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    Michael P Czech PhD

    TitleChair and Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentProgram in Molecular Medicine
    AddressUniversity of Massachusetts Medical School
    373 Plantation Street
    Worcester MA 01605
    Phone508-856-2254
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentBiochemistry and Molecular Pharmacology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBiochemistry and Molecular Pharmacology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBioinformatics and Computational Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMasters in Clinical Investigation

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMillennium MD/PhD Program

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentBioinformatics and Integrative Biology

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentCenter for AIDS Research

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentRNA Therapeutics Institute

        Overview 
        Narrative

        Academic Background

        Michael P. Czech is Professor and founding Chair of the Program in Molecular Medicine, University of Massachusetts Medical School. Molecular Medicine currently includes 43 faculty research laboratories, several Howard Hughes Investigators and over 400 scientists and staff. His research addresses mechanisms of signal transduction and insulin resistance in type 2 diabetes and obesity. His laboratory has recently applied RNAi to discover novel drug targets and to develop therapeutic strategies for alleviating inflammatory and metabolic diseases.

        Dr. Czech earned the PhD degree in biochemistry in 1972 at Brown University, and completed postdoctoral study at Duke University Medical Center. He became Assistant Professor at Brown in 1974, rising to the rank of Professor in 1980. In 1981 Dr. Czech moved to the University of Massachusetts Medical School as Professor and Chair of the Department of Biochemistry and Molecular Pharmacology, which he led until his appointment as Director of Molecular Medicine in 1989.

        Dr. Czech has authored approximately 275 publications, serves on several editorial boards, and has served on several NIH Study Sections and Review Panels of the Howard Hughes Medical Institute. He has received the Outstanding Scientific Achievement Award of the American Diabetes Association, 1982; the David Rumbough Scientific Award of the Juvenile Diabetes Foundation in 1985; NIH MERIT Awards, 1997-2005 and 2012-2018; the Elliot P. Joslin Medal in 1998, the 2000 CIIT Founder’s Award, the 2000 Banting Medal and the 2004 Albert Renold Award of the American Diabetes Association.

        RNAi-based therapeutic strategies for diseases of inflammation and metabolism

        mike czech's photo

        Many major human diseases such as diabetes, atherosclerosis and rheumatoid arthritis are promoted by excessive or dysfunctional inflammation within specific tissues. Macrophages and dendritic cells are central players in such diseases based on their ability to express antigenic peptides on their cell surfaces and secrete cytokines that attract and activate immune cells. The ability of double stranded RNA to act through RNA interference (RNAi) pathways to selectively silence normal or disease genes in vivo provides both a powerful research tool and potential approach to therapies. Experiments in our laboratory are currently devoted to 1.) applying RNAi-based screens and other methods to identify target genes in macrophages, endothelial cells and adipocytes that promote inflammation and metabolic disease, and 2.) developing strategies for therapeutic application of RNAi against these targets in such diseases.

        Unlike small molecule drugs, RNAi can target human genes without regard to the nature of the protein structure of the gene product. As a consequence, all genes become potential targets for RNAi-based therapies. However, there are over-riding roadblocks to the general use of short interfering RNA molecules (siRNA) as medicines for human disease. These include effective delivery to specific target cell types in vivo and toxicities of chemically modified siRNA species or their delivery vehicles. Developing delivery systems for siRNA that target specific tissues for gene silencing in a safe way could bring exciting new therapies to the clinic. Achieving the goal of a safe oral delivery system for therapeutic siRNA, in particular, could potentially transform the practice of medicine.

        Our laboratory is engaged in experiments designed to lead to the successful development of siRNA-based therapeutics. We employ encapsulation technology to imbed siRNA into non-toxic glucan particles that both protect the siRNA during administration in vivo as well as direct its uptake specifically into macrophages and dendritic cells. We have demonstrated that this method can be effective in mice to silence genes that promote inflammation. We are continuing to improve the delivery system by reducing the number of components and improving release of the siRNA, and we are testing its efficacy in several disease models including diabetic mice.

        Other projects in our laboratory address the underlying mechanisms whereby inflammation and other processes impair insulin signaling in obesity and type 2 diabetes. We are investigating the roles of lipid droplet proteins in regulating adipocyte metabolism and whole body glucose tolerance using mouse knockout models and adipose samples from human subjects. Our studies are also directed towards understanding the signaling pathways whereby the protein kinase Map4k4 acts to cause insulin resistance. We have discovered roles of Map4k4 in suppressing lipogenesis in adipocytes while promoting cytokine and adhesion molecule expression by macrophages and endothelial cells, respectively. Our data suggest that Map4k4 could be a potential drug target for metabolic disease and atherosclerosis.

        Figure 1

        Encapsulation of siRNA and amphipathic peptide endoporter in micron sized glucan shells prepared from yeast by solvent and acid/base extractions. See cited reference in the Figure for details of preparation and use of this siRNA delivery system for gene silencing in vivo.



        Rotation Projects

        Rotation Projects

        There are currently 10 PhD or MD/PhD students working on thesis projects in our laboratory, and we are not able to take on any new students for this coming year.


        Post Docs

        A postdoctoral position is available to study in this laboratory. Contact Dr. Czech for additional details.

