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    William H Gaasch MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressLahey Clinic
    41 Mall Road
    Burlington MA 01805
    Phone781-744-8535
        Bibliographic 
        selected publications
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        1. Gaasch WH, D'Agostino RS. Transcatheter aortic valve implantation: The transfemoral versus the transapical approach. Ann Cardiothorac Surg. 2012 Jul; 1(2):200-5.
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        2. Gaasch WH, Zile MR. Left ventricular structural remodeling in health and disease: with special emphasis on volume, mass, and geometry. J Am Coll Cardiol. 2011 Oct 18; 58(17):1733-40.
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        3. Zile MR, Gaasch WH. Abnormal calcium homeostasis: one mechanism in diastolic heart failure. J Am Coll Cardiol. 2011 Jul 5; 58(2):155-7.
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        4. Goldberg RJ, Spencer FA, Szklo-Coxe M, Tisminetzky M, Yarzebski J, Lessard D, Gore JM, Gaasch W. Symptom presentation in patients hospitalized with acute heart failure. Clin Cardiol. 2010 Jun; 33(6):E73-80.
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        5. Zile MR, Gaasch WH, Anand IS, Haass M, Little WC, Miller AB, Lopez-Sendon J, Teerlink JR, White M, McMurray JJ, Komajda M, McKelvie R, Ptaszynska A, Hetzel SJ, Massie BM, Carson PE. Mode of death in patients with heart failure and a preserved ejection fraction: results from the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trial. Circulation. 2010 Mar 30; 121(12):1393-405.
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        6. Doumas A, Draper TS, Schick EC, Gaasch WH. Prevalence and clinical characteristics of nondilated cardiomyopathy and the effect of atrial fibrillation. Am J Cardiol. 2010 Mar 15; 105(6):884-7.
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        7. Gaasch WH, Delorey DE, Kueffer FJ, Zile MR. Distribution of left ventricular ejection fraction in patients with ischemic and hypertensive heart disease and chronic heart failure. Am J Cardiol. 2009 Nov 15; 104(10):1413-5.
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        8. Gaasch WH, Meyer TE. Left ventricular response to mitral regurgitation: implications for management. Circulation. 2008 Nov 25; 118(22):2298-303.
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        9. Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT, O'Rourke RA, Otto CM, Shah PM, Shanewise JS. 2008 Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation. 2008 Oct 7; 118(15):e523-661.
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        10. Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT, O'Rourke RA, Otto CM, Shah PM, Shanewise JS, Nishimura RA, Carabello BA, Faxon DP, Freed MD, Lytle BW, O'Gara PT, O'Rourke RA, Shah PM. 2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1998 guidelines for the management of patients with valvular heart disease). Endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2008 Sep 23; 52(13):e1-142.
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        11. Nishimura RA, Carabello BA, Faxon DP, Freed MD, Lytle BW, O'Gara PT, O'Rourke RA, Shah PM, Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT, O'Rourke RA, Otto CM, Shah PM, Shanewise JS, Smith SC, Jacobs AK, Buller CE, Creager MA, Ettinger SM, Krumholz HM, Kushner FG, Lytle BW, Nishimura RA, Page RL, Tarkington LG, Yancy CW. ACC/AHA 2008 guideline update on valvular heart disease: focused update on infective endocarditis: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Catheter Cardiovasc Interv. 2008 Sep 1; 72(3):E1-12.
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        12. Nishimura RA, Carabello BA, Faxon DP, Freed MD, Lytle BW, O'Gara PT, O'Rourke RA, Shah PM, Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT, O'Rourke RA, Otto CM, Shah PM, Shanewise JS, Smith SC, Jacobs AK, Buller CE, Creager MA, Ettinger SM, Krumholz HM, Kushner FG, Lytle BW, Nishimura RA, Page RL, Tarkington LG, Yancy CW. ACC/AHA 2008 guideline update on valvular heart disease: focused update on infective endocarditis: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation. 2008 Aug 19; 118(8):887-96.
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        13. Farr MJ, Lang CC, Lamanca JJ, Zile MR, Francis G, Tavazzi L, Gaasch WH, St John Sutton M, Itoh H, Mancini D. Cardiopulmonary exercise variables in diastolic versus systolic heart failure. Am J Cardiol. 2008 Jul 15; 102(2):203-6.
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        14. Gaasch WH, Delorey DE, St John Sutton MG, Zile MR. Patterns of structural and functional remodeling of the left ventricle in chronic heart failure. Am J Cardiol. 2008 Aug 15; 102(4):459-62.
