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    Leslie J Berg PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPathology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-8371
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentImmunology and Virology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentCenter for AIDS Research

        Biography 
        awards and honors
        American Association of Immunologists2001Pharmingen Investigator Award for Outstanding Contributions to the field of Immunology
        The Medical Foundation2002Chestnut Hill Award for Excellence in Research
        UMMS2002Outstanding Educator Award
        UMMS2003Educational Achievement Star Award
        UMMS2004Women in Science and Health Achievement Award
        American Association of Immunologists2006Distinguished Service Award
        UMMS2006Outstanding Mentoring Award
        UMMS2010Lamar Souter Award for Excellence in Medical Education
        American Association of Immunologists2011President
        Overview 
        Narrative

        Dr. Leslie Berg

        T lymphocyte development and activation

        The research in my laboratory is aimed at understanding the signal transduction pathways importantforTlymphocyte development and activation. For these studies, we use a combination of mouse genetics (transgenics and knockouts), biochemistry, and cellular immunology. Our current work focuses on three projects. First, we have identified a tyrosine kinase, Jak3, involved in cytokine receptor signaling, and have generated Jak3-deficient mice. These mice have severe defects in lymphocyte development and function. Second, we have identified a novel tyrosine kinase, Itk, involved in T cell receptor signaling. Using Itk-deficient mice generated in the lab we are currently examining the role of this protein in lymphocyte development and activation.



        Rotation Projects

        Potential Rotation Projects

        Please contact me at leslie.berg@umassmed.edu for information about current rotation projects.



        Post Docs

        A postdoctoral position is available to study in this laboratory. Contact Dr. Berg for additional details.

