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    Philippe Moullier MD, PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentNeurology
    AddressUniversity of Massachusetts Medical School
    55 Lake Ave North
    Worcester MA 01605
        Bibliographic 
        selected publications
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        1. Bucher T, Colle MA, Wakeling E, Dubreil L, Fyfe J, Briot-Nivard D, Maquigneau M, Raoul S, Cherel Y, Astord S, Duque S, Marais T, Voit T, Moullier P, Barkats M, Joussemet B. scAAV9 Intracisternal Delivery Results in Efficient Gene Transfer to the Central Nervous System of a Feline Model of Motor Neuron Disease. Hum Gene Ther. 2013 Jul; 24(7):670-82.
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        2. Petit L, Lhériteau E, Weber M, Le Meur G, Deschamps JY, Provost N, Mendes-Madeira A, Libeau L, Guihal C, Colle MA, Moullier P, Rolling F. Restoration of Vision in the pde6ß-deficient Dog, a Large Animal Model of Rod-cone Dystrophy. Mol Ther. 2012 Nov; 20(11):2019-30.
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        3. Wakeling EN, Joussemet B, Costiou P, Fanuel D, Moullier P, Barkats M, Fyfe JC. Failure of lower motor neuron radial outgrowth precedes retrograde degeneration in a feline model of spinal muscular atrophy. J Comp Neurol. 2012 Jun 1; 520(8):1737-50.
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        4. Veron P, Leborgne C, Monteilhet V, Boutin S, Martin S, Moullier P, Masurier C. Humoral and cellular capsid-specific immune responses to adeno-associated virus type 1 in randomized healthy donors. J Immunol. 2012 Jun 15; 188(12):6418-24.
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        5. Ni W, Le Guiner C, Moullier P, Snyder RO. Development and Utility of an Internal Threshold Control (ITC) Real-Time PCR Assay for Exogenous DNA Detection. PLoS One. 2012; 7(5):e36461.
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        6. Denard J, Beley C, Kotin R, Lai-Kuen R, Blot S, Leh H, Asokan A, Samulski RJ, Moullier P, Voit T, Garcia L, Svinartchouk F. Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6. J Virol. 2012 Jun; 86(12):6620-31.
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        7. Nowrouzi A, Penaud-Budloo M, Kaeppel C, Appelt U, Le Guiner C, Moullier P, Kalle Cv, Snyder RO, Schmidt M. Integration Frequency and Intermolecular Recombination of rAAV Vectors in Non-human Primate Skeletal Muscle and Liver. Mol Ther. 2012 Jun; 20(6):1177-86.
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        8. Moullier P, Snyder RO. Recombinant adeno-associated viral vector reference standards. Methods Enzymol. 2012; 507:297-311.
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        9. Joussemet B, Belbellaa B, Mendes-Madeira A, Bucher T, Briot-Nivard D, Dubreil L, Colle MA, Cherel Y, Moullier P, Rolling F. Neonatal systemic delivery of scAAV9 in rodents and large animals results in gene transfer to RPE cells in the retina. Exp Eye Res. 2011 Oct; 93(4):491-502.
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        10. Léger A, Le Guiner C, Nickerson ML, McGee Im K, Ferry N, Moullier P, Snyder RO, Penaud-Budloo M. Adeno-associated viral vector-mediated transgene expression is independent of DNA methylation in primate liver and skeletal muscle. PLoS One. 2011; 6(6):e20881.
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        11. Monteilhet V, Saheb S, Boutin S, Leborgne C, Veron P, Montus MF, Moullier P, Benveniste O, Masurier C. A 10 Patient Case Report on the Impact of Plasmapheresis Upon Neutralizing Factors Against Adeno-associated Virus (AAV) Types 1, 2, 6, and 8. Mol Ther. 2011 Nov; 19(11):2084-91.
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        12. Ni W, Le Guiner C, Gernoux G, Penaud-Budloo M, Moullier P, Snyder RO. Longevity of rAAV vector and plasmid DNA in blood after intramuscular injection in nonhuman primates: implications for gene doping. Gene Ther. 2011 Jul; 18(7):709-18.
