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    Nils Henninger MD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentNeurology
    AddressUniversity of Massachusetts Medical School
    55 Lake Ave North
    Worcester MA 01605
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentPsychiatry

        Overview 
        Narrative

        Biography

        Dr. Henninger received his M.D. degree from the University of Mainz, Germany. Following residency training in Neurology at the University of Heidelberg, Germanyand University of Massachusetts Medical School, Worcester, MA he completed a fellowshipin Cerebrovascular Diseases at the Beth Israel Deaconess Medical Center/Harvard Medical School,Boston, MA before joining the University of Massachusetts Medical School in2012.

        ResearchProgram

        As a clinician and researcher, Dr. Henninger focuses on innovation in thefields of Stroke and Traumatic Brain Injury at the University of MassachusettsMedical School.

        Dr. Henninger’s main clinical interest is focused on investigating cerebralsmall vessel disease (SVD) and its impact on outcome following ischemic stroke.SVD is very common among patients older than 50 years particularly if they havevascular risk factors such as high blood pressure and diabetes. Patientsevaluated for stroke often share these risk factors and, not surprising,frequently have evidence of SVD on brain imaging. Results from Dr. Henninger’sresearch have highlighted that the severity of SVD is stronglyassociated with stroke expansion after arterial occlusion. Theseresults help explain why patients with preexisting severe SVD also have moresevere strokes, less response to treatment, and overall worse outcomes. Ongoingresearch aims at identifying those SVD patients that are at particular highrisk for complications related to their stroke-therapy to better understand howthese can be avoided.

        To facilitate translationalstroke research, Dr. Henninger’s laboratory major lines of investigation include: (1) modelingSVD and acute ischemic stroke in rodents; (2) evaluating neuroprotectivestrategies in animal models of cerebral occlusive disease; (3) serialassessment of lesion expansion and functional-cognitive recovery followingbrain ischemia using state of the art small animal MRI; (4) identifyingmolecular pathways related to the pathology of SVD.

        His laboratory’s second major interest relates totraumatic (concussion) brain injury (TBI). Seminal work from his group providedinsight into the differential recovery of behavioral status and brain functionafter mild TBI in the rat. Similar to stroke, TBI is a leadingcauses of adult disability and death with more than 5 millionAmericans suffering from long-term disability related to TBIand annualcosts in excess of 60 billion dollars in the US. Axonal injury is an importantpathological hallmark of TBI and is a critical determinant of functionalimpairment and recovery. The vast majority of preclinical studies have focusedon neuronal rather than axonal protection, yet all promising neuroprotectivecompounds have failed clinically. Hence, there is a clear need to characterizethe pathophysiology of axonal injury and its role in cerebral dysfunctionfollowing TBI. Using rodent models of mild TBI, Dr. Henninger’s group ispresently investigating molecular pathways driving axon auto-destruction incollaboration with Dr. Freeman, Department of Neurobiology. This study willprovide novel insight into the contribution of programmed axonal degenerationafter acute TBI holding great promise to aid the development of novel approachesto brain protection.

        We accept residents and fellows year round to work on mentored clinicalresearch projects. Lab rotations are available on a case-by-case basis tohighly motivated individuals.

        Those interested in providing philanthropicsupport for a specific area of interest, especially concussion studies, shouldcontact Dr. Henninger at Nils.Henninger[at]umassmed.edu.



