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    Masanori Terajima MD, PhD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-2886
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentImmunology and Virology

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentCenter for Infectious Disease and Vaccine Research

        Overview 
        Narrative

        Academic Background

        Education:

        • B.S., Tohoku University School of Medicine, Sendai, Japan, 1988
        • M.D., Tohoku University School of Medicine, Sendai, Japan, 1988
        • Ph.D., Tohoku University School of Medicine, Sendai, Japan, 1994

        Research and Professional Experience:

        • Resident, Suifu Hospital, Mito, Japan, 1988-1990
        • Graduate Student, Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan, 1990-1994
        • Medical Stuff, Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan, 1994-1997
        • Post-Doctoral Research Associate, Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, 1997-2000
        • Assistant Professor, Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, 8/2000-5/2009
        • Associate Professor, Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, 5/2009-present

        Host Immune Responses Against Viruses

        Our research interest is host (especially human) immune responses against viruses.

        We are studying (1) immune responses to influenza viruses (2) antiviral genes against vaccinia virus, (3) Immunopathogenesis of hantavirus infections.

        (1) Immune responses to influenza viruses

        We are studyinghumoral and cellular immune responses to influenza virus infection and vaccination with emphasis on subtype cross-reactive T cell responses in humans.

        (2) antiviral genes against vaccinia virus

        We are studying host range genes in vaccinia to understand the mechanisms of species specificity and to identify new antiviral mechanisms.

