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    Hongbo Yu MD, PhD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPathology
    AddressUMass Memorial Medical Center
    One Innovation Drive, Biotech Three
    Worcester MA 01605
    Phone508-793-6176
        Overview 
        Narrative

        Dr. Hongbo Yu's photo

        Academic Background

        M.D.
        Beijing Medical University, Beijing, China 1988-1993

        Ph.D.
        Brandeis University, Department of Biochemistry, Waltham, MA 1993-1999

        Postdoctoral Research Fellow:
        The Johns Hopkins University School of Medicine, Department of Molecular Biology and Genetics, Baltimore, MD 1999- 2001

        Resident (Anatomic and Clinical Pathology):
        University of Pittsburgh Medical Center, Department of Pathology, Pittsburgh, PA 2001- 2002
        Georgetown University Hospital, Department of Pathology, Washington, DC 2002- 2005

        Fellow, Hematopathology:
        Brigham and Women’s Hospital, Department of Pathology, Boston, MA 2005-2006

        Staff Pathologist and Instructor:
        Brigham and Women’s Hospital and Harvard Medical School, Department of Pathology, Boston, MA 2006- 2009

        Research Interests:

        As a hematopathologist, my research interests are disorders of hematopoietic system, including benign and neoplastic diseases. I am mainly interested in understanding the pathophysiology of hematopoietic malignancies such as various leukemias and lymphomas and also identifying diagnostic and prognostic biomarkers for these diseases.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Hao S, Andersen M, Yu H. Detection of immune suppressive neutrophils in peripheral blood samples of cancer patients. Am J Blood Res. 2013; 3(3):239-45.
          View in: PubMed
        2. Chen BJ, Chapuy B, Ouyang J, Sun HH, Roemer MG, Xu ML, Yu H, Fletcher CD, Freeman GJ, Shipp MA, Rodig SJ. PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies. Clin Cancer Res. 2013 Jul 1; 19(13):3462-73.
          View in: PubMed
        3. Shi M, Cipollini MJ, Crowley-Bish PA, Higgins AW, Yu H, Miron PM. Improved Detection Rate of Cytogenetic Abnormalities in Chronic Lymphocytic Leukemia and Other Mature B-Cell Neoplasms With Use of CpG-Oligonucleotide DSP30 and Interleukin 2 Stimulation. Am J Clin Pathol. 2013 May; 139(5):662-9.
          View in: PubMed
        4. Cerny J, Yu H, Miron PM. Novel FGFR3 rearrangement t(4;22)(p16;q11.2) in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma. Ann Hematol. 2013 Apr 13.
          View in: PubMed
        5. Morgan EA, Yu H, Pinkus JL, Pinkus GS. Immunohistochemical detection of hairy cell leukemia in paraffin sections using a highly effective CD103 rabbit monoclonal antibody. Am J Clin Pathol. 2013 Feb; 139(2):220-30.
          View in: PubMed
        6. Ramanathan M, Cerny J, Yu H, Woda BA, Nath R. A combination treatment approach and cord blood stem celltransplant for blastic plasmacytoid dendritic cell neoplasm. Haematologica. 2013 Jan 8.
          View in: PubMed
        7. Cerny J, Yu H, Ramanathan M, Raffel GD, Walsh WV, Fortier N, Shanahan L, O'Rourke E, Bednarik J, Barton B, Kroll-Desrosiers A, Hao S, Woda B, Hutchinson L, M Evens A, Rosmarin AG, Nath R. Expression of CD25 independently predicts early treatment failure of acute myeloid leukaemia (AML). Br J Haematol. 2012 Nov 1.
          View in: PubMed
