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    Doreen Brettler MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-334-6093
        Bibliographic 
        selected publications
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        1. Lui JK, Gillespie W, Gaudet R, Brettler DB. Occam's Razor and the Diagnosis of Mantle Cell Lymphoma. Am J Med. 2015 Dec; 128(12):e25-6.
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        2. Boylan B, Rice AS, Dunn AL, Tarantino MD, Brettler DB, Barrett JC, Miller CH. Characterization of the anti-factor VIII immunoglobulin profile in patients with hemophilia A by use of a fluorescence-based immunoassay. J Thromb Haemost. 2015 Jan; 13(1):47-53.
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        3. Tipirneni E, Buttar A, Brettler D, Miron P, Bathini V. Chronic myeloproliferative disorder with ETV6-PDGFRß fusion gene. Ann Hematol. 2012 Apr; 91(4):637-8.
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        4. Tang G, Woods LJ, Wang SA, Brettler D, Andersen M, Miron PM, Pechet L, Woda BA, Hao S. Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm. Hum Pathol. 2009 Aug; 40(8):1194-9.
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        5. Cerny J, Wang S, Miron P, Hutchinson L, Brettler D. EBV-negative Hodgkin lymphoma in ZAP-70-positive B-cell lymphocytic leukemia patient. Ann Hematol. 2009 May; 88(5):495-7.
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        6. Brettler DB. Gene therapy for hemophilia? J Thromb Haemost. 2005 Jun; 3(6):1317-9.
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        7. Soucie JM, Symons J, Evatt B, Brettler D, Huszti H, Linden J. Home-based factor infusion therapy and hospitalization for bleeding complications among males with haemophilia. Haemophilia. 2001 Mar; 7(2):198-206.
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        8. Engelfriet CP, Reesink HW, Mannucci PM, Gringeri A, Ingerslev J, Brettler DB, Mauser-Bunschoten EP, Negrier C, Berntorp E, Smith OP, Shapiro AD. The optimal treatment for haemophiliacs who have developed factor VIII or -IX antibodies. Vox Sang. 2000; 78(4):256-61.
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        9. Greenough TC, Brettler DB, Kirchhoff F, Alexander L, Desrosiers RC, O'Brien SJ, Somasundaran M, Luzuriaga K, Sullivan JL. Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort. J Infect Dis. 1999 Dec; 180(6):1790-802.
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        10. Kiessling AA, Fitzgerald LM, Zhang D, Chhay H, Brettler D, Eyre RC, Steinberg J, McGowan K, Byrn RA. Human immunodeficiency virus in semen arises from a genetically distinct virus reservoir. AIDS Res Hum Retroviruses. 1998 Apr; 14 Suppl 1:S33-41.
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        11. Dubin DB, Hurowitz JC, Brettler D, Bernhard JD, Kadin ME, Wallace JE, Woda B, Pihan G, Kupper TS, Harrist TJ. Adnexotropic T-cell lymphoma presenting with generalized anhidrosis, progressive alopecia, pruritus, and Sjögren's syndrome. J Am Acad Dermatol. 1998 Mar; 38(3):493-7.
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        12. Greenough TC, Brettler DB, Somasundaran M, Panicali DL, Sullivan JL. Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes (CTL), virus load, and CD4 T cell loss: evidence supporting a protective role for CTL in vivo. J Infect Dis. 1997 Jul; 176(1):118-25.
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        13. Brettler DB. A recombinant circumsporozoite protein vaccine against malaria. N Engl J Med. 1997 Jun 12; 336(24):1759; author reply 1760-1.
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        14. Ragni MV, Belle SH, Jaffe R, Locker J, Duerstein SL, Bass DC, Addiego JE, Aledort LM, Barron LE, Brettler DB, Buchanan GR, Gill JC, Ewenstein BM, Green D, Hilgartner MW, Hoots WK, Kisker CT, Lovrien EW, Rutherford CJ, Sanders NL, Smith KJ, Stabler SP, Swindells S, White GC, Kingsley LA. AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs. Hemophilia Malignancy Study Group. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Sep; 13(1):78-86.
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        15. Shopnick RI, Brettler DB. Hemostasis: a practical review of conservative and operative care. Clin Orthop Relat Res. 1996 Jul; (328):34-8.
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        16. Brettler DB. Inhibitors in congenital haemophilia. Baillieres Clin Haematol. 1996 Jun; 9(2):319-29.
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        17. Shopnick RI, Kazemi M, Brettler DB, Buckwalter C, Yang L, Bray G, Gomperts ED. Anaphylaxis after treatment with recombinant factor VIII. Transfusion. 1996 Apr; 36(4):358-61.
