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    David A Drachman MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentNeurology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-3031
        Overview 
        Narrative

        Fellowship and Residency Program Affiliations
        Neurology of Aging Fellowship Program
        Neurology Residency Program

        Research Interests

        Studies of Alzheimer's disease theneurology of aging.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Drachman DA. The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease. Alzheimers Dement. 2014 May; 10(3):372-80.
          View in: PubMed
        2. Sinha M, Khor KN, Amresh A, Drachman D, Frechette A. The use of a kiosk-model bilingual self-triage system in the pediatric emergency department. Pediatr Emerg Care. 2014 Jan; 30(1):63-8.
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        3. Matz S, Connell M, Sinha M, Goettl CS, Patel PC, Drachman D. Clinical outcomes of pediatric patients with acute abdominal pain and incidental findings of free intraperitoneal fluid on diagnostic imaging. J Ultrasound Med. 2013 Sep; 32(9):1547-53.
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        4. Orth TA, Drachman D, Habak P. Breastfeeding in obstetrics residency: exploring maternal and colleague resident perspectives. Breastfeed Med. 2013 Aug; 8(4):394-400.
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        5. Alimov V, Lovecchio F, Sinha M, Foster KN, Drachman D. Use of a silver-containing hydrofiber dressing for filling abscess cavity following incision and drainage in the emergency department: a randomized controlled trial. Adv Skin Wound Care. 2013 Jan; 26(1):20-5.
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        6. Drachman DA. Comment: Tau vs 14-3-3 protein--adjuncts for the diagnosis of CJD. Neurology. 2012 Aug 7; 79(6):551.
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        7. Coonrod DV, Jimenez BF, Sturgeon AN, Drachman D. Influenza Vaccine Coverage among Pregnant Women in a Public Hospital System during the 2009-2010 Pandemic Influenza Season. Influenza Res Treat. 2012; 2012:329506.
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        8. Kowalik J, Weller J, Venter J, Drachman D. Cognitive behavioral therapy for the treatment of pediatric posttraumatic stress disorder: a review and meta-analysis. J Behav Ther Exp Psychiatry. 2011 Sep; 42(3):405-13.
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        9. Drachman DA. The taxonomy of primary progressive aphasia: it walks and quacks like a duck ... but which duck? Neurology. 2011 Mar 15; 76(11):942-3.
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        10. Balls A, LoVecchio F, Kroeger A, Stapczynski JS, Mulrow M, Drachman D. Ultrasound guidance for central venous catheter placement: results from the Central Line Emergency Access Registry Database. Am J Emerg Med. 2010 Jun; 28(5):561-7.
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        11. Manriquez M, Srinivas G, Bollepalli S, Britt L, Drachman D. Is computed tomography a reliable diagnostic modality in detecting placental injuries in the setting of acute trauma? Am J Obstet Gynecol. 2010 Jun; 202(6):611.e1-5.
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        12. Agee N, Komenaka IK, Drachman D, Bouton ME, Caruso DM, Foster KN. The effectiveness of grand rounds lectures in a community-based teaching hospital. J Surg Educ. 2009 Nov-Dec; 66(6):361-6.
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        13. Coonrod DV, Bruce NC, Malcolm TD, Drachman D, Frey KA. Knowledge and attitudes regarding preconception care in a predominantly low-income Mexican American population. Am J Obstet Gynecol. 2009 Jun; 200(6):686.e1-7.
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        14. Kopelman TR, O'Neill PJ, Macias LH, Cox JC, Matthews MR, Drachman DA. The utility of diagnostic laparoscopy in the evaluation of anterior abdominal stab wounds. Am J Surg. 2008 Dec; 196(6):871-7; discussion 877.
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        15. Drachman DA. Memory and the brain: beyond intracranial phrenology. Curr Neurol Neurosci Rep. 2008 Jul; 8(4):269-73.
