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    Julie G Pilitsis MD, PhD

    TitleAffiliate
    InstitutionUniversity of Massachusetts Medical School
    DepartmentNeurosurgery
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-4199
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentClinical Population Health Research

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentNeuroscience

        Bibliographic 
        selected publications
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        1. Gooch MR, Pilitsis JG. Commentary: Percutaneous Balloon Compression vs Percutaneous Retrogasserian Glycerol Rhizotomy for the Primary Treatment of Trigeminal Neuralgia. Neurosurgery. 2016 Sep; 79(3):E514.
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        2. Walling IT, Kaszuba BC, Gee L, Shin D, Pilitsis JG. 120 Effects of Subthalamic Deep Brain Stimulation With Duloxetine on Mechanical and Thermal Thresholds in 6-Hydroxydopamine-Lesioned Rats. Neurosurgery. 2016 Aug; 63 Suppl 1:150.
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        3. Walling IT, Gee L, Neubauer P, Frith L, Williams E, Burdette C, Pilitsis JG. 122 Pulse Modulation of the Occipital Nerve Using Focused High-Intensity Ultrasound Improves Mechanical Thresholds in a Chronic Migraine Rat Model. Neurosurgery. 2016 Aug; 63 Suppl 1:150-1.
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        4. Youn Y, Walling IT, Gee L, Neubauer P, Frith L, Williams E, Burdette C, Pilitsis JG. 353 High-Intensity Ultrasound for the Treatment of Vincristine-Induced Neuropathic Pain. Neurosurgery. 2016 Aug; 63 Suppl 1:204.
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        5. Pilitsis JG, Barolat G, Rosenow JM, Brennan JJ, Bailey AS, Epstein JM, Hammond B, Metzger C, Huynh D, Lechleiter K, Mekel-Bobrov N. 124 Low-Back Pain Relief With a New 32-Contact Surgical Lead and Neural Targeting Algorithm. Neurosurgery. 2016 Aug; 63 Suppl 1:151.
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        6. Gee LE, Walling I, Ramirez-Zamora A, Shin DS, Pilitsis JG. Subthalamic deep brain stimulation alters neuronal firing in canonical pain nuclei in a 6-hydroxydopamine lesioned rat model of Parkinson's disease. Exp Neurol. 2016 Sep; 283(Pt A):298-307.
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        7. Ramirez-Zamora A, Kaszuba BC, Gee L, Prusik J, Danisi F, Shin D, Pilitsis JG. Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation. Tremor Other Hyperkinet Mov (N Y). 2016; 6:388.
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        8. Ramirez-Zamora A, Boggs H, Pilitsis JG. Reduction in DBS frequency improves balance difficulties after thalamic DBS for essential tremor. J Neurol Sci. 2016 Aug 15; 367:122-7.
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        9. Fama CA, Chen N, Prusik J, Kumar V, Wilock M, Roth S, Pilitsis JG. The Use of Preoperative Psychological Evaluations to Predict Spinal Cord Stimulation Success: Our Experience and a Review of the Literature. Neuromodulation. 2016 Jun; 19(4):429-36.
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        10. Ramirez-Zamora A, Smith H, Youn Y, Durphy J, Shin DS, Pilitsis JG. Hyperhidrosis associated with subthalamic deep brain stimulation in Parkinson's disease: Insights into central autonomic functional anatomy. J Neurol Sci. 2016 Jul 15; 366:59-64.
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        11. Przybyszewski AW, Ravin P, Pilitsis JG, Szymanski A, Barborica A, Novak P. Multi-parametric analysis assists in STN localization in Parkinson's patients. J Neurol Sci. 2016 Jul 15; 366:37-43.
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        12. Ramineni T, Prusik J, Patel S, Lange S, Haller J, Fama C, Argoff C, Pilitsis J. The Impact of Spinal Cord Stimulation on Sleep Patterns. Neuromodulation. 2016 Jul; 19(5):477-81.
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        13. Lange S, Smith H, Prusik J, Fama C, Pilitsis JG. Pedometry as an External Measure of Spinal Cord Stimulation Patient Outcomes. Neuromodulation. 2016 Jul; 19(5):482-6.