        Bibliographic 
        selected publications
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        1. Pereira RM, Martinez GJ, Engel I, Cruz-Guilloty F, Barboza BA, Tsagaratou A, Lio CW, Berg LJ, Lee Y, Kronenberg M, Bandukwala HS, Rao A. Jarid2 is induced by TCR signalling and controls iNKT cell maturation. Nat Commun. 2014; 5:4540.
          View in: PubMed
        2. Prince AL, Kraus Z, Carty SA, Ng C, Yin CC, Jordan MS, Schwartzberg PL, Berg LJ. Development of Innate CD4+ and CD8+ T Cells in Itk-Deficient Mice Is Regulated by Distinct Pathways. J Immunol. 2014 Jul 15; 193(2):688-99.
          View in: PubMed
        3. Kapoor VN, Shin HM, Cho OH, Berg LJ, Kang J, Welsh RM. Regulation of Tissue-Dependent Differences in CD8+ T Cell Apoptosis during Viral Infection. J Virol. 2014 Sep 1; 88(17):9490-503.
          View in: PubMed
        4. Prince AL, Watkin LB, Yin CC, Selin LK, Kang J, Schwartzberg PL, Berg LJ. Innate PLZF+CD4+ aß T Cells Develop and Expand in the Absence of Itk. J Immunol. 2014 Jul 15; 193(2):673-87.
          View in: PubMed
        5. Nayar R, Schutten E, Bautista B, Daniels K, Prince AL, Enos M, Brehm MA, Swain SL, Welsh RM, Berg LJ. Graded Levels of IRF4 Regulate CD8+ T Cell Differentiation and Expansion, but Not Attrition, in Response to Acute Virus Infection. J Immunol. 2014 Jun 15; 192(12):5881-93.
          View in: PubMed
        6. Jain N, Miu B, Jiang JK, McKinstry KK, Prince A, Swain SL, Greiner DL, Thomas CJ, Sanderson MJ, Berg LJ, Kang J. CD28 and ITK signals regulate autoreactive T cell trafficking. Nat Med. 2013 Dec; 19(12):1632-7.
          View in: PubMed
        7. Shin HM, Kapoor VN, Guan T, Kaech SM, Welsh RM, Berg LJ. Epigenetic modifications induced by Blimp-1 Regulate CD8? T cell memory progression during acute virus infection. Immunity. 2013 Oct 17; 39(4):661-75.
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        8. Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH. Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases. Sci Signal. 2013 Aug 27; 6(290):ra76.
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        9. Malhotra N, Narayan K, Cho OH, Sylvia KE, Yin C, Melichar H, Rashighi M, Lefebvre V, Harris JE, Berg LJ, Kang J. A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity. 2013 Apr 18; 38(4):681-93.
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        10. Yin CC, Cho OH, Sylvia KE, Narayan K, Prince AL, Evans JW, Kang J, Berg LJ. The Tec kinase ITK regulates thymic expansion, emigration, and maturation of ?d NKT cells. J Immunol. 2013 Mar 15; 190(6):2659-69.
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        11. Berg LJ. Signaling pathways that regulate T cell development and differentiation. J Immunol. 2012 Dec 15; 189(12):5487-8.
          View in: PubMed
        12. Nayar R, Enos M, Prince A, Shin H, Hemmers S, Jiang JK, Klein U, Thomas CJ, Berg LJ. TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. Proc Natl Acad Sci U S A. 2012 Oct 9; 109(41):E2794-802.
          View in: PubMed
        13. Narayan K, Sylvia KE, Malhotra N, Yin CC, Martens G, Vallerskog T, Kornfeld H, Xiong N, Cohen NR, Brenner MB, Berg LJ, Kang J. Intrathymic programming of effector fates in three molecularly distinct ?d T cell subtypes. Nat Immunol. 2012 May; 13(5):511-8.
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        14. Chang JT, Ciocca ML, Kinjyo I, Palanivel VR, McClurkin CE, Dejong CS, Mooney EC, Kim JS, Steinel NC, Oliaro J, Yin CC, Florea BI, Overkleeft HS, Berg LJ, Russell SM, Koretzky GA, Jordan MS, Reiner SL. Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity. 2011 Apr 22; 34(4):492-504.
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        15. Marshall HD, Prince AL, Berg LJ, Welsh RM. IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions. J Immunol. 2010 Aug 1; 185(3):1419-28.
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        16. Andreotti AH, Schwartzberg PL, Joseph RE, Berg LJ. T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harb Perspect Biol. 2010 Jul; 2(7):a002287.
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        17. Min L, Wu W, Joseph RE, Fulton DB, Berg L, Andreotti AH. Disrupting the intermolecular self-association of Itk enhances T cell signaling. J Immunol. 2010 Apr 15; 184(8):4228-35.
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        18. Berg LJ. Strength of T cell receptor signaling strikes again. Immunity. 2009 Oct 16; 31(4):529-31.
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        19. Shi M, Lin TH, Appell KC, Berg LJ. Cell cycle progression following naive T cell activation is independent of Jak3/common gamma-chain cytokine signals. J Immunol. 2009 Oct 1; 183(7):4493-501.
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        20. Sacristán C, Schattgen SA, Berg LJ, Bunnell SC, Roy AL, Rosenstein Y. Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells. Eur J Immunol. 2009 Sep; 39(9):2584-95.
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        21. Felices M, Yin CC, Kosaka Y, Kang J, Berg LJ. Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo. Proc Natl Acad Sci U S A. 2009 May 19; 106(20):8308-13.
          View in: PubMed
        22. Prince AL, Yin CC, Enos ME, Felices M, Berg LJ. The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development. Immunol Rev. 2009 Mar; 228(1):115-31.
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        23. Wu W, Berg LJ. c-Abl, an additional tyrosine kinase required for T cell development and function. Cell Cycle. 2008 Dec 15; 7(24):3791.