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        15. Gaasch WH, Little WC. Assessment of left ventricular diastolic function and recognition of diastolic heart failure. Circulation. 2007 Aug 7; 116(6):591-3.
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        16. Hurlburt HM, Aurigemma GP, Hill JC, Narayanan A, Gaasch WH, Vinch CS, Meyer TE, Tighe DA. Direct ultrasound measurement of longitudinal, circumferential, and radial strain using 2-dimensional strain imaging in normal adults. Echocardiography. 2007 Aug; 24(7):723-31.
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        17. Bermudez EA, Gaasch WH. Regurgitant lesions of the aortic and mitral valves: considerations in determining the ideal timing of surgical intervention. Heart Fail Clin. 2006 Oct; 2(4):473-82.
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        18. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. Circulation. 2006 Aug 1; 114(5):e84-231.
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        19. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing Committee to Revise the 1998 guidelines for the management of patients with valvular heart disease) developed in collaboration with the Society of Cardiovascular Anesthesiologists endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. J Am Coll Cardiol. 2006 Aug 1; 48(3):e1-148.
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        20. Aurigemma GP, Zile MR, Gaasch WH. Contractile behavior of the left ventricle in diastolic heart failure: with emphasis on regional systolic function. Circulation. 2006 Jan 17; 113(2):296-304.
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        21. Baicu CF, Zile MR, Aurigemma GP, Gaasch WH. Left ventricular systolic performance, function, and contractility in patients with diastolic heart failure. Circulation. 2005 May 10; 111(18):2306-12.
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        22. Chung EH, Gaasch WH. Exercise testing in aortic stenosis. Curr Cardiol Rep. 2005 Mar; 7(2):105-7.
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        23. Yturralde RF, Gaasch WH. Diagnostic criteria for diastolic heart failure. Prog Cardiovasc Dis. 2005 Mar-Apr; 47(5):314-9.
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        24. Aurigemma GP, Gaasch WH. Low flow-low gradient aortic stenosis: the pathologist weighs in. J Am Coll Cardiol. 2004 Nov 2; 44(9):1856-8.
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        25. Aurigemma GP, Gaasch WH. Clinical practice. Diastolic heart failure. N Engl J Med. 2004 Sep 9; 351(11):1097-105.
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        26. Aurigemma GP, Zile MR, Gaasch WH. Lack of relationship between Doppler indices of diastolic function and left ventricular pressure transients in patients with definite diastolic heart failure. Am Heart J. 2004 Sep; 148(3):E12.
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        27. Zile M, Gaasch W, Little W, Francis G, Tavazzi L, Cleland J, Davies M. A phase II, double-blind, randomized, placebo-controlled, dose comparative study of the efficacy, tolerability, and safety of MCC-135 in subjects with chronic heart failure, NYHA class II/III (MCC-135-GO1 study): rationale and design. J Card Fail. 2004 Jun; 10(3):193-9.
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        28. Zile MR, Baicu CF, Gaasch WH. Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle. N Engl J Med. 2004 May 6; 350(19):1953-9.
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        29. Gaasch WH, Zile MR. Left ventricular diastolic dysfunction and diastolic heart failure. Annu Rev Med. 2004; 55:373-94.
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        30. Zile MR, Gaasch WH. Heart failure in aortic stenosis - improving diagnosis and treatment. N Engl J Med. 2003 May 1; 348(18):1735-6.
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        31. Vinch CS, Aurigemma GP, Hill JC, Gaasch WH, Volturo G, Tighe DA, Meyer TE. Usefulness of clinical variables, echocardiography, and levels of brain natriuretic peptide and norepinephrine to distinguish systolic and diastolic causes of acute heart failure. Am J Cardiol. 2003 May 1; 91(9):1140-3.
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        32. Gaasch WH, Schick EC. Symptoms and left ventricular size and function in patients with chronic aortic regurgitation. J Am Coll Cardiol. 2003 Apr 16; 41(8):1325-8.
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        33. Gaasch WH, Brooks WW, Peralta AO, John RM, Conrad CH, Bing OH. Potentiation of atrial contractility by paired pacing augments ventricular preload and systolic performance. J Card Fail. 2003 Apr; 9(2):141-6.
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        34. Mathew RK, Gaasch WH, Guilmette NE, Schick EC, Labib SB. Anthropometric normalization of left ventricular size in chronic mitral regurgitation. Am J Cardiol. 2003 Mar 15; 91(6):762-4.
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        35. Hein S, Gaasch WH, Schaper J. Giant molecule titin and myocardial stiffness. Circulation. 2002 Sep 10; 106(11):1302-4.
