, Tuazon CU, Ennis FA. Direct detection of infectious human immunodeficiency virus type 1 (HIV-1) immune complexes in the sera of HIV-1-infected persons. J Infect Dis. 1993 Sep; 168(3):729-32.
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        136. Tamura M, Webster RG, Ennis FA. Neutralization and infection-enhancement epitopes of influenza A virus hemagglutinin. J Immunol. 1993 Aug 1; 151(3):1731-8.
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        137. Mady BJ, Kurane I, Erbe DV, Fanger MW, Ennis FA. Neuraminidase augments Fc gamma receptor II-mediated antibody-dependent enhancement of dengue virus infection. J Gen Virol. 1993 May; 74 ( Pt 5):839-44.
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        138. Demkowicz WE, Ennis FA. Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans. J Virol. 1993 Mar; 67(3):1538-44.
          View in: PubMed
        139. Kurane I, Innis BL, Nimmannitya S, Nisalak A, Meager A, Ennis FA. High levels of interferon alpha in the sera of children with dengue virus infection. Am J Trop Med Hyg. 1993 Feb; 48(2):222-9.
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        140. Rothman AL, Kurane I, Lai CJ, Bray M, Falgout B, Men R, Ennis FA. Dengue virus protein recognition by virus-specific murine CD8+ cytotoxic T lymphocytes. J Virol. 1993 Feb; 67(2):801-6.
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        141. Zivny J, Kurane I, Tacket CO, Edelman R, Ennis FA. Dengue virus-specific, human CD4+ cytotoxic T lymphocytes generated in short-term culture. Viral Immunol. 1993; 6(2):143-51.
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        142. Saikh KU, Tamura M, Kuwano K, Dai LC, West K, Ennis FA. Protective cross-reactive epitope on the nonstructural protein NS1 of influenza A virus. Viral Immunol. 1993; 6(4):229-36.
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        143. Takeda A, Robinson JE, Ho DD, Debouck C, Haigwood NL, Ennis FA. Distinction of human immunodeficiency virus type 1 neutralization and infection enhancement by human monoclonal antibodies to glycoprotein 120. J Clin Invest. 1992 Jun; 89(6):1952-7.
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        144. Dai LC, West K, Littaua R, Takahashi K, Ennis FA. Mutation of human immunodeficiency virus type 1 at amino acid 585 on gp41 results in loss of killing by CD8+ A24-restricted cytotoxic T lymphocytes. J Virol. 1992 May; 66(5):3151-4.
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        145. Littaua RA, Takeda A, Cruz J, Ennis FA. Vaccinia virus-specific human CD4+ cytotoxic T-lymphocyte clones. J Virol. 1992 Apr; 66(4):2274-80.
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        146. Haubrich RH, Takeda A, Koff W, Smith G, Ennis FA. Studies of antibody-dependent enhancement of human immunodeficiency virus (HIV) type 1 infection mediated by Fc receptors using sera from recipients of a recombinant gp160 experimental HIV-1 vaccine. J Infect Dis. 1992 Mar; 165(3):545-8.
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        147. Kurane I, Janus J, Ennis FA. Dengue virus infection of human skin fibroblasts in vitro production of IFN-beta, IL-6 and GM-CSF. Arch Virol. 1992; 124(1-2):21-30.
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        148. Littaua RA, Oldstone MB, Takeda A, Ennis FA. A CD4+ cytotoxic T-lymphocyte clone to a conserved epitope on human immunodeficiency virus type 1 p24: cytotoxic activity and secretion of interleukin-2 and interleukin-6. J Virol. 1992 Jan; 66(1):608-11.
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        149. Takahashi K, Dai LC, Fuerst TR, Biddison WE, Earl PL, Moss B, Ennis FA. Specific lysis of human immunodeficiency virus type 1-infected cells by a HLA-A3.1-restricted CD8+ cytotoxic T-lymphocyte clone that recognizes a conserved peptide sequence within the gp41 subunit of the envelope protein. Proc Natl Acad Sci U S A. 1991 Nov 15; 88(22):10277-81.
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        150. Kurane I, Innis BL, Nimmannitya S, Nisalak A, Meager A, Janus J, Ennis FA. Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue. J Clin Invest. 1991 Nov; 88(5):1473-80.
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        151. Mady BJ, Erbe DV, Kurane I, Fanger MW, Ennis FA. Antibody-dependent enhancement of dengue virus infection mediated by bispecific antibodies against cell surface molecules other than Fc gamma receptors. J Immunol. 1991 Nov 1; 147(9):3139-44.
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        152. Littaua RA, Oldstone MB, Takeda A, Debouck C, Wong JT, Tuazon CU, Moss B, Kievits F, Ennis FA. An HLA-C-restricted CD8+ cytotoxic T-lymphocyte clone recognizes a highly conserved epitope on human immunodeficiency virus type 1 gag. J Virol. 1991 Aug; 65(8):4051-6.
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        153. Tamura M, Webster RG, Ennis FA. Antibodies to HA and NA augment uptake of influenza A viruses into cells via Fc receptor entry. Virology. 1991 May; 182(1):211-9.
