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    Laura Cristina Alonso MD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    368 Plantation Street, AS7-2047
    Worcester MA 01605
    Phone508-455-3640
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

        Biography 
        awards and honors
        Harvard College1989 - 1993B.A. Biochemistry
        University of Pennsylvania1993 - 1998M.D.
        University of Chicago Hospitals1998 - 1999Internship, Internal Medicine
        University of Chicago Hospitals1999 - 2000Residency, Internal Medicine
        University of Chicago Hospitals2000 - 2002Clinical fellowship, Endocrinology
        Rockefeller University2002 - 2005Research Fellowship, Stem Cell Biology
        University of Pittsburgh2005 - 2006Postdoctoral Scholar
        University of Pittsburgh2006 - 2008Instructor of Medicine
        University of Pittsburgh2008 - 2012Assistant Professor of Medicine
        Journal of Clinical Endocrinology and Metabolism2013 - 2016Editorial Board
        Overview 
        Narrative

        Academic background

        Laura Alonso is currently Associate Professor of Medicine and Director of Beta Cell Biological Studies at the University of Massachusetts Medical School, in the Department of Medicine, Division of Diabetes. She received her undergraduate degree from Harvard in Biochemistry, and her medical diploma from the University of Pennsylvania. She performed her clinical training in Internal Medicine at the University of Chicago, followed by a fellowship in Endocrinology and Metabolism, also at the University of Chicago. Her training in the basic sciences began during a summer internship with Dr. Eleanor Blakely at the Lawrence Berkeley Laboratory, continued during her undergraduate and medical education with Dr. John Dowling and Dr. Laurence Turka, respectively, and intensified during a five-year postdoctoral fellowship with Dr. Elaine Fuchs which began at the University of Chicago and was completed at the Rockefeller University. Training in Islet Biology commenced with her move to the University of Pittsburgh, where she trained with Dr. Adolfo Garcia-Ocana and Dr. Andrew Stewart.
         

        Clinical work in Diabetes and Endocrinology

        Dr. Alonso sees patients in the Diabetes Clinic in the Ambulatory Care Center at the University of Massachusetts, University Campus, as well as rounding on the inpatient Diabetes and Endocrinology Consult service.
         

        Regulation of pancreatic beta cell mass

        Dr. Alonso's research lab is focused on finding ways to increase the number of insulin-secreting pancreatic beta cells, so as to prevent or treat diabetes. She uses mouse models to determine how nutrients influence beta cell proliferation, with the goal of identifying therapeutic pathways that can be exploited to expand human beta cell mass. 


        Post Docs
        An NIH funded postdoctoral position is currently available in the Alonso lab. The successful candidate will be highly motivated, intellectually curious and have the skills and drive to lead a funded research program in the future.

