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    Guozheng Liu PhD

    TitleResearch Associate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentRadiology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-1958
        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Liu G. Rules of thumb for maximum percent tumor accumulation. Nucl Med Biol. 2013 Aug; 40(6):865-7.
          View in: PubMed
        2. Wang Y, Chen L, Liu X, Cheng D, Liu G, Liu Y, Dou S, Hnatowich DJ, Rusckowski M. Detection of Aspergillus fumigatus pulmonary fungal infections in mice with (99m)Tc-labeled MORF oligomers targeting ribosomal RNA. Nucl Med Biol. 2013 Jan; 40(1):89-96.
          View in: PubMed
        3. Liu G, Dou S, Akalin A, Rusckowski M, Streeter PR, Shultz LD, Greiner DL. Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody. Nucl Med Biol. 2012 Jul; 39(5):645-51.
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        4. Liu G, Dou S, Liu Y, Wang Y, Rusckowski M, Hnatowich DJ. (90)Y labeled Phosphorodiamidate Morpholino Oligomer for Pretargeting Radiotherapy. Bioconjug Chem. 2011 Dec 21; 22(12):2539-45.
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        5. Chen L, Wang Y, Cheng D, Dou S, Liu X, Liu G, Hnatowich DJ, Rusckowski M. Comparing two TAG-72 binding peptides previously identified by phage display as potential imaging agents. Nucl Med Commun. 2011 Oct; 32(10):920-4.
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        6. Liu Y, Cheng D, Liu X, Liu G, Dou S, Xiao N, Chen L, Rusckowski M, Hnatowich DJ. Comparing the intracellular fate of components within a noncovalent streptavidin nanoparticle with covalent conjugation. Nucl Med Biol. 2012 Jan; 39(1):101-7.
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        7. Cheng D, Rusckowski M, Pretorius PH, Chen L, Xiao N, Liu Y, Liu G, Liang M, Liu X, Dou S, Hnatowich DJ. Improving the quantitation accuracy in noninvasive small animal single photon emission computed tomography imaging. Nucl Med Biol. 2011 Aug; 38(6):843-8.
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        8. Liu G, Dou S, Cheng D, Leif J, Rusckowski M, Streeter PR, Shultz LD, Hnatowich DJ, Greiner DL. Human Islet Cell MORF/cMORF Pretargeting in a Xenogeneic Murine Transplant Model. Mol Pharm. 2011 Jun 6; 8(3):767-73.
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        9. Cheng D, Rusckowski M, Wang Y, Liu Y, Liu G, Liu X, Hnatowich D. A Brief Evaluation of Tumor Imaging in Mice with 99mTc-glucarate Including a Comparison with 18F-FDG. Curr Radiopharm. 2011 Jan 1; 4(1):5-9.
          View in: PubMed
        10. Xiao N, Cheng D, Wang Y, Chen L, Liu X, Dou S, Liu G, Liang M, Hnatowich DJ, Rusckowski M. Identification of a high affinity TAG-72 binding peptide by phage display selection. Cancer Biol Ther. 2011 Jan 13; 11(1):22-31.
          View in: PubMed
        11. Liang M, Liu X, Liu G, Dou S, Cheng D, Liu Y, Rusckowski M, Hnatowich DJ. Reducing the background fluorescence in mice receiving fluorophore/inhibitor DNA duplexes. Mol Pharm. 2011 Feb 7; 8(1):126-32.
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        12. Liu G, Dou S, Chen X, Chen L, Liu X, Rusckowski M, Hnatowich DJ. Adding a clearing agent to pretargeting does not lower the tumor accumulation of the effector as predicted. Cancer Biother Radiopharm. 2010 Dec; 25(6):757-62.
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        13. Liu G, Dou S, Liu Y, Liang M, Chen L, Cheng D, Greiner D, Rusckowski M, Hnatowich DJ. Unexpected side products in the conjugation of an amine-derivatized morpholino oligomer with p-isothiocyanate benzyl DTPA and their removal. Nucl Med Biol. 2011 Feb; 38(2):159-63.
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        14. Liu G, Dou S, Baker S, Akalin A, Cheng D, Chen L, Rusckowski M, Hnatowich DJ. A preclinical (188) Re tumor therapeutic investigation using MORF/cMORF pretargeting and an antiTAG-72 antibody CC49. Cancer Biol Ther. 2010 Oct 15; 10(8):767-74.
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        15. He J, Wang Y, Dou S, Liu X, Zhang S, Liu G, Hnatowich D. Affinity enhancement pretargeting: synthesis and testing of a 99mTc-labeled bivalent MORF. Mol Pharm. 2010 Aug 2; 7(4):1118-24.
