Sign in to edit your profile (add interests, mentoring, photo, etc.)
    Keywords
    Last Name
    Institution

    Eduardo M Torres PhD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentProgram in Molecular Medicine
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB
    Worcester MA 01605
    Phone508-856-4353
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentProgram in Gene Function and Expression

        Overview 
        Narrative
        Aneuploidy is defined as the state of having a chromosome number that is not an exact multiple of the haploid number. In humans, aneuploidy is the major cause of miscarriages and mental retardation. Although aneuploidy was recognized as a common feature of cancer cells more than a century ago, little is known about its consequences on cellular physiology. Whether aneuploidy is a result or plays a causative role in tumor initiation, progression, or maintenance remains unclear. Our research interests are focused on understanding how aneuploidy affects cellular physiology and metabolism, and how aneuploidy influences cell evolution leading to further gross genomic alterations. Utilizing Saccharomyces cerevisiae as a model organism, we generated a series of aneuploid strains, each carrying an additional copy of 1 of the 16 yeast chromosomes and characterized their effects on cell physiology. These experiments demonstrated that aneuploidy confers a proliferation disadvantage and alters cellular metabolism independent of the identity of the extra chromosome. More recently, we showed that aneuploid yeast cells can quickly evolve and acquire common genomic alterations that lead to improved cellular fitness. Several gene mutations that we found to improve fitness regulate protein turnover and sphingolipid metabolism. These findings profoundly alter our understanding of aneuploidy and might potentially allow for the future development of novel anti-cancer therapies.

        Rotation Projects
        Rotations are available in this laboratory. Please contact Dr. Torres for details.


        Post Docs

        A postdoctoral fellow position is available for a highly motivated candidate to join us in the Program in Molecular Medicine at the University of Massachusetts Medical School. Our research interests are focused on understanding how aneuploidy affects cellular physiology and metabolism, and how aneuploidy influences cell evolution leading to further gross genomic alterations.

         

        The Candidates should have a recent Ph.D or M.D/Ph.D degree in Cancer Biology, Genetics, Biochemistry, Cell Biology or related field. The candidates must also have a proven track record of productivity and research experience. They should be highly motivated, have a strong desire to learn and excellent communication skills.

         

        Applicats should send their CV, summary of previous research and the name of three references that may be contacted to Dr. Eduardo Torres, e-mail: Eduardo.torres@umassmed.edu (address: 364 Plantation Street, LRB -523, Worcester, MA  01605-4321



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Dephoure N, Hwang S, O'Sullivan C, Dodgson SE, Gygi SP, Amon A, Torres EM. Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast. Elife. 2014; 3:e03023.
          View in: PubMed
        2. Sheltzer JM, Torres EM, Dunham MJ, Amon A. Transcriptional consequences of aneuploidy. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12644-9.
          View in: PubMed
        3. Torres EM, Williams BR, Tang YC, Amon A. Thoughts on aneuploidy. Cold Spring Harb Symp Quant Biol. 2010; 75:445-51.
          View in: PubMed
        4. Torres EM, Dephoure N, Panneerselvam A, Tucker CM, Whittaker CA, Gygi SP, Dunham MJ, Amon A. Identification of aneuploidy-tolerating mutations. Cell. 2010 Oct 1; 143(1):71-83.
          View in: PubMed
        5. Torres EM, Williams BR, Amon A. Aneuploidy: cells losing their balance. Genetics. 2008 Jun; 179(2):737-46.
          View in: PubMed
        6. Torres EM, Sokolsky T, Tucker CM, Chan LY, Boselli M, Dunham MJ, Amon A. Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science. 2007 Aug 17; 317(5840):916-24.
          View in: PubMed
        7. Torres E, Rosen MK. Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP. J Biol Chem. 2006 Feb 10; 281(6):3513-20.
          View in: PubMed
        8. Panchal SC, Kaiser DA, Torres E, Pollard TD, Rosen MK. A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex. Nat Struct Biol. 2003 Aug; 10(8):591-8.
          View in: PubMed
        9. Torres E, Rosen MK. Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP. Mol Cell. 2003 May; 11(5):1215-27.
          View in: PubMed
        For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
        Eduardo's Networks
        Click the "See All" links for more information and interactive visualizations!
        Concepts
        _
        Similar People
        _
        Same Department
        Physical Neighbors
        _

        This is an official Page/Publication of the University of Massachusetts Worcester Campus
        Office of the Vice Provost for Research, 55 Lake Ave North, Worcester, Massachusetts 01655
        Questions or Comments? Email: publicaffairs@umassmed.edu Phone: 508-856-1572