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        14. Smith H, Youn Y, Guay RC, Laufer A, Pilitsis JG. The Role of Invasive Pain Management Modalities in the Treatment of Chronic Pain. Med Clin North Am. 2016 Jan; 100(1):103-15.
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        15. O'Connor KA, Feustel PJ, Ramirez-Zamora A, Molho E, Pilitsis JG, Shin DS. Investigation of diazepam efficacy on anxiety-like behavior in hemiparkinsonian rats. Behav Brain Res. 2016 Mar 15; 301:226-37.
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        16. Yu W, Walling I, Smith AB, Ramirez-Zamora A, Pilitsis JG, Shin DS. Deep Brain Stimulation of the Ventral Pallidum Attenuates Epileptiform Activity and Seizing Behavior in Pilocarpine-Treated Rats. Brain Stimul. 2016 Mar-Apr; 9(2):285-95.
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        17. Ramineni T, Prusik J, De La Cruz P, Gee L, Kumar V, Wilock ME, Haller J, Fama C, Patel S, Pilitsis JG. The Impact of Peripheral Nerve Stimulation on Disability and Depression. Neuromodulation. 2016 Apr; 19(3):306-10.
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        18. Renfrow JJ, Rodriguez A, Liu A, Pilitsis JG, Samadani U, Ganju A, Germano IM, Benzil DL, Wolfe SQ. Positive trends in neurosurgery enrollment and attrition: analysis of the 2000-2009 female neurosurgery resident cohort. J Neurosurg. 2016 Mar; 124(3):834-9.
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        19. Roth SG, Lange S, Haller J, De La Cruz P, Kumar V, Wilock M, Paniccioli S, Briotte M, Pilitsis JG. A Prospective Study of the Intra- and Postoperative Efficacy of Intraoperative Neuromonitoring in Spinal Cord Stimulation. Stereotact Funct Neurosurg. 2015; 93(5):348-54.
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        20. Youn Y, Smith H, Morris B, Argoff C, Pilitsis JG. The Effect of High-Frequency Stimulation on Sensory Thresholds in Chronic Pain Patients. Stereotact Funct Neurosurg. 2015; 93(5):355-9.
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        21. Sweet JA, Mitchell LS, Narouze S, Sharan AD, Falowski SM, Schwalb JM, Machado A, Rosenow JM, Petersen EA, Hayek SM, Arle JE, Pilitsis JG. Occipital Nerve Stimulation for the Treatment of Patients With Medically Refractory Occipital Neuralgia: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline. Neurosurgery. 2015 Sep; 77(3):332-41.
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        22. De La Cruz P, Gee L, Walling I, Morris B, Chen N, Kumar V, Feustel P, Shin DS, Pilitsis JG. Treatment of Allodynia by Occipital Nerve Stimulation in Chronic Migraine Rodent. Neurosurgery. 2015 Sep; 77(3):479-85; discussion 485.
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        23. Gee LE, Chen N, Ramirez-Zamora A, Shin DS, Pilitsis JG. The effects of subthalamic deep brain stimulation on mechanical and thermal thresholds in 6OHDA-lesioned rats. Eur J Neurosci. 2015 Aug; 42(4):2061-9.
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        24. Hamani C, Pilitsis J, Rughani AI, Rosenow JM, Patil PG, Slavin K, Abosch A, Eskandar E, Mitchell L, Kalkanis S. In Reply: Stereotactic Microanatomy of the Nucleus Accumbens Stimulation for Obsessive-Compulsive Disorder: Reported Coordinates and Mavridis' Area. Neurosurgery. 2015 Jul; 77(1):E156-7.
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        25. De La Cruz P, Fama C, Roth S, Haller J, Wilock M, Lange S, Pilitsis J. Predictors of Spinal Cord Stimulation Success. Neuromodulation. 2015 Oct; 18(7):599-602; discussion 602.
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        26. Gee L, Smith H, De La Cruz P, Campbell J, Fama C, Haller J, Ramirez-Zamora A, Durphy J, Hanspal E, Molho E, Barba A, Shin D, Pilitsis JG. The Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on Impulsivity and Prepulse Inhibition in Parkinson's Disease Patients. Stereotact Funct Neurosurg. 2015; 93(4):265-70.
