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    Nils Henninger MD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentNeurology
    AddressUniversity of Massachusetts Medical School
    55 Lake Ave North
    Worcester MA 01605
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentPsychiatry

        Overview 
        Narrative

        Biography

        Dr. Henninger received his M.D. degree from the University of Mainz, Germany. Following residency training in Neurology at the University of Heidelberg, Germany and University of Massachusetts Medical School, Worcester, MA he completed a fellowship in Cerebrovascular Diseases at the Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA before joining the University of Massachusetts Medical School in 2012.

        ResearchProgram

        As a cerebrovascular disease-trained neurologist I mostly see stroke patients in my clinic but I am broadly interested in emergency neurology. As a physician scientist I devote ~80% of my full time effort to researching mechanisms driving brain white matter injury and how it relates to outcome.

        My main basic science research is aimed at understanding how axons in the brain’s white matter degenerate after acute brain injury. My research has provided first evidence that by blocking a key gene driving Wallerian degeneration, Sarm1, it is possible to prevent axonal degeneration and preserve neurological function after brain trauma. These fundamental observations indicate that traumatic axonal degeneration is governed by a Wallerian degeneration-like mechanism and represent the first evidence that it is possible to prevent axonal degeneration after mammalian brain trauma in vivo. This is a major step forward in the field of traumatic brain injury, which represents a leading cause of adult disability and death in the US and for which there is no specific therapy available.

        My main clinical research interest is focused on investigating chronic ischemic white matter injury in the brain termed leukoaraiosis and how it impacts outcome after ischemic stroke. Leukoaraiosis is common among patients with stroke as it shares common risk factors with stroke and has been linked to cognitive and neurological decline as well as increased stroke risk. Results from my research have highlighted that stroke patients with severe pre-existing leukoaraiosis have larger strokes, worse functional deficits at presentation, recovery to a lesser extent, and have an overall greater risk for functional dependence after their stroke as compared to patients with only mild leukoaraiosis.

        We accept residents and fellows year round to work on mentored clinical research projects. Lab rotations are available on a case-by-case basis.

        Those interested in providing philanthropic support for a specific area of interest should contact Dr. Henninger at Nils.Henninger[at]umassmed.edu.

         