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        24. Berg LJ. The "bubble boy" paradox: an answer that led to a question. J Immunol. 2008 Nov 1; 181(9):5815-6.
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        25. Shi M, Lin TH, Appell KC, Berg LJ. Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity. 2008 Jun; 28(6):763-73.
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        26. Felices M, Berg LJ. The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. J Immunol. 2008 Mar 1; 180(5):3007-18.
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        27. Lucas JA, Felices M, Evans JW, Berg LJ. Subtle defects in pre-TCR signaling in the absence of the Tec kinase Itk. J Immunol. 2007 Dec 1; 179(11):7561-7.
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        28. Berg LJ. Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development. Nat Rev Immunol. 2007 Jun; 7(6):479-85.
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        29. Felices M, Falk M, Kosaka Y, Berg LJ. Tec kinases in T cell and mast cell signaling. Adv Immunol. 2007; 93:145-84.
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        30. Kosaka Y, Felices M, Berg LJ. Itk and Th2 responses: action but no reaction. Trends Immunol. 2006 Oct; 27(10):453-60.
          View in: PubMed
        31. Atherly LO, Lucas JA, Felices M, Yin CC, Reiner SL, Berg LJ. The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity. 2006 Jul; 25(1):79-91.
          View in: PubMed
        32. Ponganis PJ, Stockard TK, Levenson DH, Berg L, Baranov EA. Intravascular pressure profiles in elephant seals: hypotheses on the caval sphincter, extradural vein and venous return to the heart. Comp Biochem Physiol A Mol Integr Physiol. 2006 Sep; 145(1):123-30.
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        33. Ponganis PJ, Stockard TK, Levenson DH, Berg L, Baranov EA. Cardiac output and muscle blood flow during rest-associated apneas of elephant seals. Comp Biochem Physiol A Mol Integr Physiol. 2006 May; 144(1):105-11.
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        34. Mayack SR, Berg LJ. Cutting edge: an alternative pathway of CD4+ T cell differentiation is induced following activation in the absence of gamma-chain-dependent cytokine signals. J Immunol. 2006 Feb 15; 176(4):2059-63.
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        35. Atherly LO, Brehm MA, Welsh RM, Berg LJ. Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help. J Immunol. 2006 Feb 1; 176(3):1571-81.
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        36. Li CR, Berg LJ. Itk is not essential for CD28 signaling in naive T cells. J Immunol. 2005 Apr 15; 174(8):4475-9.
          View in: PubMed
        37. Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL. Tec family kinases in T lymphocyte development and function. Annu Rev Immunol. 2005; 23:549-600.
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        38. Miller AT, Wilcox HM, Lai Z, Berg LJ. Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. Immunity. 2004 Jul; 21(1):67-80.
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        39. Berg LJ, Nussenzweig M. Signals that regulate lymphocyte development and differentiation. Curr Opin Immunol. 2004 Apr; 16(2):163-6.
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        40. Wilcox HM, Berg LJ. Itk phosphorylation sites are required for functional activity in primary T cells. J Biol Chem. 2003 Sep 26; 278(39):37112-21.
          View in: PubMed
        41. Lucas JA, Miller AT, Atherly LO, Berg LJ. The role of Tec family kinases in T cell development and function. Immunol Rev. 2003 Feb; 191:119-38.
          View in: PubMed
        42. Vergara-Silva A, Schaefer KL, Berg LJ. Compartmentalized Eph receptor and ephrin expression in the thymus. Gene Expr Patterns. 2002 Dec; 2(3-4):261-5.
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        43. Vergara-Silva A, Schaefer KL, Berg LJ. Compartmentalized Eph receptor and ephrin expression in the thymus. Mech Dev. 2002 Dec; 119 Suppl 1:S225-9.
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        44. Lucas JA, Atherly LO, Berg LJ. The absence of Itk inhibits positive selection without changing lineage commitment. J Immunol. 2002 Jun 15; 168(12):6142-51.
          View in: PubMed
        45. Miller AT, Berg LJ. New insights into the regulation and functions of Tec family tyrosine kinases in the immune system. Curr Opin Immunol. 2002 Jun; 14(3):331-40.
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        46. Miller AT, Berg LJ. Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase. J Immunol. 2002 Mar 1; 168(5):2163-72.
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        47. Soldevila G, Castellanos C, Malissen M, Berg LJ. Analysis of the individual role of the TCRzeta chain in transgenic mice after conditional activation with chemical inducers of dimerization. Cell Immunol. 2001 Dec 15; 214(2):123-38.
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        48. Cui Y, Hackenmiller R, Berg L, Jean F, Nakayama T, Thomas G, Christian JL. The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor. Genes Dev. 2001 Nov 1; 15(21):2797-802.
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        49. Berg LJ, Kang J. Molecular determinants of TCR expression and selection. Curr Opin Immunol. 2001 Apr; 13(2):232-41.