        8. Yu H, Ok CY, Hesse A, Nordell P, Connor D, Sjostedt E, Pechet L, Michael Snyder L. Evaluation of an automated digital imaging system, nextslide digital review network, for examination of peripheral blood smears. Arch Pathol Lab Med. 2012 Jun; 136(6):660-7.
          View in: PubMed
        9. Hure MC, Elco CP, Ward D, Hutchinson L, Meng X, Dorfman DM, Yu H. Histiocytic sarcoma arising from clonally related mantle cell lymphoma. J Clin Oncol. 2012 Feb 10; 30(5):e49-53.
          View in: PubMed
        10. Shi M, Minehart Miron P, Hutchinson L, Woda BA, Nath R, Cerny J, Yu H. Anaplastic lymphoma kinase-positive large B-cell lymphoma with complex karyotype and novel ALK gene rearrangements. Hum Pathol. 2011 Oct; 42(10):1562-7.
          View in: PubMed
        11. Yu H, Li Y, Gao C, Fabien L, Jia Y, Lu J, Silberstein LE, Pinkus GS, Ye K, Chai L, Luo HR. Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN. Leukemia. 2010 May; 24(5):1077-80.
          View in: PubMed
        12. Yu H, Shahsafaei A, Dorfman DM. Germinal-center T-helper-cell markers PD-1 and CXCL13 are both expressed by neoplastic cells in angioimmunoblastic T-cell lymphoma. Am J Clin Pathol. 2009 Jan; 131(1):33-41.
          View in: PubMed
        13. Yu H, Pinkus GS, Hornick JL. Diffuse membranous immunoreactivity for podoplanin (D2-40) distinguishes primary and metastatic seminomas from other germ cell tumors and metastatic neoplasms. Am J Clin Pathol. 2007 Nov; 128(5):767-75.
          View in: PubMed
        14. Yu H, Gibson JA, Pinkus GS, Hornick JL. Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors. Am J Clin Pathol. 2007 Nov; 128(5):776-82.
          View in: PubMed
        15. Chen YB, Yu H, Gillani A, Brown JR. AIDS-associated plasmablastic lymphoma presenting at the insertion site of a peritoneal dialysis catheter. J Clin Oncol. 2007 Jul 20; 25(21):3176-8.
          View in: PubMed
        16. Sandler SG, Yu H, Rassai N. Risks of blood transfusion and their prevention. Clin Adv Hematol Oncol. 2003 May; 1(5):307-13.
          View in: PubMed
        17. Luo HR, Saiardi A, Yu H, Nagata E, Ye K, Snyder SH. Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast. Biochemistry. 2002 Feb 26; 41(8):2509-15.
          View in: PubMed
        18. Luo HR, Saiardi A, Nagata E, Ye K, Yu H, Jung TS, Luo X, Jain S, Sawa A, Snyder SH. GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase. Neuron. 2001 Aug 16; 31(3):439-51.
          View in: PubMed
        19. Struthers M, Yu H, Oprian DD. G protein-coupled receptor activation: analysis of a highly constrained, "straitjacketed" rhodopsin. Biochemistry. 2000 Jul 11; 39(27):7938-42.
          View in: PubMed
        20. Yu H, Kono M, Oprian DD. State-dependent disulfide cross-linking in rhodopsin. Biochemistry. 1999 Sep 14; 38(37):12028-32.
          View in: PubMed
        21. Yu H, Oprian DD. Tertiary interactions between transmembrane segments 3 and 5 near the cytoplasmic side of rhodopsin. Biochemistry. 1999 Sep 14; 38(37):12033-40.
          View in: PubMed
        22. Struthers M, Yu H, Kono M, Oprian DD. Tertiary interactions between the fifth and sixth transmembrane segments of rhodopsin. Biochemistry. 1999 May 18; 38(20):6597-603.
          View in: PubMed
        23. Kono M, Yu H, Oprian DD. Disulfide bond exchange in rhodopsin. Biochemistry. 1998 Feb 3; 37(5):1302-5.
          View in: PubMed
        24. Yu H, Kono M, McKee TD, Oprian DD. A general method for mapping tertiary contacts between amino acid residues in membrane-embedded proteins. Biochemistry. 1995 Nov 21; 34(46):14963-9.
          View in: PubMed
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