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        13. Ellinwood NM, Ausseil J, Desmaris N, Bigou S, Liu S, Jens JK, Snella EM, Mohammed EE, Thomson CB, Raoul S, Joussemet B, Roux F, Chérel Y, Lajat Y, Piraud M, Benchaouir R, Hermening S, Petry H, Froissart R, Tardieu M, Ciron C, Moullier P, Parkes J, Kline KL, Maire I, Vanier MT, Heard JM, Colle MA. Safe, efficient, and reproducible gene therapy of the brain in the dog models of Sanfilippo and Hurler syndromes. Mol Ther. 2011 Feb; 19(2):251-9.
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        14. Lock M, McGorray S, Auricchio A, Ayuso E, Beecham EJ, Blouin-Tavel V, Bosch F, Bose M, Byrne BJ, Caton T, Chiorini JA, Chtarto A, Clark KR, Conlon T, Darmon C, Doria M, Douar A, Flotte TR, Francis JD, Francois A, Giacca M, Korn MT, Korytov I, Leon X, Leuchs B, Lux G, Melas C, Mizukami H, Moullier P, Müller M, Ozawa K, Philipsberg T, Poulard K, Raupp C, Rivière C, Roosendaal SD, Samulski RJ, Soltys SM, Surosky R, Tenenbaum L, Thomas DL, van Montfort B, Veres G, Wright JF, Xu Y, Zelenaia O, Zentilin L, Snyder RO. Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material. Hum Gene Ther. 2010 Oct; 21(10):1273-85.
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        15. Lhériteau E, Libeau L, Mendes-Madeira A, Deschamps JY, Weber M, Le Meur G, Provost N, Guihal C, Moullier P, Rolling F. Regulation of retinal function but nonrescue of vision in RPE65-deficient dogs treated with doxycycline-regulatable AAV vectors. Mol Ther. 2010 Jun; 18(6):1085-93.
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        16. Colle MA, Piguet F, Bertrand L, Raoul S, Bieche I, Dubreil L, Sloothaak D, Bouquet C, Moullier P, Aubourg P, Cherel Y, Cartier N, Sevin C. Efficient intracerebral delivery of AAV5 vector encoding human ARSA in non-human primate. Hum Mol Genet. 2010 Jan 1; 19(1):147-58.
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        17. Toromanoff A, Adjali O, Larcher T, Hill M, Guigand L, Chenuaud P, Deschamps JY, Gauthier O, Blancho G, Vanhove B, Rolling F, Chérel Y, Moullier P, Anegon I, Le Guiner C. Lack of immunotoxicity after regional intravenous (RI) delivery of rAAV to nonhuman primate skeletal muscle. Mol Ther. 2010 Jan; 18(1):151-60.
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        18. Moreau A, Hill M, Thébault P, Deschamps JY, Chiffoleau E, Chauveau C, Moullier P, Anegon I, Alliot-Licht B, Cuturi MC. Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates. FASEB J. 2009 Sep; 23(9):3070-7.
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        19. Stieger K, Belbellaa B, Le Guiner C, Moullier P, Rolling F. In vivo gene regulation using tetracycline-regulatable systems. Adv Drug Deliv Rev. 2009 Jul 2; 61(7-8):527-41.
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        20. Duque S, Joussemet B, Riviere C, Marais T, Dubreil L, Douar AM, Fyfe J, Moullier P, Colle MA, Barkats M. Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons. Mol Ther. 2009 Jul; 17(7):1187-96.
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        21. Ciron C, Cressant A, Roux F, Raoul S, Cherel Y, Hantraye P, Déglon N, Schwartz B, Barkats M, Heard JM, Tardieu M, Moullier P, Colle MA. Human alpha-iduronidase gene transfer mediated by adeno-associated virus types 1, 2, and 5 in the brain of nonhuman primates: vector diffusion and biodistribution. Hum Gene Ther. 2009 Apr; 20(4):350-60.