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        16. Rimmer RB, Weigand S, Foster KN, Wadsworth MM, Jacober K, Matthews MR, Drachman D, Caruso DM. Scald burns in young children--a review of Arizona burn center pediatric patients and a proposal for prevention in the Hispanic community. J Burn Care Res. 2008 Jul-Aug; 29(4):595-605.
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        17. Coonrod DV, Drachman D, Hobson P, Manriquez M. Nulliparous term singleton vertex cesarean delivery rates: institutional and individual level predictors. Am J Obstet Gynecol. 2008 Jun; 198(6):694.e1-11; discussion 694.e11.
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        18. Drachman DA. Nature or nurture: education and the trajectory of declining brain function with age and Alzheimer disease. Neurology. 2008 May 6; 70(19 Pt 2):1725-7.
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        19. Drachman DA. Commentary on "a roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." Prevention of dementia: roadmap or maintenance manual? Alzheimers Dement. 2008 May; 4(3):169-70.
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        20. Kopelman TR, O'Neill PJ, Kanneganti SR, Davis KM, Drachman DA. The relationship of plasma glucose and glycosylated hemoglobin A1C levels among nondiabetic trauma patients. J Trauma. 2008 Jan; 64(1):30-3; discussion 33-4.
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        21. Watts GD, Thomasova D, Ramdeen SK, Fulchiero EC, Mehta SG, Drachman DA, Weihl CC, Jamrozik Z, Kwiecinski H, Kaminska A, Kimonis VE. Novel VCP mutations in inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia. Clin Genet. 2007 Nov; 72(5):420-6.
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        22. Drachman DA. Rethinking Alzheimer's disease: the role of age-related changes. Curr Neurol Neurosci Rep. 2007 Jul; 7(4):265-8.
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        23. Miller N, Drachman DA. The optic nerve: a window into diseases of the brain? Neurology. 2006 Nov 28; 67(10):1742-3.
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        24. Drachman DA. Aging of the brain, entropy, and Alzheimer disease. Neurology. 2006 Oct 24; 67(8):1340-52.
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        25. Drachman DA. Robert Katzman and Alzheimer's disease: an appreciation. Alzheimer Dis Assoc Disord. 2006 Jul-Sep; 20(3 Suppl 2):S29-30.
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        26. Drachman DA. Commentary on "Diagnosis of Alzheimer's disease: two decades of progress." Alzheimer's disease: years of progress, and an army of researchers recruited; AD remains an elusive adversary. Alzheimers Dement. 2005 Oct; 1(2):109-11.
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        27. Butler RN, Warner HR, Williams TF, Austad SN, Brody JA, Campisi J, Cerami A, Cohen G, Cristofalo VJ, Drachman DA, Finch CE, Fridovich I, Harley CB, Havlik RJ, Martin GM, Miller RA, Olshansky SJ, Pereira-Smith OM, Smith JR, Sprott RL, West MD, Wilmoth JR, Wright WE. The aging factor in health and disease: the promise of basic research on aging. Aging Clin Exp Res. 2004 Apr; 16(2):104-11; discussion 111-2.
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        28. Ellis BH, Bannister WM, Cox JK, Fowler BM, Shannon ED, Drachman D, Adams RW, Giordano LA. Utilization of the propensity score method: an exploratory comparison of proxy-completed to self-completed responses in the Medicare Health Outcomes Survey. Health Qual Life Outcomes. 2003; 1:47.
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        29. Drachman DA. Preventing and treating Alzheimer's disease: strategies and prospects. Expert Rev Neurother. 2003 Sep; 3(5):565-9.
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        30. Drachman DA. Hat size, brain size, intelligence, and dementia: what morphometry can tell us about brain function and disease. Neurology. 2002 Jul 23; 59(2):156-7.
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        31. Umapathi T, Chaudhry V, Cornblath D, Drachman D, Griffin J, Kuncl R. Head drop and camptocormia. J Neurol Neurosurg Psychiatry. 2002 Jul; 73(1):1-7.
