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    Samuel Nurko MPH

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPediatrics
    AddressChildrens Hospital Boston
    300 Longwood Avenue
    Boston MA 02115
    Phone617-355-6058
        Bibliographic 
        selected publications
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        1. Hubbard CS, Becerra L, Heinz N, Ludwick A, Rasooly T, Wu R, Johnson A, Schechter NL, Borsook D, Nurko S. Abdominal Pain, the Adolescent and Altered Brain Structure and Function. PLoS One. 2016; 11(5):e0156545.
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        2. Ganesh M, Hertzberg A, Nurko S, Needleman H, Rosen R. Acid Rather Than Nonacid Reflux Burden Is a Predictor of Tooth Erosion. J Pediatr Gastroenterol Nutr. 2016 Feb; 62(2):309-13.
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        3. Martinez EE, Douglas K, Nurko S, Mehta NM. Gastric Dysmotility in Critically Ill Children: Pathophysiology, Diagnosis, and Management. Pediatr Crit Care Med. 2015 Nov; 16(9):828-36.
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        4. Varni JW, Nurko S, Shulman RJ, Self MM, Saps M, Bendo CB, Vaughan Dark C, Pohl JF. Pediatric Functional Constipation Gastrointestinal Symptom Profile Compared With Healthy Controls. J Pediatr Gastroenterol Nutr. 2015 Oct; 61(4):424-30.
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        5. Varni JW, Shulman RJ, Self MM, Nurko S, Saps M, Saeed SA, Bendo CB, Patel AS, Dark CV, Zacur GM, Pohl JF. Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls. J Pediatr Gastroenterol Nutr. 2015 Sep; 61(3):323-9.
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        6. Rommel N, Omari TI, Selleslagh M, Kritas S, Cock C, Rosan R, Rodriguez L, Nurko S. High-resolution manometry combined with impedance measurements discriminates the cause of dysphagia in children. Eur J Pediatr. 2015 Dec; 174(12):1629-37.
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        7. Hubert K, Sideridis G, Sherlock R, Queally J, Rosoklija I, Kringle G, Johnson K, Nurko S, Bauer S. Validation of a bowel dysfunction instrument for adolescents with spina bifida. J Pediatr Urol. 2015 Aug; 11(4):199.e1-7.
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        8. Kovacic K, Sood MR, Mugie S, Di Lorenzo C, Nurko S, Heinz N, Ponnambalam A, Beesley C, Sanghavi R, Silverman AH. A multicenter study on childhood constipation and fecal incontinence: effects on quality of life. J Pediatr. 2015 Jun; 166(6):1482-7.e1.
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        9. Varni JW, Franciosi JP, Shulman RJ, Saeed S, Nurko S, Neigut DA, Bendo CB, Patel AS, Self MM, Saps M, Zacur GM, Denham J, Dark CV, Pohl JF. PedsQL gastrointestinal symptoms scales and gastrointestinal worry scales in pediatric patients with inflammatory bowel disease in comparison with healthy controls. Inflamm Bowel Dis. 2015 May; 21(5):1115-24.
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        10. Mallon D, Vernacchio L, Trudell E, Antonelli R, Nurko S, Leichtner AM, Lightdale JR. Shared care: a quality improvement initiative to optimize primary care management of constipation. Pediatrics. 2015 May; 135(5):e1300-7.
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        11. Silverman AH, Berlin KS, Di Lorenzo C, Nurko S, Kamody RC, Ponnambalam A, Mugie S, Gorges C, Sanghavi R, Sood MR. Measuring Health-Related Quality of Life With the Parental Opinions of Pediatric Constipation Questionnaire. J Pediatr Psychol. 2015 Sep; 40(8):814-24.
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        12. Sommers T, Corban C, Sengupta N, Jones M, Cheng V, Bollom A, Nurko S, Kelley J, Lembo A. Emergency department burden of constipation in the United States from 2006 to 2011. Am J Gastroenterol. 2015 Apr; 110(4):572-9.