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        22. Van Vliet K, Mohiuddin Y, McClung S, Blouin V, Rolling F, Moullier P, Agbandje-McKenna M, Snyder RO. Adeno-associated virus capsid serotype identification: Analytical methods development and application. J Virol Methods. 2009 Aug; 159(2):167-77.
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        23. Lhériteau E, Libeau L, Stieger K, Deschamps JY, Mendes-Madeira A, Provost N, Lemoine F, Mellersh C, Ellinwood NM, Cherel Y, Moullier P, Rolling F. The RPGRIP1-deficient dog, a promising canine model for gene therapy. Mol Vis. 2009; 15:349-61.
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        24. Stieger K, Schroeder J, Provost N, Mendes-Madeira A, Belbellaa B, Le Meur G, Weber M, Deschamps JY, Lorenz B, Moullier P, Rolling F. Detection of intact rAAV particles up to 6 years after successful gene transfer in the retina of dogs and primates. Mol Ther. 2009 Mar; 17(3):516-23.
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        25. Moreau A, Vicente R, Dubreil L, Adjali O, Podevin G, Jacquet C, Deschamps JY, Klatzmann D, Cherel Y, Taylor N, Moullier P, Zimmermann VS. Efficient intrathymic gene transfer following in situ administration of a rAAV serotype 8 vector in mice and nonhuman primates. Mol Ther. 2009 Mar; 17(3):472-9.
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        26. Moullier P, Snyder RO. International efforts for recombinant adeno-associated viral vector reference standards. Mol Ther. 2008 Jul; 16(7):1185-8.
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        27. Penaud-Budloo M, Le Guiner C, Nowrouzi A, Toromanoff A, Chérel Y, Chenuaud P, Schmidt M, von Kalle C, Rolling F, Moullier P, Snyder RO. Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle. J Virol. 2008 Aug; 82(16):7875-85.
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        28. Moreau A, Chiffoleau E, Beriou G, Deschamps JY, Heslan M, Ashton-Chess J, Rolling F, Josien R, Moullier P, Cuturi MC, Alliot-Licht B. Superiority of bone marrow-derived dendritic cells over monocyte-derived ones for the expansion of regulatory T cells in the macaque. Transplantation. 2008 May 15; 85(9):1351-6.
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        29. Toromanoff A, Chérel Y, Guilbaud M, Penaud-Budloo M, Snyder RO, Haskins ME, Deschamps JY, Guigand L, Podevin G, Arruda VR, High KA, Stedman HH, Rolling F, Anegon I, Moullier P, Le Guiner C. Safety and efficacy of regional intravenous (r.i.) versus intramuscular (i.m.) delivery of rAAV1 and rAAV8 to nonhuman primate skeletal muscle. Mol Ther. 2008 Jul; 16(7):1291-9.
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        30. Stieger K, Colle MA, Dubreil L, Mendes-Madeira A, Weber M, Le Meur G, Deschamps JY, Provost N, Nivard D, Cherel Y, Moullier P, Rolling F. Subretinal delivery of recombinant AAV serotype 8 vector in dogs results in gene transfer to neurons in the brain. Mol Ther. 2008 May; 16(5):916-23.
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        31. Guilbaud M, Chadeuf G, Avolio F, François A, Moullier P, Recchia A, Salvetti A. Relative influence of the adeno-associated virus (AAV) type 2 p5 element for recombinant AAV vector site-specific integration. J Virol. 2008 Mar; 82(5):2590-3.
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        32. Stieger K, Mendes-Madeira A, Meur GL, Weber M, Deschamps JY, Nivard D, Provost N, Moullier P, Rolling F. Oral administration of doxycycline allows tight control of transgene expression: a key step towards gene therapy of retinal diseases. Gene Ther. 2007 Dec; 14(23):1668-73.
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        33. Le Guiner C, Stieger K, Snyder RO, Rolling F, Moullier P. Immune responses to gene product of inducible promoters. Curr Gene Ther. 2007 Oct; 7(5):334-46.
