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    Michael J Mitchell MD

    TitleClinical Associate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPathology
    AddressUMass Memorial Health Care Inc.
    365 Plantation Street, Biotech One
    Worcester MA 01605
        Overview 
        Narrative

        Academic Background

          Present Position:
          Director, Microbiology Services
          Department of Hospital Laboratories
          Address:
          89 Puritan Road
          Waban, MA 02468
          Medical School:
          Yale University School of Medicine, MD (1978)

        Graduate Medical Education:

          1978-1981 Resident in Pediatrics, Yale-New Haven Hospital
          1981-1984 Fellow, Pediatric Infectious Diseases, Johns Hopkins Hospital
          1984-1987 Fellow, Microbiology Service, National Institutes of Health
          1990-1992 Fellow, Combined Program in Human Genetics, Harvard Medical School

        Certification:

          National Board of Medical Examiners (#201579), 1980.
          American Academy of Pediatrics, (#29383), 1983.
          American Board of Pathology, Medical Microbiology, 1986.
          American Board of Medical Genetics, Clinical Cytogenetics, 1993

        Licensure:

          The Board of Medical Examiners of the State of Maryland, D33781 (expired 1987).
          Commonwealth of Massachusetts Board of Registration in Medicine, (Reg.#: 58562, Expires 6/18/03).

        Current Academic Appointment(s):

          Assistant Professor, Department of Pathology, University of Massachusetts School of Medicine

        Current Medical Staff Appointment(s):