        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J, Tam J, Han T, Mukhopadhyay B, Skarulis MC, Ju C, Aouadi M, Czech MP, Kunos G. Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat Med. 2013 Sep; 19(9):1132-40.
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        2. Danai LV, Guilherme A, Guntur KV, Straubhaar J, Nicoloro SM, Czech MP. Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling. J Lipid Res. 2013 Oct; 54(10):2697-707.
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        3. Czech MP. Obesity Notches up fatty liver. Nat Med. 2013 Aug 6; 19(8):969-71.
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        4. Aouadi M, Tencerova M, Vangala P, Yawe JC, Nicoloro SM, Amano SU, Cohen JL, Czech MP. Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8278-83.
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        5. Guo CA, Kogan S, Amano SU, Wang M, Dagdeviren S, Friedline RH, Aouadi M, Kim JK, Czech MP. CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance. J Cell Biol. 2013 May 1; 304(9):E951-63.
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        6. Czech MP, Tencerova M, Pedersen DJ, Aouadi M. Insulin signalling mechanisms for triacylglycerol storage. Diabetologia. 2013 May; 56(5):949-64.
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        7. Roth Flach RJ, Matevossian A, Akie TE, Negrin KA, Paul MT, Czech MP. ß3-Adrenergic Receptor Stimulation Induces E-Selectin-mediated Adipose Tissue Inflammation. J Biol Chem. 2013 Jan 25; 288(4):2882-92.
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        8. Wang M, Amano SU, Flach RJ, Chawla A, Aouadi M, Czech MP. Identification of map4k4 as a novel suppressor of skeletal muscle differentiation. Mol Cell Biol. 2013 Feb; 33(4):678-87.
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        9. Sartorius T, Staiger H, Ketterer C, Heni M, Machicao F, Guilherme A, Grallert H, Schulze MB, Boeing H, Stefan N, Fritsche A, Czech MP, Häring HU. Association of Common Genetic Variants in the MAP4K4 Locus with Prediabetic Traits in Humans. PLoS One. 2012; 7(10):e47647.
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        10. Hardy OT, Czech MP, Corvera S. What causes the insulin resistance underlying obesity? Curr Opin Endocrinol Diabetes Obes. 2012 Apr; 19(2):81-7.
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        11. Young JL, Mora A, Cerny A, Czech MP, Woda B, Kurt-Jones EA, Finberg RW, Corvera S. CD14 Deficiency Impacts Glucose Homeostasis in Mice through Altered Adrenal Tone. PLoS One. 2012; 7(1):e29688.
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        12. Xie X, Gong Z, Mansuy-Aubert V, Zhou QL, Tatulian SA, Sehrt D, Gnad F, Brill LM, Motamedchaboki K, Chen Y, Czech MP, Mann M, Krüger M, Jiang ZY. C2 Domain-Containing Phosphoprotein CDP138 Regulates GLUT4 Insertion into the Plasma Membrane. Cell Metab. 2011 Sep 7; 14(3):378-89.
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        13. Fitzgibbons TP, Kogan S, Aouadi M, Hendricks GM, Straubhaar J, Czech MP. Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1425-37.
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        14. Corvera S, Czech MP. Tensions rise and blood flows over dysfunctional fat. Circulation. 2011 Jul 5; 124(1):13-6.
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        15. Tesz GJ, Aouadi M, Prot M, Nicoloro SM, Boutet E, Amano SU, Goller A, Wang M, Guo CA, Salomon WE, Virbasius JV, Baum RA, O'Connor MJ, Soto E, Ostroff GR, Czech MP. Glucan particles for selective delivery of siRNA to phagocytic cells in mice. Biochem J. 2011 Jun 1; 436(2):351-62.
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        16. Mudhasani R, Puri V, Hoover K, Czech MP, Imbalzano AN, Jones SN. Dicer is required for the formation of white but not brown adipose tissue. J Cell Physiol. 2011 May; 226(5):1399-406.
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        17. Czech MP, Aouadi M, Tesz GJ. RNAi-based therapeutic strategies for metabolic disease. Nat Rev Endocrinol. 2011; 7(8):473-84.
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        18. Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz GJ, Zhang DX, Yao J, Czech MP, Goode BL, Rosenfeld MG, Glass CK. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature. 2011 Feb 17; 470(7334):414-8.
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        19. Gealekman O, Guseva N, Hartigan C, Apotheker S, Gorgoglione M, Gurav K, Tran KV, Straubhaar J, Nicoloro S, Czech MP, Thompson M, Perugini RA, Corvera S. Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity. Circulation. 2011 Jan 18; 123(2):186-94.
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        20. Ranjit S, Boutet E, Gandhi P, Prot M, Tamori Y, Chawla A, Greenberg AS, Puri V, Czech MP. Regulation of fat specific protein 27 by isoproterenol and TNF-{alpha} to control lipolysis in murine adipocytes. J Lipid Res. 2011 Feb; 52(2):221-36.
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        21. Christianson JL, Boutet E, Puri V, Chawla A, Czech MP. Identification of the lipid droplet targeting domain of the Cidea protein. J Lipid Res. 2010 Dec; 51(12):3455-62.
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        22. Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP. A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem. 2010 Sep 3; 285(36):27581-9.
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        23. Hardy OT, Perugini RA, Nicoloro SM, Gallagher-Dorval K, Puri V, Straubhaar J, Czech MP. Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. Surg Obes Relat Dis. 2011 Jan-Feb; 7(1):60-7.
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        24. Guntur KV, Guilherme A, Xue L, Chawla A, Czech MP. Map4k4 negatively regulates peroxisome proliferator-activated receptor (PPAR) gamma protein translation by suppressing the mammalian target of rapamycin (mTOR) signaling pathway in cultured adipocytes. J Biol Chem. 2010 Feb 26; 285(9):6595-603.
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        25. Rubio-Cabezas O, Puri V, Murano I, Saudek V, Semple RK, Dash S, Hyden CS, Bottomley W, Vigouroux C, Magré J, Raymond-Barker P, Murgatroyd PR, Chawla A, Skepper JN, Chatterjee VK, Suliman S, Patch AM, Agarwal AK, Garg A, Barroso I, Cinti S, Czech MP, Argente J, O'Rahilly S, Savage DB. Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. EMBO Mol Med. 2009 Aug; 1(5):280-7.
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        26. Marchand P, Antoine M, Le Baut G, Czech M, Baasner S, Günther E. Synthesis and structure-activity relationships of N-aryl(indol-3-yl)glyoxamides as antitumor agents. Bioorg Med Chem. 2009 Sep 15; 17(18):6715-27.
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        27. Aouadi M, Tesz GJ, Nicoloro SM, Wang M, Chouinard M, Soto E, Ostroff GR, Czech MP. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature. 2009 Apr 30; 458(7242):1180-4.
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        28. Guilherme A, Tesz GJ, Guntur KV, Czech MP. Tumor necrosis factor-alpha induces caspase-mediated cleavage of peroxisome proliferator-activated receptor gamma in adipocytes. J Biol Chem. 2009 Jun 19; 284(25):17082-91.
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        29. Padmanabhan S, Mukhopadhyay A, Narasimhan SD, Tesz G, Czech MP, Tissenbaum HA. A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell. 2009 Mar 6; 136(5):939-51.
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        30. Bishop KD, Harris JE, Mordes JP, Greiner DL, Rossini AA, Czech MP, Phillips NE. Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism. Cell Immunol. 2009; 256(1-2):86-91.
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        31. Antoine M, Marchand P, Le Baut G, Czech M, Baasner S, Gunther E. Side chain modifications of (indol-3-yl)glyoxamides as antitumor agents. J Enzyme Inhib Med Chem. 2008 Oct; 23(5):686-95.
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        32. Shi X, Burkart A, Nicoloro SM, Czech MP, Straubhaar J, Corvera S. Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells. J Biol Chem. 2008 Nov 7; 283(45):30658-67.
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        33. Puri V, Czech MP. Lipid droplets: FSP27 knockout enhances their sizzle. J Clin Invest. 2008 Aug; 118(8):2693-6.
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        34. Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, Chouinard M, Lin C, Burkart A, Corvera S, Perugini RA, Czech MP. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci U S A. 2008 Jun 3; 105(22):7833-8.
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        35. Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 2008 May; 9(5):367-77.
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        36. Zhou QL, Jiang ZY, Holik J, Chawla A, Hagan GN, Leszyk J, Czech MP. Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes. Biochem J. 2008 May 1; 411(3):647-55.
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        37. Hagan GN, Lin Y, Magnuson MA, Avruch J, Czech MP. A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol. 2008 Jul; 28(13):4215-26.
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        38. Wang H, Zhang Y, Yehuda-Shnaidman E, Medvedev AV, Kumar N, Daniel KW, Robidoux J, Czech MP, Mangelsdorf DJ, Collins S. Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol Cell Biol. 2008 Apr; 28(7):2187-200.