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Helenius J, Henninger N. Response to Letter Regarding Article, "Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke". Stroke. 2015 Aug; 46(8):e197.
          View in: PubMed
        2. Turetsky A, Goddeau RP, Henninger N. Low Serum Vitamin D Is Independently Associated with Larger Lesion Volumes after Ischemic Stroke. J Stroke Cerebrovasc Dis. 2015 Jul; 24(7):1555-63.
          View in: PubMed
        3. Helenius J, Henninger N. Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke. Stroke. 2015 Jul; 46(7):1857-63.
          View in: PubMed
        4. Osgood M, Budman E, Carandang R, Goddeau RP, Henninger N. Prevalence of Pelvic Vein Pathology in Patients with Cryptogenic Stroke and Patent Foramen Ovale Undergoing MRV Pelvis. Cerebrovasc Dis. 2015; 39(3-4):216-23.
          View in: PubMed
        5. Henninger N, Izzy S, Carandang R, Hall W, Muehlschlegel S. Severe leukoaraiosis portends a poor outcome after traumatic brain injury. Neurocrit Care. 2014 Dec; 21(3):483-95.
          View in: PubMed
        6. Moonis M, Kumar R, Henninger N, Kane K, Fisher M. Pre and Post-stroke Use of Statins Improves Stroke Outcome. Indian J Community Med. 2014 Oct; 39(4):214-7.
          View in: PubMed
        7. Khan M, Goddeau RP, Zhang J, Moonis M, Henninger N. Predictors of Outcome following Stroke due to Isolated M2 Occlusions. Cerebrovasc Dis Extra. 2014 Jan; 4(1):52-60.
          View in: PubMed
        8. Henninger N, Khan MA, Zhang J, Moonis M, Goddeau RP. Leukoaraiosis predicts cortical infarct volume after distal middle cerebral artery occlusion. Stroke. 2014 Mar; 45(3):689-95.
          View in: PubMed
        9. Marinescu M, Bouley J, Chueh J, Fisher M, Henninger N. Clot injection technique affects thrombolytic efficacy in a rat embolic stroke model: implications for translaboratory collaborations. J Cereb Blood Flow Metab. 2014 Apr; 34(4):677-82.
          View in: PubMed
        10. Henninger N, Haussen DC, Kakouros N, Selim M, Searls DE, Kumar S, Schlaug G, Caplan LR. QTc-prolongation in posterior circulation stroke. Neurocrit Care. 2013 Oct; 19(2):167-75.
          View in: PubMed
        11. Henninger N, Lin E, Haussen DC, Lehman LL, Takhtani D, Selim M, Moonis M. Leukoaraiosis and sex predict the hyperacute ischemic core volume. Stroke. 2013 Jan; 44(1):61-7.
          View in: PubMed
        12. Krishnan V, Searls DE, Haussen DC, Henninger N, Thomas A. Venous ischemia secondary to drainage constriction in a carotid-cavernous arteriovenous fistula. Clin Neurol Neurosurg. 2013 Aug; 115(8):1476-8.
          View in: PubMed
        13. Haussen DC, Henninger N, Selim M. Diffusion-weighted imaging of intramural hematoma in internal carotid artery dissection. Acta Neurol Belg. 2013 Mar; 113(1):109-10.
          View in: PubMed
        14. Eder KE, Haussen DC, Searls DE, Henninger N. Reverberating TCD flow pattern in brain death. Neurology. 2012 Aug 28; 79(9):e79.
          View in: PubMed
        15. Haussen DC, Henninger N, Kumar S, Selim M. Statin use and microbleeds in patients with spontaneous intracerebral hemorrhage. Stroke. 2012 Oct; 43(10):2677-81.
          View in: PubMed
        16. Henninger N, Haussen DC, Kumar S. Teaching neuroimages: ictal hyperperfusion. Neurology. 2012 Jun 5; 78(23):e146.
          View in: PubMed
        17. Henninger N, Lin E, Baker SP, Wakhloo AK, Takhtani D, Moonis M. Leukoaraiosis predicts poor 90-day outcome after acute large cerebral artery occlusion. Cerebrovasc Dis. 2012; 33(6):525-31.
          View in: PubMed
        18. Henninger N, Haussen DC, Caplan LR. Pathology of Cerebral Subcortical Infarction. Int. Rev. Thrombosis. 2012; 7:34-43.
        19. Mehra M, Henninger N, Hirsch JA, Chueh J, Wakhloo AK, Gounis MJ. Preclinical acute ischemic stroke modeling. J Neurointerv Surg. 2012 Jul; 4(4):307-13.
          View in: PubMed
        20. Walvick RP, Bråtane BT, Henninger N, Sicard KM, Bouley J, Yu Z, Lo E, Wang X, Fisher M. Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy. Stroke. 2011 Apr; 42(4):1110-5.
          View in: PubMed
        21. Rivera-Lara L, Henninger N. Delayed sudden coma due to artery of percheron infarction. Arch Neurol. 2011 Mar; 68(3):386-7.
          View in: PubMed
        22. Henninger N, Kumar R, Fisher M. Acute ischemic stroke therapy. Expert Rev Cardiovasc Ther. 2010 Oct; 8(10):1389-98.
          View in: PubMed
        23. Zhou X, Sun Y, Mazzanti M, Henninger N, Mansour J, Fisher M, Albert M. MRI of stroke using hyperpolarized 129Xe. NMR Biomed. 2011 Feb; 24(2):170-5.
          View in: PubMed
        24. Kollmar R, Henninger N, Urbanek C, Schwab S. G-CSF, rt-PA and combination therapy after experimental thromboembolic stroke. Exp Transl Stroke Med. 2010; 2:9.
          View in: PubMed
        25. Henninger N, Ahmad N, Morris JG. Intravenous thrombolysis in a patient with known cavernous malformation: a first case report. Am J Emerg Med. 2010 Jan; 28(1):117.e1-3.
          View in: PubMed
        26. Bråtane BT, Bouley J, Schneider A, Bastan B, Henninger N, Fisher M. Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat. Stroke. 2009 Sep; 40(9):3102-6.
          View in: PubMed
        27. Henninger N, Chowdhury N, Fisher M, Moonis M. Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke. Cerebrovasc Dis. 2009; 27 Suppl 4:9-14.