          Staff Physician, UMass Memorial Group Practice

        Interests

        I oversee laboratory and clinical aspects of the microbiology laboratories, including aerobicmichael Mitchell andanaerobicbacteriology, mycobacteriology, mycology, parasitology, and virology. I am involved with teachingandtraining of Medical Students, Pathology Residents, and Infectious Diseases Fellows (Department of Medicine). I am a member of the Steering Committee in the Department of Hospital Labs. I sit on the UMMMC Clinical Process Improvement Committee, and chair its Laboratory Advisory subcommittee. I also sit on the UMMMC Pharmacy and Therapeutics Antimicrobial Subcommittee, the UMMMC Infection Control Committee, and theUMMMC Disaster Committee.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Cao TM, Mitchell MJ, Liesveld J, King MR. Stem Cell Enrichment with Selectin Receptors: Mimicking the pH Environment of Trauma. Sensors (Basel). 2013; 13(9):12516-26.
          View in: PubMed
        2. Mitchell MJ, King MR. Computational and experimental models of cancer cell response to fluid shear stress. Front Oncol. 2013; 3:44.
          View in: PubMed
        3. Mitchell MJ, King MR. Shear-Induced Resistance to Neutrophil Activation via the Formyl Peptide Receptor. Biophys J. 2012 Apr 18; 102(8):1804-14.
          View in: PubMed
        4. Streichemberger E, Perrin J, Saias-Magnan J, Karsenty G, Malzac P, Grillo JM, Mitchell MJ, Metzler-Guillemain C. Case report of apoptosis in testis of four AZFc-deleted patients: increased DNA fragmentation during meiosis, but decreased apoptotic markers in post-meiotic germ cells. Hum Reprod. 2012 Jul; 27(7):1939-45.
          View in: PubMed
        5. Decarpentrie F, Vernet N, Mahadevaiah SK, Longepied G, Streichemberger E, Aknin-Seifer I, Ojarikre OA, Burgoyne PS, Metzler-Guillemain C, Mitchell MJ. Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential. Hum Mol Genet. 2012 Jun 15; 21(12):2631-45.
          View in: PubMed
        6. Mitchell MJ, Chen CS, Ponmudi V, Hughes AD, King MR. E-selectin liposomal and nanotube-targeted delivery of doxorubicin to circulating tumor cells. J Control Release. 2012 Jun 28; 160(3):609-17.
          View in: PubMed
        7. Schlaberg R, Mitchell MJ, Taggart EW, She RC. Verification of Performance Specifications for a US Food and Drug Administration-Approved Molecular Microbiology Test: Clostridium difficile Cytotoxin B Using the Becton, Dickinson and Company GeneOhm Cdiff Assay. Arch Pathol Lab Med. 2012 Jan; 136(1):20-5.
          View in: PubMed
        8. Kichine E, Rozé V, Di Cristofaro J, Taulier D, Navarro A, Streichemberger E, Decarpentrie F, Metzler-Guillemain C, Lévy N, Chiaroni J, Paquis-Flucklinger V, Fellmann F, Mitchell MJ. HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation. Hum Reprod. 2012 Feb; 27(2):615-24.
          View in: PubMed
        9. Vernet N, Mahadevaiah SK, Ojarikre OA, Longepied G, Prosser HM, Bradley A, Mitchell MJ, Burgoyne PS. The y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice. Curr Biol. 2011 May 10; 21(9):787-93.
          View in: PubMed
        10. Hayden RT, Wick MT, Rodriguez AB, Caliendo AM, Mitchell MJ, Ginocchio CC. A survey-based assessment of United States clinical laboratory response to the 2009 H1N1 influenza outbreak. Arch Pathol Lab Med. 2010 Nov; 134(11):1671-8.
          View in: PubMed
        11. Wagar EA, Mitchell MJ, Carroll KC, Beavis KG, Petti CA, Schlaberg R, Yasin B. A review of sentinel laboratory performance: identification and notification of bioterrorism agents. Arch Pathol Lab Med. 2010 Oct; 134(10):1490-503.
          View in: PubMed
        12. Longepied G, Saut N, Aknin-Seifer I, Levy R, Frances AM, Metzler-Guillemain C, Guichaoua MR, Mitchell MJ. Complete deletion of the AZFb interval from the Y chromosome in an oligozoospermic man. Hum Reprod. 2010 Oct; 25(10):2655-63.
          View in: PubMed
        13. Msaidie S, Ducourneau A, Boetsch G, Longepied G, Papa K, Allibert C, Yahaya AA, Chiaroni J, Mitchell MJ. Genetic diversity on the Comoros Islands shows early seafaring as major determinant of human biocultural evolution in the Western Indian Ocean. Eur J Hum Genet. 2011 Jan; 19(1):89-94.
          View in: PubMed
        14. Chiaroni J, King RJ, Myres NM, Henn BM, Ducourneau A, Mitchell MJ, Boetsch G, Sheikha I, Lin AA, Nik-Ahd M, Ahmad J, Lattanzi F, Herrera RJ, Ibrahim ME, Brody A, Semino O, Kivisild T, Underhill PA. The emergence of Y-chromosome haplogroup J1e among Arabic-speaking populations. Eur J Hum Genet. 2010 Mar; 18(3):348-53.
          View in: PubMed
        15. Mitchell MJ, Stubbs BA, Eisenberg MS. Socioeconomic status is associated with provision of bystander cardiopulmonary resuscitation. Prehosp Emerg Care. 2009 Oct-Dec; 13(4):478-86.
          View in: PubMed
        16. Metzler-Guillemain C, Depetris D, Luciani JJ, Mignon-Ravix C, Mitchell MJ, Mattei MG. In human pachytene spermatocytes, SUMO protein is restricted to the constitutive heterochromatin. Chromosome Res. 2008; 16(5):761-82.
          View in: PubMed
        17. Mitchell MJ, Montgomery M, Reiter CG, Culp WC. Pericardial tamponade following CT-guided lung biopsy. Cardiovasc Intervent Radiol. 2008 Jul; 31 Suppl 2:S227-30.
          View in: PubMed
        18. Mitchell MJ, Dai L, Clarke JB, Bolton-Maggs PH, Savidge GF, Alhaq A. Characterisation of five factor XI mutations. Thromb Haemost. 2007 Jun; 97(6):884-9.
          View in: PubMed
        19. Bolton-Maggs PH, Hay CR, Shanks D, Mitchell MJ, McVey JH. The importance of tissue factor source in the management of Factor VII deficiency. Thromb Haemost. 2007 Jan; 97(1):151-2.
          View in: PubMed
        20. Turner JM, Mahadevaiah SK, Ellis PJ, Mitchell MJ, Burgoyne PS. Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids. Dev Cell. 2006 Apr; 10(4):521-9.
          View in: PubMed
        21. Perrin J, Metzler-Guillemain C, Karsenty G, Grillo JM, Mitchell MJ, Guichaoua MR. Meiotic arrest at the midpachytene stage in a patient with complete azoospermia factor b deletion of the Y chromosome. Fertil Steril. 2006 Feb; 85(2):494.e5-8.
          View in: PubMed
        22. Cutler JA, Patel R, Mitchell MJ, Savidge GF. The significance of published polymorphisms in 14 cases of mild factor VII deficiency. Blood Coagul Fibrinolysis. 2005 Mar; 16(2):91-5.
          View in: PubMed
        23. Cutler JA, Mitchell MJ, Smith MP, Savidge GF. Germline mosaicism resulting in the transmission of severe hemophilia B from a grandfather with a mild deficiency. Am J Med Genet A. 2004 Aug 15; 129A(1):13-5.
          View in: PubMed
        24. Cutler JA, Mitchell MJ, Savidge GF. More on: unusual expression of the F9 gene in peripheral lymphocytes hinders investigation of F9 mRNA in hemophilia B patients. J Thromb Haemost. 2004 Jun; 2(6):1021.
          View in: PubMed
        25. Delbridge ML, Longepied G, Depetris D, Mattei MG, Disteche CM, Marshall Graves JA, Mitchell MJ. TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X - implications for Y chromosome evolution. Chromosome Res. 2004; 12(4):345-56.
          View in: PubMed
        26. McElreavey K, Mitchell MJ. The sexually transmitted genome. Trends Genet. 2002 Jan; 18(1):13-4.
          View in: PubMed
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