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        13. Varni JW, Bendo CB, Shulman RJ, Self MM, Nurko S, Franciosi JP, Saps M, Saeed S, Zacur GM, Vaughan Dark C, Pohl JF. Interpretability of the PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in Pediatric Patients With Functional and Organic Gastrointestinal Diseases. J Pediatr Psychol. 2015 Jul; 40(6):591-601.
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        14. Nurko S, Saps M. Treating constipation with prucalopride: one size does not fit all. Gastroenterology. 2014 Dec; 147(6):1214-6.
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        15. Varni JW, Bendo CB, Nurko S, Shulman RJ, Self MM, Franciosi JP, Saps M, Pohl JF. Health-related quality of life in pediatric patients with functional and organic gastrointestinal diseases. J Pediatr. 2015 Jan; 166(1):85-90.
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        16. Varni JW, Bendo CB, Denham J, Shulman RJ, Self MM, Neigut DA, Nurko S, Patel AS, Franciosi JP, Saps M, Verga B, Smith A, Yeckes A, Heinz N, Langseder A, Saeed S, Zacur GM, Pohl JF. PedsQL gastrointestinal symptoms module: feasibility, reliability, and validity. J Pediatr Gastroenterol Nutr. 2014 Sep; 59(3):347-55.
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        17. Varni JW, Bendo CB, Denham J, Shulman RJ, Self MM, Neigut DA, Nurko S, Patel AS, Franciosi JP, Saps M, Yeckes A, Langseder A, Saeed S, Pohl JF. PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with functional and organic gastrointestinal diseases in comparison to healthy controls. Qual Life Res. 2015 Feb; 24(2):363-78.
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        18. Nurko S, Zimmerman LA. Evaluation and treatment of constipation in children and adolescents. Am Fam Physician. 2014 Jul 15; 90(2):82-90.
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        19. Bromberg MH, Schechter NL, Nurko S, Zempsky WT, Schanberg LE. Persistent pain in chronically ill children without detectable disease activity. Pain Manag. 2014 May; 4(3):211-9.
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        20. Ganesh M, Nurko S. Functional dyspepsia in children. Pediatr Ann. 2014 Apr; 43(4):e101-5.
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        21. Lexmond WS, Neves JF, Nurko S, Olszak T, Exley MA, Blumberg RS, Fiebiger E. Involvement of the iNKT cell pathway is associated with early-onset eosinophilic esophagitis and response to allergen avoidance therapy. Am J Gastroenterol. 2014 May; 109(5):646-57.
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        22. Rosen R, Amirault J, Giligan E, Khatwa U, Nurko S. Intraesophageal pressure recording improves the detection of cough during multichannel intraluminal impedance testing in children. J Pediatr Gastroenterol Nutr. 2014 Jan; 58(1):22-6.
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        23. Mohammad S, Di Lorenzo C, Youssef NN, Miranda A, Nurko S, Hyman P, Saps M. Assessment of abdominal pain through global outcomes and recent FDA recommendations in children: are we ready for change? J Pediatr Gastroenterol Nutr. 2014 Jan; 58(1):46-50.
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        24. Rosen R, Amirault J, Johnston N, Haver K, Khatwa U, Rubinstein E, Nurko S. The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing. Pediatr Pulmonol. 2014 Nov; 49(11):1090-6.
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        25. Ambartsumyan L, Rodriguez L, Morera C, Nurko S. Longitudinal and radial characteristics of intra-anal pressures in children using 3D high-definition anorectal manometry: new observations. Am J Gastroenterol. 2013 Dec; 108(12):1918-28.
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        26. Ambartsumyan L, Nurko S. Review of organic causes of fecal incontinence in children: evaluation and treatment. Expert Rev Gastroenterol Hepatol. 2013 Sep; 7(7):657-67.
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        27. Zimmerman LA, Srinath AI, Goyal A, Bousvaros A, Ducharme P, Szigethy E, Nurko S. The overlap of functional abdominal pain in pediatric Crohn's disease. Inflamm Bowel Dis. 2013 Mar-Apr; 19(4):826-31.
