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    Chinmay M Trivedi MD, PhD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    368 Plantation Street
    Worcester MA 01605
    Phone508-856-6947
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

        Overview 
        Narrative

        Congenital and adult heart diseases are the leading causes of mortality in the developed world. Improper development of cardiomyocytes leads to the devastating heart defects in newborn children and loss of diseased cardiomyocytes leads to heart failure in adults. Heart is one of the least regenerative organs in the body with negligible endogenous capacity to repair or replace affected cardiomyocytes. Ability of pluripotent stem cells and cardiac progenitor cells to progressively differentiate into various lineages, including cardiomyocytes, provide tantalizing promise for cell-based therapy. Our main focus is to understand regulatory functions of chromatin and epigenetic modifications during lineage commitment and differentiation of these progenitor cells to harness its therapeutic potential.



        Rotation Projects

        Rotation Projects:

        Please contact Chinmay Trivedi (chinmay.trivedi@umassmed.edu) for information regarding potential rotation projects. We will develop a specific rotation project based on student's interest, background, and goals of the rotation. Students can rotate either for a half- or full-semester.

        Project 1: Characterize progressive lineage restriction of cardiac progenitor cells in murine model.
        Project 2: Identify novel chromatin modifiers regulating specification of murine cardiac progenitor cells. 
        Project 3: Characterize cellular interactions during murine cardiac development and diseases.
        Project 4: Determine novel roles of epigenetic modifications during cardiac diseases.


        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Lewandowski SL, Janardhan HP, Smee KM, Bachman M, Sun Z, Lazar MA, Trivedi CM. Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis. Hum Mol Genet. 2014 Feb 23.
          View in: PubMed
        2. Singh N, Gupta M, Trivedi CM, Singh MK, Li L, Epstein JA. Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Dev Biol. 2013 Mar 15.
          View in: PubMed
        3. Banerjee A, Trivedi CM, Damera G, Jiang M, Jester W, Hoshi T, Epstein JA, Panettieri RA. Trichostatin a abrogates airway constriction, but not inflammation, in murine and human asthma models. Am J Respir Cell Mol Biol. 2012 Feb; 46(2):132-8.
          View in: PubMed
        4. Singh N, Trivedi CM, Lu M, Mullican SE, Lazar MA, Epstein JA. Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract. Circ Res. 2011 Nov 11; 109(11):1240-9.
          View in: PubMed
        5. Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, Morrisey EE. Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency. Cell Stem Cell. 2011 Apr 8; 8(4):376-88.
          View in: PubMed
        6. Pillai VB, Sundaresan NR, Samant SA, Wolfgeher D, Trivedi CM, Gupta MP. Acetylation of a Conserved Lysine Residue in the ATP Binding Pocket of p38 Augments Its Kinase Activity during Hypertrophy of Cardiomyocytes. Mol Cell Biol. 2011 Jun; 31(11):2349-63.
          View in: PubMed
        7. Trivedi CM, Cappola TP, Margulies KB, Epstein JA. Homeodomain Only Protein X is down-regulated in human heart failure. J Mol Cell Cardiol. 2011 Jun; 50(6):1056-8.
          View in: PubMed
        8. Trivedi CM, Epstein JA. Heart-healthy hypertrophy. Cell Metab. 2011 Jan 5; 13(1):3-4.
          View in: PubMed
        9. Trivedi CM, Zhu W, Wang Q, Jia C, Kee HJ, Li L, Hannenhalli S, Epstein JA. Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev Cell. 2010 Sep 14; 19(3):450-9.
          View in: PubMed
        10. Chokas AL, Trivedi CM, Lu MM, Tucker PW, Li S, Epstein JA, Morrisey EE. Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6. J Biol Chem. 2010 Apr 23; 285(17):13304-13.
          View in: PubMed
        11. Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM, Epstein JA. Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. Circ Res. 2009 Dec 4; 105(12):1240-7.
          View in: PubMed
        12. Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS. Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. J Clin Invest. 2008 Nov; 118(11):3609-18.
          View in: PubMed
        13. Trivedi CM, Lu MM, Wang Q, Epstein JA. Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy. J Biol Chem. 2008 Sep 26; 283(39):26484-9.
          View in: PubMed
        14. Trivedi CM, Patel RC, Patel CV. Differential regulation of HOXA9 expression by nuclear factor kappa B (NF-kappaB) and HOXA9. Gene. 2008 Jan 31; 408(1-2):187-95.
          View in: PubMed
        15. Trivedi CM, Patel RC, Patel CV. Homeobox gene HOXA9 inhibits nuclear factor-kappa B dependent activation of endothelium. Atherosclerosis. 2007 Dec; 195(2):e50-60.
          View in: PubMed
        16. Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar; 13(3):324-31.
          View in: PubMed
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