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        18. Shopnick RI, Brettler DB, Bolivar E. Hepatitis C virus transmission by monoclonal purified viral-attenuated factor VIII concentrate. Lancet. 1995 Sep 2; 346(8975):645.
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        19. Brettler D, Soudry M. Tibial bone plug resorption with extra-articular cyst: a rare complication of anterior cruciate ligament reconstruction. Arthroscopy. 1995 Aug; 11(4):478-81.
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        20. Kirchhoff F, Greenough TC, Brettler DB, Sullivan JL, Desrosiers RC. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med. 1995 Jan 26; 332(4):228-32.
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        21. Berntorp E, Boulyjenkov V, Brettler D, Chandy M, Jones P, Lee C, Lusher J, Mannucci P, Peak I, Rickard K, et al. Modern treatment of haemophilia. Bull World Health Organ. 1995; 73(5):691-701.
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        22. Brettler D. Menisectomy used to describe removal of meniscal tissue from the knee. Arthroscopy. 1994 Dec; 10(6):700.
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        23. Mendes DG, Soudry M, Brettler D, Beer R. [Stabilization double osteotomy of the knee]. Harefuah. 1994 May 15; 126(10):576-9, 627.
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        24. Mannucci PM, Brettler DB, Aledort LM, Lusher JM, Abildgaard CF, Schwartz RS, Hurst D. Immune status of human immunodeficiency virus seropositive and seronegative hemophiliacs infused for 3.5 years with recombinant factor VIII. The Kogenate Study Group. Blood. 1994 Apr 1; 83(7):1958-62.
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        25. Greenough TC, Somasundaran M, Brettler DB, Hesselton RM, Alimenti A, Kirchhoff F, Panicali D, Sullivan JL. Normal immune function and inability to isolate virus in culture in an individual with long-term human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses. 1994 Apr; 10(4):395-403.
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        26. Brettler D. A 3.5-year study of immune function in persons with hemophilia infusing recombinant factor VIII. Ann Hematol. 1994; 68 Suppl 3:S49-50.
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        27. Seremetis SV, Aledort LM, Bergman GE, Bona R, Bray G, Brettler D, Eyster ME, Kessler C, Lau TS, Lusher J, et al. Three-year randomised study of high-purity or intermediate-purity factor VIII concentrates in symptom-free HIV-seropositive haemophiliacs: effects on immune status. Lancet. 1993 Sep 18; 342(8873):700-3.
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        28. Kiessling AA, Crowell RC, Brettler D, Forsberg A, Wolf B. Human immunodeficiency virus detection and differential leukocyte counts are accurate and safer with formaldehyde-fixed blood. Blood. 1993 Feb 1; 81(3):864-5.
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        29. Brettler DB. Inhibitors of factor VIII: detection and treatment. Southeast Asian J Trop Med Public Health. 1993; 24 Suppl 1:21-5.
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        30. Brettler DB. Comprehensive hemophilia care and home factor infusions. Southeast Asian J Trop Med Public Health. 1993; 24 Suppl 1:41-2.
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        31. Brettler DB, Somasundaran M, Forsberg AF, Krause E, Sullivan JL. Silent human immunodeficiency virus type 1 infection: a rare occurrence in a high-risk heterosexual population. Blood. 1992 Nov 1; 80(9):2396-400.
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        32. Brettler DB, Mannucci PM, Gringeri A, Rasko JE, Forsberg AD, Rumi MG, Garsia RJ, Rickard KA, Colombo M. The low risk of hepatitis C virus transmission among sexual partners of hepatitis C-infected hemophilic males: an international, multicenter study. Blood. 1992 Jul 15; 80(2):540-3.
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        33. Bauer KA, Mannucci PM, Gringeri A, Tradati F, Barzegar S, Kass BL, ten Cate H, Kestin AS, Brettler DB, Rosenberg RD. Factor IXa-factor VIIIa-cell surface complex does not contribute to the basal activation of the coagulation mechanism in vivo. Blood. 1992 Apr 15; 79(8):2039-47.
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        34. Mannucci PM, Schimpf K, Abe T, Aledort LM, Anderle K, Brettler DB, Hilgartner MW, Kernoff PB, Kunschak M, McMillan CW, et al. Low risk of viral infection after administration of vapor-heated factor VIII concentrate. International Investigator Group. Transfusion. 1992 Feb; 32(2):134-8.