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        39. Puri V, Virbasius JV, Guilherme A, Czech MP. RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27. Acta Physiol (Oxf). 2008 Jan; 192(1):103-15.
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        40. DiNitto JP, Delprato A, Gabe Lee MT, Cronin TC, Huang S, Guilherme A, Czech MP, Lambright DG. Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell. 2007 Nov 30; 28(4):569-83.
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        41. Christianson JL, Nicoloro S, Straubhaar J, Czech MP. Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells. J Biol Chem. 2008 Feb 1; 283(5):2906-16.
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        42. Puri V, Konda S, Ranjit S, Aouadi M, Chawla A, Chouinard M, Chakladar A, Czech MP. Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J Biol Chem. 2007 Nov 23; 282(47):34213-8.
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        43. Saito T, Jones CC, Huang S, Czech MP, Pilch PF. The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. J Biol Chem. 2007 Nov 2; 282(44):32280-7.
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        44. Tesz GJ, Guilherme A, Guntur KV, Hubbard AC, Tang X, Chawla A, Czech MP. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem. 2007 Jul 6; 282(27):19302-12.
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        45. Huang S, Czech MP. The GLUT4 glucose transporter. Cell Metab. 2007 Apr; 5(4):237-52.
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        46. Huang S, Lifshitz LM, Jones C, Bellve KD, Standley C, Fonseca S, Corvera S, Fogarty KE, Czech MP. Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes. Mol Cell Biol. 2007 May; 27(9):3456-69.
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        47. Puri V, Chakladar A, Virbasius JV, Konda S, Powelka AM, Chouinard M, Hagan GN, Perugini R, Czech MP. RNAi-based gene silencing in primary mouse and human adipose tissues. J Lipid Res. 2007 Feb; 48(2):465-71.
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        48. Czech MP. MicroRNAs as therapeutic targets. N Engl J Med. 2006 Mar 16; 354(11):1194-5.
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        49. Tang X, Guilherme A, Chakladar A, Powelka AM, Konda S, Virbasius JV, Nicoloro SM, Straubhaar J, Czech MP. An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2087-92.
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        50. Czech MP. ARNT misbehavin' in diabetic beta cells. Nat Med. 2006 Jan; 12(1):39-40.
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        51. Powelka AM, Seth A, Virbasius JV, Kiskinis E, Nicoloro SM, Guilherme A, Tang X, Straubhaar J, Cherniack AD, Parker MG, Czech MP. Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest. 2006 Jan; 116(1):125-36.
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        52. Liu L, Song X, He D, Komma C, Kita A, Virbasius JV, Huang G, Bellamy HD, Miki K, Czech MP, Zhou GW. Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha. J Biol Chem. 2006 Feb 17; 281(7):4254-60.
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        53. Bose A, Guilherme A, Huang S, Hubbard AC, Lane CR, Soriano NA, Czech MP. The v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes. J Biol Chem. 2005 Nov 4; 280(44):36946-51.
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        54. Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A. PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes. J Biol Chem. 2005 Jun 10; 280(23):22523-9.
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        55. Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP. Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem. 2005 Jun 3; 280(22):21622-8.
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        56. Harris JE, Bishop KD, Phillips NE, Mordes JP, Greiner DL, Rossini AA, Czech MP. Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells. J Immunol. 2004 Dec 15; 173(12):7331-8.
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        57. Mello CC, Czech MP. Micromanaging insulin secretion. Nat Med. 2004 Dec; 10(12):1297-8.
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        58. Zhou QL, Park JG, Jiang ZY, Holik JJ, Mitra P, Semiz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP. Analysis of insulin signalling by RNAi-based gene silencing. Biochem Soc Trans. 2004 Nov; 32(Pt 5):817-21.
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        59. Wilson-Fritch L, Nicoloro S, Chouinard M, Lazar MA, Chui PC, Leszyk J, Straubhaar J, Czech MP, Corvera S. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest. 2004 Nov; 114(9):1281-9.
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        60. Huang S, Lifshitz L, Patki-Kamath V, Tuft R, Fogarty K, Czech MP. Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes. Mol Cell Biol. 2004 Oct; 24(20):9102-23.
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        61. Cronin TC, DiNitto JP, Czech MP, Lambright DG. Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. EMBO J. 2004 Oct 1; 23(19):3711-20.
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        62. Jaeschke A, Czech MP, Davis RJ. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev. 2004 Aug 15; 18(16):1976-80.
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        63. Mitra P, Zheng X, Czech MP. RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin. J Biol Chem. 2004 Sep 3; 279(36):37431-5.
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        64. Guilherme A, Soriano NA, Furcinitti PS, Czech MP. Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. J Biol Chem. 2004 Sep 17; 279(38):40062-75.
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        65. Bose A, Robida S, Furcinitti PS, Chawla A, Fogarty K, Corvera S, Czech MP. Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway. Mol Cell Biol. 2004 Jun; 24(12):5447-58.
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        66. Guilherme A, Soriano NA, Bose S, Holik J, Bose A, Pomerleau DP, Furcinitti P, Leszyk J, Corvera S, Czech MP. EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. J Biol Chem. 2004 Mar 12; 279(11):10593-605.
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        67. Czech MP. Insulin's expanding control of forkheads. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11198-200.
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        68. Jiang ZY, Zhou QL, Coleman KA, Chouinard M, Boese Q, Czech MP. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7569-74.
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        69. Semiz S, Park JG, Nicoloro SM, Furcinitti P, Zhang C, Chawla A, Leszyk J, Czech MP. Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules. EMBO J. 2003 May 15; 22(10):2387-99.
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        70. Wilson-Fritch L, Burkart A, Bell G, Mendelson K, Leszyk J, Nicoloro S, Czech M, Corvera S. Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol Cell Biol. 2003 Feb; 23(3):1085-94.
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        71. Bose A, Guilherme A, Robida SI, Nicoloro SM, Zhou QL, Jiang ZY, Pomerleau DP, Czech MP. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature. 2002 Dec 19-26; 420(6917):821-4.
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        72. Czech MP. Dynamics of phosphoinositides in membrane retrieval and insertion. Annu Rev Physiol. 2003; 65:791-815.
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        73. Czech MP. Fat targets for insulin signaling. Mol Cell. 2002 Apr; 9(4):695-6.
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        74. Jiang ZY, Chawla A, Bose A, Way M, Czech MP. A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling. J Biol Chem. 2002 Jan 4; 277(1):509-15.
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        75. Virbasius JV, Song X, Pomerleau DP, Zhan Y, Zhou GW, Czech MP. Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A. 2001 Nov 6; 98(23):12908-13.
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        76. Park JG, Bose A, Leszyk J, Czech MP. PYK2 as a mediator of endothelin-1/G alpha 11 signaling to GLUT4 glucose transporters. J Biol Chem. 2001 Dec 21; 276(51):47751-4.
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        77. Bose A, Cherniack AD, Langille SE, Nicoloro SM, Buxton JM, Park JG, Chawla A, Czech MP. G(alpha)11 signaling through ARF6 regulates F-actin mobilization and GLUT4 glucose transporter translocation to the plasma membrane. Mol Cell Biol. 2001 Aug; 21(15):5262-75.
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        78. Song X, Xu W, Zhang A, Huang G, Liang X, Virbasius JV, Czech MP, Zhou GW. Phox homology domains specifically bind phosphatidylinositol phosphates. Biochemistry. 2001 Jul 31; 40(30):8940-4.
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        79. Klarlund JK, Holik J, Chawla A, Park JG, Buxton J, Czech MP. Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1. J Biol Chem. 2001 Oct 26; 276(43):40065-70.
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        80. Emoto M, Langille SE, Czech MP. A role for kinesin in insulin-stimulated GLUT4 glucose transporter translocation in 3T3-L1 adipocytes. J Biol Chem. 2001 Apr 6; 276(14):10677-82.
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        81. Klarlund JK, Czech MP. Isolation and properties of GRP1, an ADP-ribosylation factor (ARF)-guanine nucleotide exchange protein regulated by phosphatidylinositol 3,4,5-trisphosphate. Methods Enzymol. 2001; 329:279-89.