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        36. Brooks WW, Bing OH, Gaasch WH, Karlinsky JB, Goldstein RH, Conrad CH. Comparison of contractile function of diaphragm and cardiac muscle in response to paired electrical stimulation. Comp Biochem Physiol A Mol Integr Physiol. 2002 Sep; 133(1):53-62.
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        37. Gaasch WH, Aurigemma GP. Inhibition of the renin-angiotensin system and the left ventricular adaptation to mitral regurgitation. J Am Coll Cardiol. 2002 Apr 17; 39(8):1380-3.
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        38. Norton GR, Woodiwiss AJ, Gaasch WH, Mela T, Chung ES, Aurigemma GP, Meyer TE. Heart failure in pressure overload hypertrophy. The relative roles of ventricular remodeling and myocardial dysfunction. J Am Coll Cardiol. 2002 Feb 20; 39(4):664-71.
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        39. Zile MR, Gaasch WH, Carroll JD, Feldman MD, Aurigemma GP, Schaer GL, Ghali JK, Liebson PR. Heart failure with a normal ejection fraction: is measurement of diastolic function necessary to make the diagnosis of diastolic heart failure? Circulation. 2001 Aug 14; 104(7):779-82.
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        40. Aurigemma GP, Williams D, Gaasch WH, Reda DJ, Materson BJ, Gottdiener JS. Ventricular and myocardial function following treatment of hypertension. Am J Cardiol. 2001 Mar 15; 87(6):732-6.
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        41. Nagahama Y, Schick EC, Gaasch WH. Interval-dependent potentiation of left ventricular contractility is preserved in patients with atrial fibrillation and depressed ejection fraction. Am J Cardiol. 2001 Feb 1; 87(3):342-6, A9.
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        42. Peralta AO, John RM, Gaasch WH, Taggart PI, Martin DT, Venditti FJ. The class III antiarrhythmic effect of sotalol exerts a reverse use-dependent positive inotropic effect in the intact canine heart. J Am Coll Cardiol. 2000 Oct; 36(4):1404-10.
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        43. Effat M, Schick EC, Martin DT, Gaasch WH. Effect of rhythm regularization on left ventricular contractility in patients with atrial fibrillation. Am J Cardiol. 2000 Jan 1; 85(1):114-6, A9.
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        44. Cannistra LB, Gaasch WH. Appetite-suppressing drugs and valvular heart disease. Cardiol Rev. 1999 Nov-Dec; 7(6):356-61.
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        45. Aurigemma GP, Meyer TE, Sharma M, Sweeney A, Gaasch WH. Evaluation of extent of shortening versus velocity of shortening at the endocardium and midwall in hypertensive heart disease. Am J Cardiol. 1999 Mar 1; 83(5):792-4, A10.
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        46. Bonow RO, Carabello B, de Leon AC, Edmunds LH, Fedderly BJ, Freed MD, Gaasch WH, McKay CR, Nishimura RA, O'Gara PT, O'Rourke RA, Rahimtoola SH, Ritchie JL, Cheitlin MD, Eagle KA, Gardner TJ, Garson A, Gibbons RJ, Russell RO, Ryan TJ, Smith SC. Guidelines for the management of patients with valvular heart disease: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients with Valvular Heart Disease). Circulation. 1998 Nov 3; 98(18):1949-84.
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        47. Bonow RO, Carabello B, de Leon AC, Edmunds LH, Fedderly BJ, Freed MD, Gaasch WH, McKay CR, Nishimura RA, O'Gara PT, O'Rourke RA, Rahimtoola SH, Ritchie JL, Cheitlin MD, Eagle KA, Gardner TJ, Garson A, Gibbons RJ, Russell RO, Ryan TJ, Smith SC. ACC/AHA Guidelines for the Management of Patients With Valvular Heart Disease. Executive Summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Valvular Heart Disease). J Heart Valve Dis. 1998 Nov; 7(6):672-707.
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        48. Aurigemma GP, Gaasch WH. Valve disease and diet pills--where do we stand? Am Fam Physician. 1998 Feb 15; 57(4):656, 659-60.
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        49. Sorgato A, Faggiano P, Aurigemma GP, Rusconi C, Gaasch WH. Ventricular arrhythmias in adult aortic stenosis: prevalence, mechanisms, and clinical relevance. Chest. 1998 Feb; 113(2):482-91.
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        50. Goldfine H, Aurigemma GP, Zile MR, Gaasch WH. Left ventricular length-force-shortening relations before and after surgical correction of chronic mitral regurgitation. J Am Coll Cardiol. 1998 Jan; 31(1):180-5.