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        35. Kasper CK, Mannucci PM, Bulyzhenkov V, Brettler DB, Chuansumrit A, Heijnen L, Isarankura P, Kernoff PB, Peake I, Rickard KA, et al. Hemophilia in the 1990s: principles of management and improved access to care. Semin Thromb Hemost. 1992 Jan; 18(1):1-10.
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        36. Koup RA, Pikora CA, Luzuriaga K, Brettler DB, Day ES, Mazzara GP, Sullivan JL. Limiting dilution analysis of cytotoxic T lymphocytes to human immunodeficiency virus gag antigens in infected persons: in vitro quantitation of effector cell populations with p17 and p24 specificities. J Exp Med. 1991 Dec 1; 174(6):1593-600.
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        37. Kraus EM, Brettler DB, Forsberg AD, Sullivan JL. Pregnancy in a cohort of long-term partners of human immunodeficiency virus-seropositive hemophiliacs. Obstet Gynecol. 1991 Nov; 78(5 Pt 1):735-8.
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        38. Merigan TC, Amato DA, Balsley J, Power M, Price WA, Benoit S, Perez-Michael A, Brownstein A, Kramer AS, Brettler D, et al. Placebo-controlled trial to evaluate zidovudine in treatment of human immunodeficiency virus infection in asymptomatic patients with hemophilia. NHF-ACTG 036 Study Group. Blood. 1991 Aug 15; 78(4):900-6.
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        39. Luzuriaga K, Koup RA, Pikora CA, Brettler DB, Sullivan JL. Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected children. J Pediatr. 1991 Aug; 119(2):230-6.
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        40. Colombo M, Mannucci PM, Brettler DB, Girolami A, Lian EC, Rodeghiero F, Scharrer I, Smith PS, White GC. Hepatocellular carcinoma in hemophilia. Am J Hematol. 1991 Aug; 37(4):243-6.
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        41. Brettler DB. Comments on the development of inhibitor antibodies in patients using recombinant factor VIII concentrates. Semin Hematol. 1991 Apr; 28(2 Suppl 1):45-6.
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        42. Kasper CK, Mannucci PM, Bulyzhenkov V, Brettler DB, Chuansumrit A, Heijnen L, Isarankura P, Kernoff PB, Peake I, Rickard KA, et al. Haemophilia in the 1990s: report of a joint meeting of the World Health Organization and World Federation of Hemophilia. Vox Sang. 1991; 61(3):221-4.
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        43. Schwartz RS, Abildgaard CF, Aledort LM, Arkin S, Bloom AL, Brackmann HH, Brettler DB, Fukui H, Hilgartner MW, Inwood MJ, et al. Human recombinant DNA-derived antihemophilic factor (factor VIII) in the treatment of hemophilia A. recombinant Factor VIII Study Group. N Engl J Med. 1990 Dec 27; 323(26):1800-5.
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        44. Canavaggio M, Leckie G, Allain JP, Steaffens JW, Laurian Y, Brettler D, Lee H. The prevalence of antibody to HTLV-I/II in United States plasma donors and in United States and French hemophiliacs. Transfusion. 1990 Nov-Dec; 30(9):780-2.
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        45. Brettler DB, Forsberg A, Bolivar E, Brewster F, Sullivan J. Growth failure as a prognostic indicator for progression to acquired immunodeficiency syndrome in children with hemophilia. J Pediatr. 1990 Oct; 117(4):584-8.
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        46. Brettler DB, Alter HJ, Dienstag JL, Forsberg AD, Levine PH. Prevalence of hepatitis C virus antibody in a cohort of hemophilia patients. Blood. 1990 Jul 1; 76(1):254-6.
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        47. Mannucci PM, Schimpf K, Brettler DB, Ciavarella N, Colombo M, Haschke F, Lechner K, Lusher J, Weissbach G. Low risk for hepatitis C in hemophiliacs given a high-purity, pasteurized factor VIII concentrate. International Study Group. Ann Intern Med. 1990 Jul 1; 113(1):27-32.
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        48. Brettler DB. Proposed protocol for the evaluation of the effect of high purity factor concentrates on the immune system of hemophilia patients. Thromb Haemost. 1989 Sep 29; 62(2):811-2.
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        49. Brettler DB, Levine PH. Factor concentrates for treatment of hemophilia: which one to choose? Blood. 1989 Jun; 73(8):2067-73.
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        50. Brettler DB, Forsberg AD, Levine PH, Aledort LM, Hilgartner MW, Kasper CK, Lusher JM, McMillan C, Roberts H. The use of porcine factor VIII concentrate (Hyate:C) in the treatment of patients with inhibitor antibodies to factor VIII. A multicenter US experience. Arch Intern Med. 1989 Jun; 149(6):1381-5.