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        34. Le Meur G, Stieger K, Smith AJ, Weber M, Deschamps JY, Nivard D, Mendes-Madeira A, Provost N, Péréon Y, Cherel Y, Ali RR, Hamel C, Moullier P, Rolling F. Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium. Gene Ther. 2007 Feb; 14(4):292-303.
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        35. Ciron C, Desmaris N, Colle MA, Raoul S, Joussemet B, Vérot L, Ausseil J, Froissart R, Roux F, Chérel Y, Ferry N, Lajat Y, Schwartz B, Vanier MT, Maire I, Tardieu M, Moullier P, Heard JM. Gene therapy of the brain in the dog model of Hurler's syndrome. Ann Neurol. 2006 Aug; 60(2):204-13.
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        36. Stieger K, Le Meur G, Lasne F, Weber M, Deschamps JY, Nivard D, Mendes-Madeira A, Provost N, Martin L, Moullier P, Rolling F. Long-term doxycycline-regulated transgene expression in the retina of nonhuman primates following subretinal injection of recombinant AAV vectors. Mol Ther. 2006 May; 13(5):967-75.
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        37. Rolling F, Le Meur G, Stieger K, Smith AJ, Weber M, Deschamps JY, Nivard D, Mendes-Madeira A, Provost N, Péréon Y, Cherel Y, Ali RR, Hamel C, Moullier P, Rolling F. Gene therapeutic prospects in early onset of severe retinal dystrophy: restoration of vision in RPE65 Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium. Bull Mem Acad R Med Belg. 2006; 161(10-12):497-508; discussion 508-9.
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        38. Chadeuf G, Ciron C, Moullier P, Salvetti A. Evidence for encapsidation of prokaryotic sequences during recombinant adeno-associated virus production and their in vivo persistence after vector delivery. Mol Ther. 2005 Oct; 12(4):744-53.
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        39. François A, Guilbaud M, Awedikian R, Chadeuf G, Moullier P, Salvetti A. The cellular TATA binding protein is required for rep-dependent replication of a minimal adeno-associated virus type 2 p5 element. J Virol. 2005 Sep; 79(17):11082-94.
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        40. Fraefel C, Mendes-Madeira A, Mabon O, Lefebvre A, Le Meur G, Ackermann M, Moullier P, Rolling F. In vivo gene transfer to the rat retina using herpes simplex virus type 1 (HSV-1)-based amplicon vectors. Gene Ther. 2005 Aug; 12(16):1283-8.
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        41. Awedikian R, François A, Guilbaud M, Moullier P, Salvetti A. Intracellular route and biological activity of exogenously delivered Rep proteins from the adeno-associated virus type 2. Virology. 2005 May 10; 335(2):252-63.
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        42. Le Meur G, Weber M, Péréon Y, Mendes-Madeira A, Nivard D, Deschamps JY, Moullier P, Rolling F. Postsurgical assessment and long-term safety of recombinant adeno-associated virus-mediated gene transfer into the retinas of dogs and primates. Arch Ophthalmol. 2005 Apr; 123(4):500-6.
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        43. Grez M, Galun E, Moullier P. The twelfth annual meeting of the European Society of Gene Therapy. Mol Ther. 2005 Feb; 11(2):178-9.
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        44. Provost N, Le Meur G, Weber M, Mendes-Madeira A, Podevin G, Cherel Y, Colle MA, Deschamps JY, Moullier P, Rolling F. Biodistribution of rAAV vectors following intraocular administration: evidence for the presence and persistence of vector DNA in the optic nerve and in the brain. Mol Ther. 2005 Feb; 11(2):275-83.
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        45. Geoffroy MC, Epstein AL, Toublanc E, Moullier P, Salvetti A. Herpes simplex virus type 1 ICP0 protein mediates activation of adeno-associated virus type 2 rep gene expression from a latent integrated form. J Virol. 2004 Oct; 78(20):10977-86.