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        32. Drachman DA. The treatment of Alzheimer's disease: where have we been, and where are we going? Am J Alzheimers Dis Other Demen. 2002 May-Jun; 17(3):133-4.
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        33. Swearer JM, Drachman DA, Li L, Kane KJ, Dessureau B, Tabloski P. Screening for dementia in "real world" settings: the cognitive assessment screening test: CAST. Clin Neuropsychol. 2002 May; 16(2):128-35.
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        34. Henderson VW, Drachman DA. Dementia, butterfly ballots, and voter competence. Neurology. 2002 Apr 9; 58(7):995-6.
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        35. Selim M, Drachman DA. Ataxia associated with Hashimoto's disease: progressive non-familial adult onset cerebellar degeneration with autoimmune thyroiditis. J Neurol Neurosurg Psychiatry. 2001 Jul; 71(1):81-7.
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        36. Swearer JM, O'Donnell BF, Parker M, Kane KJ, Drachman DA. Psychological features in persons at risk for familial Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2001 May-Jun; 16(3):157-62.
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        37. Seshadri S, Zornberg GL, Derby LE, Myers MW, Jick H, Drachman DA. Postmenopausal estrogen replacement therapy and the risk of Alzheimer disease. Arch Neurol. 2001 Mar; 58(3):435-40.
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        38. Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. Statins and the risk of dementia. Lancet. 2000 Nov 11; 356(9242):1627-31.
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        39. Lippa CF, Swearer JM, Kane KJ, Nochlin D, Bird TD, Ghetti B, Nee LE, St George-Hyslop P, Pollen DA, Drachman DA. Familial Alzheimer's disease: site of mutation influences clinical phenotype. Ann Neurol. 2000 Sep; 48(3):376-9.
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        40. Albert MS, Drachman DA. Alzheimer's disease: what is it, how many people have it, and why do we need to know? Neurology. 2000 Jul 25; 55(2):166-8.
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        41. Drachman DA. Risk factors for seizure-related motor vehicle crashes in patients with epilepsy. Neurology. 1999 Dec 10; 53(9):2214-5.
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        42. Selvaraj N, Drachman DA, Ravin P, Knorr JR. Myocardial infarction, seizure and an abnormal head CT scan. Postgrad Med J. 1999 Dec; 75(890):757-9.
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        43. Drachman DA. A 69-year-old man with chronic dizziness. JAMA. 1998 Dec 23-30; 280(24):2111-8.
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        44. Drachman DA, Swearer JM. Screening for dementia: Cognitive Assessment Screening Test (CAST). Am Fam Physician. 1996 Nov 1; 54(6):1957-62.
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        45. Drachman DA, Swearer JM, Kane K, Osgood D, O'Toole C, Moonis M. The cognitive assessment screening test (CAST) for dementia. J Geriatr Psychiatry Neurol. 1996 Oct; 9(4):200-8.
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        46. Lippa CF, Saunders AM, Smith TW, Swearer JM, Drachman DA, Ghetti B, Nee L, Pulaski-Salo D, Dickson D, Robitaille Y, Bergeron C, Crain B, Benson MD, Farlow M, Hyman BT, George-Hyslop SP, Roses AD, Pollen DA. Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway. Neurology. 1996 Feb; 46(2):406-12.
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        47. Swearer JM, O'Donnell BF, Ingram SM, Drachman DA. Rate of progression in familial Alzheimer's disease. J Geriatr Psychiatry Neurol. 1996 Jan; 9(1):22-5.
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        48. Swearer JM, Drachman DA. Caretaker Obstreperous Behavior Rating Scale. Int Psychogeriatr. 1996; 8 Suppl 3:321-4.
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        49. Seshadri S, Drachman DA, Lippa CF. Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know. Arch Neurol. 1995 Nov; 52(11):1074-9.
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        50. Drachman DA. If we live long enough, will we all be demented? Neurology. 1994 Sep; 44(9):1563-5.