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        82. Iwanishi M, Czech MP, Cherniack AD. The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinase. J Biol Chem. 2000 Dec 15; 275(50):38995-9000.
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        83. Guilherme A, Emoto M, Buxton JM, Bose S, Sabini R, Theurkauf WE, Leszyk J, Czech MP. Perinuclear localization and insulin responsiveness of GLUT4 requires cytoskeletal integrity in 3T3-L1 adipocytes. J Biol Chem. 2000 Dec 8; 275(49):38151-9.
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        84. Klarlund JK, Tsiaras W, Holik JJ, Chawla A, Czech MP. Distinct polyphosphoinositide binding selectivities for pleckstrin homology domains of GRP1-like proteins based on diglycine versus triglycine motifs. J Biol Chem. 2000 Oct 20; 275(42):32816-21.
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        85. Czech MP. Lipid rafts and insulin action. Nature. 2000 Sep 14; 407(6801):147-8.
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        86. Lietzke SE, Bose S, Cronin T, Klarlund J, Chawla A, Czech MP, Lambright DG. Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. Mol Cell. 2000 Aug; 6(2):385-94.
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        87. Czech MP. PIP2 and PIP3: complex roles at the cell surface. Cell. 2000 Mar 17; 100(6):603-6.
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        89. Langille SE, Patki V, Klarlund JK, Buxton JM, Holik JJ, Chawla A, Corvera S, Czech MP. ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1. J Biol Chem. 1999 Sep 17; 274(38):27099-104.
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        90. Fernández B, Czech MP, Meisner H. Role of protein kinase C in signal attenuation following T cell receptor engagement. J Biol Chem. 1999 Jul 16; 274(29):20244-50.
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        93. Clodi M, Vollenweider P, Klarlund J, Nakashima N, Martin S, Czech MP, Olefsky JM. Effects of general receptor for phosphoinositides 1 on insulin and insulin-like growth factor I-induced cytoskeletal rearrangement, glucose transporter-4 translocation, and deoxyribonucleic acid synthesis. Endocrinology. 1998 Dec; 139(12):4984-90.
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        94. VanRenterghem B, Morin M, Czech MP, Heller-Harrison RA. Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes. J Biol Chem. 1998 Nov 6; 273(45):29942-9.
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        96. Guilherme A, Torres K, Czech MP. Cross-talk between insulin receptor and integrin alpha5 beta1 signaling pathways. J Biol Chem. 1998 Sep 4; 273(36):22899-903.
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        97. Sleeman MW, Donegan NP, Heller-Harrison R, Lane WS, Czech MP. Association of acyl-CoA synthetase-1 with GLUT4-containing vesicles. J Biol Chem. 1998 Feb 6; 273(6):3132-5.
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        98. Klarlund JK, Rameh LE, Cantley LC, Buxton JM, Holik JJ, Sakelis C, Patki V, Corvera S, Czech MP. Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem. 1998 Jan 23; 273(4):1859-62.
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        99. Rameh LE, Arvidsson A, Carraway KL, Couvillon AD, Rathbun G, Crompton A, VanRenterghem B, Czech MP, Ravichandran KS, Burakoff SJ, Wang DS, Chen CS, Cantley LC. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains. J Biol Chem. 1997 Aug 29; 272(35):22059-66.
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        100. Shisheva A, Czech MP. Association of cytosolic Rab4 with GDI isoforms in insulin-sensitive 3T3-L1 adipocytes. Biochemistry. 1997 Jun 3; 36(22):6564-70.
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        101. Meisner H, Daga A, Buxton J, Fernández B, Chawla A, Banerjee U, Czech MP. Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. Mol Cell Biol. 1997 Apr; 17(4):2217-25.
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        102. Klarlund JK, Guilherme A, Holik JJ, Virbasius JV, Chawla A, Czech MP. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science. 1997 Mar 28; 275(5308):1927-30.
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        103. Guilherme A, Klarlund JK, Krystal G, Czech MP. Regulation of phosphatidylinositol 3,4,5-trisphosphate 5'-phosphatase activity by insulin. J Biol Chem. 1996 Nov 22; 271(47):29533-6.
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        104. Rigby MR, Bortell R, Greiner DL, Czech MP, Klarlund JK, Mordes JP, Rossini AA. The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal. Diabetes. 1996 Oct; 45(10):1419-26.
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        105. Klarlund JK, Cherniack AD, McMahon M, Czech MP. Role of the Raf/mitogen-activated protein kinase pathway in p21ras desensitization. J Biol Chem. 1996 Jul 12; 271(28):16674-7.
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        106. Virbasius JV, Guilherme A, Czech MP. Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J Biol Chem. 1996 Jun 7; 271(23):13304-7.
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        107. Heller-Harrison RA, Morin M, Guilherme A, Czech MP. Insulin-mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containing vesicles. J Biol Chem. 1996 Apr 26; 271(17):10200-4.
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        108. Baltensperger K, Karoor V, Paul H, Ruoho A, Czech MP, Malbon CC. The beta-adrenergic receptor is a substrate for the insulin receptor tyrosine kinase. J Biol Chem. 1996 Jan 12; 271(2):1061-4.
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        109. Meisner H, Czech MP. Coupling of the proto-oncogene product c-Cbl to the epidermal growth factor receptor. J Biol Chem. 1995 Oct 27; 270(43):25332-5.
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        110. Karoor V, Baltensperger K, Paul H, Czech MP, Malbon CC. Phosphorylation of tyrosyl residues 350/354 of the beta-adrenergic receptor is obligatory for counterregulatory effects of insulin. J Biol Chem. 1995 Oct 27; 270(43):25305-8.
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        111. Heller-Harrison RA, Morin M, Czech MP. Insulin regulation of membrane-associated insulin receptor substrate 1. J Biol Chem. 1995 Oct 13; 270(41):24442-50.
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        112. Klarlund JK, Cherniack AD, Czech MP. Divergent mechanisms for homologous desensitization of p21ras by insulin and growth factors. J Biol Chem. 1995 Oct 6; 270(40):23421-8.
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        113. Shisheva A, Doxsey SJ, Buxton JM, Czech MP. Pericentriolar targeting of GDP-dissociation inhibitor isoform 2. Eur J Cell Biol. 1995 Oct; 68(2):143-58.
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        114. Meisner H, Czech MP. A 115 kDa tyrosine phosphorylated protein associates with Grb-2 in activated Jurkat cells. Ann N Y Acad Sci. 1995 Sep 7; 766:204-5.
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        115. McCollam L, Bonfini L, Karlovich CA, Conway BR, Kozma LM, Banerjee U, Czech MP. Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless. J Biol Chem. 1995 Jul 7; 270(27):15954-7.
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        116. Meisner H, Conway BR, Hartley D, Czech MP. Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells. Mol Cell Biol. 1995 Jul; 15(7):3571-8.
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        117. Karlovich CA, Bonfini L, McCollam L, Rogge RD, Daga A, Czech MP, Banerjee U. In vivo functional analysis of the Ras exchange factor son of sevenless. Science. 1995 Apr 28; 268(5210):576-9.
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        118. Cherniack AD, Klarlund JK, Conway BR, Czech MP. Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin. J Biol Chem. 1995 Jan 27; 270(4):1485-8.
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        119. Czech MP. Molecular actions of insulin on glucose transport. Annu Rev Nutr. 1995; 15:441-71.
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        120. Baltensperger K, Kozma LM, Jaspers SR, Czech MP. Regulation by insulin of phosphatidylinositol 3'-kinase bound to alpha- and beta-isoforms of p85 regulatory subunit. J Biol Chem. 1994 Nov 18; 269(46):28937-46.
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        121. Shisheva A, Buxton J, Czech MP. Differential intracellular localizations of GDP dissociation inhibitor isoforms. Insulin-dependent redistribution of GDP dissociation inhibitor-2 in 3T3-L1 adipocytes. J Biol Chem. 1994 Sep 30; 269(39):23865-8.
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        122. Corvera S, Chawla A, Chakrabarti R, Joly M, Buxton J, Czech MP. A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal. J Cell Biol. 1994 Sep; 126(6):1625.
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        123. Corvera S, Chawla A, Chakrabarti R, Joly M, Buxton J, Czech MP. A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal. J Cell Biol. 1994 Aug; 126(4):979-89.
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        124. Shisheva A, Südhof TC, Czech MP. Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle. Mol Cell Biol. 1994 May; 14(5):3459-68.
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        125. Cherniack AD, Klarlund JK, Czech MP. Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase. J Biol Chem. 1994 Feb 18; 269(7):4717-20.
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        126. Czech MP, Chawla A, Woon CW, Buxton J, Armoni M, Tang W, Joly M, Corvera S. Exofacial epitope-tagged glucose transporter chimeras reveal COOH-terminal sequences governing cellular localization. J Cell Biol. 1993 Oct; 123(1):127-35.
