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    Stephen P Baker MSCPH

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentQuantitative Health Sciences
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-2625
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentCell and Developmental Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBiomedical Engineering and Medical Physiology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCell Biology

        Overview 
        Narrative
        Academic Appointments
      • 1983-Present, The University of Massachusetts Medical School:
      • 2004-Present, Instructor in Biostatistics, Dept. of Cell Biology
      • 1992-Present, Associate Faculty, Graduate School of Nursing,
      • 1986-2004, Lecturer of Biomedical Sciences in Biostatistics, Graduate School of Biomed¬ical Sciences .
      • Professional Positions
      • 1983-Present, The University of Massachusetts Medical School:
      • 1998-Present, Senior Biostatistician, Academic Computing Services
      • 1997-1998, Director of Research and Evaluation, Office of Clinical Affairs, Executive Office of Health and Human Services, Division of Medical Assistance and The University of Massachusetts Medical School Commonwealth Medicine Program.
      • 1990-1991 Associate Director for Academic Computing Programs, Department of Academic Computing
      • 1983-1997, Biostatistician, Department of Academic Computing.
      • 1980-1983, The University of Massachusetts, Amherst:
      • 1981-1983, Project Statistician, Mastitis Control Program, Lactation and Reproductive Physiology Laboratories, Dept. of Veterinary and Animal Science.
      • 1980-1981, Research Assistant, Biopharmaceutical Research Unit, Department of Biostatistics and Epidemiology, School of Public Health
      • 1973-1980 Astra Pharmaceutical Products, Inc., Framingham Massachusetts:
      • 1976-1980, Clinical Research Monitor, Cardiovascular And Psychotropic Drug Development Programs, Medical Department
      • 1973-1976, Clinical Data Analyst, Pulmonary, Pain Control And Cardiovas¬cular Drug Development Programs, Medical Department
      • Editorial Activities
      • Editorial Board Member
      • Chest
      • Referee:
      • Bioinformatics
      • Chest
      • Clinical Infectious Disease
      • The Journal of Clinical Care Medicine
      • The Journal of Clinical Endocrinology and Metabolism
      • The Journal of Physiology
      • Statistical Research
      • General and Generalized linear mixed models
      • Missing Data problems
      • Multiple Comparisons Procedures
      • Problems in estimation in finite populations.
      • Methods for the analysis of microarray experiments
      • Professional Memberships
      • American Statistical Association
      • The Biometric Society (ENAR)
      • The International Biometric Society


      • Bibliographic 
        selected publications
        List All   |   Timeline
        1. Borgert CJ, Baker SP, Matthews JC. Potency matters: Thresholds govern endocrine activity. Regul Toxicol Pharmacol. 2013 Oct; 67(1):83-8.
          View in: PubMed
        2. Vedantham S, Karellas A, Emmons MM, Moss LJ, Hussain S, Baker SP. Dedicated breast CT: geometric design considerations to maximize posterior breast coverage. Phys Med Biol. 2013 May 17; 58(12):4099-4118.
          View in: PubMed
        3. Silverman J, Baker SP, Lidz CW. A self-assessment survey of the Institutional Animal Care and Use Committee, Part 2: structure and organizational functions. Lab Anim (NY). 2012 Sep 19; 41(10):289-94.
          View in: PubMed
        4. Silverman J, Baker SP, Lidz CW. A self-assessment survey of the Institutional Animal Care and Use Committee, Part 1: animal welfare and protocol compliance. Lab Anim (NY). 2012; 41(8):230-5.
          View in: PubMed
        5. Gosling JI, Baker SP, Haynes JM, Kassiou M, Pouton CW, Warfe L, White PJ, Scammells PJ. Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic n(6) -substituents as adenosine a(1) receptor agonists. ChemMedChem. 2012 Jul; 7(7):1191-201.
          View in: PubMed
        6. Henninger N, Lin E, Baker SP, Wakhloo AK, Takhtani D, Moonis M. Leukoaraiosis predicts poor 90-day outcome after acute large cerebral artery occlusion. Cerebrovasc Dis. 2012; 33(6):525-31.