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        51. Lippa CF, Hamos JE, Smith TW, Pulaski-Salo D, Drachman DA. Vascular amyloid deposition in Alzheimer's disease. Neither necessary nor sufficient for the local formation of plaques or tangles. Arch Neurol. 1993 Oct; 50(10):1088-92.
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        52. Drachman DA. New criteria for the diagnosis of vascular dementia: do we know enough yet? Neurology. 1993 Feb; 43(2):243-5.
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        53. Davis KL, Thal LJ, Gamzu ER, Davis CS, Woolson RF, Gracon SI, Drachman DA, Schneider LS, Whitehouse PJ, Hoover TM, et al. A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group. N Engl J Med. 1992 Oct 29; 327(18):1253-9.
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        54. Lippa CF, Hamos JE, Pulaski-Salo D, DeGennaro LJ, Drachman DA. Alzheimer's disease and aging: effects on perforant pathway perikarya and synapses. Neurobiol Aging. 1992 May-Jun; 13(3):405-11.
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        55. Drachman DA, Swearer JM, O'Donnell BF, Mitchell AL, Maloon A. The Caretaker Obstreperous-Behavior Rating Assessment (COBRA) Scale. J Am Geriatr Soc. 1992 May; 40(5):463-70.
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        56. O'Donnell BF, Friedman S, Swearer JM, Drachman DA. Active and passive P3 latency and psychometric performance: influence of age and individual differences. Int J Psychophysiol. 1992 Mar; 12(2):187-95.
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        57. Drachman DA. Section of geriatric neurology. Neurology. 1991 Sep; 41(9):1333-4.
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        58. Lippa CF, Cohen R, Smith TW, Drachman DA. Primary progressive aphasia with focal neuronal achromasia. Neurology. 1991 Jun; 41(6):882-6.
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        59. Hamos JE, Oblas B, Pulaski-Salo D, Welch WJ, Bole DG, Drachman DA. Expression of heat shock proteins in Alzheimer's disease. Neurology. 1991 Mar; 41(3):345-50.
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        60. Lippa CF, Smith TW, Degirolami U, Drachman DA. The indusium griseum: is it involved in Alzheimer's disease? Neurobiol Aging. 1990 Sep-Oct; 11(5):551-4.
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        61. Drachman DA, O'Donnell BF, Lew RA, Swearer JM. The prognosis in Alzheimer's disease. 'How far' rather than 'how fast' best predicts the course. Arch Neurol. 1990 Aug; 47(8):851-6.
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        62. Larson EB, Katzman R, Brody EM, Drachman DA. First report of the congressionally appointed Advisory Panel on Alzheimer's Disease. J Gerontol. 1990 May; 45(3):M120.
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        63. Hamos JE, DeGennaro LJ, Drachman DA. Synaptic loss in Alzheimer's disease and other dementias. Neurology. 1989 Mar; 39(3):355-61.
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        64. Recht LD, McCarthy K, O'Donnell BF, Cohen R, Drachman DA. Tumor-associated aphasia in left hemisphere primary brain tumors: the importance of age and tumor grade. Neurology. 1989 Jan; 39(1):48-50.
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        65. Deymeer F, Smith TW, DeGirolami U, Drachman DA. Thalamic dementia and motor neuron disease. Neurology. 1989 Jan; 39(1):58-61.
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        66. O'Donnell BF, Drachman DA, Lew RA, Swearer JM. Measuring dementia: assessment of multiple deficit domains. J Clin Psychol. 1988 Nov; 44(6):916-23.
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        67. Swearer JM, Drachman DA, O'Donnell BF, Mitchell AL. Troublesome and disruptive behaviors in dementia. Relationships to diagnosis and disease severity. J Am Geriatr Soc. 1988 Sep; 36(9):784-90.
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        68. Smith TW, Anwer U, DeGirolami U, Drachman DA. Vacuolar change in Alzheimer's disease. Arch Neurol. 1987 Dec; 44(12):1225-8.
