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    Paul S Furcinitti PhD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentProgram in Molecular Medicine
    AddressUniversity of Massachusetts Medical School
    373 Plantation Street
    Worcester MA 01605
    Phone508-856-0045
        Overview 
        Narrative

        Academic Background

        B.S., Worcester Polytechnic Institute, 1971
        M.S. University of New Hampshire, 1974
        Ph.D. University of New Hampshire, 1975

        Postdoctoral Research Associate, Worcester Polytechnic Institute, 1976
        Postdoctoral Research Associate, Pennsylvania State University, 1976-1978
        Research Associate, Oak Ridge National Laboratory, 1978-1979
        Research Associate, Columbia University, 1979-1982
        Senior Research Associate, Brookhaven National Laboratory, 1982-1985
        Assistant Biophysicist, Brookhaven National Laboratory, 1985-1987
        Associate Biophysicist, Brookhaven National Laboratory, 1987-1988
        Assistant Research Scientist, University of Michigan, 1988-1990
        Senior Research Associate, University of Colorado, 1990-1995
        Image Analysis Specialist, Micro Video Instruments, 1995-1999

        Director of the Digital Imaging Core Facility

        High Resolution Multi-mode Digital Microscopy and Image Analysis

        Photo: Paul S. FurcinittiMy current research interest is to collaborate with other researchers at the Univ. of Mass. Medical School to determine structure function relationships in biological systems by acquiring high resolution light microscope images of cellular organelles which are specifically labeled with fluorescent probes. The facilities of the digital imaging core facility allows the researcher to acquire a 3-D thru - focus image series at a single or at multiple wavelengths or to acquire time lapse images or high resolution 2-D images. Digital deconvolution algorithms can be used to remove out-of-focus haze from the 3-D image sets and 3-D volume rendering of the resulting images allows spatial relationships between cellular organelles and probes to be determined. Image averaging and other image analysis techniques can also be applied, when appropriate, to extract the maximum amount of information from the data.

        The Digital Imaging Core Facility was established by the University of Massachusetts Medical School Research Council in 1997 and is hosted by the Department of Pharmacology and Molecular Toxicology in room S7-105. The facility is available to all on campus researchers for a modest fee. The facility consists of an Olympus IX-70 inverted light microscope, a Roper Scientific high resolution, thinned, back-illuminated cooled CCD digital camera, a Sutter filter wheel and shutter and a PZT piezoelectric focus drive . The shutter, filter wheel, focus drive and digital camera are controlled by a PC running the Metamorph image acquisition and analysis software package. A separate Metamorph workstation is available for off-line image analysis. There are also 3 SGI workstations available for digital deconvolution to remove out of focus haze and for 3-D volume rendering. Digital deconvolution is performed using the exhaustive photon reassignment (EPR) algorithm developed by the Biomedical Imaging Group under the direction of the late Dr. Frederick Fay. A Condonics Dye sublimation printer and an Opal film recorder (slide maker) are also available to users of the facility.



        Bibliographic 
        selected publications
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        1. Young DW, Hassan MQ, Yang XQ, Galindo M, Javed A, Zaidi SK, Furcinitti P, Lapointe D, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3189-94.
          View in: PubMed
        2. Young DW, Hassan MQ, Pratap J, Galindo M, Zaidi SK, Lee SH, Yang X, Xie R, Javed A, Underwood JM, Furcinitti P, Imbalzano AN, Penman S, Nickerson JA, Montecino MA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Nature. 2007 Jan 25; 445(7126):442-6.
          View in: PubMed
        3. Young DW, Zaidi SK, Furcinitti PS, Javed A, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Quantitative signature for architectural organization of regulatory factors using intranuclear informatics. J Cell Sci. 2004 Oct 1; 117(Pt 21):4889-96.
          View in: PubMed
        4. Guilherme A, Soriano NA, Furcinitti PS, Czech MP. Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. J Biol Chem. 2004 Sep 17; 279(38):40062-75.
          View in: PubMed
        5. Bose A, Robida S, Furcinitti PS, Chawla A, Fogarty K, Corvera S, Czech MP. Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway. Mol Cell Biol. 2004 Jun; 24(12):5447-58.
          View in: PubMed
        6. Guilherme A, Soriano NA, Bose S, Holik J, Bose A, Pomerleau DP, Furcinitti P, Leszyk J, Corvera S, Czech MP. EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. J Biol Chem. 2004 Mar 12; 279(11):10593-605.
          View in: PubMed
        7. Semiz S, Park JG, Nicoloro SM, Furcinitti P, Zhang C, Chawla A, Leszyk J, Czech MP. Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules. EMBO J. 2003 May 15; 22(10):2387-99.
          View in: PubMed
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