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        127. Baltensperger K, Kozma LM, Cherniack AD, Klarlund JK, Chawla A, Banerjee U, Czech MP. Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes. Science. 1993 Jun 25; 260(5116):1950-2.
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        128. Kozma L, Baltensperger K, Klarlund J, Porras A, Santos E, Czech MP. The ras signaling pathway mimics insulin action on glucose transporter translocation. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4460-4.
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        129. Czech MP, Buxton JM. Insulin action on the internalization of the GLUT4 glucose transporter in isolated rat adipocytes. J Biol Chem. 1993 May 5; 268(13):9187-90.
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        130. Klarlund JK, Khalaf N, Kozma L, Czech MP. Activation of protein kinases by insulin and non-hydrolyzable GTP analogs in permeabilized 3T3-L1 adipocytes. J Biol Chem. 1993 Apr 15; 268(11):7646-9.
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        131. Li L, Zhou J, James G, Heller-Harrison R, Czech MP, Olson EN. FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains. Cell. 1992 Dec 24; 71(7):1181-94.
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        132. Li L, Heller-Harrison R, Czech M, Olson EN. Cyclic AMP-dependent protein kinase inhibits the activity of myogenic helix-loop-helix proteins. Mol Cell Biol. 1992 Oct; 12(10):4478-85.
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        133. Baltensperger K, Lewis RE, Woon CW, Vissavajjhala P, Ross AH, Czech MP. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A. 1992 Sep 1; 89(17):7885-9.
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        134. Wolfe L, Bradford AP, Klarlund JK, Czech MP. Purification and characterization of a cytosolic insulin-stimulated serine kinase from rat liver. J Biol Chem. 1992 May 15; 267(14):9749-56.
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        135. Czech MP, Clancy BM, Pessino A, Woon CW, Harrison SA. Complex regulation of simple sugar transport in insulin-responsive cells. Trends Biochem Sci. 1992 May; 17(5):197-201.
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        136. Harrison SA, Clancy BM, Pessino A, Czech MP. Activation of cell surface glucose transporters measured by photoaffinity labeling of insulin-sensitive 3T3-L1 adipocytes. J Biol Chem. 1992 Feb 25; 267(6):3783-8.
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        137. Pessino A, Hebert DN, Woon CW, Harrison SA, Clancy BM, Buxton JM, Carruthers A, Czech MP. Evidence that functional erythrocyte-type glucose transporters are oligomers. J Biol Chem. 1991 Oct 25; 266(30):20213-7.
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        138. Harrison SA, Buxton JM, Clancy BM, Czech MP. Evidence that erythroid-type glucose transporter intrinsic activity is modulated by cadmium treatment of mouse 3T3-L1 cells. J Biol Chem. 1991 Oct 15; 266(29):19438-49.
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        139. Harrison SA, Buxton JM, Czech MP. Suppressed intrinsic catalytic activity of GLUT1 glucose transporters in insulin-sensitive 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 1991 Sep 1; 88(17):7839-43.
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        140. Heller-Harrison RA, Czech MP. Enhanced casein kinase II activity in COS-1 cells upon overexpression of either its catalytic or noncatalytic subunit. J Biol Chem. 1991 Aug 5; 266(22):14435-9.
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        141. Clairmont KB, Czech MP. Extracellular release as the major degradative pathway of the insulin-like growth factor II/mannose 6-phosphate receptor. J Biol Chem. 1991 Jul 5; 266(19):12131-4.
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        142. Clancy BM, Harrison SA, Buxton JM, Czech MP. Protein synthesis inhibitors activate glucose transport without increasing plasma membrane glucose transporters in 3T3-L1 adipocytes. J Biol Chem. 1991 Jun 5; 266(16):10122-30.
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        143. Meisner H, Czech MP. Phosphorylation of transcriptional factors and cell-cycle-dependent proteins by casein kinase II. Curr Opin Cell Biol. 1991 Jun; 3(3):474-83.
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        144. Klarlund JK, Jaspers SR, Khalaf N, Bradford AP, Miller TB, Czech MP. An insulin-stimulated kemptide kinase purified from rat liver is deactivated by phosphatase 2A. J Biol Chem. 1991 Mar 5; 266(7):4052-5.
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        145. Harrison SA, Buxton JM, Clancy BM, Czech MP. Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter. J Biol Chem. 1990 Nov 25; 265(33):20106-16.
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        146. Clairmont KB, Czech MP. Insulin injection increases the levels of serum receptors for transferrin and insulin-like growth factor-II/mannose-6-phosphate in intact rats. Endocrinology. 1990 Oct; 127(4):1568-73.
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        147. Crisá L, Greiner DL, Mordes JP, MacDonald RG, Handler ES, Czech MP, Rossini AA. Biochemical studies of RT6 alloantigens in BB/Wor and normal rats. Evidence for intact unexpressed RT6a structural gene in diabetes-prone BB rats. Diabetes. 1990 Oct; 39(10):1279-88.
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        148. Clancy BM, Czech MP. Hexose transport stimulation and membrane redistribution of glucose transporter isoforms in response to cholera toxin, dibutyryl cyclic AMP, and insulin in 3T3-L1 adipocytes. J Biol Chem. 1990 Jul 25; 265(21):12434-43.
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        149. Yu KT, Benjamin WB, Ramakrishna S, Khalaf N, Czech MP. An insulin-sensitive cytosolic protein kinase accounts for the regulation of ATP citrate-lyase phosphorylation. Biochem J. 1990 Jun 15; 268(3):539-45.
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        150. Harrison SA, Buxton JM, Helgerson AL, MacDonald RG, Chlapowski FJ, Carruthers A, Czech MP. Insulin action on activity and cell surface disposition of human HepG2 glucose transporters expressed in Chinese hamster ovary cells. J Biol Chem. 1990 Apr 5; 265(10):5793-801.
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        151. Lewis RE, Cao L, Perregaux D, Czech MP. Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C. Biochemistry. 1990 Feb 20; 29(7):1807-13.
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        152. Lewis RE, Wu GP, MacDonald RG, Czech MP. Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase. J Biol Chem. 1990 Jan 15; 265(2):947-54.
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        153. Klarlund JK, Bradford AP, Milla MG, Czech MP. Purification of a novel insulin-stimulated protein kinase from rat liver. J Biol Chem. 1990 Jan 5; 265(1):227-34.
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        154. Heller-Harrison RA, Meisner H, Czech MP. Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II. Biochemistry. 1989 Nov 14; 28(23):9053-8.
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        155. Czech MP. Signal transmission by the insulin-like growth factors. Cell. 1989 Oct 20; 59(2):235-8.
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        156. Clairmont KB, Czech MP. Chicken and Xenopus mannose 6-phosphate receptors fail to bind insulin-like growth factor II. J Biol Chem. 1989 Oct 5; 264(28):16390-2.
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        157. Meisner H, Heller-Harrison R, Buxton J, Czech MP. Molecular cloning of the human casein kinase II alpha subunit. Biochemistry. 1989 May 2; 28(9):4072-6.
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        158. MacDonald RG, Tepper MA, Clairmont KB, Perregaux SB, Czech MP. Serum form of the rat insulin-like growth factor II/mannose 6-phosphate receptor is truncated in the carboxyl-terminal domain. J Biol Chem. 1989 Feb 25; 264(6):3256-61.
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        159. Czech MP, Lewis RE, Corvera S. Multifunctional glycoprotein receptors for insulin and the insulin-like growth factors. Ciba Found Symp. 1989; 145:27-41; discussion 42-4.
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        160. Cariani E, Lasserre C, Seurin D, Hamelin B, Kemeny F, Franco D, Czech MP, Ullrich A, Brechot C. Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis. Cancer Res. 1988 Dec 1; 48(23):6844-9.
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        161. Klarlund JK, Czech MP. Insulin-like growth factor I and insulin rapidly increase casein kinase II activity in BALB/c 3T3 fibroblasts. J Biol Chem. 1988 Nov 5; 263(31):15872-5.
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        162. Corvera S, Folander K, Clairmont KB, Czech MP. A highly phosphorylated subpopulation of insulin-like growth factor II/mannose 6-phosphate receptors is concentrated in a clathrin-enriched plasma membrane fraction. Proc Natl Acad Sci U S A. 1988 Oct; 85(20):7567-71.
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        163. Czech MP, Klarlund JK, Yagaloff KA, Bradford AP, Lewis RE. Insulin receptor signaling. Activation of multiple serine kinases. J Biol Chem. 1988 Aug 15; 263(23):11017-20.