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        28. Rodriguez L, Diaz J, Nurko S. Safety and efficacy of cyproheptadine for treating dyspeptic symptoms in children. J Pediatr. 2013 Jul; 163(1):261-7.
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        29. Chogle A, Sztainberg M, Bass L, Youssef NN, Miranda A, Nurko S, Hyman P, Cocjin J, Di Lorenzo C, Saps M. Accuracy of pain recall in children. J Pediatr Gastroenterol Nutr. 2012 Sep; 55(3):288-91.
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        30. Bannert C, Bidmon-Fliegenschnee B, Stary G, Hotzy F, Stift J, Nurko S, Szépfalusi Z, Fiebiger E, Dehlink E. Fc-epsilon-RI, the high affinity IgE-receptor, is robustly expressed in the upper gastrointestinal tract and modulated by mucosal inflammation. PLoS One. 2012; 7(7):e42066.
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        31. Rodriguez L, Rosen R, Manfredi M, Nurko S. Endoscopic intrapyloric injection of botulinum toxin A in the treatment of children with gastroparesis: a retrospective, open-label study. Gastrointest Endosc. 2012 Feb; 75(2):302-9.
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        32. Morera C, Nurko S. Heterogeneity of lower esophageal sphincter function in children with achalasia. J Pediatr Gastroenterol Nutr. 2012 Jan; 54(1):34-40.
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        33. Nurko S. Eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2011 Dec; 53 Suppl 2:S13-5.
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        34. Nurko S. Extra-esophageal symptoms: how do we treat them? J Pediatr Gastroenterol Nutr. 2011 Dec; 53 Suppl 2:S22-3.
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        35. Siddiqui A, Rosen R, Nurko S. Anorectal manometry may identify children with spinal cord lesions. J Pediatr Gastroenterol Nutr. 2011 Nov; 53(5):507-11.
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        36. Jadcherla SR, Nurko S. Esophageal disease in pediatrics. Ann N Y Acad Sci. 2011 Sep; 1232:401-4.
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        37. Lexmond W, der Mee Jv, Ruiter F, Platzer B, Stary G, Yen EH, Dehlink E, Nurko S, Fiebiger E. Development and validation of a standardized ELISA for the detection of soluble Fc-epsilon-RI in human serum. J Immunol Methods. 2011 Oct 28; 373(1-2):192-9.
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        38. Rosen R, Johnston N, Hart K, Khatwa U, Katz E, Nurko S. Higher rate of bronchoalveolar lavage culture positivity in children with nonacid reflux and respiratory disorders. J Pediatr. 2011 Sep; 159(3):504-6.
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        39. Chumpitazi BP, Nurko S. Defecation disorders in children after surgery for Hirschsprung disease. J Pediatr Gastroenterol Nutr. 2011 Jul; 53(1):75-9.
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        40. Siddiqui AA, Fishman SJ, Bauer SB, Nurko S. Long-term follow-up of patients after antegrade continence enema procedure. J Pediatr Gastroenterol Nutr. 2011 May; 52(5):574-80.
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        41. Raphael BP, Nurko S, Jiang H, Hart K, Kamin DS, Jaksic T, Duggan C. Cisapride improves enteral tolerance in pediatric short-bowel syndrome with dysmotility. J Pediatr Gastroenterol Nutr. 2011 May; 52(5):590-4.
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        42. Dehlink E, Platzer B, Baker AH, Larosa J, Pardo M, Dwyer P, Yen EH, Szépfalusi Z, Nurko S, Fiebiger E. A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum. PLoS One. 2011; 6(4):e19098.
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        43. Sood MR, Di Lorenzo C, Hyams J, Miranda A, Simpson P, Mousa H, Nurko S. Beliefs and attitudes of general pediatricians and pediatric gastroenterologists regarding functional gastrointestinal disorders: a survey study. Clin Pediatr (Phila). 2011 Oct; 50(10):891-6.
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        44. Rosen R, Hart K, Nurko S. Does reflux monitoring with multichannel intraluminal impedance change clinical decision making? J Pediatr Gastroenterol Nutr. 2011 Apr; 52(4):404-7.