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        16. Liang M, Liu X, Cheng D, Liu G, Dou S, Wang Y, Rusckowski M, Hnatowich DJ. Multimodality nuclear and fluorescence tumor imaging in mice using a streptavidin nanoparticle. Bioconjug Chem. 2010 Jul 21; 21(7):1385-8.
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        17. Liu G, Dou S, Rusckowski M, Greiner D, Hnatowich D. Preparation of (111)In-DTPA morpholino oligomer for low abdominal accumulation. Appl Radiat Isot. 2010 Sep; 68(9):1709-14.
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        18. Liu G, Dou S, Pretorius PH, Liu X, Chen L, Rusckowski M, Hnatowich DJ. Tumor pretargeting in mice using MORF conjugated CC49 antibody and radiolabeled complimentary cMORF effector. Q J Nucl Med Mol Imaging. 2010 Jun; 54(3):333-40.
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        19. Liu G, Dou S, Liang M, Chen X, Rusckowski M, Hnatowich DJ. The ratio of maximum percent tumour accumulations of the pretargeting agent and the radiolabelled effector is independent of tumour size. Eur J Cancer. 2009 Nov; 45(17):3098-103.
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        20. Liang M, Liu X, Cheng D, Nakamura K, Wang Y, Dou S, Liu G, Rusckowski M, Hnatowich DJ. Optical antisense tumor targeting in vivo with an improved fluorescent DNA duplex probe. Bioconjug Chem. 2009 Jun; 20(6):1223-7.
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        21. Liang M, Liu X, Nakamura K, Chen X, Cheng D, Liu G, Dou S, Wang Y, Rusckowski M, Hnatowich DJ. A convenient thiazole orange fluorescence assay for the evaluation of DNA duplex hybridization stability. Mol Imaging Biol. 2009 Nov-Dec; 11(6):439-45.
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        22. Liu G, Cheng D, Dou S, Chen X, Liang M, Pretorius PH, Rusckowski M, Hnatowich DJ. Replacing 99mTc with 111In improves MORF/cMORF pretargeting by reducing intestinal accumulation. Mol Imaging Biol. 2009 Sep-Oct; 11(5):303-7.
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        23. Liu G, Hnatowich DJ. A semiempirical model of tumor pretargeting. Bioconjug Chem. 2008 Nov 19; 19(11):2095-104.
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        24. Chen L, Wang Y, Liu X, Dou S, Liu G, Hnatowich DJ, Rusckowski M. A new TAG-72 cancer marker peptide identified by phage display. Cancer Lett. 2008 Dec 8; 272(1):122-32.
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        25. Chen X, Dou S, Liu G, Liu X, Wang Y, Chen L, Rusckowski M, Hnatowich DJ. Synthesis and in vitro characterization of a dendrimer-MORF conjugate for amplification pretargeting. Bioconjug Chem. 2008 Aug; 19(8):1518-25.
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        26. Liu G, Dou S, Rusckowski M, Hnatowich DJ. An experimental and theoretical evaluation of the influence of pretargeting antibody on the tumor accumulation of effector. Mol Cancer Ther. 2008 May; 7(5):1025-32.
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        27. Rusckowski M, Gupta S, Liu G, Dou S, Hnatowich DJ. Investigation of four (99m)Tc-labeled bacteriophages for infection-specific imaging. Nucl Med Biol. 2008 May; 35(4):433-40.
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        28. Liu X, Wang Y, Nakamura K, Liu G, Dou S, Kubo A, Rusckowski M, Hnatowich DJ. Optical antisense imaging of tumor with fluorescent DNA duplexes. Bioconjug Chem. 2007 Nov-Dec; 18(6):1905-11.
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        29. Liu G, Dou S, Pretorius PH, Liu X, Rusckowski M, Hnatowich DJ. Pretargeting CWR22 prostate tumor in mice with MORF-B72.3 antibody and radiolabeled cMORF. Eur J Nucl Med Mol Imaging. 2008 Feb; 35(2):272-80.
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        30. Rusckowski M, Gupta S, Liu G, Dou S, Hnatowich DJ. Evidence of specificity of radiolabeled phage display peptides for the TAG-72 antigen. Cancer Biother Radiopharm. 2007 Aug; 22(4):564-72.