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        27. Yu W, Smith AB, Pilitsis JG, Shin DS. Isovaline attenuates generalized epileptiform activity in hippocampal and primary sensory cortices and seizure behavior in pilocarpine treated rats. Neurosci Lett. 2015 Jul 10; 599:125-8.
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        28. Smith H, Gee L, Kumar V, Ramirez-Zamora A, Durphy J, Hanspal E, Barba A, Molho E, Shin D, Pilitsis JG. Deep brain stimulation significantly decreases disability from low back pain in patients with advanced Parkinson's disease. Stereotact Funct Neurosurg. 2015; 93(3):206-11.
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        29. Li G, Su H, Cole GA, Shang W, Harrington K, Camilo A, Pilitsis JG, Fischer GS. Robotic system for MRI-guided stereotactic neurosurgery. IEEE Trans Biomed Eng. 2015 Apr; 62(4):1077-88.
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        30. Smith H, Youn Y, Pilitsis JG. Successful use of high-frequency spinal cord stimulation following traditional treatment failure. Stereotact Funct Neurosurg. 2015; 93(3):190-3.
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        31. Phookan S, Sutton AC, Walling I, Smith A, O'Connor KA, Campbell JC, Calos M, Yu W, Pilitsis JG, Brotchie JM, Shin DS. Gap junction blockers attenuate beta oscillations and improve forelimb function in hemiparkinsonian rats. Exp Neurol. 2015 Mar; 265:160-70.
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        32. Lobel DA, Kahn M, Rosen CL, Pilitsis JG. Medical student education in neurosurgery: optional or essential? Teach Learn Med. 2015; 27(2):201-4.
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        33. Ramirez-Zamora A, Kahn M, Campbell J, DeLaCruz P, Pilitsis JG. Interleaved programming of subthalamic deep brain stimulation to avoid adverse effects and preserve motor benefit in Parkinson's disease. J Neurol. 2015 Mar; 262(3):578-84.
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        34. Lynch G, Nieto K, Puthenveettil S, Reyes M, Jureller M, Huang JH, Grady MS, Harris OA, Ganju A, Germano IM, Pilitsis JG, Pannullo SC, Benzil DL, Abosch A, Fouke SJ, Samadani U. Attrition rates in neurosurgery residency: analysis of 1361 consecutive residents matched from 1990 to 1999. J Neurosurg. 2015 Feb; 122(2):240-9.
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        35. Tong F, Ramirez-Zamora A, Gee L, Pilitsis J. Unusual complications of deep brain stimulation. Neurosurg Rev. 2015 Apr; 38(2):245-52; discussion 252.
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        36. Hamani C, Pilitsis J, Rughani AI, Rosenow JM, Patil PG, Slavin KS, Abosch A, Eskandar E, Mitchell LS, Kalkanis S. Deep brain stimulation for obsessive-compulsive disorder: systematic review and evidence-based guideline sponsored by the American Society for Stereotactic and Functional Neurosurgery and the Congress of Neurological Surgeons (CNS) and endorsed by the CNS and American Association of Neurological Surgeons. Neurosurgery. 2014 Oct; 75(4):327-33; quiz 333.
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        37. Campbell JC, Jeyamohan SB, De La Cruz P, Chen N, Shin D, Pilitsis JG. Place conditioning to apomorphine in rat models of Parkinson's disease: differences by dose and side-effect expression. Behav Brain Res. 2014 Dec 15; 275:114-9.
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        38. Sutton AC, O'Connor KA, Pilitsis JG, Shin DS. Stimulation of the subthalamic nucleus engages the cerebellum for motor function in parkinsonian rats. Brain Struct Funct. 2015 Nov; 220(6):3595-609.
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        39. Parmar VK, Gee L, Smith H, Pilitsis JG. Supraspinal stimulation for treatment of refractory pain. Clin Neurol Neurosurg. 2014 Aug; 123:155-63.
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        40. Yu W, Smith AB, Pilitsis J, Shin DS. Isovaline attenuates epileptiform activity and seizure behavior in 4-aminopyridine treated rats. Epilepsy Res. 2014 Feb; 108(2):331-5.