        (3) Immunopathogenesis of hantavirus infections

        Hantavirus infection causes two clinically different diseases, hantavirus pulmonary syndrome (HPS) and hemorrhagic fever renal syndrome (HFRS) depending on the hantavirus species infecting the patients. We are studying immunopathological mechanisms of these diseases focusing on the virus-specific T cells-endothelial cells interaction.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Terajima M, Babon JA, Co MD, Ennis FA. Cross-reactive human B cell and T cell epitopes between influenza A and B viruses. Virol J. 2013; 10:244.
          View in: PubMed
        2. Kondo Y, Uno K, Machida K, Terajima M. PPARs and Liver Disease. PPAR Res. 2013; 2013:896412.
          View in: PubMed
        3. Terajima M, Urban SL, Leporati AM. The N-terminus of vaccinia virus host range protein C7L is essential for function. Virus Genes. 2013 Feb; 46(1):20-7.
          View in: PubMed
        4. Terajima M, Ennis FA. Nuclear Export Signal and Immunodominant CD8+ T Cell Epitope in Influenza A Virus Matrix Protein 1. J Virol. 2012 Sep; 86(18):10258.
          View in: PubMed
        5. Dawn Co M, Cruz J, Takeda A, Ennis F, Terajima M. Comparison of complement dependent lytic, hemagglutination inhibition and microneutralization antibody responses in influenza vaccinated individuals. Hum Vaccin Immunother. 2012 Sep 1; 8(9):1218-22.
          View in: PubMed
        6. Terajima M, Babon JA, Ennis FA. Epidemiology of the Influenza A Virus H5N1 Subtype and Memory of Immunity to the H2N2 Subtype. MBio. 2012; 3(4).
          View in: PubMed
        7. Babon JA, Cruz J, Ennis FA, Yin L, Terajima M. A Human CD4+ T Cell Epitope in the Influenza Hemagglutinin Is Cross-Reactive to Influenza A Virus Subtypes and to Influenza B Virus. J Virol. 2012 Sep; 86(17):9233-43.
          View in: PubMed
        8. Terajima M, Cruz J, Co MD, Lee JH, Kaur K, Wilson PC, Ennis FA. Complement-dependent lysis of influenza a virus-infected cells by broadly cross-reactive human monoclonal antibodies. J Virol. 2011 Dec; 85(24):13463-7.
          View in: PubMed
        9. Terajima M, Ennis FA. T cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic Fever with renal syndrome. Viruses. 2011 Jul; 3(7):1059-73.
          View in: PubMed
        10. Smith HL, Monath TP, Pazoles P, Rothman AL, Casey DM, Terajima M, Ennis FA, Guirakhoo F, Green S. Development of Antigen-Specific Memory CD8+ T Cells Following Live-Attenuated Chimeric West Nile Virus Vaccination. J Infect Dis. 2011 Feb; 203(4):513-22.
          View in: PubMed
        11. Jameson JM, Cruz J, Costanzo A, Terajima M, Ennis FA. A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes. Cell Immunol. 2010; 264(1):71-7.
          View in: PubMed
        12. Moutaftsi M, Tscharke DC, Vaughan K, Koelle DM, Stern L, Calvo-Calle M, Ennis F, Terajima M, Sutter G, Crotty S, Drexler I, Franchini G, Yewdell JW, Head SR, Blum J, Peters B, Sette A. Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens. Future Microbiol. 2010 Feb; 5(2):221-39.
          View in: PubMed
        13. Babon JA, Cruz J, Orphin L, Pazoles P, Co MD, Ennis FA, Terajima M. Genome-wide screening of human T-cell epitopes in influenza A virus reveals a broad spectrum of CD4(+) T-cell responses to internal proteins, hemagglutinins, and neuraminidases. Hum Immunol. 2009 Sep; 70(9):711-21.
          View in: PubMed
        14. Co MD, Orphin L, Cruz J, Pazoles P, Green KM, Potts J, Leporati AM, Babon JA, Evans JE, Ennis FA, Terajima M. In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses. Vaccine. 2009 Jan 7; 27(2):319-27.
          View in: PubMed
        15. Terajima M, Orphin L, Leporati AM, Pazoles P, Cruz J, Rothman AL, Ennis FA. Vaccinia virus-specific CD8(+) T-cell responses target a group of epitopes without a strong immunodominance hierarchy in humans. Hum Immunol. 2008 Dec; 69(12):815-25.
          View in: PubMed
        16. Mathew A, O'Bryan J, Marshall W, Kotwal GJ, Terajima M, Green S, Rothman AL, Ennis FA. Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus. PLoS One. 2008; 3(10):e3323.
          View in: PubMed
        17. Terajima M, Cruz J, Leporati AM, Orphin L, Babon JA, Co MD, Pazoles P, Jameson J, Ennis FA. Influenza A virus matrix protein 1-specific human CD8+ T-cell response induced in trivalent inactivated vaccine recipients. J Virol. 2008 Sep; 82(18):9283-7.
          View in: PubMed
        18. Co MD, Orphin L, Cruz J, Pazoles P, Rothman AL, Ennis FA, Terajima M. Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine. Vaccine. 2008 Apr 7; 26(16):1990-8.