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        164. Corvera S, Roach PJ, DePaoli-Roach AA, Czech MP. Insulin action inhibits insulin-like growth factor-II (IGF-II) receptor phosphorylation in H-35 hepatoma cells. IGF-II receptors isolated from insulin-treated cells exhibit enhanced in vitro phosphorylation by casein kinase II. J Biol Chem. 1988 Mar 5; 263(7):3116-22.
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        165. MacDonald RG, Pfeffer SR, Coussens L, Tepper MA, Brocklebank CM, Mole JE, Anderson JK, Chen E, Czech MP, Ullrich A. A single receptor binds both insulin-like growth factor II and mannose-6-phosphate. Science. 1988 Mar 4; 239(4844):1134-7.
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        166. Corvera S, Yagaloff KA, Whitehead RE, Czech MP. Tyrosine phosphorylation of the receptor for insulin-like growth factor II is inhibited in plasma membranes from insulin-treated rat adipocytes. Biochem J. 1988 Feb 15; 250(1):47-52.
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        167. Lewis RE, Czech MP. Phospholipid environment alters hormone-sensitivity of the purified insulin receptor kinase. Biochem J. 1987 Dec 15; 248(3):829-36.
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        168. Yu KT, Khalaf N, Czech MP. Insulin stimulates a novel Mn2+-dependent cytosolic serine kinase in rat adipocytes. J Biol Chem. 1987 Dec 5; 262(34):16677-85.
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        169. Davis RJ, Faucher M, Racaniello LK, Carruthers A, Czech MP. Insulin-like growth factor I and epidermal growth factor regulate the expression of transferrin receptors at the cell surface by distinct mechanisms. J Biol Chem. 1987 Sep 25; 262(27):13126-34.
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        170. Yu KT, Khalaf N, Czech MP. Insulin stimulates the tyrosine phosphorylation of a Mr = 160,000 glycoprotein in rat adipocyte plasma membranes. J Biol Chem. 1987 Jun 5; 262(16):7865-73.
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        171. Yu KT, Khalaf N, Czech MP. Insulin stimulates a membrane-bound serine kinase that may be phosphorylated on tyrosine. Proc Natl Acad Sci U S A. 1987 Jun; 84(12):3972-6.
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        172. Davis RJ, Czech MP. Stimulation of epidermal growth factor receptor threonine 654 phosphorylation by platelet-derived growth factor in protein kinase C-deficient human fibroblasts. J Biol Chem. 1987 May 15; 262(14):6832-41.
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        173. Davis RJ, Czech MP. Regulatory control of the epidermal growth factor receptor tyrosine kinase. Haematol Blood Transfus. 1987; 31:228-32.
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        174. Yu KT, Czech MP. Mechanism of signaling by insulin receptor kinase. Prog Clin Biol Res. 1987; 249:99-112.
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        175. Mottola C, MacDonald RG, Brackett JL, Mole JE, Anderson JK, Czech MP. Purification and amino-terminal sequence of an insulin-like growth factor-binding protein secreted by rat liver BRL-3A cells. J Biol Chem. 1986 Aug 25; 261(24):11180-8.
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        176. Yu KT, Peters MA, Czech MP. Similar control mechanisms regulate the insulin and type I insulin-like growth factor receptor kinases. Affinity-purified insulin-like growth factor I receptor kinase is activated by tyrosine phosphorylation of its beta subunit. J Biol Chem. 1986 Aug 25; 261(24):11341-9.
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        177. Oka Y, Czech MP. The type II insulin-like growth factor receptor is internalized and recycles in the absence of ligand. J Biol Chem. 1986 Jul 15; 261(20):9090-3.
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        178. Davis RJ, Corvera S, Czech MP. Insulin stimulates cellular iron uptake and causes the redistribution of intracellular transferrin receptors to the plasma membrane. J Biol Chem. 1986 Jul 5; 261(19):8708-11.
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        179. Davis RJ, Johnson GL, Kelleher DJ, Anderson JK, Mole JE, Czech MP. Identification of serine 24 as the unique site on the transferrin receptor phosphorylated by protein kinase C. J Biol Chem. 1986 Jul 5; 261(19):9034-41.
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        180. Corvera S, Whitehead RE, Mottola C, Czech MP. The insulin-like growth factor II receptor is phosphorylated by a tyrosine kinase in adipocyte plasma membranes. J Biol Chem. 1986 Jun 15; 261(17):7675-9.
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        181. Yu KT, Czech MP. Tyrosine phosphorylation of insulin receptor beta subunit activates the receptor tyrosine kinase in intact H-35 hepatoma cells. J Biol Chem. 1986 Apr 5; 261(10):4715-22.
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        182. Davis RJ, Czech MP. Regulation of transferrin receptor expression at the cell surface by insulin-like growth factors, epidermal growth factor and platelet-derived growth factor. EMBO J. 1986 Apr; 5(4):653-8.
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        183. Davis RJ, Czech MP. Inhibition of the apparent affinity of the epidermal growth factor receptor caused by phorbol diesters correlates with phosphorylation of threonine-654 but not other sites on the receptor. Biochem J. 1986 Jan 15; 233(2):435-41.
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        184. Corvera S, Davis RJ, Roach PJ, DePaoli-Roach A, Czech MP. Mechanism of receptor kinase action on membrane protein recycling. Ann N Y Acad Sci. 1986; 488:419-29.
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        185. Yu KT, Czech MP. The role of tyrosine phosphorylation in the regulation of insulin and insulin-like growth factor-I receptor kinase activities. Adv Exp Med Biol. 1986; 205:165-83.
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        186. Corvera S, Czech MP. Mechanism of insulin action on membrane protein recycling: a selective decrease in the phosphorylation state of insulin-like growth factor II receptors in the cell surface membrane. Proc Natl Acad Sci U S A. 1985 Nov; 82(21):7314-8.
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        187. Yu KT, Pessin JE, Czech MP. Regulation of insulin receptor kinase by multisite phosphorylation. Biochimie. 1985 Oct-Nov; 67(10-11):1081-93.
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        188. MacDonald RG, Czech MP. Biosynthesis and processing of the type II insulin-like growth factor receptor in H-35 hepatoma cells. J Biol Chem. 1985 Sep 15; 260(20):11357-65.
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        189. Oka Y, Rozek LM, Czech MP. Direct demonstration of rapid insulin-like growth factor II Receptor internalization and recycling in rat adipocytes. Insulin stimulates 125I-insulin-like growth factor II degradation by modulating the IGF-II receptor recycling process. J Biol Chem. 1985 Aug 5; 260(16):9435-42.
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        190. Davis RJ, Czech MP. Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654. Proc Natl Acad Sci U S A. 1985 Jun; 82(12):4080-4.
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        191. Yu KT, Werth DK, Pastan IH, Czech MP. src kinase catalyzes the phosphorylation and activation of the insulin receptor kinase. J Biol Chem. 1985 May 10; 260(9):5838-46.
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        192. Davis RJ, Ganong BR, Bell RM, Czech MP. Structural requirements for diacylglycerols to mimic tumor-promoting phobol diester action on the epidermal growth factor receptor. J Biol Chem. 1985 May 10; 260(9):5315-22.
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        194. Davis RJ, Czech MP. Amiloride directly inhibits growth factor receptor tyrosine kinase activity. J Biol Chem. 1985 Feb 25; 260(4):2543-51.
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        195. Davis RJ, Ganong BR, Bell RM, Czech MP. sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis. J Biol Chem. 1985 Feb 10; 260(3):1562-6.
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        196. Czech MP, Yu KT, Lewis RE, Davis RJ, Mottola C, MacDonald RG, Necessary PC, Corvera S. Insulin receptor kinase and its mode of signaling membrane components. Diabetes Metab Rev. 1985; 1(1-2):33-58.
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        198. Mottola C, Czech MP. The type II insulin-like growth factor receptor does not mediate increased DNA synthesis in H-35 hepatoma cells. J Biol Chem. 1984 Oct 25; 259(20):12705-13.
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        199. Oka Y, Czech MP. Photoaffinity labeling of insulin-sensitive hexose transporters in intact rat adipocytes. Direct evidence that latent transporters become exposed to the extracellular space in response to insulin. J Biol Chem. 1984 Jul 10; 259(13):8125-33.
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        201. Oka Y, Mottola C, Oppenheimer CL, Czech MP. Insulin activates the appearance of insulin-like growth factor II receptors on the adipocyte cell surface. Proc Natl Acad Sci U S A. 1984 Jul; 81(13):4028-32.
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        202. Pessin JE, Tillotson LG, Isselbacher KJ, Czech MP. Photoaffinity labeling of the stereospecific D-glucose transport system with cytochalasin B. Fed Proc. 1984 May 15; 43(8):2258-61.
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        203. Czech MP, Yu KT, Seals JR. Cellular signaling by the insulin receptor. Diabetes Care. 1984 May-Jun; 7 Suppl 1:8-16.