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        51. Brettler DB, Forsberg AD, Levine PH, Petillo J, Lamon K, Sullivan JL. Factor VIII:C concentrate purified from plasma using monoclonal antibodies: human studies. Blood. 1989 May 15; 73(7):1859-63.
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        52. Koup RA, Sullivan JL, Levine PH, Brettler D, Mahr A, Mazzara G, McKenzie S, Panicali D. Detection of major histocompatibility complex class I-restricted, HIV-specific cytotoxic T lymphocytes in the blood of infected hemophiliacs. Blood. 1989 May 15; 73(7):1909-14.
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        53. Kraus EM, Brettler DB. Assessment of reproductive risks and intentions by mothers of children with hemophilia. Am J Med Genet. 1988 Oct; 31(2):259-67.
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        54. Goldsmith GH, Baily RG, Brettler DB, Davidson WR, Ballard JO, Driscol TE, Greenberg JM, Kasper CK, Levine PH, Ratnoff OD. Primary pulmonary hypertension in patients with classic hemophilia. Ann Intern Med. 1988 Jun; 108(6):797-9.
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        55. Brettler DB, Forsberg AD, Levine PH, Andrews CA, Baker S, Sullivan JL. Human immunodeficiency virus isolation studies and antibody testing. Household contacts and sexual partners of persons with hemophilia. Arch Intern Med. 1988 Jun; 148(6):1299-301.
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        56. Andrews CA, Sullivan JL, Brettler DB, Brewster FE, Forsberg AD, Scesney S, Levine PH. Isolation of human immunodeficiency virus from hemophiliacs: correlation with clinical symptoms and immunologic abnormalities. J Pediatr. 1987 Nov; 111(5):672-7.
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        57. Brettler DB, Brewster F, Levine PH, Forsberg A, Baker S, Sullivan JL. Immunologic aberrations, HIV seropositivity and seroconversion rates in patients with hemophilia B. Blood. 1987 Jul; 70(1):276-81.
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        58. Brettler DB, Forsberg AD, Brewster F, Sullivan JL, Levine PH. Delayed cutaneous hypersensitivity reactions in hemophiliac subjects treated with factor concentrate. Am J Med. 1986 Oct; 81(4):607-11.
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        59. Sullivan JL, Brewster FE, Brettler DB, Forsberg AD, Cheeseman SH, Byron KS, Baker SM, Willitts DL, Lew RA, Levine PH. Hemophiliac immunodeficiency: influence of exposure to factor VIII concentrate, LAV/HTLV-III, and herpesviruses. J Pediatr. 1986 Apr; 108(4):504-10.
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        60. Jacobson IM, Dienstag JL, Werner BG, Brettler DB, Levine PH, Mushahwar IK. Epidemiology and clinical impact of hepatitis D virus (delta) infection. Hepatology. 1985 Mar-Apr; 5(2):188-91.
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        61. Levine PH, Brettler DB, Sullivan JL. Hemophilia and acquired immune deficiency syndrome. Prog Clin Biol Res. 1985; 182:287-96.
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        62. Brettler DB, Forsberg AD, O'Connell FD, Cederbaum AI, Chaitman AK, Levine PH. A long-term study of hemophilic arthropathy of the knee joint on a program of Factor VIII replacement given at time of each hemarthrosis. Am J Hematol. 1985 Jan; 18(1):13-8.
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        63. Kitchen LW, Barin F, Sullivan JL, McLane MF, Brettler DB, Levine PH, Essex M. Aetiology of AIDS--antibodies to human T-cell leukaemia virus (type III) in haemophiliacs. Nature. 1984 Nov 22-28; 312(5992):367-9.
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        64. Cheeseman SH, Sullivan JL, Brettler DB, Levine PH. Analysis of cytomegalovirus and Epstein-Barr virus antibody responses in treated hemophiliacs. Implications for the study of acquired immune deficiency syndrome. JAMA. 1984 Jul 6; 252(1):83-5.
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        65. Tauber AI, Brettler DB, Kennington EA, Blumberg PM. Relation of human neutrophil phorbol ester receptor occupancy and NADPH-oxidase activity. Blood. 1982 Aug; 60(2):333-9.
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        66. Brettler D, Sedlin ED, Mendes DG. Conservative treatment of low velocity gunshot wounds. Clin Orthop Relat Res. 1979 May; (140):26-31.
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