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        51. Schneider F, Martin DT, Schick EC, Gaasch WH. Interval-dependent changes in left ventricular contractile state in lone atrial fibrillation and in atrial fibrillation associated with coronary artery disease. Am J Cardiol. 1997 Sep 1; 80(5):586-90.
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        52. Meyer TE, Casadei B, Aurigemma GP, Gaasch WH. Which indexes of filling behavior should be used to characterize left ventricular diastolic function when changes in heart rate and atrioventricular delay occur? J Am Soc Echocardiogr. 1997 Sep; 10(7):689-98.
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        53. Gaasch WH, Sundaram M, Meyer TE. Managing asymptomatic patients with chronic aortic regurgitation. Chest. 1997 Jun; 111(6):1702-9.
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        54. Shimizu G, Wiegner AW, Gaasch WH, Conrad CH, Cicogna AC, Bing OH. Force pattern of hypoxic myocardium applied to oxygenated muscle preparations: comparison with effects of regional ischemia on the contraction of non-ischemic myocardium. Cardiovasc Res. 1996 Dec; 32(6):1038-46.
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        55. Levine HJ, Gaasch WH. Vasoactive drugs in chronic regurgitant lesions of the mitral and aortic valves. J Am Coll Cardiol. 1996 Nov 1; 28(5):1083-91.
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        56. Faggiano P, Aurigemma GP, Rusconi C, Gaasch WH. Progression of valvular aortic stenosis in adults: literature review and clinical implications. Am Heart J. 1996 Aug; 132(2 Pt 1):408-17.
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        57. Sharma M, Aurigemma GP, Meyer TE, Gaasch WH. Recurrent syncope after successful aortic valve replacement. Am Heart J. 1996 Jul; 132(1 Pt 1):194-7.
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        58. Gaasch WH, Eisenhauer AC. The management of mitral valve disease. Curr Opin Cardiol. 1996 Mar; 11(2):114-9.
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        59. Aurigemma GP, Gaasch WH, McLaughlin M, McGinn R, Sweeney A, Meyer TE. Reduced left ventricular systolic pump performance and depressed myocardial contractile function in patients > 65 years of age with normal ejection fraction and a high relative wall thickness. Am J Cardiol. 1995 Oct 1; 76(10):702-5.
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        60. Gaasch WH, John RM, Aurigemma GP. Managing asymptomatic patients with chronic mitral regurgitation. Chest. 1995 Sep; 108(3):842-7.
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        61. Aurigemma GP, Silver KH, Priest MA, Gaasch WH. Geometric changes allow normal ejection fraction despite depressed myocardial shortening in hypertensive left ventricular hypertrophy. J Am Coll Cardiol. 1995 Jul; 26(1):195-202.
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        62. Aurigemma GP, Gaasch WH, Villegas B, Meyer TE. Noninvasive assessment of left ventricular mass, chamber volume, and contractile function. Curr Probl Cardiol. 1995 Jun; 20(6):361-440.
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        63. Aurigemma GP, Gaasch WH. Gender differences in older patients with pressure-overload hypertrophy of the left ventricle. Cardiology. 1995; 86(4):310-7.
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        64. Aurigemma GP, Silver KH, McLaughlin M, Mauser J, Gaasch WH. Impact of chamber geometry and gender on left ventricular systolic function in patients > 60 years of age with aortic stenosis. Am J Cardiol. 1994 Oct 15; 74(8):794-8.
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        65. Gaasch WH. Diagnosis and treatment of heart failure based on left ventricular systolic or diastolic dysfunction. JAMA. 1994 Apr 27; 271(16):1276-80.
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        66. Dell'Italia LJ, Freeman GL, Gaasch WH. Cardiac function and functional capacity: implications for the failing heart. Curr Probl Cardiol. 1993 Dec; 18(12):705-58.
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        67. Orsinelli DA, Aurigemma GP, Battista S, Krendel S, Gaasch WH. Left ventricular hypertrophy and mortality after aortic valve replacement for aortic stenosis. A high risk subgroup identified by preoperative relative wall thickness. J Am Coll Cardiol. 1993 Nov 15; 22(6):1679-83.
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        68. Cicogna AC, Padovani CR, Brooks WW, Schine L, Robinson KG, Conrad CH, Gaasch WH, Bing OH. Protective effects of diltiazem on the mechanical performance of the hypoxic myocardium. Braz J Med Biol Res. 1993 Aug; 26(8):859-68.