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        50. Gozalo-Sanmillan S, McNally JM, Lin MY, Chambers CA, Berg LJ. Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice. J Immunol. 2001 Jan 15; 166(2):727-30.
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        51. Yang WC, Ching KA, Tsoukas CD, Berg LJ. Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain. J Immunol. 2001 Jan 1; 166(1):387-95.
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        52. Baird AM, Lucas JA, Berg LJ. A profound deficiency in thymic progenitor cells in mice lacking Jak3. J Immunol. 2000 Oct 1; 165(7):3680-8.
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        53. Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. J Biol Chem. 2000 Jan 21; 275(3):2219-30.
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        54. Berg L, Rönnelid J, Sanjeevi CB, Lampa J, Klareskog L. Interferon-gamma production in response to in vitro stimulation with collagen type II in rheumatoid arthritis is associated with HLA-DRB1(*)0401 and HLA-DQ8. Arthritis Res. 2000; 2(1):75-84.
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        55. Thomis DC, Aramburu J, Berg LJ. The Jak family tyrosine kinase Jak3 is required for IL-2 synthesis by naive/resting CD4+ T cells. J Immunol. 1999 Nov 15; 163(10):5411-7.
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        56. Grossman WJ, Verbsky JW, Yang L, Berg LJ, Fields LE, Chaplin DD, Ratner L. Dysregulated myelopoiesis in mice lacking Jak3. Blood. 1999 Aug 1; 94(3):932-9.
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        57. Fernandes DM, Baird AM, Berg LJ, Rock KL. A monoclonal antibody reactive with a 40-kDa molecule on fetal thymocytes and tumor cells blocks proliferation and stimulates aggregation and apoptosis. J Immunol. 1999 Aug 1; 163(3):1306-14.
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        58. Baird AM, Gerstein RM, Berg LJ. The role of cytokine receptor signaling in lymphocyte development. Curr Opin Immunol. 1999 Apr; 11(2):157-66.
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        59. Yelon D, Schaefer KL, Berg LJ. Alterations in CD4-binding regions of the MHC class II molecule I-Ek do not impede CD4+ T cell development. J Immunol. 1999 Feb 1; 162(3):1348-58.
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        60. Durum SK, Candèias S, Nakajima H, Leonard WJ, Baird AM, Berg LJ, Muegge K. Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility. J Exp Med. 1998 Dec 21; 188(12):2233-41.
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        61. Baird AM, Thomis DC, Berg LJ. T cell development and activation in Jak3-deficient mice. J Leukoc Biol. 1998 Jun; 63(6):669-77.
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        62. Liu KQ, Bunnell SC, Gurniak CB, Berg LJ. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J Exp Med. 1998 May 18; 187(10):1721-7.
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        63. Bunnell SC, Berg LJ. The signal transduction of motion and antigen recognition: factors affecting T cell function and differentiation. Genet Eng (N Y). 1998; 20:63-110.
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        64. Thomis DC, Lee W, Berg LJ. T cells from Jak3-deficient mice have intact TCR signaling, but increased apoptosis. J Immunol. 1997 Nov 15; 159(10):4708-19.
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        65. Heyeck SD, Wilcox HM, Bunnell SC, Berg LJ. Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. J Biol Chem. 1997 Oct 3; 272(40):25401-8.
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        66. Ohta K, Pang XP, Berg L, Hershman JM. Growth inhibition of new human thyroid carcinoma cell lines by activation of adenylate cyclase through the beta-adrenergic receptor. J Clin Endocrinol Metab. 1997 Aug; 82(8):2633-8.
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        67. Thomis DC, Berg LJ. The role of Jak3 in lymphoid development, activation, and signaling. Curr Opin Immunol. 1997 Aug; 9(4):541-7.
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        68. Yelon D, Berg LJ. Structurally similar TCRs differ in their efficiency of positive selection. J Immunol. 1997 Jun 1; 158(11):5219-28.
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        69. Thomis DC, Berg LJ. Peripheral expression of Jak3 is required to maintain T lymphocyte function. J Exp Med. 1997 Jan 20; 185(2):197-206.
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        70. Andreotti AH, Bunnell SC, Feng S, Berg LJ, Schreiber SL. Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature. 1997 Jan 2; 385(6611):93-7.
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        71. Gurniak CB, Thomis DC, Berg LJ. Genomic structure and promoter region of the murine Janus-family tyrosine kinase, Jak3. DNA Cell Biol. 1997 Jan; 16(1):85-94.
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        72. Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ. Identification of Itk/Tsk Src homology 3 domain ligands. J Biol Chem. 1996 Oct 11; 271(41):25646-56.
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        73. Kammer W, Lischke A, Moriggl R, Groner B, Ziemiecki A, Gurniak CB, Berg LJ, Friedrich K. Homodimerization of interleukin-4 receptor alpha chain can induce intracellular signaling. J Biol Chem. 1996 Sep 27; 271(39):23634-7.
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        74. Fayolle C, Abdel-Motal UM, Berg L, Deriaud E, Jondal M, Leclerc C. Induction of cytotoxic T-cell response by optimal-length peptides does not require CD4+ T-cell help. Immunology. 1996 Sep; 89(1):41-5.
