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    Ashraf Khan MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPathology
    AddressUniversity of Massachusetts Medical School
    One Innovation Drive, Biotech Three
    Worcester MA 01605
    Phone508-856-6214
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCancer Biology

        Overview 
        Narrative

        Academic Background:

        MBBSJN Medical College, Aligarh University, Aligarh, INDIA

        MDPathology, JN Medical College, Aligarh University, Aligarh, INDIA

        ResidencyHistopathology, Lewisham & Guy’s Hospital, University of London, London, UK

        FRCPath Histopathology, Royal College of Pathologists, London, UK

        Fellowship Surgical Pathology, University of Massachusetts Medical Center, Worcester, MA

        Dr. Khan's pictureResearch Interests:

        Dr. Ashraf Khan’s clinical interest includes diagnostic surgical pathology of Breast and Endocrine system. Dr. Khan is actively involved in clinical translational research focused in the field of thyroid and breast cancer investigating biomarkers that help in the diagnosis and prediction of outcome in these tumors. Over the past decade Dr. Khan has published several papers on the role of cell cycle regulatory proteins, translation initiation factors and cell adhesion molecules in the diagnosis of thyroid follicular tumors and progression of thyroid cancer. Dr. Khan was a key contributor of one large multi-institution international study published in The Lancet on the role of galectin 3 and CD44 in the diagnosis of thyroid malignancy. Dr. Khan’s collaboration with the basic scientists in the department of cancer biology at UMass has resulted in multiple projects includingb4-integrin signature in basal-like breast cancer which was recently published and Sox-9 expression in breast cancer which is work in progress. In addition Dr. Khan is a PI on a Department of Defense Grant in collaboration with Dr. Leslie Shaw in department of cancer biology looking at the Insulin Receptor Substrate Proteins (IRS1 and IRS2) in breast cancer with special focus on potential role they may play in Herceptin resistance in HER-2 positive breast cancer. He is also currently involved in studying the micro RNA signature in breast cancer especially estrogen receptor positive node negative tumors with potential therapeutic implications. Dr. Khan is a member of the UMASS graduate school of biomedical sciences representing cancer biology.

        Dr. Khan is the past President and Secretary of the Endocrine Pathology Society, a companion society of the US and Canadian Academy of Pathology. He is a reviewer for a number of pathology and endocrinology journals, serves on the editorial board of the journal Endocrine Pathology and is the Section Editor (Endocrine Pathology) of the Archives of Pathology and Laboratory Medicine. In addition to numerous original articles, Dr. Khan has authored many book chapters and invited reviews and is currently editing a text book on surgical pathology of endocrine tumors.