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        45. Chiou E, Rosen R, Nurko S. Effect of different pH criteria on dual-sensor pH monitoring in the evaluation of supraesophageal gastric reflux in children. J Pediatr Gastroenterol Nutr. 2011 Apr; 52(4):399-403.
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        46. Nurko S, Scott SM. Coexistence of constipation and incontinence in children and adults. Best Pract Res Clin Gastroenterol. 2011 Feb; 25(1):29-41.
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        47. Mousa HM, Rosen R, Woodley FW, Orsi M, Armas D, Faure C, Fortunato J, O'connor J, Skaggs B, Nurko S. Esophageal impedance monitoring for gastroesophageal reflux. J Pediatr Gastroenterol Nutr. 2011 Feb; 52(2):129-39.
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        48. Yen EH, Hornick JL, Dehlink E, Dokter M, Baker A, Fiebiger E, Nurko S. Comparative analysis of FceRI expression patterns in patients with eosinophilic and reflux esophagitis. J Pediatr Gastroenterol Nutr. 2010 Nov; 51(5):584-92.
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        49. Dehlink E, Baker AH, Yen E, Nurko S, Fiebiger E. Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. PLoS One. 2010; 5(8):e12204.
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        50. Pensabene L, Buonomo C, Fishman L, Chitkara D, Nurko S. Lack of utility of abdominal x-rays in the evaluation of children with constipation: comparison of different scoring methods. J Pediatr Gastroenterol Nutr. 2010 Aug; 51(2):155-9.
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        51. Chiou E, Nurko S. Management of functional abdominal pain and irritable bowel syndrome in children and adolescents. Expert Rev Gastroenterol Hepatol. 2010 Jun; 4(3):293-304.
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        52. Rosen R, Levine P, Lewis J, Mitchell P, Nurko S. Reflux events detected by pH-MII do not determine fundoplication outcome. J Pediatr Gastroenterol Nutr. 2010 Mar; 50(3):251-5.
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        53. Nurko S, Rosen R, Furuta GT. Esophageal dysmotility in children with eosinophilic esophagitis: a study using prolonged esophageal manometry. Am J Gastroenterol. 2009 Dec; 104(12):3050-7.
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        54. Saps M, Youssef N, Miranda A, Nurko S, Hyman P, Cocjin J, Di Lorenzo C. Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders. Gastroenterology. 2009 Oct; 137(4):1261-9.
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        55. Mallory LA, Shaw JG, Burgess SL, Estrella E, Nurko S, Burpee TM, Agus MS, Darras BT, Kunkel LM, Kang PB. Congenital myasthenic syndrome with episodic apnea. Pediatr Neurol. 2009 Jul; 41(1):42-5.
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        56. Chumpitazi BP, Fishman SJ, Nurko S. Long-term clinical outcome after botulinum toxin injection in children with nonrelaxing internal anal sphincter. Am J Gastroenterol. 2009 Apr; 104(4):976-83.
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        57. Nurko S. The tip of the iceberg: the prevalence of functional gastrointestinal diseases in children. J Pediatr. 2009 Mar; 154(3):313-5.
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        58. Modi BP, Ching YA, Langer M, Donovan K, Fauza DO, Kim HB, Jaksic T, Nurko S. Preservation of intestinal motility after the serial transverse enteroplasty procedure in a large animal model of short bowel syndrome. J Pediatr Surg. 2009 Jan; 44(1):229-35; discussion 235.
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        59. Nurko S, Di Lorenzo C. Functional abdominal pain: time to get together and move forward. J Pediatr Gastroenterol Nutr. 2008 Nov; 47(5):679-80.
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        60. Pai SY, Levy O, Jabara HH, Glickman JN, Stoler-Barak L, Sachs J, Nurko S, Orange JS, Geha RS. Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. J Allergy Clin Immunol. 2008 Dec; 122(6):1113-1118.e1.