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        31. Zhang S, Liu G, Liu X, Yin D, Dou S, He J, Rusckowski M, Hnatowich DJ. Comparison of several linear fluorophore- and quencher-conjugated oligomer duplexes for stability, fluorescence quenching, and kinetics in vitro and in vivo in mice. Bioconjug Chem. 2007 Jul-Aug; 18(4):1170-5.
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        32. Liu G, Hnatowich DJ. Labeling biomolecules with radiorhenium: a review of the bifunctional chelators. Anticancer Agents Med Chem. 2007 May; 7(3):367-77.
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        33. He J, Liu G, Dou S, Gupta S, Rusckowski M, Hnatowich D. An improved method for covalently conjugating morpholino oligomers to antitumor antibodies. Bioconjug Chem. 2007 May-Jun; 18(3):983-8.
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        34. Liu G, Dou S, He J, Liu X, Rusckowski M, Hnatowich DJ. Predicting the biodistribution of radiolabeled cMORF effector in MORF-pretargeted mice. Eur J Nucl Med Mol Imaging. 2007 Feb; 34(2):237-46.
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        35. Liu G, Dou S, Yin D, Squires S, Liu X, Wang Y, Rusckowski M, Hnatowich DJ. A novel pretargeting method for measuring antibody internalization in tumor cells. Cancer Biother Radiopharm. 2007 Feb; 22(1):33-9.
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        36. Wang Y, Liu X, Zhang Y, Liu G, Rusckowski M, Hnatowich DJ. Nonspecific cellular accumulation of 99mTc-labeled oligonucleotides in culture is influenced by their guanine content. Nucl Med Biol. 2007 Jan; 34(1):47-54.
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        37. Liu X, Nakamura K, Wang Y, Zhang S, He J, Liu G, Dou S, Kubo A, Rusckowski M, Hnatowich D. Improved delivery in cell culture of radiolabeled antisense DNAs by duplex formation. Mol Imaging Biol. 2006 Sep-Oct; 8(5):278-83.
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        38. Liu G, Dou S, Mardirossian G, He J, Zhang S, Liu X, Rusckowski M, Hnatowich DJ. Successful radiotherapy of tumor in pretargeted mice by 188Re-radiolabeled phosphorodiamidate morpholino oligomer, a synthetic DNA analogue. Clin Cancer Res. 2006 Aug 15; 12(16):4958-64.
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        39. Liu G, Dou S, He J, Yin D, Gupta S, Zhang S, Wang Y, Rusckowski M, Hnatowich DJ. Radiolabeling of MAG3-morpholino oligomers with 188Re at high labeling efficiency and specific radioactivity for tumor pretargeting. Appl Radiat Isot. 2006 Sep; 64(9):971-8.
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        40. Zhang YM, Tung CH, He J, Liu N, Yanachkov I, Liu G, Rusckowski M, Vanderheyden JL. Construction of a novel chimera consisting of a chelator-containing Tat peptide conjugated to a morpholino antisense oligomer for technetium-99m labeling and accelerating cellular kinetics. Nucl Med Biol. 2006 Feb; 33(2):263-9.
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        41. Liu X, Nakamura K, Wang Y, Wang Y, Liu G, He J, Ding H, Lu P, Rusckowski M, Kubo A, Hnatowich DJ. Initial mechanistic studies of antisense targeting in cells. J Nucl Med. 2006 Feb; 47(2):360-8.
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        42. Vanderheyden JL, Liu G, He J, Patel B, Tait JF, Hnatowich DJ. Evaluation of 99mTc-MAG3-annexin V: influence of the chelate on in vitro and in vivo properties in mice. Nucl Med Biol. 2006 Jan; 33(1):135-44.
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        43. Wang Y, Liu G, Hnatowich DJ. Methods for MAG3 conjugation and 99mTc radiolabeling of biomolecules. Nat Protoc. 2006; 1(3):1477-80.
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        44. He J, Liu X, Zhang S, Liu G, Hnatowich DJ. Affinity enhancement bivalent morpholinos for pretargeting: surface plasmon resonance studies of molecular dimensions. Bioconjug Chem. 2005 Sep-Oct; 16(5):1098-104.
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        45. Liu G, He J, Dou S, Gupta S, Rusckowski M, Hnatowich DJ. Further investigations of morpholino pretargeting in mice--establishing quantitative relations in tumor. Eur J Nucl Med Mol Imaging. 2005 Sep; 32(9):1115-23.
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        46. He J, Liu G, Vanderheyden JL, Dou S, Mary R, Hnatowich DJ. Affinity enhancement bivalent morpholino for pretargeting: initial evidence by surface plasmon resonance. Bioconjug Chem. 2005 Mar-Apr; 16(2):338-45.