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        46. Lasne F, Martin L, de Ceaurriz J, Larcher T, Moullier P, Chenuaud P. "Genetic Doping" with erythropoietin cDNA in primate muscle is detectable. Mol Ther. 2004 Sep; 10(3):409-10.
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        47. Serhan F, Penaud M, Petit C, Leste-Lasserre T, Trajcevski S, Klatzmann D, Duisit G, Sonigo P, Moullier P. Early detection of a two-long-terminal-repeat junction molecule in the cytoplasm of recombinant murine leukemia virus-infected cells. J Virol. 2004 Jun; 78(12):6190-9.
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        48. Toublanc E, Benraiss A, Bonnin D, Blouin V, Brument N, Cartier N, Epstein AL, Moullier P, Salvetti A. Identification of a replication-defective herpes simplex virus for recombinant adeno-associated virus type 2 (rAAV2) particle assembly using stable producer cell lines. J Gene Med. 2004 May; 6(5):555-64.
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        49. Chenuaud P, Larcher T, Rabinowitz JE, Provost N, Joussemet B, Bujard H, Samulski RJ, Favre D, Moullier P. Optimal design of a single recombinant adeno-associated virus derived from serotypes 1 and 2 to achieve more tightly regulated transgene expression from nonhuman primate muscle. Mol Ther. 2004 Mar; 9(3):410-8.
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        50. Blouin V, Brument N, Toublanc E, Raimbaud I, Moullier P, Salvetti A. Improving rAAV production and purification: towards the definition of a scaleable process. J Gene Med. 2004 Feb; 6 Suppl 1:S223-8.
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        51. Chenuaud P, Larcher T, Rabinowitz JE, Provost N, Cherel Y, Casadevall N, Samulski RJ, Moullier P. Autoimmune anemia in macaques following erythropoietin gene therapy. Blood. 2004 May 1; 103(9):3303-4.
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        52. Podevin G, Otta E, Nguyen JM, Pichard V, Aubert D, Moullier P, Ferry N. Factors influencing immune response after in vivo retrovirus-mediated gene transfer to the liver. J Gene Med. 2004 Jan; 6(1):16-21.
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        53. Weber M, Rabinowitz J, Provost N, Conrath H, Folliot S, Briot D, Chérel Y, Chenuaud P, Samulski J, Moullier P, Rolling F. Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subretinal delivery. Mol Ther. 2003 Jun; 7(6):774-81.
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        54. Folliot S, Briot D, Conrath H, Provost N, Cherel Y, Moullier P, Rolling F. Sustained tetracycline-regulated transgene expression in vivo in rat retinal ganglion cells using a single type 2 adeno-associated viral vector. J Gene Med. 2003 Jun; 5(6):493-501.
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        55. Aubert D, Pichard V, Durand S, Moullier P, Ferry N. Cytotoxic immune response after retroviral-mediated hepatic gene transfer in rat does not preclude expression from adeno-associated virus 1 transduced muscles. Hum Gene Ther. 2003 Mar 20; 14(5):473-81.
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        56. Nony P, Chadeuf G, Tessier J, Moullier P, Salvetti A. Evidence for packaging of rep-cap sequences into adeno-associated virus (AAV) type 2 capsids in the absence of inverted terminal repeats: a model for generation of rep-positive AAV particles. J Virol. 2003 Jan; 77(1):776-81.
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        57. Favre D, Blouin V, Provost N, Spisek R, Porrot F, Bohl D, Marmé F, Chérel Y, Salvetti A, Hurtrel B, Heard JM, Rivière Y, Moullier P. Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus. J Virol. 2002 Nov; 76(22):11605-11.
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        58. Brument N, Morenweiser R, Blouin V, Toublanc E, Raimbaud I, Chérel Y, Folliot S, Gaden F, Boulanger P, Kroner-Lux G, Moullier P, Rolling F, Salvetti A. A versatile and scalable two-step ion-exchange chromatography process for the purification of recombinant adeno-associated virus serotypes-2 and -5. Mol Ther. 2002 Nov; 6(5):678-86.