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        75. Gurniak CB, Berg LJ. A new member of the Eph family of receptors that lacks protein tyrosine kinase activity. Oncogene. 1996 Aug 15; 13(4):777-86.
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        76. Lyons DS, Lieberman SA, Hampl J, Boniface JJ, Chien Y, Berg LJ, Davis MM. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity. 1996 Jul; 5(1):53-61.
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        77. Yelon D, Spain LM, Lim K, Berg LJ. Alterations in CD4 dependence accompany T cell development and differentiation. Int Immunol. 1996 Jul; 8(7):1077-90.
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        78. Gurniak CB, Berg LJ. Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells. Blood. 1996 Apr 15; 87(8):3151-60.
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        79. Abdel-Motal UM, Berg L, Rosén A, Bengtsson M, Thorpe CJ, Kihlberg J, Dahmén J, Magnusson G, Karlsson KA, Jondal M. Immunization with glycosylated Kb-binding peptides generates carbohydrate-specific, unrestricted cytotoxic T cells. Eur J Immunol. 1996 Mar; 26(3):544-51.
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        80. Abdel-Motal UM, Berg L, Bengtsson M, Dahmén J, Kihlberg J, Magnusson G, Nilsson U, Jondal M. Major histocompatibility complex class I binding glycopeptides for the estimation of 'empty' class I molecules. J Immunol Methods. 1995 Dec 15; 188(1):21-31.
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        81. Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science. 1995 Nov 3; 270(5237):794-7.
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        82. Liao JC, Berg LJ, Jay DG. Chromophore-assisted laser inactivation of subunits of the T-cell receptor in living cells is spatially restricted. Photochem Photobiol. 1995 Nov; 62(5):923-9.
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        83. Raab M, Cai YC, Bunnell SC, Heyeck SD, Berg LJ, Rudd CE. p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8891-5.
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        84. Stowers L, Yelon D, Berg LJ, Chant J. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):5027-31.
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        85. Lieberman SA, Spain LM, Wang L, Berg LJ. Enhanced T cell maturation and altered lineage commitment in T cell receptor/CD4-transgenic mice. Cell Immunol. 1995 Apr 15; 162(1):56-67.
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        86. Spain LM, Yelon D, Berg LJ. Do the CD4 and CD8 lineages represent parallel pathways? Semin Immunol. 1994 Aug; 6(4):213-20.
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        87. Spain LM, Jorgensen JL, Davis MM, Berg LJ. A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes. J Immunol. 1994 Feb 15; 152(4):1709-17.
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        88. Sakaguchi S, Ermak TH, Toda M, Berg LJ, Ho W, Fazekas de St Groth B, Peterson PA, Sakaguchi N, Davis MM. Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression. J Immunol. 1994 Feb 1; 152(3):1471-84.
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        89. Berg LJ. Insights into the role of the immune system in prion diseases. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):429-32.
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        90. Spain LM, Berg LJ. Quantitative analysis of the efficiency of clonal deletion in the thymus. Dev Immunol. 1994; 4(1):43-53.
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        91. Heyeck SD, Berg LJ. Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):669-73.
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        92. Spain LM, Berg LJ. Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide. J Exp Med. 1992 Jul 1; 176(1):213-23.
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        93. Berg LJ, Frank GD, Davis MM. The effects of MHC gene dosage and allelic variation on T cell receptor selection. Cell. 1990 Mar 23; 60(6):1043-53.
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        94. Berg LJ, Davis MM. T-cell development in T cell receptor alphabeta transgenic mice. Semin Immunol. 1989 Nov; 1(2):105-16.
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        95. Berg LJ. Generation of the T cell repertoire. Curr Opin Immunol. 1989 Oct; 2(1):87-92.
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        96. Berg LJ, Pullen AM, Fazekas de St Groth B, Mathis D, Benoist C, Davis MM. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell. 1989 Sep 22; 58(6):1035-46.
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        97. Berg LJ, Fazekas de St Groth B, Pullen AM, Davis MM. Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection. Nature. 1989 Aug 17; 340(6234):559-62.
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        98. Davis MM, Berg LJ, Lin AY, Fazekas de St Groth B, Devaux B, Sagerstrom CG, Bjorkman PJ, Elliott JF. TCR recognition and selection in vivo. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:119-28.
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        99. Berg LJ, Fazekas de St Groth B, Ivars F, Goodnow CC, Gilfillan S, Garchon HJ, Davis MM. Expression of T-cell receptor alpha-chain genes in transgenic mice. Mol Cell Biol. 1988 Dec; 8(12):5459-69.
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