          View in: PubMed
        19. Terajima M, Hayasaka D, Maeda K, Ennis FA. Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: Do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers? Immunol Lett. 2007 Nov 15; 113(2):117-20.
          View in: PubMed
        20. Mitra-Kaushik S, Cruz J, Stern LJ, Ennis FA, Terajima M. Human cytotoxic CD4+ T cells recognize HLA-DR1-restricted epitopes on vaccinia virus proteins A24R and D1R conserved among poxviruses. J Immunol. 2007 Jul 15; 179(2):1303-12.
          View in: PubMed
        21. Hayasaka D, Ennis FA, Terajima M. Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses. Virol J. 2007; 4:22.
          View in: PubMed
        22. Hayasaka D, Maeda K, Ennis FA, Terajima M. Increased permeability of human endothelial cell line EA.hy926 induced by hantavirus-specific cytotoxic T lymphocytes. Virus Res. 2007 Feb; 123(2):120-7.
          View in: PubMed
        23. Terajima M, Cruz J, Leporati AM, Demkowicz WE, Kennedy JS, Ennis FA. Identification of vaccinia CD8+ T-cell epitopes conserved among vaccinia and variola viruses restricted by common MHC class I molecules, HLA-A2 or HLA-B7. Hum Immunol. 2006 Jul; 67(7):512-20.
          View in: PubMed
        24. Terajima M, Ennis FA. Using HLA-transgenic mice to identify immunodominant human CD8+ T cell epitopes--does (genome) size matter? Immunol Lett. 2006 May 15; 105(1):97-8.
          View in: PubMed
        25. Bradley RR, Terajima M. Vaccinia virus K1L protein mediates host-range function in RK-13 cells via ankyrin repeat and may interact with a cellular GTPase-activating protein. Virus Res. 2005 Dec; 114(1-2):104-12.
          View in: PubMed
        26. Mathew A, Terajima M, West K, Green S, Rothman AL, Ennis FA, Kennedy JS. Identification of murine poxvirus-specific CD8+ CTL epitopes with distinct functional profiles. J Immunol. 2005 Feb 15; 174(4):2212-9.
          View in: PubMed
        27. Terajima M, Leporati AM. Role of Indoleamine 2,3-Dioxygenase in Antiviral Activity of Interferon-gamma Against Vaccinia Virus. Viral Immunol. 2005; 18(4):722-9.
          View in: PubMed
        28. Maeda K, West K, Hayasaka D, Ennis FA, Terajima M. Recombinant adenovirus vector vaccine induces stronger cytotoxic T-cell responses than recombinant vaccinia virus vector, plasmid DNA, or a combination of these. Viral Immunol. 2005; 18(4):657-67.
          View in: PubMed
        29. Maeda K, West K, Toyosaki-Maeda T, Rothman AL, Ennis FA, Terajima M. Identification and analysis for cross-reactivity among hantaviruses of H-2b-restricted cytotoxic T-lymphocyte epitopes in Sin Nombre virus nucleocapsid protein. J Gen Virol. 2004 Jul; 85(Pt 7):1909-19.
          View in: PubMed
        30. Kilpatrick ED, Terajima M, Koster FT, Catalina MD, Cruz J, Ennis FA. Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome. J Immunol. 2004 Mar 1; 172(5):3297-304.
          View in: PubMed
        31. Terajima M, Vapalahti O, Van Epps HL, Vaheri A, Ennis FA. Immune responses to Puumala virus infection and the pathogenesis of nephropathia epidemica. Microbes Infect. 2004 Feb; 6(2):238-45.
          View in: PubMed
        32. Terajima M, Ennis FA. Quantitation of antibody-bound and unbound Sin Nombre virus in the plasma of patient with hantavirus pulmonary syndrome. J Virol Methods. 2003 Jun 30; 110(2):159-62.
          View in: PubMed
        33. Terajima M, Cruz J, Raines G, Kilpatrick ED, Kennedy JS, Rothman AL, Ennis FA. Quantitation of CD8+ T cell responses to newly identified HLA-A*0201-restricted T cell epitopes conserved among vaccinia and variola (smallpox) viruses. J Exp Med. 2003 Apr 7; 197(7):927-32.
          View in: PubMed
        34. Van Epps HL, Terajima M, Mustonen J, Arstila TP, Corey EA, Vaheri A, Ennis FA. Long-lived memory T lymphocyte responses after hantavirus infection. J Exp Med. 2002 Sep 2; 196(5):579-88.
          View in: PubMed
        35. Terajima M, Van Epps HL, Li D, Leporati AM, Juhlin SE, Mustonen J, Vaheri A, Ennis FA. Generation of recombinant vaccinia viruses expressing Puumala virus proteins and use in isolating cytotoxic T cells specific for Puumala virus. Virus Res. 2002 Mar 20; 84(1-2):67-77.
          View in: PubMed
        36. Co MD, Terajima M, Cruz J, Ennis FA, Rothman AL. Human cytotoxic T lymphocyte responses to live attenuated 17D yellow fever vaccine: identification of HLA-B35-restricted CTL epitopes on nonstructural proteins NS1, NS2b, NS3, and the structural protein E. Virology. 2002 Feb 1; 293(1):151-63.
          View in: PubMed
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