        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Sharma RB, Alonso LC. Lipotoxicity in the pancreatic Beta cell: not just survival and function, but proliferation as well? Curr Diab Rep. 2014 Jun; 14(6):492.
          View in: PubMed
        2. Jurczyk A, Bortell R, Alonso LC. Human ß-cell regeneration: progress, hurdles, and controversy. Curr Opin Endocrinol Diabetes Obes. 2014 Apr; 21(2):102-8.
          View in: PubMed
        3. Song WJ, Mondal P, Wolfe A, Alonso LC, Stamateris R, Ong BW, Lim OC, Yang KS, Radovick S, Novaira HJ, Farber EA, Farber CR, Turner SD, Hussain MA. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014 Apr 1; 19(4):667-81.
          View in: PubMed
        4. Kilic G, Alvarez-Mercado AI, Zarrouki B, Opland D, Liew CW, Alonso LC, Myers MG, Jonas JC, Poitout V, Kulkarni RN, Mauvais-Jarvis F. The Islet Estrogen Receptor-a Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes. PLoS One. 2014; 9(2):e87941.
          View in: PubMed
        5. Watanabe Y, Singamsetty S, Zou B, Guo L, Stefanovski D, Alonso LC, Garcia-Ocana A, O'Donnell CP, McVerry BJ. Exogenous glucose administration impairs glucose tolerance and pancreatic insulin secretion during acute sepsis in non-diabetic mice. PLoS One. 2013; 8(6):e67716.
          View in: PubMed
        6. Stamateris RE, Sharma RB, Hollern DA, Alonso LC. Adaptive ß-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression. Am J Physiol Endocrinol Metab. 2013 Jul 1; 305(1):E149-59.
          View in: PubMed
        7. Lee EJ, Alonso LC, Stefanovski D, Strollo HC, Romano LC, Zou B, Singamsetty S, Yester KA, McGaffin KR, Garcia-Ocana A, O'Donnell CP. Time-dependent changes in glucose and insulin regulation during intermittent hypoxia and continuous hypoxia. Eur J Appl Physiol. 2013 Feb; 113(2):467-78.
          View in: PubMed
        8. Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK. ChREBP mediates glucose-stimulated pancreatic ß-cell proliferation. Diabetes. 2012 Aug; 61(8):2004-15.
          View in: PubMed
        9. Demirci C, Ernst S, Alvarez-Perez JC, Rosa T, Valle S, Shridhar V, Casinelli GP, Alonso LC, Vasavada RC, García-Ocana A. Loss of HGF/c-Met signaling in pancreatic ß-cells leads to incomplete maternal ß-cell adaptation and gestational diabetes mellitus. Diabetes. 2012 May; 61(5):1143-52.
          View in: PubMed
        10. Alonso LC, Watanabe Y, Stefanovski D, Lee EJ, Singamsetty S, Romano LC, Zou B, Garcia-Ocaña A, Bergman RN, O'Donnell CP. Simultaneous measurement of insulin sensitivity, insulin secretion, and the disposition index in conscious unhandled mice. Obesity (Silver Spring). 2012 Jul; 20(7):1403-12.
          View in: PubMed
        11. Pascoe J, Hollern D, Stamateris R, Abbasi M, Romano LC, Zou B, O'Donnell CP, Garcia-Ocana A, Alonso LC. Free fatty acids block glucose-induced ß-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18. Diabetes. 2012 Mar; 61(3):632-41.
          View in: PubMed
        12. Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC, Alonso LC, Garcia-Ocaña A. Activation of protein kinase C-? in pancreatic ß-cells in vivo improves glucose tolerance and induces ß-cell expansion via mTOR activation. Diabetes. 2011 Oct; 60(10):2546-59.
          View in: PubMed
        13. Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC, Garcia-Ocaña A. Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. Diabetes. 2011 Feb; 60(2):525-36.
          View in: PubMed
        14. Levitt HE, Cyphert TJ, Pascoe JL, Hollern DA, Abraham N, Lundell RJ, Rosa T, Romano LC, Zou B, O'Donnell CP, Stewart AF, Garcia-Ocaña A, Alonso LC. Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice. Diabetologia. 2011 Mar; 54(3):572-82.
          View in: PubMed
        15. Woodske ME, Yokoe T, Zou B, Romano LC, Rosa TC, Garcia-Ocana A, Alonso LC, O'Donnell CP, McVerry BJ. Hyperinsulinemia predicts survival in a hyperglycemic mouse model of critical illness. Crit Care Med. 2009 Sep; 37(9):2596-603.
          View in: PubMed
        16. Yokoe T, Alonso LC, Romano LC, Rosa TC, O'Doherty RM, Garcia-Ocana A, Minoguchi K, O'Donnell CP. Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice. J Physiol. 2008 Feb 1; 586(3):899-911.
          View in: PubMed
        17. Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, O'Donnell CP, Garcia-Ocaña A. Glucose infusion in mice: a new model to induce beta-cell replication. Diabetes. 2007 Jul; 56(7):1792-801.
          View in: PubMed
        18. Iiyori N, Alonso LC, Li J, Sanders MH, Garcia-Ocana A, O'Doherty RM, Polotsky VY, O'Donnell CP. Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am J Respir Crit Care Med. 2007 Apr 15; 175(8):851-7.
          View in: PubMed
        19. Alonso L, Fuchs E. The hair cycle. J Cell Sci. 2006 Feb 1; 119(Pt 3):391-3.
          View in: PubMed
        20. Alonso L, Okada H, Pasolli HA, Wakeham A, You-Ten AI, Mak TW, Fuchs E. Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle. J Cell Biol. 2005 Aug 15; 170(4):559-70.
          View in: PubMed
        21. Kobielak K, Pasolli HA, Alonso L, Polak L, Fuchs E. Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol. 2003 Nov 10; 163(3):609-23.
          View in: PubMed
        22. Alonso L, Fuchs E. Stem cells of the skin epithelium. Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11830-5.
          View in: PubMed
        23. Alonso L, Fuchs E. Stem cells in the skin: waste not, Wnt not. Genes Dev. 2003 May 15; 17(10):1189-200.
          View in: PubMed
        24. Alonso LC, Rosenfield RL. Molecular genetic and endocrine mechanisms of hair growth. Horm Res. 2003; 60(1):1-13.
          View in: PubMed
        25. Alonso LC, Rosenfield RL. Oestrogens and puberty. Best Pract Res Clin Endocrinol Metab. 2002 Mar; 16(1):13-30.
          View in: PubMed
        26. Pohlenz J, Manders L, Sadow PM, Kansal PC, Refetoff S, Weiss RE. A novel point mutation in cluster 3 of the thyroid hormone receptor beta gene (P247L) causing mild resistance to thyroid hormone. Thyroid. 1999 Dec; 9(12):1195-203.
          View in: PubMed
        27. Rosengard AM, Alonso LC, Korb LC, Baldwin WM, Sanfilippo F, Turka LA, Ahearn JM. Functional characterization of soluble and membrane-bound forms of vaccinia virus complement control protein (VCP). Mol Immunol. 1999 Jul; 36(10):685-97.
          View in: PubMed
        28. Judge TA, Desai NM, Yang Z, Rostami S, Alonso L, Zhang H, Chen Y, Markman JF, DeMateo RP, Barker CF, Naji A, Turka LA. Utility of adenoviral-mediated Fas ligand gene transfer to modulate islet allograft survival. Transplantation. 1998 Aug 27; 66(4):426-34.
          View in: PubMed
        29. Budenz DL, Bennett J, Alonso L, Maguire A. In vivo gene transfer into murine corneal endothelial and trabecular meshwork cells. Invest Ophthalmol Vis Sci. 1995 Oct; 36(11):2211-5.
          View in: PubMed
        30. Blakely EA, Daftari IK, Meecham WJ, Alonso LC, Collier JM, Kroll SM, Gillette EL, Lee AC, Lett JT, Cox AB, Castro JR, Char DH. Helium-ion-induced human cataractogenesis. Adv Space Res. 1994 Oct; 14(10):501-5.
          View in: PubMed
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