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        69. Johnstone D, Limacher M, Rousseau M, Liang CS, Ekelund L, Herman M, Stewart D, Guillotte M, Bjerken G, Gaasch W, et al. Clinical characteristics of patients in studies of left ventricular dysfunction (SOLVD). Am J Cardiol. 1992 Oct 1; 70(9):894-900.
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        70. Zile MR, Gaasch WH. Load-dependent left ventricular relaxation in conscious dogs. Am J Physiol. 1991 Sep; 261(3 Pt 2):H691-9.
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        71. Izzi G, Zile MR, Gaasch WH. Myocardial oxygen consumption and the left ventricular pressure-volume area in normal and hypertrophic canine hearts. Circulation. 1991 Sep; 84(3):1384-92.
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        72. Gaasch WH, Folland ED. Left ventricular function in rheumatic mitral stenosis. Eur Heart J. 1991 Jul; 12 Suppl B:66-9.
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        73. Gaasch WH, Zile MR. Left ventricular function after surgical correction of chronic mitral regurgitation. Eur Heart J. 1991 Jul; 12 Suppl B:48-51.
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        74. Shimizu G, Hirota Y, Kita Y, Kawamura K, Saito T, Gaasch WH. Left ventricular midwall mechanics in systemic arterial hypertension. Myocardial function is depressed in pressure-overload hypertrophy. Circulation. 1991 May; 83(5):1676-84.
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        75. Zile MR, Izzi G, Gaasch WH. Left ventricular diastolic dysfunction limits use of maximum systolic elastance as an index of contractile function. Circulation. 1991 Feb; 83(2):674-80.
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        76. Gaasch WH. Congestive heart failure in patients with normal left ventricular systolic function: a manifestation of diastolic dysfunction. Herz. 1991 Feb; 16(1):22-32.
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        77. Gaasch WH, Zile MR, Hoshino PK, Weinberg EO, Rhodes DR, Apstein CS. Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy. Circulation. 1990 May; 81(5):1644-53.
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        78. Stauffer JC, Gaasch WH. Recognition and treatment of left ventricular diastolic dysfunction. Prog Cardiovasc Dis. 1990 Mar-Apr; 32(5):319-32.
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        79. Zile MR, Gaasch WH. Mechanical loads and the isovolumic and filling indices of left ventricular relaxation. Prog Cardiovasc Dis. 1990 Mar-Apr; 32(5):333-46.
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        80. Zile MR, Conrad CH, Gaasch WH, Robinson KG, Bing OH. Preload does not affect relaxation rate in normal, hypoxic, or hypertrophic myocardium. Am J Physiol. 1990 Jan; 258(1 Pt 2):H191-7.
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        81. Gaasch WH. Diastolic dysfunction of the left ventricle: importance to the clinician. Adv Intern Med. 1990; 35:311-40.
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        82. Zile MR, Blaustein AS, Gaasch WH. The effect of acute alterations in left ventricular afterload and beta-adrenergic tone on indices of early diastolic filling rate. Circ Res. 1989 Aug; 65(2):406-16.
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        83. Gaasch WH, Zile MR, Hoshino PK, Apstein CS, Blaustein AS. Stress-shortening relations and myocardial blood flow in compensated and failing canine hearts with pressure-overload hypertrophy. Circulation. 1989 Apr; 79(4):872-83.
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        84. Leonard JJ, Swan HJ, Dracup K, Gaasch WH, Gobel FL, Levey GS, Messer JV, Parker JO. Adult cardiology and the expanding supply of physicians. J Am Coll Cardiol. 1988 Sep; 12(3):858-62.
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        85. Ascher EK, Stauffer JC, Gaasch WH. Coronary artery spasm, cardiac arrest, transient electrocardiographic Q waves and stunned myocardium in cocaine-associated acute myocardial infarction. Am J Cardiol. 1988 Apr 15; 61(11):939-41.
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        86. Hoshino PK, Blaustein AS, Gaasch WH. Effect of propranolol on the left ventricular response to the Valsalva maneuver in normal subjects. Am J Cardiol. 1988 Feb 1; 61(4):400-4.
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        87. Zile MR, Neill WA, Gaasch WH, Oxendine J, Apstein CS, Weinberg E, Bing OH. Distribution of a neutral cardioplegic vehicle during the development of ischemic myocardial contracture. J Mol Cell Cardiol. 1987 Oct; 19(10):977-89.
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        88. Zile MR, Blaustein AS, Shimizu G, Gaasch WH. Right ventricular pacing reduces the rate of left ventricular relaxation and filling. J Am Coll Cardiol. 1987 Sep; 10(3):702-9.