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        47. Zhang Y, He J, Liu G, Venderheyden JL, Gupta S, Rusckowski M, Hnatowich DJ. Initial observations of 99mTc labelled locked nucleic acids for antisense targeting. Nucl Med Commun. 2004 Nov; 25(11):1113-8.
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        48. Liu G, Dou S, He J, Vanderheyden JL, Rusckowski M, Hnatowich DJ. Preparation and properties of 99mTc(CO)3+-labeled N,N-bis(2-pyridylmethyl)-4-aminobutyric acid. Bioconjug Chem. 2004 Nov-Dec; 15(6):1441-6.
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        49. He J, Liu C, Vanderheyden JL, Liu G, Dou S, Rusckowski M, Hnatowich DJ. Radiolabelling morpholinos with 188Re tricarbonyl provides improved in vitro and in vivo stability to re-oxidation. Nucl Med Commun. 2004 Jul; 25(7):731-6.
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        50. Rusckowski M, Gupta S, Liu G, Dou S, Hnatowich DJ. Investigations of a (99m)Tc-labeled bacteriophage as a potential infection-specific imaging agent. J Nucl Med. 2004 Jul; 45(7):1201-8.
          View in: PubMed
        51. He J, Liu G, Gupta S, Zhang Y, Rusckowski M, Hnatowich DJ. Amplification targeting: a modified pretargeting approach with potential for signal amplification-proof of a concept. J Nucl Med. 2004 Jun; 45(6):1087-95.
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        52. Liu G, He J, Dou S, Gupta S, Vanderheyden JL, Rusckowski M, Hnatowich DJ. Pretargeting in tumored mice with radiolabeled morpholino oligomer showing low kidney uptake. Eur J Nucl Med Mol Imaging. 2004 Mar; 31(3):417-24.
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        53. He J, Liu G, Zhang S, Rusckowski M, Hnatowich DJ. Pharmacokinetics in mice of four oligomer-conjugated polymers for amplification targeting. Cancer Biother Radiopharm. 2003 Dec; 18(6):941-7.
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        54. He J, Liu G, Zhang S, Vanderheyden JL, Liu N, Liu C, Zhang Y, Gupta S, Rusckowski M, Hnatowich DJ. A comparison of in vitro and in vivo stability in mice of two morpholino duplexes differing in chain length. Bioconjug Chem. 2003 Sep-Oct; 14(5):1018-23.
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        55. Liu CB, Liu GZ, Liu N, Zhang YM, He J, Rusckowski M, Hnatowich DJ. Radiolabeling morpholinos with 90Y, 111In, 188Re and 99mTc. Nucl Med Biol. 2003 Feb; 30(2):207-14.
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        56. Liu G, He J, Zhang S, Liu C, Rusckowski M, Hnatowich DJ. Cytosine residues influence kidney accumulations of 99mTc-labeled morpholino oligomers. Antisense Nucleic Acid Drug Dev. 2002 Dec; 12(6):393-8.
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        57. Liu G, Zhang S, He J, Zhu Z, Rusckowski M, Hnatowich DJ. Improving the labeling of S-acetyl NHS-MAG(3)-conjugated morpholino oligomers. Bioconjug Chem. 2002 Jul-Aug; 13(4):893-7.
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        58. Liu G, Zhang C, Liu F, Wang R, Fu Z, Li G, Miao Z. 99mTc-N, N'-bis(aminoethyl)propanediamine hexaacetic acid (BPHA): a glomerular filtration agent similar to 99mTc-DTPA. Nucl Med Biol. 2002 May; 29(4):399-404.
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        59. Su ZF, Liu G, Gupta S, Zhu Z, Rusckowski M, Hnatowich DJ. In vitro and in vivo evaluation of a Technetium-99m-labeled cyclic RGD peptide as a specific marker of alpha(V)beta(3) integrin for tumor imaging. Bioconjug Chem. 2002 May-Jun; 13(3):561-70.
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        60. Liu G, Mang'era K, Liu N, Gupta S, Rusckowski M, Hnatowich DJ. Tumor pretargeting in mice using (99m)Tc-labeled morpholino, a DNA analog. J Nucl Med. 2002 Mar; 43(3):384-91.
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        61. Liu G, Wescott C, Sato A, Wang Y, Liu N, Zhang YM, Rusckowski M, Hnatowich DJ. Nitriles form mixed-coligand complexes with (99m)Tc-HYNIC-peptide. Nucl Med Biol. 2002 Jan; 29(1):107-13.
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