          View in: PubMed
        7. Chin MS, Freniere BB, Lo YC, Saleeby JH, Baker SP, Strom HM, Ignotz RA, Lalikos JF, Fitzgerald TJ. Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin. J Biomed Opt. 2012 Feb; 17(2):026010.
          View in: PubMed
        8. Jonassen JA, Sanagustin J, Baker SP, Pazour GJ. Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle Misorientation. J Am Soc Nephrol. 2012 Jan 26.
          View in: PubMed
        9. Corwin MT, Karam AR, Baker SP, Kim YH. Determination of cystic duct patency using hepatobiliary MRI with gadoxetate disodium: Is T1 precontrast imaging necessary? J Magn Reson Imaging. 2012 Mar; 35(3):601-6.
          View in: PubMed
        10. Zhao G, Walsh E, Shryock JC, Messina E, Wu Y, Zeng D, Xu X, Ochoa M, Baker SP, Hintze TH, Belardinelli L. Antiadrenergic and hemodynamic effects of ranolazine in conscious dogs. J Cardiovasc Pharmacol. 2011 Jun; 57(6):639-47.
          View in: PubMed
        11. Lilly CM, Cody S, Zhao H, Landry K, Baker SP, McIlwaine J, Chandler MW, Irwin RS. Hospital mortality, length of stay, and preventable complications among critically ill patients before and after tele-ICU reengineering of critical care processes. JAMA. 2011 Jun 1; 305(21):2175-83.
          View in: PubMed
        12. Mellios N, Galdzicka M, Ginns E, Baker SP, Rogaev E, Xu J, Akbarian S. Gender-Specific Reduction of Estrogen-Sensitive Small RNA, miR-30b, in Subjects With Schizophrenia. Schizophr Bull. 2012 May; 38(3):433-43.
          View in: PubMed
        13. Baker SP, Phillips J, Anderson S, Qiu Q, Shabanowitz J, Smith MM, Yates JR, Hunt DF, Grant PA. Histone H3 Thr 45 phosphorylation is a replication-associated post-translational modification in S. cerevisiae. Nat Cell Biol. 2010 Mar; 12(3):294-8.
          View in: PubMed
        14. Evans BA, Evans JE, Baker SP, Kane K, Swearer J, Hinerfeld D, Caselli R, Rogaeva E, St George-Hyslop P, Moonis M, Pollen DA. Long-term statin therapy and CSF cholesterol levels: implications for Alzheimer's disease. Dement Geriatr Cogn Disord. 2009; 27(6):519-24.
          View in: PubMed
        15. Silverman J, Bays DW, Baker SP. Ammonia and carbon dioxide concentrations in disposable and reusable static mouse cages. Lab Anim (NY). 2009 Jan; 38(1):16-23.
          View in: PubMed
        16. Mellios N, Huang HS, Baker SP, Galdzicka M, Ginns E, Akbarian S. Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia. Biol Psychiatry. 2009 Jun 15; 65(12):1006-14.
          View in: PubMed
        17. Karellas P, McNaughton M, Baker SP, Scammells PJ. Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands. J Med Chem. 2008 Oct 9; 51(19):6128-37.
          View in: PubMed
        18. Tresoldi S, Kim YH, Blake MA, Harisinghani MG, Hahn PF, Baker SP, Mueller PR, Kandarpa K. Adult intestinal intussusception: can abdominal MDCT distinguish an intussusception caused by a lead point? Abdom Imaging. 2008 Sep-Oct; 33(5):582-8.
          View in: PubMed
        19. Silverman J, Bays DW, Cooper SF, Baker SP. Ammonia and carbon dioxide concentrations in disposable and reusable ventilated mouse cages. J Am Assoc Lab Anim Sci. 2008 Mar; 47(2):57-62.
          View in: PubMed
        20. Ashton TD, Baker SP, Hutchinson SA, Scammells PJ. N6-substituted C5'-modified adenosines as A1 adenosine receptor agonists. Bioorg Med Chem. 2008 Feb 15; 16(4):1861-73.