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        89. Zile MR, Gaasch WH, Wiegner AW, Robinson KG, Bing OH. Mechanical determinants of maximum isotonic lengthening rate in rat left ventricular myocardium. Circ Res. 1987 Jun; 60(6):815-23.
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        90. Ariel Y, Gaasch WH, Bogen DK, McMahon TA. Load-dependent relaxation with late systolic volume steps: servo-pump studies in the intact canine heart. Circulation. 1987 Jun; 75(6):1287-94.
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        91. Berko B, Gaasch WH, Tanigawa N, Smith D, Craige E. Disparity between ejection and end-systolic indexes of left ventricular contractility in mitral regurgitation. Circulation. 1987 Jun; 75(6):1310-9.
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        92. Shimizu G, Conrad CH, Gaasch WH. Phase-plane analysis of left ventricular chamber filling and midwall fiber lengthening in patients with left ventricular hypertrophy. Circulation. 1987 Jan; 75(1 Pt 2):I34-9.
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        93. Gaasch WH, Carroll JD, Blaustein AS, Bing OH. Myocardial relaxation: effects of preload on the time course of isovolumetric relaxation. Circulation. 1986 May; 73(5):1037-41.
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        94. Hoshino PK, Gaasch WH. When to intervene in chronic aortic regurgitation. Arch Intern Med. 1986 Feb; 146(2):349-52.
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        95. Bogen DK, Ariel Y, McMahon TA, Gaasch WH. Measurement of peak systolic elastance in intact canine circulation with servo pump. Am J Physiol. 1985 Sep; 249(3 Pt 2):H585-93.
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        96. Zile MR, Gaasch WH, Levine HJ. Left ventricular stress-dimension-shortening relations before and after correction of chronic aortic and mitral regurgitation. Am J Cardiol. 1985 Jul 1; 56(1):99-105.
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        97. Gaasch WH, Blaustein AS, Bing OH. Asynchronous (segmental early) relaxation of the left ventricle. J Am Coll Cardiol. 1985 Apr; 5(4):891-7.
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        98. Shimizu G, Zile MR, Blaustein AS, Gaasch WH. Left ventricular chamber filling and midwall fiber lengthening in patients with left ventricular hypertrophy: overestimation of fiber velocities by conventional midwall measurements. Circulation. 1985 Feb; 71(2):266-72.
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        99. Gaasch WH, Zile MR. Evaluation of myocardial function in cardiomyopathic states. Prog Cardiovasc Dis. 1984 Sep-Oct; 27(2):115-32.
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        100. Zile MR, Gaasch WH, Carroll JD, Levine HJ. Chronic mitral regurgitation: predictive value of preoperative echocardiographic indexes of left ventricular function and wall stress. J Am Coll Cardiol. 1984 Feb; 3(2 Pt 1):235-42.
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        101. Nakamura Y, Wiegner AW, Gaasch WH, Bing OH. Systolic time intervals: assessment by isolated cardiac muscle studies. J Am Coll Cardiol. 1983 Nov; 2(5):973-8.
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        102. Levine HJ, Gaasch WH. Ratio of regurgitant volume to end-diastolic volume: a major determinant of ventricular response to surgical correction of chronic volume overload. Am J Cardiol. 1983 Aug; 52(3):406-10.
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        103. Gaasch WH, Carroll JD, Levine HJ, Criscitiello MG. Chronic aortic regurgitation: prognostic value of left ventricular end-systolic dimension and end-diastolic radius/thickness ratio. J Am Coll Cardiol. 1983 Mar; 1(3):775-82.
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        104. Blaustein AS, Gaasch WH. Myocardial relaxation. VI. Effects of beta-adrenergic tone and asynchrony on LV relaxation rate. Am J Physiol. 1983 Mar; 244(3):H417-22.
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        105. Carroll JD, Gaasch WH, Zile MR, Levine HJ. Serial changes in left ventricular function after correction of chronic aortic regurgitation. Dependence on early changes in preload and subsequent regression of hypertrophy. Am J Cardiol. 1983 Feb; 51(3):476-82.
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        106. Bornstein A, Gaasch WH, Harrington J. Assessment of the cardiac effects of hemodialysis with systolic time intervals and echocardiography. Am J Cardiol. 1983 Jan 15; 51(2):332-5.
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        107. Vogel WM, Apstein CS, Briggs LL, Gaasch WH, Ahn J. Acute alterations in left ventricular diastolic chamber stiffness. Role of the "erectile" effect of coronary arterial pressure and flow in normal and damaged hearts. Circ Res. 1982 Oct; 51(4):465-78.