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        59. Duisit G, Conrath H, Saleun S, Folliot S, Provost N, Cosset FL, Sandrin V, Moullier P, Rolling F. Five recombinant simian immunodeficiency virus pseudotypes lead to exclusive transduction of retinal pigmented epithelium in rat. Mol Ther. 2002 Oct; 6(4):446-54.
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        60. Serhan F, Jourdan N, Saleun S, Moullier P, Duisit G. Characterization of producer cell-dependent restriction of murine leukemia virus replication. J Virol. 2002 Jul; 76(13):6609-17.
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        61. Aubert D, Ménoret S, Chiari E, Pichard V, Durand S, Tesson L, Moullier P, Anegon I, Ferry N. Cytotoxic immune response blunts long-term transgene expression after efficient retroviral-mediated hepatic gene transfer in rat. Mol Ther. 2002 Apr; 5(4):388-96.
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        62. Nègre D, Duisit G, Mangeot PE, Moullier P, Darlix JL, Cosset FL. Lentiviral vectors derived from simian immunodeficiency virus. Curr Top Microbiol Immunol. 2002; 261:53-74.
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        63. Favre D, Provost N, Blouin V, Blancho G, Chérel Y, Salvetti A, Moullier P. Immediate and long-term safety of recombinant adeno-associated virus injection into the nonhuman primate muscle. Mol Ther. 2001 Dec; 4(6):559-66.
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        64. Verdugo ME, Scarpino V, Moullier P, Haskins ME, Aguirre GD, Ray J. Adenoviral vector-mediated beta-glucuronidase cDNA transfer to treat MPS VII RPE in vitro. Curr Eye Res. 2001 Nov; 23(5):357-67.
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        65. Nony P, Tessier J, Chadeuf G, Ward P, Giraud A, Dugast M, Linden RM, Moullier P, Salvetti A. Novel cis-acting replication element in the adeno-associated virus type 2 genome is involved in amplification of integrated rep-cap sequences. J Virol. 2001 Oct; 75(20):9991-4.
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        66. Serguera C, Sarkis C, Ridet JL, Colin P, Moullier P, Mallet J. Primary adult human astrocytes as an ex vivo vehicle for beta-glucuronidase delivery in the brain. Mol Ther. 2001 Jun; 3(6):875-81.
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        67. Agard C, Ligeza C, Dupas B, Izembart A, El Kouri C, Moullier P, Ferry N. Immune-dependent distant bystander effect after adenovirus-mediated suicide gene transfer in a rat model of liver colorectal metastasis. Cancer Gene Ther. 2001 Feb; 8(2):128-36.
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        68. Tessier J, Chadeuf G, Nony P, Avet-Loiseau H, Moullier P, Salvetti A. Characterization of adenovirus-induced inverted terminal repeat-independent amplification of integrated adeno-associated virus rep-cap sequences. J Virol. 2001 Jan; 75(1):375-83.
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        69. Favre D, Ferry N, Moullier P. Critical aspects of viral vectors for gene transfer into the kidney. J Am Soc Nephrol. 2000 Nov; 11 Suppl 16:S149-53.
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        70. Nègre D, Mangeot PE, Duisit G, Blanchard S, Vidalain PO, Leissner P, Winter AJ, Rabourdin-Combe C, Mehtali M, Moullier P, Darlix JL, Cosset FL. Characterization of novel safe lentiviral vectors derived from simian immunodeficiency virus (SIVmac251) that efficiently transduce mature human dendritic cells. Gene Ther. 2000 Oct; 7(19):1613-23.
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        71. Favre D, Cherel Y, Provost N, Blouin V, Ferry N, Moullier P, Salvetti A. Hyaluronidase enhances recombinant adeno-associated virus (rAAV)-mediated gene transfer in the rat skeletal muscle. Gene Ther. 2000 Aug; 7(16):1417-20.
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        72. Chadeuf G, Favre D, Tessier J, Provost N, Nony P, Kleinschmidt J, Moullier P, Salvetti A. Efficient recombinant adeno-associated virus production by a stable rep-cap HeLa cell line correlates with adenovirus-induced amplification of the integrated rep-cap genome. J Gene Med. 2000 Jul-Aug; 2(4):260-8.