        Bibliographic 
        selected publications
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        1. Henninger N, Khan MA, Zhang J, Moonis M, Goddeau RP. Leukoaraiosis predicts cortical infarct volume after distal middle cerebral artery occlusion. Stroke. 2014 Mar; 45(3):689-95.
          View in: PubMed
        2. Marinescu M, Bouley J, Chueh J, Fisher M, Henninger N. Clot injection technique affects thrombolytic efficacy in a rat embolic stroke model: implications for translaboratory collaborations. J Cereb Blood Flow Metab. 2014 Jan 15.
          View in: PubMed
        3. Henninger N, Haussen DC, Kakouros N, Selim M, Searls DE, Kumar S, Schlaug G, Caplan LR. QTc-prolongation in posterior circulation stroke. Neurocrit Care. 2013 Oct; 19(2):167-75.
          View in: PubMed
        4. Henninger N, Lin E, Haussen DC, Lehman LL, Takhtani D, Selim M, Moonis M. Leukoaraiosis and sex predict the hyperacute ischemic core volume. Stroke. 2013 Jan; 44(1):61-7.
          View in: PubMed
        5. Krishnan V, Eric Searls D, Haussen DC, Henninger N, Thomas A. Venous ischemia secondary to drainage constriction in a carotid-cavernous arteriovenous fistula. Clin Neurol Neurosurg. 2013 Aug; 115(8):1476-8.
          View in: PubMed
        6. Haussen DC, Henninger N, Selim M. Diffusion-weighted imaging of intramural hematoma in internal carotid artery dissection. Acta Neurol Belg. 2013 Mar; 113(1):109-10.
          View in: PubMed
        7. Eder KE, Haussen DC, Searls DE, Henninger N. Teaching NeuroImages: Reverberating TCD flow pattern in brain death. Neurology. 2012 Aug 28; 79(9):e79.
          View in: PubMed
        8. Haussen DC, Henninger N, Kumar S, Selim M. Statin use and microbleeds in patients with spontaneous intracerebral hemorrhage. Stroke. 2012 Oct; 43(10):2677-81.
          View in: PubMed
        9. Henninger N, Haussen DC, Kumar S. Teaching NeuroImages: Ictal hyperperfusion. Neurology. 2012 Jun 5; 78(23):e146.
          View in: PubMed
        10. Henninger N, Lin E, Baker SP, Wakhloo AK, Takhtani D, Moonis M. Leukoaraiosis predicts poor 90-day outcome after acute large cerebral artery occlusion. Cerebrovasc Dis. 2012; 33(6):525-31.
          View in: PubMed
        11. Henninger N, Haussen DC, Caplan LR. Pathology of Cerebral Subcortical Infarction. Int. Rev. Thrombosis. 2012; 7:34-43.
        12. Mehra M, Henninger N, Hirsch JA, Chueh J, Wakhloo AK, Gounis MJ. Preclinical acute ischemic stroke modeling. J Neurointerv Surg. 2012 Jul 1; 4(4):307-13.
          View in: PubMed
        13. Walvick RP, Bråtane BT, Henninger N, Sicard KM, Bouley J, Yu Z, Lo E, Wang X, Fisher M. Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy. Stroke. 2011 Apr; 42(4):1110-5.
          View in: PubMed
        14. Rivera-Lara L, Henninger N. Delayed sudden coma due to artery of percheron infarction. Arch Neurol. 2011 Mar; 68(3):386-7.
          View in: PubMed
        15. Henninger N, Kumar R, Fisher M. Acute ischemic stroke therapy. Expert Rev Cardiovasc Ther. 2010 Oct; 8(10):1389-98.
          View in: PubMed
        16. Zhou X, Sun Y, Mazzanti M, Henninger N, Mansour J, Fisher M, Albert M. MRI of stroke using hyperpolarized (129) Xe. NMR Biomed. 2011 Feb; 24(2):170-5.
          View in: PubMed
        17. Kollmar R, Henninger N, Urbanek C, Schwab S. G-CSF, rt-PA and combination therapy after experimental thromboembolic stroke. Exp Transl Stroke Med. 2010; 2:9.
          View in: PubMed
        18. Henninger N, Ahmad N, Morris JG. Intravenous thrombolysis in a patient with known cavernous malformation: a first case report. Am J Emerg Med. 2010 Jan; 28(1):117.e1-3.
          View in: PubMed
        19. Bråtane BT, Bouley J, Schneider A, Bastan B, Henninger N, Fisher M. Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat. Stroke. 2009 Sep; 40(9):3102-6.
          View in: PubMed
        20. Henninger N, Chowdhury N, Fisher M, Moonis M. Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke. Cerebrovasc Dis. 2009; 27 Suppl 4:9-14.
          View in: PubMed
        21. Henninger N, Lin E, Fischer A, Kheradmand A. Leptomeningeal carcinomatosis: a rare complication in esophageal cancer. Acta Neurol Belg. 2009 Jun; 109(2):162.
          View in: PubMed
        22. Bråtane BT, Bastan B, Fisher M, Bouley J, Henninger N. Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps. Brain Res. 2009 Jul 7; 1279:182-8.
          View in: PubMed
        23. Marfella CG, Henninger N, LeBlanc SE, Krishnan N, Garlick DS, Holzman LB, Imbalzano AN. A mutation in the mouse Chd2 chromatin remodeling enzyme results in a complex renal phenotype. Kidney Blood Press Res. 2008; 31(6):421-32.
          View in: PubMed