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        61. Pensabene L, Nurko S. Approach to the child who has persistent dysphagia after surgical treatment for esophageal achalasia. J Pediatr Gastroenterol Nutr. 2008 Jul; 47(1):92-7.
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        62. Berde C, Nurko S. Opioid side effects--mechanism-based therapy. N Engl J Med. 2008 May 29; 358(22):2400-2.
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        63. Rosen R, Furuta G, Fritz J, Donovan K, Nurko S. Role of acid and nonacid reflux in children with eosinophilic esophagitis compared with patients with gastroesophageal reflux and control patients. J Pediatr Gastroenterol Nutr. 2008 May; 46(5):520-3.
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        64. Rosen R, Fritz J, Nurko A, Simon D, Nurko S. Lipid-laden macrophage index is not an indicator of gastroesophageal reflux-related respiratory disease in children. Pediatrics. 2008 Apr; 121(4):e879-84.
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        65. Nurko S, Youssef NN, Sabri M, Langseder A, McGowan J, Cleveland M, Di Lorenzo C. PEG3350 in the treatment of childhood constipation: a multicenter, double-blinded, placebo-controlled trial. J Pediatr. 2008 Aug; 153(2):254-61, 261.e1.
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        66. Chumpitazi B, Nurko S. Pediatric gastrointestinal motility disorders: challenges and a clinical update. Gastroenterol Hepatol (N Y). 2008 Feb; 4(2):140-8.
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        67. Nurko S, Rosen R. Esophageal dysmotility in patients who have eosinophilic esophagitis. Gastrointest Endosc Clin N Am. 2008 Jan; 18(1):73-89; ix.
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        68. Rosen R, Lord C, Nurko S. The sensitivity of multichannel intraluminal impedance and the pH probe in the evaluation of gastroesophageal reflux in children. Clin Gastroenterol Hepatol. 2006 Feb; 4(2):167-72.
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        69. Nurko S. What's the value of diagnostic tools in defecation disorders? J Pediatr Gastroenterol Nutr. 2005 Sep; 41 Suppl 1:S53-5.
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        70. Nurko S, Rosen R. Use of multi-channel intraluminal impedance (MII) in the evaluation of children with respiratory symptoms: a new phenomenon? J Pediatr Gastroenterol Nutr. 2005 Aug; 41(2):166-8.
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        71. Benninga M, Candy DC, Catto-Smith AG, Clayden G, Loening-Baucke V, Di Lorenzo C, Nurko S, Staiano A. The Paris Consensus on Childhood Constipation Terminology (PACCT) Group. J Pediatr Gastroenterol Nutr. 2005 Mar; 40(3):273-5.
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        72. Chitkara DK, Fortunato C, Nurko S. Esophageal motor activity in children with gastro-esophageal reflux disease and esophagitis. J Pediatr Gastroenterol Nutr. 2005 Jan; 40(1):70-5.
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        73. Rosen R, Nurko S. The importance of multichannel intraluminal impedance in the evaluation of children with persistent respiratory symptoms. Am J Gastroenterol. 2004 Dec; 99(12):2452-8.
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        74. Rosen R, Buonomo C, Andrade R, Nurko S. Incidence of spinal cord lesions in patients with intractable constipation. J Pediatr. 2004 Sep; 145(3):409-11.
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        75. Fishman L, Lenders C, Fortunato C, Noonan C, Nurko S. Increased prevalence of constipation and fecal soiling in a population of obese children. J Pediatr. 2004 Aug; 145(2):253-4.
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        76. Prasad C, Nurko S, Borovoy J, Korson MS. The importance of gut motility in the metabolic control of propionic acidemia. J Pediatr. 2004 Apr; 144(4):532-5.
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        77. Nurko S, Teitelbaum JE, Husain K, Buonomo C, Fox VL, Antonioli D, Fortunato C, Badizadegan K, Furuta GT. Association of Schatzki ring with eosinophilic esophagitis in children. J Pediatr Gastroenterol Nutr. 2004 Apr; 38(4):436-41.