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        108. Spadaro J, Bing OH, Gaasch WH, Laraia P, Franklin A, Weintraub RM. Effects of perfusion pressure on myocardial performance, metabolism, wall thickness, and compliance: comparison of the beating and fibrillating heart. J Thorac Cardiovasc Surg. 1982 Sep; 84(3):398-405.
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        109. Gaasch WH. Management of aortic valve disease. Hosp Pract (Off Ed). 1982 Sep; 17(9):133-8.
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        110. Bing OH, LaRaia PJ, Gaasch WH, Spadaro J, Franklin A, Weintraub RM. Independent protection provided by red blood cells during cardioplegia. Circulation. 1982 Aug; 66(2 Pt 2):I81-4.
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        111. Carroll JD, Gaasch WH, Naimi S, Levine HJ. Regression of myocardial hypertrophy: electrocardiographic-echocardiographic correlations after aortic valve replacement in patients with chronic aortic regurgitation. Circulation. 1982 May; 65(5):980-7.
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        112. Gaasch WH, Bing OH, Mirsky I. Chamber compliance and myocardial stiffness in left ventricular hypertrophy. Eur Heart J. 1982 Apr; 3 Suppl A:139-45.
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        113. Carroll JD, Gaasch WH, McAdam KP. Amyloid cardiomyopathy: characterization by a distinctive voltage/mass relation. Am J Cardiol. 1982 Jan; 49(1):9-13.
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        114. Blaustein AS, Gaasch WH. Myocardial relaxation. III. Reoxygenation mechanics in the intact dog heart. Circ Res. 1981 Sep; 49(3):633-9.
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        115. LaRaia PJ, Bing OH, Gaasch WH, Levine FH, Pine MB, Spadaro J, Crawford FD, Weintraub RM. Myocardial protection by coronary washout during global ischemic cardiac arrest. J Surg Res. 1981 Sep; 31(3):179-87.
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        116. Blaustein AS, Gaasch WH, Adam D, Levine HJ. Myocardial relaxation. V. Postextrasystolic contraction-relaxation in the intact dog heart. Circulation. 1981 Aug; 64(2):345-51.
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        117. Carroll JD, Gaasch WH. Left ventricular volume, mass, and function following surgical correction of chronic aortic regurgitation. Herz. 1981 Jun; 6(3):131-7.
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        118. Spadaro J, Bing OH, Gaasch WH, Weintraub RM. Pericardial modulation of right and left ventricular diastolic interaction. Circ Res. 1981 Feb; 48(2):233-8.
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        119. Gaasch WH, Blaustein AS, Andrias CW, Donahue RP, Avitall B. Myocardial relaxation. II. Hemodynamic determinants of rate of left ventricular isovolumic pressure decline. Am J Physiol. 1980 Jul; 239(1):H1-6.
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        120. Gaasch WH, Blaustein AS, Adam D. Myocardial relaxation IV: mechanical determinants of the time course of left ventricular pressure decline during isovolumic relaxation. Eur Heart J. 1980; Suppl A:111-7.
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        121. Gaasch WH, Bing OH. Myocardial relaxation. I. Effect of nitroprusside on the tension prolongation phenomenon. Am J Physiol. 1979 Aug; 237(2):H185-90.
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        122. Gaasch WH. Left ventricular radius to wall thickness ratio. Am J Cardiol. 1979 Jun; 43(6):1189-94.
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        123. Gaasch WH, Bing OH, Pine MB, Franklin A, Clement J, Rhodes D, Phear WP, Weintraub RM. Myocardial contracture during prolonged ischemic arrest and reperfusion. Am J Physiol. 1978 Dec; 235(6):H619-27.
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        124. Gaasch WH, Andrias CW, Levine HJ. Chronic aortic regurgitation: the effect of aortic valve replacement on left ventricular volume, mass and function. Circulation. 1978 Nov; 58(5):825-36.
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        125. Levine HJ, Gaasch WH. Diastolic compliance of the left ventricle. II: chamber and muscle stiffness, the volume/mass ratio and clinical implications. Mod Concepts Cardiovasc Dis. 1978 Sep; 47(9):99-102.
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        126. Levine HJ, Gaasch WH. Diastolic compliance of the left ventricle. I: causes of a noncompliant ventricular chamber. Mod Concepts Cardiovasc Dis. 1978 Aug; 47(8):95-8.