        24. Henninger N, Bouley J, Bråtane BT, Bastan B, Shea M, Fisher M. Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke. Exp Neurol. 2009 Feb; 215(2):290-7.
          View in: PubMed
        25. Henninger N, Bratane BT, Bastan B, Bouley J, Fisher M. Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model. J Cereb Blood Flow Metab. 2009 Jan; 29(1):119-29.
          View in: PubMed
        26. Henninger N, Sicard KM, Li Z, Kulkarni P, Dützmann S, Urbanek C, Schwab S, Fisher M. Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat. Crit Care Med. 2007 Nov; 35(11):2607-14.
          View in: PubMed
        27. Henninger N, Fisher M. Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke. Stroke. 2007 Oct; 38(10):2779-86.
          View in: PubMed
        28. Henninger N, Heimann A, Kempski O. Electrophysiology and neuronal integrity following systemic arterial hypotension in a rat model of unilateral carotid artery occlusion. Brain Res. 2007 Aug 13; 1163:119-29.
          View in: PubMed
        29. Henninger N, Sicard KM, Fisher M. Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats. J Cereb Blood Flow Metab. 2007 Oct; 27(10):1756-63.
          View in: PubMed
        30. Henninger N, Feldmann RE, Fütterer CD, Schrempp C, Maurer MH, Waschke KF, Kuschinsky W, Schwab S. Spatial learning induces predominant downregulation of cytosolic proteins in the rat hippocampus. Genes Brain Behav. 2007 Mar; 6(2):128-40.
          View in: PubMed
        31. Bardutzky J, Shen Q, Henninger N, Schwab S, Duong TQ, Fisher M. Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging. Stroke. 2007 Apr; 38(4):1336-44.
          View in: PubMed
        32. Henninger N, Bouley J, Nelligan JM, Sicard KM, Fisher M. Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2007 Sep; 27(9):1632-42.
          View in: PubMed
        33. Henninger N, Wang Q, Okun JG, Schwab S, Krause M. Nitrous oxide promotes hyperhomocysteinemia in levodopa treated rats. Parkinsonism Relat Disord. 2007 Dec; 13(8):524-7.
          View in: PubMed
        34. Fisher M, Henninger N. Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials. Curr Neurol Neurosci Rep. 2007 Jan; 7(1):35-41.
          View in: PubMed
        35. Bouley J, Fisher M, Henninger N. Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging. Neurosci Lett. 2007 Feb 2; 412(3):185-90.
          View in: PubMed
        36. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats. Stroke. 2006 Oct; 37(10):2593-600.
          View in: PubMed
        37. Henninger N, Küppers-Tiedt L, Sicard KM, Günther A, Schneider D, Schwab S. Neuroprotective effect of hyperbaric oxygen therapy monitored by MR-imaging after embolic stroke in rats. Exp Neurol. 2006 Oct; 201(2):316-23.
          View in: PubMed
        38. Henninger N, Sicard KM, Schmidt KF, Bardutzky J, Fisher M. Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging. Stroke. 2006 May; 37(5):1283-7.
          View in: PubMed
        39. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2006 Nov; 26(11):1451-62.
          View in: PubMed
        40. Henninger N, Eberius KH, Sicard KM, Kollmar R, Sommer C, Schwab S, Schäbitz WR. A new model of thromboembolic stroke in the posterior circulation of the rat. J Neurosci Methods. 2006 Sep 30; 156(1-2):1-9.
          View in: PubMed
        41. Henninger N, Sicard KM, Bouley J, Fisher M, Stagliano NE. The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia. Neurosci Lett. 2006 May 8; 398(3):300-5.
          View in: PubMed
        42. Henninger N, Fisher M. Normobaric hyperoxia - a promising approach to expand the time window for acute stroke treatment. Cerebrovasc Dis. 2006; 21(1-2):134-6.
          View in: PubMed
        43. Henninger N, Dützmann S, Sicard KM, Kollmar R, Bardutzky J, Schwab S. Impaired spatial learning in a novel rat model of mild cerebral concussion injury. Exp Neurol. 2005 Oct; 195(2):447-57.
          View in: PubMed
        44. Bardutzky J, Shen Q, Henninger N, Bouley J, Duong TQ, Fisher M. Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging. Stroke. 2005 Sep; 36(9):2000-5.
          View in: PubMed
        45. Kollmar R, Henninger N, Bardutzky J, Schellinger PD, Schäbitz WR, Schwab S. Combination therapy of moderate hypothermia and thrombolysis in experimental thromboembolic stroke--an MRI study. Exp Neurol. 2004 Nov; 190(1):204-12.
          View in: PubMed
        46. Schäbitz WR, Schade H, Heiland S, Kollmar R, Bardutzky J, Henninger N, Müller H, Carl U, Toyokuni S, Sommer C, Schwab S. Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MRI. Stroke. 2004 May; 35(5):1175-9.
          View in: PubMed
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