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        41. Ramirez-Zamora A, Levine D, Sommer DB, Dalfino J, Novak P, Pilitsis JG. Intraparenchymal cyst development after deep brain stimulator placement. Stereotact Funct Neurosurg. 2013; 91(5):338-41.
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        42. Smith HS, Pilitsis JG. Neuromodulation and palliative medicine. Am J Hosp Palliat Care. 2014 Mar; 31(2):211-9.
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        43. Pilitsis J, Atwater B, Warden D, Deck G, Carroll J, Smith J, Ng SC, Tseng J. Outcomes in octogenarians with subdural hematomas. Clin Neurol Neurosurg. 2013 Aug; 115(8):1429-32.
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        44. Yu W, Calos M, Pilitsis J, Shin DS. Deconstructing the neural and ionic involvement of seizure-like events in the striatal network. Neurobiol Dis. 2013 Apr; 52:128-36.
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        45. Sutton AC, Yu W, Calos ME, Smith AB, Ramirez-Zamora A, Molho ES, Pilitsis JG, Brotchie JM, Shin DS. Deep brain stimulation of the substantia nigra pars reticulata improves forelimb akinesia in the hemiparkinsonian rat. J Neurophysiol. 2013 Jan; 109(2):363-74.
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        46. Parmar V, Seward C, Huho A, Qian J, Gandhi R, Pilitsis JG. Rosai-Dorfman disease presenting as cervical radiculopathy. Clin Neurol Neurosurg. 2013 Jun; 115(6):808-10.
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        47. Verhagen Metman L, Pilitsis JG, Stebbins GT, Bot M, Bakay RA. Intraoperative x-ray to measure distance between DBS leads: A reliability study. Mov Disord. 2012 Jul; 27(8):1056-9.
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        48. Burrows AM, Ravin PD, Novak P, Peters ML, Dessureau B, Swearer J, Pilitsis JG. Limbic and motor function comparison of deep brain stimulation of the zona incerta and subthalamic nucleus. Neurosurgery. 2012 Mar; 70(1 Suppl Operative):125-30; discussion 130-1.
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        49. Toleikis JR, Metman LV, Pilitsis JG, Barborica A, Toleikis SC, Bakay RA. Effect of intraoperative subthalamic nucleus DBS on human single-unit activity in the ipsilateral and contralateral subthalamic nucleus. J Neurosurg. 2012 May; 116(5):1134-43.
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        50. Pilitsis JG, Burrows A, Peters ML, Sargent J, Ng SC, Tseng JF. Changing practice patterns of deep brain stimulation in Parkinson's disease and essential tremor in the USA. Stereotact Funct Neurosurg. 2012; 90(1):25-9.
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        51. Novak P, Przybyszewski AW, Barborica A, Ravin P, Margolin L, Pilitsis JG. Localization of the subthalamic nucleus in Parkinson disease using multiunit activity. J Neurol Sci. 2011 Nov 15; 310(1-2):44-9.
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        52. Burrows AM, Smith TW, Hall WR, Pilitsis JG. Neurological picture. Ascending paralysis from malignant leptomeningeal melanomatosis. J Neurol Neurosurg Psychiatry. 2010 Apr; 81(4):449-50.
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        53. Burrows AM, Moser RP, Weaver JP, Litwin DE, Pilitsis JG. Massachusetts health insurance mandate: effects on neurosurgical practice. J Neurosurg. 2010 Jan; 112(1):202-7.
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        54. Wang Y, Cole GA, Su H, Pilitsis JG, Fischer GS. MRI compatibility evaluation of a piezoelectric actuator system for a neural interventional robot. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:6072-5.
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        55. Pilitsis JG, Metman LV, Toleikis JR, Hughes LE, Sani SB, Bakay RA. Factors involved in long-term efficacy of deep brain stimulation of the thalamus for essential tremor. J Neurosurg. 2008 Oct; 109(4):640-6.
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        56. Pilitsis JG, Chu Y, Kordower J, Bergen DC, Cochran EJ, Bakay RA. Postmortem study of deep brain stimulation of the anterior thalamus: case report. Neurosurgery. 2008 Feb; 62(2):E530-2; discussion E532.
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        57. Lee AW, Pilitsis JG. Spinal cord stimulation: indications and outcomes. Neurosurg Focus. 2006; 21(6):E3.