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        204. Yu KT, Czech MP. Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity. J Biol Chem. 1984 Apr 25; 259(8):5277-86.
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        205. Yu KT, Czech MP. The type I insulin-like growth factor receptor mediates the rapid effects of multiplication-stimulating activity on membrane transport systems in rat soleus muscle. J Biol Chem. 1984 Mar 10; 259(5):3090-5.
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        206. Borland K, Mita M, Oppenheimer CL, Blinderman LA, Massague J, Hall PF, Czech MP. The actions of insulin-like growth factors I and II on cultured Sertoli cells. Endocrinology. 1984 Jan; 114(1):240-6.
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        207. Czech MP. New perspectives on the mechanism of insulin action. Recent Prog Horm Res. 1984; 40:347-77.
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        208. Chlapowski FJ, Bertrand BK, Pessin J, Oka Y, Czech MP. The relationship of microvesicles to the plasmalemma of rat adipocytes. Eur J Cell Biol. 1983 Nov; 32(1):24-30.
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        209. Oppenheimer CL, Czech MP. Purification of the type II insulin-like growth factor receptor from rat placenta. J Biol Chem. 1983 Jul 25; 258(14):8539-42.
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        210. Pessin JE, Gitomer W, Oka Y, Oppenheimer CL, Czech MP. beta-Adrenergic regulation of insulin and epidermal growth factor receptors in rat adipocytes. J Biol Chem. 1983 Jun 25; 258(12):7386-94.
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        211. Czech MP, Oppenheimer CL, Massagué J. Interrelationships among receptor structures for insulin and peptide growth factors. Fed Proc. 1983 Jun; 42(9):2598-601.
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        212. Smith OL, Czech MP. Insulin sensitivity and response in eviscerated obese Zucker rats. Metabolism. 1983 Jun; 32(6):597-602.
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        213. Massague J, Freidenberg GF, Olefsky JM, Czech MP. Parallel decreases in the expression of receptors for insulin and insulin-like growth factor I in a mutant human fibroblast line. Diabetes. 1983 Jun; 32(6):541-4.
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        214. Oppenheimer CL, Pessin JE, Massague J, Gitomer W, Czech MP. Insulin action rapidly modulates the apparent affinity of the insulin-like growth factor II receptor. J Biol Chem. 1983 Apr 25; 258(8):4824-30.
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        215. Bradshaw RA, Morgan CJ, Massague J, Czech MP, Costrini NV, Tait JF, Weinman SA. Receptors for nerve growth factor in responsive peripheral neurons. Birth Defects Orig Artic Ser. 1983; 19(4):47-59.
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        216. Massagué J, Blinderman LA, Czech MP. The high affinity insulin receptor mediates growth stimulation in rat hepatoma cells. J Biol Chem. 1982 Dec 10; 257(23):13958-63.
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        217. Massague J, Buxser S, Johnson GL, Czech MP. Affinity labeling of a nerve growth factor receptor component on rat pheochromocytoma (PC12) cells. Biochim Biophys Acta. 1982 Dec 8; 693(1):205-12.
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        218. Massague J, Czech MP, Iwata K, DeLarco JE, Todaro GJ. Affinity labeling of a transforming growth factor receptor that does not interact with epidermal growth factor. Proc Natl Acad Sci U S A. 1982 Nov; 79(22):6822-6.
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        219. Czech MP. Structural and functional homologies in the receptors for insulin and the insulin-like growth factors. Cell. 1982 Nov; 31(1):8-10.
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        220. Seals JR, Czech MP. Production by plasma membranes of a chemical mediator of insulin action. Fed Proc. 1982 Sep; 41(11):2730-5.
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        221. Czech MP, Massague J. Subunit structure and dynamics of the insulin receptor. Fed Proc. 1982 Sep; 41(11):2719-23.
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        222. Massagué J, Czech MP. Role of disulfides in the subunit structure of the insulin receptor. Reduction of class I disulfides does not impair transmembrane signalling. J Biol Chem. 1982 Jun 25; 257(12):6729-38.
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        223. Carter-Su C, Pessin JE, Mora R, Gitomer W, Czech MP. Photoaffinity labeling of the human erythrocyte D-glucose transporter. J Biol Chem. 1982 May 25; 257(10):5419-25.
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        224. Massagué J, Czech MP. The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor. J Biol Chem. 1982 May 10; 257(9):5038-45.
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        225. Pessin JE, Tillotson LG, Yamada K, Gitomer W, Carter-Su C, Mora R, Isselbacher KJ, Czech MP. Identification of the stereospecific hexose transporter from starved and fed chicken embryo fibroblasts. Proc Natl Acad Sci U S A. 1982 Apr; 79(7):2286-90.
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        226. Beachy JC, Goldman D, Czech MP. Lectins activate lymphocyte pyruvate dehydrogenase by a mechanism sensitive to protease inhibitors. Proc Natl Acad Sci U S A. 1981 Oct; 78(10):6256-60.
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        227. Massague J, Guillette BJ, Czech MP, Morgan CJ, Bradshaw RA. Identification of a nerve growth factor receptor protein in sympathetic ganglia membranes by affinity labeling. J Biol Chem. 1981 Sep 25; 256(18):9419-24.
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        228. Massague J, Pilch PF, Czech MP. A unique proteolytic cleavage site on the beta subunit of the insulin receptor. J Biol Chem. 1981 Apr 10; 256(7):3182-90.
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        229. Seals JR, Czech MP. Characterization of a pyruvate dehydrogenase activator released by adipocyte plasma membranes in response to insulin. J Biol Chem. 1981 Mar 25; 256(6):2894-9.
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        230. Massague J, Guillette BJ, Czech MP. Affinity labeling of multiplication stimulating activity receptors in membranes from rat and human tissues. J Biol Chem. 1981 Mar 10; 256(5):2122-5.
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        231. Pilch PF, Axelrod JD, Colello J, Czech MP. Unimpaired signal transduction by the adipocyte insulin receptor following its partial proteolytic fragmentation. J Biol Chem. 1981 Feb 25; 256(4):1570-5.
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        232. Carter-Su C, Pilch PF, Czech MP. Chromatographic resolution of insulin receptor from insulin-sensitive D-glucose transporter of adipocyte plasma membranes. Biochemistry. 1981 Jan 6; 20(1):216-21.
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        233. Pilch PF, Czech MP. Hormone binding alters the conformation of the insulin receptor. Science. 1980 Dec 5; 210(4474):1152-3.
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        234. Massague J, Pilch PF, Czech MP. Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries. Proc Natl Acad Sci U S A. 1980 Dec; 77(12):7137-41.
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        235. Carter-Su C, Czech MP. Reconstitution of D-glucose transport activity from cytoplasmic membranes. Evidence against recruitment of cytoplasmic membrane transporters into the plasma membrane as the sole action of insulin. J Biol Chem. 1980 Nov 10; 255(21):10382-6.
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        236. Massaqué J, Czech MP. Multiple redox forms of the insulin receptor in native liver membranes. Diabetes. 1980 Nov; 29(11):945-7.
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        237. Pillion DJ, Carter-Su CA, Pilch PF, Czech MP. Isolation of adipocyte plasma membrane antigens by immunoaffinity chromatography. Insulinomimetic antibodies do not bind directly to the insulin receptor or the glucose transport system. J Biol Chem. 1980 Oct 10; 255(19):9168-76.
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        238. Czech MP, Malbon CC, Kerman K, Gitomer W, Pilch PF. Effect of thyroid status on insulin action in rat adipocytes and skeletal muscle. J Clin Invest. 1980 Sep; 66(3):574-82.
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        239. Seals JR, Czech MP. Evidence that insulin activates an intrinsic plasma membrane protease in generating a secondary chemical mediator. J Biol Chem. 1980 Jul 25; 255(14):6529-31.
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        240. Cowett RM, Czech MP, Susa JB, Schwartz R, Oh W. Blunted muscle responsiveness to insulin in the neonatal rat. Metabolism. 1980 Jun; 29(6):563-7.
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        241. Carter-Su C, Pillion DJ, Czech MP. Reconstituted D-glucose transport from the adipocyte plasma membrane. Chromatographic resolution of transport activity from membrane glycoproteins using immobilized concanavalin A. Biochemistry. 1980 May 27; 19(11):2374-85.
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        242. Czech MP. Insulin action and the regulation of hexose transport. Diabetes. 1980 May; 29(5):399-409.
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        243. Heinrich J, Pilch PF, Czech MP. Purification of the adipocyte insulin receptor by immunoaffinity chromatography. J Biol Chem. 1980 Feb 25; 255(4):1732-7.