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        127. Gaasch WH, Bing OH, Franklin A, Rhodes D, Bernard SA, Weintraub RM. The influence of acute alterations in coronary blood flow on left ventricular diastolic compliance and wall thickness. Eur J Cardiol. 1978 Jun; 7 Suppl:147-61.
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        128. Gaasch WH, Bernard SA. The effect of acute changes in coronary blood flow on left ventricular end-diastolic wall thickness. An echocardiographic study. Circulation. 1977 Oct; 56(4 Pt 1):593-8.
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        129. Gaasch WH, Bing OH, Cole JS, Hanley HG. Postextrasystolic compliance of the left ventricle. Circulation. 1977 Oct; 56(4 Pt 1):540-4.
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        130. Gaasch WH, Levine HJ, Quinones MA, Alexander JK. Left ventricular compliance: mechanisms and clinical implications. Am J Cardiol. 1976 Nov 4; 38(5):645-53.
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        131. Quinones MA, Gaasch WH, Alexander JK. Influence of acute changes in preload, afterload, contractile state and heart rate on ejection and isovolumic indices of myocardial contractility in man. Circulation. 1976 Feb; 53(2):293-302.
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        132. Anastassiades PC, Quinones MA, Gaasch WH, Adyanthaya AV, Waggoner AD, Alexander JK. Aortic valve closure: echocardiographic, phonocardiographic, and hemodynamic assessment. Am Heart J. 1976 Feb; 91(2):228-32.
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        133. Gaasch WH, Quinones MA, Waisser E, Thiel HG, Alexander JK. Diastolic compliance of the left ventricle in man. Am J Cardiol. 1975 Aug; 36(2):193-201.
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        134. Gaasch WH, Adyanthaya AV, Wang VH, Pickering E, Quinones MA, Alexander JK. Prinzmetal's variant angina: hemodynamic and angiographic observations during pain. Am J Cardiol. 1975 May; 35(5):683-90.
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        135. Quinones MA, Gaasch WH, Cole JS, Alexander JK. Echocardiographic determination of left ventricular stress-velocity relations. Circulation. 1975 Apr; 51(4):689-700.
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        136. Quinones MA, Gaasch WH, Cole JS, Alexander JK. Determination of the time course of left ventricular wall stress and velocity of fiber shortening in man by simultaneous left ventricular pressure and echocardiographic recording: preliminary report. Cardiovasc Res Cent Bull. 1975 Apr-Jun; 13(4):63-77.
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        137. Gaasch WH, Cole JS, Quinones MA, Alexander JK. Dynamic determinants of letf ventricular diastolic pressure-volume relations in man. Circulation. 1975 Feb; 51(2):317-23.
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        138. Waisser E, Gaasch WH, Quinones MA, Alexander JK. His bundle electrograms in patients with congestive cardiomyopathy. Eur J Cardiol. 1975 Jan; 2(3):343-50.
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        139. Gaasch WH, Lufschanowski R, Leachman RD, Alexander JK. Surgical management of Prinzmetal's variant angina. Chest. 1974 Dec; 66(6):614-21.
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        140. Hernandez-Lattuf PR, Quinones MA, Gaasch WH. Usefulness and limitations of circumferential fibre shortening velocity in evaluating segmental disorders of left ventricular contraction. Br Heart J. 1974 Dec; 36(12):1167-74.
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        141. Quinones MA, Gaasch WH, Waisser E, Thiel HG, Alexander JK. An analysis of the left ventricular response to isometric exercise. Am Heart J. 1974 Jul; 88(1):29-36.
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        142. Quinones MA, Gaasch WH, Alexander JK. Echocardiographic assessment of left ventricular function with special reference to normalized velocities. Circulation. 1974 Jul; 50(1):42-51.
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        143. Gaasch WH, Peterson KL, Shabetai R. Left ventricular function in chronic constrictive pericarditis. Am J Cardiol. 1974 Jul; 34(1):107-10.
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        144. Quinones MA, Gaasch WH, Waisser E, Alexander JK. Reduction in the rate of diastolic descent of the mitral valve echogram in patients with altered left ventricular diastolic pressure-volume relations. Circulation. 1974 Feb; 49(2):246-54.
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        145. Oboler AA, Keefe JF, Gaasch WH, Banas JS, Levine HJ. Influence of left ventricular isovolumic pressure upon right ventricular pressure transients. Cardiology. 1973; 58(1):32-44.
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        146. Gaasch WH, Battle WE, Oboler AA, Banas JS, Levine HJ. Left ventricular stress and compliance in man. With special reference to normalized ventricular function curves. Circulation. 1972 Apr; 45(4):746-62.
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