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        78. Chitkara DK, Fortunato C, Nurko S. Prolonged monitoring of esophageal motor function in healthy children. J Pediatr Gastroenterol Nutr. 2004 Feb; 38(2):192-7.
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        79. Köhler H, Nurko S, Glickman J, Furuta GT. Acute myeloid leukemia presenting as non-neutropenic colitis in an infant. J Pediatr Gastroenterol Nutr. 2003 Nov; 37(5):631-3.
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        80. Rosen R, Nurko S, Furuta GT. Impeding gastroesophageal refluxate: a new application of an old medication. Gastroenterology. 2003 Sep; 125(3):984-5; discussion 985-6.
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        81. Ciamarra P, Nurko S, Barksdale E, Fishman S, Di Lorenzo C. Internal anal sphincter achalasia in children: clinical characteristics and treatment with Clostridium botulinum toxin. J Pediatr Gastroenterol Nutr. 2003 Sep; 37(3):315-9.
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        82. Hadigan C, Fishman SJ, Connolly LP, Treves ST, Nurko S. Stimulation with fatty meal (Lipomul) to assess gallbladder emptying in children with chronic acalculous cholecystitis. J Pediatr Gastroenterol Nutr. 2003 Aug; 37(2):178-82.
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        83. Morera C, Nurko S. Rectal manometry in patients with isolated sacral agenesis. J Pediatr Gastroenterol Nutr. 2003 Jul; 37(1):47-52.
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        84. Fishman L, Rappaport L, Schonwald A, Nurko S. Trends in referral to a single encopresis clinic over 20 years. Pediatrics. 2003 May; 111(5 Pt 1):e604-7.
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        85. Chitkara DK, Nurko S, Shoffner JM, Buie T, Flores A. Abnormalities in gastrointestinal motility are associated with diseases of oxidative phosphorylation in children. Am J Gastroenterol. 2003 Apr; 98(4):871-7.
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        86. Kim HB, Fauza D, Garza J, Oh JT, Nurko S, Jaksic T. Serial transverse enteroplasty (STEP): a novel bowel lengthening procedure. J Pediatr Surg. 2003 Mar; 38(3):425-9.
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        87. Heuschkel RB, Fletcher K, Hill A, Buonomo C, Bousvaros A, Nurko S. Isolated neonatal swallowing dysfunction: a case series and review of the literature. Dig Dis Sci. 2003 Jan; 48(1):30-5.
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        88. Fox VL, Nurko S, Teitelbaum JE, Badizadegan K, Furuta GT. High-resolution EUS in children with eosinophilic "allergic" esophagitis. Gastrointest Endosc. 2003 Jan; 57(1):30-6.
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        89. Fox VL, Nurko S, Furuta GT. Eosinophilic esophagitis: it's not just kid's stuff. Gastrointest Endosc. 2002 Aug; 56(2):260-70.
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        90. Rakhit A, Nurko S, Gauvreau K, Mayer JE, Blume ED. Gastrointestinal complications after pediatric cardiac transplantation. J Heart Lung Transplant. 2002 Jul; 21(7):751-9.
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        91. Simanovsky N, Buonomo C, Nurko S. The infant with chronic vomiting: the value of the upper GI series. Pediatr Radiol. 2002 Aug; 32(8):549-50; discussion 551.
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        92. Orange JS, Brodeur SR, Jain A, Bonilla FA, Schneider LC, Kretschmer R, Nurko S, Rasmussen WL, Köhler JR, Gellis SE, Ferguson BM, Strominger JL, Zonana J, Ramesh N, Ballas ZK, Geha RS. Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations. J Clin Invest. 2002 Jun; 109(11):1501-9.
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        93. Teitelbaum JE, Fox VL, Twarog FJ, Nurko S, Antonioli D, Gleich G, Badizadegan K, Furuta GT. Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology. 2002 May; 122(5):1216-25.
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        94. Fishman L, Rappaport L, Cousineau D, Nurko S. Early constipation and toilet training in children with encopresis. J Pediatr Gastroenterol Nutr. 2002 Apr; 34(4):385-8.
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