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        73. Izembart A, Aguado E, Gauthier O, Aubert D, Moullier P, Ferry N. In vivo retrovirus-mediated gene transfer to the liver of dogs results in transient expression and induction of a cytotoxic immune response. Hum Gene Ther. 1999 Dec 10; 10(18):2917-25.
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        74. Guillot C, David A, Coathalem H, Froud D, Tesson L, Moullier P, Le Mauff B, Usal C, Soulillou JP, Cuturi MC, Anegon I. Adenovirus-mediated cytokine gene transfer in heart allograft transplantation. Biochem Soc Trans. 1999 Dec; 27(6):864-9.
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        75. Duisit G, Saleun S, Douthe S, Barsoum J, Chadeuf G, Moullier P. Baculovirus vector requires electrostatic interactions including heparan sulfate for efficient gene transfer in mammalian cells. J Gene Med. 1999 Mar-Apr; 1(2):93-102.
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        76. Duisit G, Salvetti A, Moullier P, Cosset FL. Functional characterization of adenoviral/retroviral chimeric vectors and their use for efficient screening of retroviral producer cell lines. Hum Gene Ther. 1999 Jan 20; 10(2):189-200.
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        77. Bohl D, Salvetti A, Moullier P, Heard JM. Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vector. Blood. 1998 Sep 1; 92(5):1512-7.
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        78. Salvetti A, Orève S, Chadeuf G, Favre D, Cherel Y, Champion-Arnaud P, David-Ameline J, Moullier P. Factors influencing recombinant adeno-associated virus production. Hum Gene Ther. 1998 Mar 20; 9(5):695-706.
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        79. Ledoux S, Leroy C, Siegfried G, Prie D, Moullier P, Friedlander G. Overexpression of ecto-5'-nucleotidase promotes P-glycoprotein expression in renal epithelial cells. Kidney Int. 1997 Oct; 52(4):953-61.
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        80. Moullier P, Ferry N, Heard JM. [Principles and stakes of gene therapy]. Rev Prat. 1997 Jan 15; 47(2):174-81.
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        81. Rougier JP, Moullier P, Piedagnel R, Ronco PM. Hyperosmolality suppresses but TGF beta 1 increases MMP9 in human peritoneal mesothelial cells. Kidney Int. 1997 Jan; 51(1):337-47.
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        82. Moullier P, Salvetti A, Champion-Arnaud P, Ronco PM. Gene transfer into the kidney: current status and limitations. Nephron. 1997; 77(2):139-51.
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        83. Moullier P, Salvetti A, Bohl D, Danos O, Heard JM. [Gene therapy of lysosomal diseases]. Arch Pediatr. 1996; 3 Suppl 1:65s-68s.
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        84. Moullier P, Salvetti A, Bohl D, Danos O, Heard JM. [Gene therapy in lysosomal diseases]. C R Seances Soc Biol Fil. 1996; 190(1):45-51.
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        85. Salvetti A, Moullier P, Cornet V, Brooks D, Hopwood JJ, Danos O, Heard JM. In vivo delivery of human alpha-L-iduronidase in mice implanted with neo-organs. Hum Gene Ther. 1995 Sep; 6(9):1153-9.
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        86. Naffakh N, Henri A, Villeval JL, Rouyer-Fessard P, Moullier P, Blumenfeld N, Danos O, Vainchenker W, Heard JM, Beuzard Y. Sustained delivery of erythropoietin in mice by genetically modified skin fibroblasts. Proc Natl Acad Sci U S A. 1995 Apr 11; 92(8):3194-8.
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        96. Pontillon F, Moullier P, Ronco PM, Verroust PJ. Angiotensin II (AII)-related idiotypic network. I. Common occurrence of AII internal image on rabbit anti-idiotypic antibodies. J Immunol. 1988 May 1; 140(9):3052-8.
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