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    James G Dobson PhD

    TitleProfessor Emeritus
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMicrobiology and Physiological Systems
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-3775
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentMedicine
      DivisionCardiovascular Medicine

        Overview 
        Narrative

        Academic Background

        1965, B.S., Central Connecticut State University
        1967, M.A., Wesleyan University
        1971, Ph.D., University of Virginia

        2008 - 2010, Professor & Interim Chairman of Physiology

        2011 - Professor Emeritus

        Regulation of neurotransmitter signal transduction in the heart

        The research in this laboratory is concerned with investigating transmembrane signaling and the mechanisms which regulate cardiac muscle force development and myocardial energy utilization. Emphasis isJim Dobson Photo given to the importance of adenosinergic modulation of the regulatory mechanisms particularly upon beta-adrenoceptor stimulation. The importance of the phosphorylation-dephosphorylation of proteins involved in the regulatory processes is a keen area of interest. Of additional interest is the role of adenosine in endothelial cell proliferation, aging of the cardiovascular system and heart failure. Mainly, isolated perfused hearts, dispersed ventricular myocytes and cultured endothelial cells are used in these studies.

        The main emphasis is that by using current biochemical and molecular approaches and techniques the physiological mechanisms regulating cardiac mechanical performance and metabolism can be elucidated in the normal heart. This will foster a better understanding of how these neuro-regulatory mechanisms are altered in the diseased and aging cells that comprise the cardiovasculary system.

        Research Figure

        Adenosine and the Catecholamine Responses in Heart

          A scheme illustrating that any one of the following: catacholamine stimulation of the heart, myocardial ischemia and adult heart aging, increases the concentration of myocardial adenosine. The increased adenosine in turn reduces the Beta-adrenergic induced increases in the myocardial chronotropic, inotropic and glycogenolytic responses of the heart and enhances coronary blood flow.


        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Fenton RA, Dobson JG. Reduced adenosine release from the aged mammalian heart. J Cell Physiol. 2012 Nov; 227(11):3709-14.
          View in: PubMed
        2. Komatsu S, Dobson JG, Ikebe M, Shea LG, Fenton RA. Crosstalk between adenosine A(1) and ß(1) -adrenergic receptors regulates translocation of PKCe in isolated rat cardiomyocytes. J Cell Physiol. 2012 Sep; 227(9):3201-7.
          View in: PubMed
        3. Fenton RA, Shea LG, Doddi C, Dobson JG. Myocardial adenosine A(1)-receptor-mediated adenoprotection involves phospholipase C, PKC-epsilon, and p38 MAPK, but not HSP27. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1671-8.
          View in: PubMed
        4. Fenton RA, Komatsu S, Ikebe M, Shea LG, Dobson JG. Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H718-25.
          View in: PubMed
        5. Dobson JG, Shea LG, Fenton RA. Adenosine A2A and beta-adrenergic calcium transient and contractile responses in rat ventricular myocytes. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2364-72.
          View in: PubMed
        6. Tikh EI, Fenton RA, Chen JF, Schwarzschild MA, Dobson JG. Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart. J Cell Physiol. 2008 Jul; 216(1):83-90.
          View in: PubMed
        7. Fenton RA, Dobson JG. Adenosine A1 and A2A receptor effects on G-protein cycling in beta-adrenergic stimulated ventricular membranes. J Cell Physiol. 2007 Dec; 213(3):785-92.
          View in: PubMed
        8. Knott TK, Marrero HG, Fenton RA, Custer EE, Dobson JG, Lemos JR. Endogenous adenosine inhibits CNS terminal Ca(2+) currents and exocytosis. J Cell Physiol. 2007 Feb; 210(2):309-14.
          View in: PubMed
        9. Tikh EI, Fenton RA, Dobson JG. Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts. Am J Physiol Heart Circ Physiol. 2006 Jan; 290(1):H348-56.
          View in: PubMed
        10. Fenton RA, Dickson EW, Dobson JG. Inhibition of phosphatase activity enhances preconditioning and limits cell death in the ischemic/reperfused aged rat heart. Life Sci. 2005 Nov 12; 77(26):3375-88.
          View in: PubMed
        11. Lorbar M, Chung ES, Nabi A, Skalova K, Fenton RA, Dobson JG, Meyer TE. Receptors subtypes involved in adenosine-mediated modulation of norepinephrine release from cardiac nerve terminals. Can J Physiol Pharmacol. 2004 Nov; 82(11):1026-31.
          View in: PubMed
        12. Miyazaki K, Komatsu S, Ikebe M, Fenton RA, Dobson JG. Protein kinase Cepsilon and the antiadrenergic action of adenosine in rat ventricular myocytes. Am J Physiol Heart Circ Physiol. 2004 Oct; 287(4):H1721-9.
          View in: PubMed
        13. Dobson JG, Fray J, Leonard JL, Pratt RE. Molecular mechanisms of reduced beta-adrenergic signaling in the aged heart as revealed by genomic profiling. Physiol Genomics. 2003 Oct 17; 15(2):142-7.
          View in: PubMed
        14. Dobson JG, Shea LG, Fenton RA. Beta-adrenergic and antiadrenergic modulation of cardiac adenylyl cyclase is influenced by phosphorylation. Am J Physiol Heart Circ Physiol. 2003 Oct; 285(4):H1471-8.
          View in: PubMed
        15. Reisert PS, Dobson JG, Fenton RA. Anoxia-induced changes in purine nucleoside metabolism of in vitro aged human fibroblasts. Life Sci. 2002 Feb 8; 70(12):1369-82.
          View in: PubMed
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