          View in: PubMed
        21. Hinerfeld DA, Moonis M, Swearer JM, Baker SP, Caselli RJ, Rogaeva E, St George-Hyslop P, Pollen DA. Statins differentially affect amyloid precursor protein metabolism in presymptomatic PS1 and non-PS1 subjects. Arch Neurol. 2007 Nov; 64(11):1672-3.
          View in: PubMed
        22. Ashton TD, Aumann KM, Baker SP, Schiesser CH, Scammells PJ. Structure-activity relationships of adenosines with heterocyclic N6-substituents. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6779-84.
          View in: PubMed
        23. Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, Akbarian S. Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J Neurosci. 2007 Oct 17; 27(42):11254-62.
          View in: PubMed
        24. Calvo-Calle JM, Strug I, Nastke MD, Baker SP, Stern LJ. Human CD4+ T cell epitopes from vaccinia virus induced by vaccination or infection. PLoS Pathog. 2007 Oct 12; 3(10):1511-29.
          View in: PubMed
        25. Istvanic S, Yantiss RK, Baker SP, Banner BF. Normal variation in intraepithelial lymphocytes of the terminal ileum. Am J Clin Pathol. 2007 May; 127(5):816-9.
          View in: PubMed
        26. Lai KK, Fontecchio S, Melvin Z, Baker SP. Impact of alcohol-based, waterless hand antiseptic on the incidence of infection and colonization with methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. Infect Control Hosp Epidemiol. 2006 Oct; 27(10):1018-24.
          View in: PubMed
        27. Romagnoli R, Baraldi PG, Moorman AR, Iaconinoto MA, Carrion MD, Cara CL, Tabrizi MA, Preti D, Fruttarolo F, Baker SP, Varani K, Borea PA. Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A(1) receptor. Bioorg Med Chem Lett. 2006 Nov 1; 16(21):5530-3.
          View in: PubMed
        28. De Crescenzo V, Fogarty KE, Zhuge R, Tuft RA, Lifshitz LM, Carmichael J, Bellvé KD, Baker SP, Zissimopoulos S, Lai FA, Lemos JR, Walsh JV. Dihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals. J Neurosci. 2006 Jul 19; 26(29):7565-74.
          View in: PubMed
        29. Morse AN, O'dell KK, Howard AE, Baker SP, Aronson MP, Young SB. Midline anterior repair alone vs anterior repair plus vaginal paravaginal repair: a comparison of anatomic and quality of life outcomes. Int Urogynecol J Pelvic Floor Dysfunct. 2007 Mar; 18(3):245-9.
          View in: PubMed
        30. Yousef MM, Yantiss RK, Baker SP, Banner BF. Duodenal intraepithelial lymphocytes in inflammatory disorders of the esophagus and stomach. Clin Gastroenterol Hepatol. 2006 May; 4(5):631-4.
          View in: PubMed
        31. Huang J, Kim YH, Shankar S, Tyagi G, Baker SP. Multidetector CT urography: comparison of two different scanning protocols for improved visualization of the urinary tract. J Comput Assist Tomogr. 2006 Jan-Feb; 30(1):33-6.
          View in: PubMed
        32. Baker SP, Grant PA. The proteasome: not just degrading anymore. Cell. 2005 Nov 4; 123(3):361-3.
          View in: PubMed
        33. Patel PK, Arcangioli B, Baker SP, Bensimon A, Rhind N. DNA replication origins fire stochastically in fission yeast. Mol Biol Cell. 2006 Jan; 17(1):308-16.
          View in: PubMed
        34. Akbarian S, Ruehl MG, Bliven E, Luiz LA, Peranelli AC, Baker SP, Roberts RC, Bunney WE, Conley RC, Jones EG, Tamminga CA, Guo Y. Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia. Arch Gen Psychiatry. 2005 Aug; 62(8):829-40.
          View in: PubMed
        35. Stadler F, Kolb G, Rubusch L, Baker SP, Jones EG, Akbarian S. Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain. J Neurochem. 2005 Jul; 94(2):324-36.