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        244. Pilch PF, Czech MP. The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes. J Biol Chem. 1980 Feb 25; 255(4):1722-31.
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        245. Pilch PF, Thompson PA, Czech MP. Coordinate modulation of D-glucose transport activity and bilayer fluidity in plasma membranes derived from control and insulin-treated adipocytes. Proc Natl Acad Sci U S A. 1980 Feb; 77(2):915-8.
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        246. Beachy JC, Czech MP. Production of insulinomimetic antibodies against rat adipocyte membranes by hybridoma cells. J Supramol Struct. 1980; 13(4):447-56.
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        247. Czech MP, Massague J, Pilch PF, Carter-Su C. Structural features of the insulin effector system: relation to hexose transport activation. Ann N Y Acad Sci. 1980; 358:282-91.
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        248. Pilch PF, Czech MP. Hexose transport in adipocytes: stimulation by insulin in the absence of intact receptor. Ann N Y Acad Sci. 1980; 358:356.
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        249. Carter-Su C, Czech MP. Retention of insulin-stimulated D-glucose transport by detergent-solubilized adipocyte plasma membrane proteins reconstituted into phospholipid vesicles. Ann N Y Acad Sci. 1980; 358:332-3.
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        250. Melchior DL, Czech MP. Sensitivity of the adipocyte D-glucose transport system to membrane fluidity in reconstituted vesicles. J Biol Chem. 1979 Sep 25; 254(18):8744-7.
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        251. Richardson DK, Czech MP. Diminished activities of fatty acid synthesis enzymes in insulin-resistant adipocytes from spontaneously obese rats. Horm Metab Res. 1979 Jul; 11(7):427-31.
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        252. Pilch PF, Czech MP. Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons. J Biol Chem. 1979 May 10; 254(9):3375-81.
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        253. Pillion DJ, Grantham JR, Czech MP. Biological properties of antibodies against rat adipocyte intrinsic membrane proteins. Dependence on multivalency for insulin-like activity. J Biol Chem. 1979 May 10; 254(9):3211-20.
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        254. Czech MP, Richardson DK, Becker SG, Walters CG, Gitomer W, Heinrich J. Insulin response in skeletal muscle and fat cells of the genetically obese Zucker rat. Metabolism. 1978 Dec; 27(12 Suppl 2):1967-81.
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        255. Pillion DJ, Czech MP. Antibodies against intrinsic adipocyte plasma membrane proteins activate D-glucose transport independent of interaction with insulin binding sites. J Biol Chem. 1978 Jun 10; 253(11):3761-4.
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        256. Becker SG, Smollin PF, Richardson DK, Czech MP. Insulin resistance in epitrochlearis muscles in the spontaneously obese rat. Horm Metab Res. 1978 May; 10(3):204-8.
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        257. Richardson DK, Czech MP. Primary role of decreased fatty acid synthesis in insulin resistance of large rat adipocytes. Am J Physiol. 1978 Feb; 234(2):E182-9.
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        258. Hawksley CA, Guggenheim NZ, Czech MP. Thiol-dependent subunit interactions of a major fat cell plasma membrane glycoprotein. Membr Biochem. 1978; 2(1):97-115.
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        259. Pillion DJ, Shanahan MF, Czech MP. Retention of insulin-stimulated D-glucose transport activity by adipocyte plasma membranes following extraction of extrinsic proteins. J Supramol Struct. 1978; 8(3):269-77.
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        260. Czech MP, Pillion DJ, Shanahan MF. Resistance of the intact and reconstituted adipocyte hexose transport system to irreversible inhibition by sulfhydryl and amino reagents. J Supramol Struct. 1978; 9(3):363-71.
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        261. Shanahan MF, Czech MP. Purification and reconstitution of the adipocyte plasma membrane D-glucose transport system. J Biol Chem. 1977 Dec 10; 252(23):8341-3.
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        262. Greenbaum CJ, Shanahan MF, Pillion DJ, Czech MP. Selective extraction of an intrinsic fat-cell plasma-membrane glycoprotein by Triton X-100. Correlation with [3H]cytochalasin B binding activity. FEBS Lett. 1977 Nov 1; 83(1):71-5.
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        263. Shanahan MF, Czech MP. Partial purification of the D-glucose transport system in rat adipocyte plasma membranes. J Biol Chem. 1977 Sep 25; 252(18):6554-61.
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        264. Czech MP, Richardson DK, Smith CJ. Biochemical basis of fat cell insulin resistance in obese rodents and man. Metabolism. 1977 Sep; 26(9):1057-78.
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        265. Czech MP. Molecular basis of insulin action. Annu Rev Biochem. 1977; 46:359-84.
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        266. Czech MP. Current status of the thiol redox model for the regulation of hexose transport by insulin. J Cell Physiol. 1976 Dec; 89(4):661-8.
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        267. Czech MP. Cellular basis of insulin insensitivity in large rat adipocytes. J Clin Invest. 1976 Jun; 57(6):1523-32.
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        268. Czech MP. Characterization of (3H)cytochalasin B binding to the fat cell plasma membrane. J Biol Chem. 1976 May 25; 251(10):2905-10.
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        269. Czech MP. Regulation of the D-glucose transport system in isolated fat cells. Mol Cell Biochem. 1976 Mar 26; 11(1):51-63.
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        270. Czech MP. Differential effects of sulfhydryl reagents on activation and deactivation of the fat cell hexose transport system. J Biol Chem. 1976 Feb 25; 251(4):1164-70.
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        271. Czech MP, Lawrence JC, Lynn WS. Activation of hexose transport by concanavalin A in isolated brown fat cells. Effects of cell surface modification with neuraminidase and trypsin on lectin and insulin action. J Biol Chem. 1974 Dec 10; 249(23):7499-505.
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        272. Czech MP, Lawrence JC, Lynn WS. Evidence for the involvement of sulfhydryl oxidation in the regulation of fat cell hexose transport by insulin. Proc Natl Acad Sci U S A. 1974 Oct; 71(10):4173-7.
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        273. Czech MP, Lawrence JC, Lynn WS. Hexose transport in isolated brown fat cells. A model system for investigating insulin action on membrane transport. J Biol Chem. 1974 Sep 10; 249(17):5421-7.
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        274. Czech MP, Lawrence JC, Lynn WS. Evidence for electron transfer reactions involved in the Cu2+ -dependent thiol activation of fat cell glucose utilization. J Biol Chem. 1974 Feb 25; 249(4):1001-6.
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        275. Czech MP, Lynn DG, Lynn WS. Phlorizin--receptor interactions in fat cell plasma membranes. Biochim Biophys Acta. 1973 Nov 16; 323(4):639-42.
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        276. Czech MP, Lynn WS. Studies on the topography of the fat cell plasma membrane. Biochemistry. 1973 Sep 11; 12(19):3597-601.
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        277. Czech MP, Lynn WS. The plasma membrane of isolated fat cells. I. Identification of trypsin-sensitive membrane peptides by sodium dodecyl sulfate polyacrylamide gel electrophoresis. J Biol Chem. 1973 Jul 25; 248(14):5081-8.
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        278. Czech MP, Lynn DG, Lynn WS. Cytochalasin B-sensitive 2-deoxy-D-glucose transport in adipose cell ghosts. J Biol Chem. 1973 May 25; 248(10):3636-41.
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        279. Czech MP, Lynn WS. Stimulation of glucose metabolism by lectins in isolated white fat cells. Biochim Biophys Acta. 1973 Feb 28; 297(2):368-77.
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        280. Czech MP, Fain JN. Cu ++ -dependent thiol stimulation of glucose metabolism in white fat cells. J Biol Chem. 1972 Oct 10; 247(19):6218-23.
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        281. Czech MP, Fain JN. Antagonism of insulin action on glucose metabolism in white fat cells by dexamethasone. Endocrinology. 1972 Aug; 91(2):518-22.
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        282. Czech MP, Fain JN. Dactinomycin inhibition of dexamethasone action on glucose metabolism in white fat cells. Biochim Biophys Acta. 1971 Feb 23; 230(2):185-93.
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        283. Czech MP, Fain JN. Insulin protection against fat cell receptor inactivation by trypsin. Endocrinology. 1970 Jul; 87(1):191-4.
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        284. Fain JN, Loken SC, Czech MP. Oligomycin effects on lipolysis and the oxidative metabolism of brown fat cells. Biochim Biophys Acta. 1970 Jan 13; 197(1):40-8.
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