        Bibliographic 
        selected publications
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        1. Moghaddam PA, Cornejo KM, Khan A. Metastatic carcinoma to the thyroid gland: a single institution 20-year experience and review of the literature. Endocr Pathol. 2013 Sep; 24(3):116-24.
          View in: PubMed
        2. Karam AR, Vijayaraghavan G, Khan A, Ustun B, Hussain S. Renal biopsy: Comparative yield of cranial versus caudal needle trajectory. An ex vivo analysis. Nephrology (Carlton). 2013 Apr; 18(4):304-6.
          View in: PubMed
        3. Patel R, Khan A, Kamionek M, Kandil D, Quinlan R, Yaroslavsky AN. Delineating breast ductal carcinoma using combined dye-enhanced wide-field polarization imaging and optical coherence tomography. J Biophotonics. 2013 Sep; 6(9):679-86.
          View in: PubMed
        4. Patel R, Khan A, Wirth D, Kamionek M, Kandil D, Quinlan R, Yaroslavsky AN. Multimodal optical imaging for detecting breast cancer. J Biomed Opt. 2012 Jun; 17(6):066008.
          View in: PubMed
        5. Gerson KD, Maddula VS, Seligmann BE, Shearstone JR, Khan A, Mercurio AM. Effects of ß4 integrin expression on microRNA patterns in breast cancer. Biol Open. 2012 Jul 15; 1(7):658-66.
          View in: PubMed
        6. Ortiz-Pagan S, Cunto-Amesty G, Narayan S, Crawford S, Derrick C, Larkin A, Khan A, Quinlan R, Layeequr Rahman R. Effect of Paget's Disease on Survival in Breast Cancer: An Exploratory Study. Arch Surg. 2011 Nov; 146(11):1267-70.
          View in: PubMed
        7. Buttar A, Mittal K, Khan A, Bathini V. Effective role of hormonal therapy in metastatic primary neuroendocrine breast carcinoma. Clin Breast Cancer. 2011 Oct; 11(5):342-5.
          View in: PubMed
        8. Clark JL, Dresser K, Hsieh CC, Sabel M, Kleer CG, Khan A, Shaw LM. Membrane localization of insulin receptor substrate-2 (IRS-2) is associated with decreased overall survival in breast cancer. Breast Cancer Res Treat. 2011 Dec; 130(3):759-72.
          View in: PubMed
        9. Virk RK, Khan A. Pseudoangiomatous stromal hyperplasia: an overview. Arch Pathol Lab Med. 2010 Jul; 134(7):1070-4.
          View in: PubMed
        10. Karam AR, Nugent W, Khan A, Desai D, Shankar S. Curved stylet core biopsy results in larger cores. AJR Am J Roentgenol. 2010 Jul; 195(1):242-4.
          View in: PubMed
        11. Karam AR, Nugent W, Falardeau J, Desai D, Khan A, Shankar S. Multifocal extra-adrenal myelolipoma arising in the greater omentum. J Radiol Case Rep. 2009; 3(11):20-3.
          View in: PubMed
        12. Walter O, Prasad M, Lu S, Quinlan RM, Edmiston KL, Khan A. IMP3 is a novel biomarker for triple negative invasive mammary carcinoma associated with a more aggressive phenotype. Hum Pathol. 2009 Nov; 40(11):1528-33.
          View in: PubMed
        13. Menon MP, Khan A. Micro-RNAs in thyroid neoplasms: molecular, diagnostic and therapeutic implications. J Clin Pathol. 2009 Nov; 62(11):978-85.
          View in: PubMed
        14. Jaffar R, Mohanty SK, Khan A, Fischer AH. Hemosiderin laden macrophages and hemosiderin within follicular cells distinguish benign follicular lesions from follicular neoplasms. Cytojournal. 2009; 6:3.
          View in: PubMed
        15. Slosar M, Vohra P, Prasad M, Fischer A, Quinlan R, Khan A. Insulin-like growth factor mRNA binding protein 3 (IMP3) is differentially expressed in benign and malignant follicular patterned thyroid tumors. Endocr Pathol. 2009; 20(3):149-57.
          View in: PubMed
        16. Lee CW, Simin K, Liu Q, Plescia J, Guha M, Khan A, Hsieh CC, Altieri DC. A functional Notch-survivin gene signature in basal breast cancer. Breast Cancer Res. 2008; 10(6):R97.
          View in: PubMed
        17. Lu S, Simin K, Khan A, Mercurio AM. Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance. Clin Cancer Res. 2008 Feb 15; 14(4):1050-8.
          View in: PubMed
        18. Nelson EJ, Chowdhury A, Harris JB, Begum YA, Chowdhury F, Khan AI, Larocque RC, Bishop AL, Ryan ET, Camilli A, Qadri F, Calderwood SB. Complexity of rice-water stool from patients with Vibrio cholerae plays a role in the transmission of infectious diarrhea. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):19091-6.
          View in: PubMed
        19. Sharma V, Cui H, Whalen G, Khan A, Torres M. A case of trabecular adenoma of the thyroid with black pigmentation. Thyroid. 2007 Jun; 17(6):593-4.
          View in: PubMed
        20. Istvanic S, Fischer AH, Banner BF, Eaton DM, Larkin AC, Khan A. Cell blocks of breast FNAs frequently allow diagnosis of invasion or histological classification of proliferative changes. Diagn Cytopathol. 2007 May; 35(5):263-9.
          View in: PubMed
        21. Khan A, Vohra P, Quinlan RF. The role of sentinel lymph node biopsy in the management of breast cancer. Indian J Pathol Microbiol. 2007 Apr; 50(2):261-9.
          View in: PubMed
        22. Schmidt M, Khan A, Schmidt AM, Heinze B, Hack E, Waltenberger J, Kreienberg R. A novel breast cancer cell line initially established from pleural effusion: evolution towards a more aggressive phenotype. Int J Oncol. 2007 Mar; 30(3):565-72.
          View in: PubMed
        23. Ciampa A, Xu B, Ayata G, Baiyee D, Wallace J, Wertheimer M, Edmiston K, Khan A. HER-2 status in breast cancer: correlation of gene amplification by FISH with immunohistochemistry expression using advanced cellular imaging system. Appl Immunohistochem Mol Morphol. 2006 Jun; 14(2):132-7.
          View in: PubMed
        24. Harris JB, Khan AI, LaRocque RC, Dorer DJ, Chowdhury F, Faruque AS, Sack DA, Ryan ET, Qadri F, Calderwood SB. Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity. Infect Immun. 2005 Nov; 73(11):7422-7.
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        25. Rezk S, Khan A. Role of immunohistochemistry in the diagnosis and progression of follicular epithelium-derived thyroid carcinoma. Appl Immunohistochem Mol Morphol. 2005 Sep; 13(3):256-64.
          View in: PubMed
        26. Larocque RC, Harris JB, Dziejman M, Li X, Khan AI, Faruque AS, Faruque SM, Nair GB, Ryan ET, Qadri F, Mekalanos JJ, Calderwood SB. Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infection. Infect Immun. 2005 Aug; 73(8):4488-93.
          View in: PubMed
        27. Ciampa A, Fanger G, Khan A, Rock KL, Xu B. Mammaglobin and CRxA-01 in pleural effusion cytology: potential utility of distinguishing metastatic breast carcinomas from other cytokeratin 7-positive/cytokeratin 20-negative carcinomas. Cancer. 2004 Dec 25; 102(6):368-72.
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        28. Rezk S, Yousef M, Zamansky M, Khan A. Solitary fibrous tumor of the auditory canal. Arch Pathol Lab Med. 2004 Dec; 128(12):e169-71.
          View in: PubMed
        29. Khan A, Tischler AS, Patwardhan NA, DeLellis RA. Calcitonin immunoreactivity in neoplastic and hyperplastic parathyroid glands: an immunohistochemical study. Endocr Pathol. 2003; 14(3):249-55.
          View in: PubMed
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