          View in: PubMed
        36. Aronson MP, Aronson PK, Howard AE, Morse AN, Baker SP, Young SB. Low risk of ureteral obstruction with "deep" (dorsal/posterior) uterosacral ligament suture placement for transvaginal apical suspension. Am J Obstet Gynecol. 2005 May; 192(5):1530-6.
          View in: PubMed
        37. Hake SB, Garcia BA, Kauer M, Baker SP, Shabanowitz J, Hunt DF, Allis CD. Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes. Proc Natl Acad Sci U S A. 2005 May 3; 102(18):6344-9.
          View in: PubMed
        38. Li Y, Ayata G, Baker SP, Banner BF. Cholangitis: a histologic classification based on patterns of injury in liver biopsies. Pathol Res Pract. 2005; 201(8-9):565-72.
          View in: PubMed
        39. Wu X, Arumugam R, Baker SP, Lee MM. Pubertal and adult Leydig cell function in Mullerian inhibiting substance-deficient mice. Endocrinology. 2005 Feb; 146(2):589-95.
          View in: PubMed
        40. Hutchinson SA, Baker SP, Linden J, Scammells PJ. New potent and selective A1 adenosine receptor agonists. Bioorg Med Chem. 2004 Sep 15; 12(18):4877-84.
          View in: PubMed
        41. Lai KK, Baker SP, Fontecchio SA. Rapid eradication of a cluster of Serratia marcescens in a neonatal intensive care unit: use of epidemiologic chromosome profiling by pulsed-field gel electrophoresis. Infect Control Hosp Epidemiol. 2004 Sep; 25(9):730-4.
          View in: PubMed
        42. Zhuge R, Fogarty KE, Baker SP, McCarron JG, Tuft RA, Lifshitz LM, Walsh JV. Ca(2+) spark sites in smooth muscle cells are numerous and differ in number of ryanodine receptors, large-conductance K(+) channels, and coupling ratio between them. Am J Physiol Cell Physiol. 2004 Dec; 287(6):C1577-88.
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        43. Li JM, Singh MJ, Itani M, Vasiliu C, Hendricks G, Baker SP, Hale JE, Rohrer MJ, Cutler BS, Nelson PR. Recombinant human thrombomodulin inhibits arterial neointimal hyperplasia after balloon injury. J Vasc Surg. 2004 May; 39(5):1074-83.
          View in: PubMed
        44. Young SB, Kohorn EI, Braz-Martin S, Baker SP. A survey of the complications of vaginal prolapse surgery performed by members of the Society Of Gynecologic Surgeons. Int Urogynecol J Pelvic Floor Dysfunct. 2004 May-Jun; 15(3):165-70.
          View in: PubMed
        45. Lai KK, Baker SP, Fontecchio SA. Impact of a program of intensive surveillance and interventions targeting ventilated patients in the reduction of ventilator-associated pneumonia and its cost-effectiveness. Infect Control Hosp Epidemiol. 2003 Nov; 24(11):859-63.
          View in: PubMed
        46. Suryanarayanan S, Karellas A, Vedantham S, Ved H, Baker SP, D'Orsi CJ. Flat-panel digital mammography system: contrast-detail comparison between screen-film radiographs and hard-copy images. Radiology. 2002 Dec; 225(3):801-7.
          View in: PubMed
        47. Beauglehole AR, Baker SP, Scammells PJ. New irreversible adenosine A(1) antagonists based on FSCPX. Bioorg Med Chem Lett. 2002 Nov 4; 12(21):3179-82.
          View in: PubMed
        48. Del Prete Z, Baker SP, Grigg P. Stretch responses of cutaneous RA afferent neurons in mouse hairy skin. J Neurophysiol. 2003 Mar; 89(3):1649-59.
          View in: PubMed
        49. Hutchinson SA, Baker SP, Scammells PJ. New 2,N6-disubstituted adenosines: potent and selective A1 adenosine receptor agonists. Bioorg Med Chem. 2002 Apr; 10(4):1115-22.
          View in: PubMed
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