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        58. Pilitsis JG, Rezai AR, Boulis NM, Henderson JM, Busch RM, Kubu CS. A preliminary study of transient confusional states following bilateral subthalamic stimulation for Parkinson's disease. Stereotact Funct Neurosurg. 2005; 83(2-3):67-70.
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        59. Brown JA, Pilitsis JG. Percutaneous balloon compression for the treatment of trigeminal neuralgia: results in 56 patients based on balloon compression pressure monitoring. Neurosurg Focus. 2005; 18(5):E10.
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        60. Brown JA, Pilitsis JG. Motor cortex stimulation for central and neuropathic facial pain: a prospective study of 10 patients and observations of enhanced sensory and motor function during stimulation. Neurosurgery. 2005 Feb; 56(2):290-7; discussion 290-7.
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        61. Pilitsis JG, Coplin WM, O'Regan MH, Wellwood JM, Diaz FG, Fairfax MR, Michael DB, Phillis JW. Free fatty acids in cerebrospinal fluids from patients with traumatic brain injury. Neurosci Lett. 2003 Oct 2; 349(2):136-8.
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        62. Pilitsis JG, Coplin WM, O'Regan MH, Wellwood JM, Diaz FG, Fairfax MR, Michael DB, Phillis JW. Measurement of free fatty acids in cerebrospinal fluid from patients with hemorrhagic and ischemic stroke. Brain Res. 2003 Sep 26; 985(2):198-201.
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        63. Pilitsis JG, Lucas DR, Rengachary SS. Bone healing and spinal fusion. Neurosurg Focus. 2002 Dec 15; 13(6):e1.
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        64. Phillis JW, Diaz FG, O'Regan MH, Pilitsis JG. Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex. Brain Res. 2002 Dec 6; 957(1):12-24.
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        65. Pilitsis JG, Diaz FG, O'Regan MH, Phillis JW. Differential effects of phospholipase inhibitors on free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury. Brain Res. 2002 Sep 27; 951(1):96-106.
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        66. Pilitsis JG, Coplin WM, O'Regan MH, Wellwood JM, Diaz FG, Fairfax MR, Michael DB, Phillis JW. Free fatty acids in human cerebrospinal fluid following subarachnoid hemorrhage and their potential role in vasospasm: a preliminary observation. J Neurosurg. 2002 Aug; 97(2):272-9.
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        67. Pilitsis JG, Diaz FG, O'Regan MH, Phillis JW. Inhibition of mitochondrial Na(+)/Ca(2+) exchange by 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury. Neurosci Lett. 2002 Mar 15; 321(1-2):1-4.
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        68. Pilitsis JG, Rengachary SS. The role of vertebroplasty in metastatic spinal disease. Neurosurg Focus. 2001 Dec 15; 11(6):e9.
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        69. Pilitsis JG, Diaz FG, Wellwood JM, Oregan MH, Fairfax MR, Phillis JW, Coplin WM. Quantification of free fatty acids in human cerebrospinal fluid. Neurochem Res. 2001 Dec; 26(12):1265-70.
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        70. Pilitsis JG, Diaz FG, O'Regan MH, Phillis JW. Inhibition of Na(+)/Ca(2+) exchange by KB-R7943, a novel selective antagonist, attenuates phosphoethanolamine and free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury. Brain Res. 2001 Oct 19; 916(1-2):192-8.
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        71. Pilitsis JG, Diaz FG, O'Regan MH, Phillis JW. Inhibition of Na(+)/H(+) exchange by SM-20220 attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury. Brain Res. 2001 Sep 21; 913(2):156-8.
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        72. Vinas FC, Pilitsis J, Wilner H. Spontaneous resolution of a syrinx. J Clin Neurosci. 2001 Mar; 8(2):170-2.
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        73. Pilitsis JG, Rengachary SS. Complications of head injury. Neurol Res. 2001 Mar-Apr; 23(2-3):227-36.
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        74. Pilitsis JG, Kimelberg HK. Adenosine receptor mediated stimulation of intracellular calcium in acutely isolated astrocytes. Brain Res. 1998 Jul 6; 798(1-2):294-303.
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