          View in: PubMed
        28. Henninger N, Lin E, Fischer A, Kheradmand A. Leptomeningeal carcinomatosis: a rare complication in esophageal cancer. Acta Neurol Belg. 2009 Jun; 109(2):162.
          View in: PubMed
        29. Bråtane BT, Bastan B, Fisher M, Bouley J, Henninger N. Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps. Brain Res. 2009 Jul 7; 1279:182-8.
          View in: PubMed
        30. Marfella CG, Henninger N, LeBlanc SE, Krishnan N, Garlick DS, Holzman LB, Imbalzano AN. A mutation in the mouse Chd2 chromatin remodeling enzyme results in a complex renal phenotype. Kidney Blood Press Res. 2008; 31(6):421-32.
          View in: PubMed
        31. Henninger N, Bouley J, Bråtane BT, Bastan B, Shea M, Fisher M. Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke. Exp Neurol. 2009 Feb; 215(2):290-7.
          View in: PubMed
        32. Henninger N, Bratane BT, Bastan B, Bouley J, Fisher M. Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model. J Cereb Blood Flow Metab. 2009 Jan; 29(1):119-29.
          View in: PubMed
        33. Henninger N, Sicard KM, Li Z, Kulkarni P, Dützmann S, Urbanek C, Schwab S, Fisher M. Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat. Crit Care Med. 2007 Nov; 35(11):2607-14.
          View in: PubMed
        34. Henninger N, Fisher M. Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke. Stroke. 2007 Oct; 38(10):2779-86.
          View in: PubMed
        35. Henninger N, Heimann A, Kempski O. Electrophysiology and neuronal integrity following systemic arterial hypotension in a rat model of unilateral carotid artery occlusion. Brain Res. 2007 Aug 13; 1163:119-29.
          View in: PubMed
        36. Henninger N, Sicard KM, Fisher M. Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats. J Cereb Blood Flow Metab. 2007 Oct; 27(10):1756-63.
          View in: PubMed
        37. Henninger N, Feldmann RE, Fütterer CD, Schrempp C, Maurer MH, Waschke KF, Kuschinsky W, Schwab S. Spatial learning induces predominant downregulation of cytosolic proteins in the rat hippocampus. Genes Brain Behav. 2007 Mar; 6(2):128-40.
          View in: PubMed
        38. Bardutzky J, Shen Q, Henninger N, Schwab S, Duong TQ, Fisher M. Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging. Stroke. 2007 Apr; 38(4):1336-44.
          View in: PubMed
        39. Henninger N, Bouley J, Nelligan JM, Sicard KM, Fisher M. Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2007 Sep; 27(9):1632-42.
          View in: PubMed
        40. Henninger N, Wang Q, Okun JG, Schwab S, Krause M. Nitrous oxide promotes hyperhomocysteinemia in levodopa treated rats. Parkinsonism Relat Disord. 2007 Dec; 13(8):524-7.
          View in: PubMed
        41. Fisher M, Henninger N. Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials. Curr Neurol Neurosci Rep. 2007 Jan; 7(1):35-41.
          View in: PubMed
        42. Bouley J, Fisher M, Henninger N. Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging. Neurosci Lett. 2007 Feb 2; 412(3):185-90.
          View in: PubMed
        43. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats. Stroke. 2006 Oct; 37(10):2593-600.
          View in: PubMed
        44. Henninger N, Küppers-Tiedt L, Sicard KM, Günther A, Schneider D, Schwab S. Neuroprotective effect of hyperbaric oxygen therapy monitored by MR-imaging after embolic stroke in rats. Exp Neurol. 2006 Oct; 201(2):316-23.
          View in: PubMed
        45. Henninger N, Sicard KM, Schmidt KF, Bardutzky J, Fisher M. Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging. Stroke. 2006 May; 37(5):1283-7.
          View in: PubMed
        46. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2006 Nov; 26(11):1451-62.
          View in: PubMed
        47. Henninger N, Eberius KH, Sicard KM, Kollmar R, Sommer C, Schwab S, Schäbitz WR. A new model of thromboembolic stroke in the posterior circulation of the rat. J Neurosci Methods. 2006 Sep 30; 156(1-2):1-9.
          View in: PubMed
        48. Henninger N, Sicard KM, Bouley J, Fisher M, Stagliano NE. The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia. Neurosci Lett. 2006 May 8; 398(3):300-5.
          View in: PubMed
        49. Henninger N, Fisher M. Normobaric hyperoxia - a promising approach to expand the time window for acute stroke treatment. Cerebrovasc Dis. 2006; 21(1-2):134-6.
          View in: PubMed
        50. Henninger N, Dützmann S, Sicard KM, Kollmar R, Bardutzky J, Schwab S. Impaired spatial learning in a novel rat model of mild cerebral concussion injury. Exp Neurol. 2005 Oct; 195(2):447-57.
          View in: PubMed
        51. Bardutzky J, Shen Q, Henninger N, Bouley J, Duong TQ, Fisher M. Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging. Stroke. 2005 Sep; 36(9):2000-5.
          View in: PubMed
        52. Kollmar R, Henninger N, Bardutzky J, Schellinger PD, Schäbitz WR, Schwab S. Combination therapy of moderate hypothermia and thrombolysis in experimental thromboembolic stroke--an MRI study. Exp Neurol. 2004 Nov; 190(1):204-12.
          View in: PubMed
        53. Schäbitz WR, Schade H, Heiland S, Kollmar R, Bardutzky J, Henninger N, Müller H, Carl U, Toyokuni S, Sommer C, Schwab S. Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MRI. Stroke. 2004 May; 35(5):1175-9.
          View in: PubMed
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