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        154. Kurane I, Brinton MA, Samson AL, Ennis FA. Dengue virus-specific, human CD4+ CD8- cytotoxic T-cell clones: multiple patterns of virus cross-reactivity recognized by NS3-specific T-cell clones. J Virol. 1991 Apr; 65(4):1823-8.
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        155. Kuwano K, Reyes VE, Humphreys RE, Ennis FA. Recognition of disparate HA and NS1 peptides by an H-2Kd-restricted, influenza specific CTL clone. Mol Immunol. 1991 Jan-Feb; 28(1-2):1-7.
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        156. Kurane I, Innis BL, Nimmannitya S, Nisalak A, Rothman AL, Livingston PG, Janus J, Ennis FA. Human immune responses to dengue viruses. Southeast Asian J Trop Med Public Health. 1990 Dec; 21(4):658-62.
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        157. Takeda A, Sweet RW, Ennis FA. Two receptors are required for antibody-dependent enhancement of human immunodeficiency virus type 1 infection: CD4 and Fc gamma R. J Virol. 1990 Nov; 64(11):5605-10.
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        158. Kuwano K, Tamura M, Ennis FA. Cross-reactive protection against influenza A virus infections by an NS1-specific CTL clone. Virology. 1990 Sep; 178(1):174-9.
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        159. Takeda A, Ennis FA. FcR-mediated enhancement of HIV-1 infection by antibody. AIDS Res Hum Retroviruses. 1990 Aug; 6(8):999-1004.
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        160. Littaua R, Kurane I, Ennis FA. Human IgG Fc receptor II mediates antibody-dependent enhancement of dengue virus infection. J Immunol. 1990 Apr 15; 144(8):3183-6.
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        161. Herrmann JE, West K, Bruns M, Ennis FA. Effect of rimantadine on cytotoxic T lymphocyte responses and immunity to reinfection in mice infected with influenza A virus. J Infect Dis. 1990 Feb; 161(2):180-4.
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        162. Kurane I, Kontny U, Janus J, Ennis FA. Dengue-2 virus infection of human mononuclear cell lines and establishment of persistent infections. Arch Virol. 1990; 110(1-2):91-101.
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        163. Bukowski JF, Kurane I, Lai CJ, Bray M, Falgout B, Ennis FA. Dengue virus-specific cross-reactive CD8+ human cytotoxic T lymphocytes. J Virol. 1989 Dec; 63(12):5086-91.
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        164. Kurane I, Meager A, Ennis FA. Dengue virus-specific human T cell clones. Serotype crossreactive proliferation, interferon gamma production, and cytotoxic activity. J Exp Med. 1989 Sep 1; 170(3):763-75.
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        165. Rothman AL, Kurane I, Zhang YM, Lai CJ, Ennis FA. Dengue virus-specific murine T-lymphocyte proliferation: serotype specificity and response to recombinant viral proteins. J Virol. 1989 Jun; 63(6):2486-91.
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        166. Herrmann JE, Bruns M, West K, Ennis FA. Efficacy of rimantadine hydrochloride in the treatment of influenza infection of mice. Antiviral Res. 1989 Apr; 11(3):127-35.
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        167. Kuwano K, Scott M, Young JF, Ennis FA. Active immunization against virus infections due to antigenic drift by induction of crossreactive cytotoxic T lymphocytes. J Exp Med. 1989 Apr 1; 169(4):1361-71.
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        168. Kurane I, Innis BL, Nisalak A, Hoke C, Nimmannitya S, Meager A, Ennis FA. Human T cell responses to dengue virus antigens. Proliferative responses and interferon gamma production. J Clin Invest. 1989 Feb; 83(2):506-13.
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        169. Kuwano K, Braciale TJ, Ennis FA. Cytotoxic T lymphocytes recognize a cross-reactive epitope on the transmembrane region of influenza H1 and H2 hemagglutinins. Viral Immunol. 1989; 2(3):163-73.
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        170. Kontny U, Kurane I, Ennis FA. Gamma interferon augments Fc gamma receptor-mediated dengue virus infection of human monocytic cells. J Virol. 1988 Nov; 62(11):3928-33.
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        171. Takeda A, Tuazon CU, Ennis FA. Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry. Science. 1988 Oct 28; 242(4878):580-3.
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        172. Kuwano K, Scott M, Young JF, Ennis FA. HA2 subunit of influenza A H1 and H2 subtype viruses induces a protective cross-reactive cytotoxic T lymphocyte response. J Immunol. 1988 Feb 15; 140(4):1264-8.
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        173. Kurane I, Ennis FA. Production of interferon alpha by dengue virus-infected human monocytes. J Gen Virol. 1988 Feb; 69 ( Pt 2):445-9.
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        174. Kurane I, Ennis FA. Induction of interferon alpha from human lymphocytes by autologous, dengue virus-infected monocytes. J Exp Med. 1987 Oct 1; 166(4):999-1010.
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        175. Jaffe PA, Kuwano K, Yamada A, Scott M, Young JF, Ennis FA. Kinetics and specificity at the clonal level of the cytotoxic T lymphocyte response to influenza pneumonia. Viral Immunol. 1987-1988; 1(4):259-66.
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