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        69. St George-Hyslop PH, Tanzi RE, Polinsky RJ, Haines JL, Nee L, Watkins PC, Myers RH, Feldman RG, Pollen D, Drachman D, et al. The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science. 1987 Feb 20; 235(4791):885-90.
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        70. Rudnicki S, Chad DA, Drachman DA, Smith TW, Anwer UE, Levitan N. Motor neuron disease and paraproteinemia. Neurology. 1987 Feb; 37(2):335-7.
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        71. St George-Hyslop P, Polinsky R, Haines J, Nee L, Tanzi R, Conneally P, Growdon J, Myers R, Pollen D, Drachman D, et al. Search for the familial Alzheimer's disease gene. J Neural Transm Suppl. 1987; 24:13-21.
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        72. Kapen S, Fleming PD, Drachman DA. Cholinergic enhancement and REM sleep latency in the aged: lecithin does not reproduce physostigmine effect. Neurology. 1986 Aug; 36(8):1079-83.
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        73. Russell J, Fisher M, Zivin JA, Sullivan J, Drachman DA. Status epilepticus and Epstein-Barr virus encephalopathy. Diagnosis by modern serologic techniques. Arch Neurol. 1985 Aug; 42(8):789-92.
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        74. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984 Jul; 34(7):939-44.
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        75. Fisher M, Levine PH, Fullerton AL, Forsberg A, Duffy CP, Hoogasian JJ, Drachman DA. Marker proteins of platelet activation in patients with cerebrovascular disease. Arch Neurol. 1982 Nov; 39(11):692-5.
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        76. Drachman DA, Sahakian BJ. Memory and cognitive function in the elderly. A preliminary trial of physostigmine. Arch Neurol. 1980 Oct; 37(10):674-5.
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        77. Drachman DA, Noffsinger D, Sahakian BJ, Kurdziel S, Fleming P. Aging, memory, and the cholinergic system: a study of dichotic listening. Neurobiol Aging. 1980; 1(1):39-43.
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        78. Fisher M, Sargent J, Drachman D. Familial inverted choreoathetosis. Neurology. 1979 Dec; 29(12):1627-31.
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        79. Drachman DA, Apfelbaum RI, Posner JB. Dizziness and disorders of equilibrium--panel 8. Arch Neurol. 1979 Nov 16; 36(12):806-10.
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        80. Drachman DA. Memory and cognitive function in man: does the cholinergic system have a specific role? Neurology. 1977 Aug; 27(8):783-90.
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        81. Drachman DA, Davison WC, Mittal KK. Histocompatibility (HL-A) factors in familial multiple sclerosis. Is multiple sclerosis susceptibility inherited via the HL-A chromosome? Arch Neurol. 1976 Jun; 33(6):406-13.
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        82. Drachman DA, Leavitt J. Human memory and the cholinergic system. A relationship to aging? Arch Neurol. 1974 Feb; 30(2):113-21.
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        83. Drachman DA, Hart CW. Complaint-oriented clinics. JAMA. 1973 Aug 20; 225(8):996.
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        84. Drachman DA, Hughes JR. Memory and the hippocampal complexes. 3. Aging and temporal EEG abnormalities. Neurology. 1971 Jan; 21(1):1-14.
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        85. Drachman DA, Paterson PY, Berlin BS, Roguska J. Immunosuppression and the Guillain-Barré syndrome. Arch Neurol. 1970 Nov; 23(5):385-93.
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        86. Drachman DA, Paterson PY, Berlin B, Roguska J. Immunosuppression and the Guillain-Barré syndrome. Neurology. 1970 Apr; 20(4):390.
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        87. Drachman DA, Skom JH. Procainamide---a hazard in myasthenia gravis. Arch Neurol. 1965 Sep; 13(3):316-20.
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        88. SILBERBERG DH, DRACHMAN DA. Late-life myopathy occurring with Sjogren's syndrome. Arch Neurol. 1962 Jun; 6:428-38.
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