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    Last Name
    Institution

    Marc Fisher MD

    TitleProfessor Emeritus
    InstitutionUniversity of Massachusetts Medical School
    DepartmentNeurology
    AddressUMass Memorial Medical Center
    108 Belmont Street
    Worcester MA 01605
    Phone508-334-6641
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentRadiology

        Bibliographic 
        selected publications
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        1. Saposnik G, Ovbiagele B, Raptis S, Fisher M, Johnston SC. Effect of english proficiency and research funding on acceptance of submitted articles to stroke journal. Stroke. 2014 Jun; 45(6):1862-8.
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        2. Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, Fang MC, Fisher M, Furie KL, Heck DV, Johnston SC, Kasner SE, Kittner SJ, Mitchell PH, Rich MW, Richardson D, Schwamm LH, Wilson JA. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the american heart association/american stroke association. Stroke. 2014 Jul; 45(7):2160-236.
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        3. Moonis M, Srivastava P, Selim M, Fisher M. Advances and potential new treatments in stroke management. Stroke Res Treat. 2014; 2014:120384.
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        4. Marinescu M, Bouley J, Chueh J, Fisher M, Henninger N. Clot injection technique affects thrombolytic efficacy in a rat embolic stroke model: implications for translaboratory collaborations. J Cereb Blood Flow Metab. 2014 Apr; 34(4):677-82.
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        5. Sikoglu EM, Heffernan ME, Tam K, Sicard KM, Bratane BT, Quan M, Fisher M, King JA. Enhancement in cognitive function recovery by granulocyte-colony stimulating factor in a rodent model of traumatic brain injury. Behav Brain Res. 2014 Feb 1; 259:354-6.
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        6. Fisher M. Acute ischemic stroke therapy: current status and future directions. Expert Rev Cardiovasc Ther. 2013 Sep; 11(9):1097-9.
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        7. Ringelstein EB, Thijs V, Norrving B, Chamorro A, Aichner F, Grond M, Saver J, Laage R, Schneider A, Rathgeb F, Vogt G, Charissé G, Fiebach JB, Schwab S, Schäbitz WR, Kollmar R, Fisher M, Brozman M, Skoloudik D, Gruber F, Serena Leal J, Veltkamp R, Köhrmann M, Berrouschot J. Granulocyte colony-stimulating factor in patients with acute ischemic stroke: results of the AX200 for Ischemic Stroke trial. Stroke. 2013 Oct; 44(10):2681-7.
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        8. Kheradmand A, Fisher M, Paydarfar D. Ischemic stroke in evolution: predictive value of perfusion computed tomography. J Stroke Cerebrovasc Dis. 2014 May-Jun; 23(5):836-43.
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        9. Saposnik G, Johnston SC, Raptis S, Ovbiagele B, Fisher M. Stroke journal: what is being published to advance the field? Stroke. 2013 Sep; 44(9):2644-9.
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        10. Heffernan ME, Huang W, Sicard KM, Bratane BT, Sikoglu EM, Zhang N, Fisher M, King JA. Multi-modal approach for investigating brain and behavior changes in an animal model of traumatic brain injury. J Neurotrauma. 2013 Jun 1; 30(11):1007-12.
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        11. Fox K, Bousser MG, Amarenco P, Chamorro A, Fisher M, Ford I, Hennerici MG, Mattle HP, Rothwell PM. Heart rate is a prognostic risk factor for myocardial infarction: a post hoc analysis in the PERFORM (Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke or tRansient ischeMic attack) study population. Int J Cardiol. 2013 Oct 9; 168(4):3500-5.
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        12. Dirnagl U, Hakim A, Macleod M, Fisher M, Howells D, Alan SM, Steinberg G, Planas A, Boltze J, Savitz S, Iadecola C, Meairs S. A concerted appeal for international cooperation in preclinical stroke research. Stroke. 2013 Jun; 44(6):1754-60.
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        13. Fisher M. The spectrum of translational stroke research. Neurol Res. 2013 Jun; 35(5):443-7.
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        14. Landis S, Fisher M. Why the United States needs a network for stroke clinical trials. Stroke. 2013 May; 44(5):1217-8.
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        15. Fisher M, Albers GW. Advanced imaging to extend the therapeutic time window of acute ischemic stroke. Ann Neurol. 2013 Jan; 73(1):4-9.
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        16. Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012 Oct 11; 490(7419):187-91.
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        17. Fisher M, Bastan B. Identifying and utilizing the ischemic penumbra. Neurology. 2012 Sep 25; 79(13 Suppl 1):S79-85.
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        18. Fisher M. Endovascular acute ischemic stroke therapy: applying basic science to clinical decisions. Neurology. 2012 Sep 25; 79(13 Suppl 1):S42-3.
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        19. Tao WD, Liu M, Fisher M, Wang DR, Li J, Furie KL, Hao ZL, Lin S, Zhang CF, Zeng QT, Wu B. Posterior versus anterior circulation infarction: how different are the neurological deficits? Stroke. 2012 Aug; 43(8):2060-5.
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        20. Fisher M, Moonis M. Neuroprotective effects of statins: evidence from preclinical and clinical studies. Curr Treat Options Cardiovasc Med. 2012 Jun; 14(3):252-9.
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        21. Dirnagl U, Fisher M. REPRINT: International, multicenter randomized preclinical trials in translational stroke research: it is time to act. Stroke. 2012 Jun; 43(6):1453-4.
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        22. Dirnagl U, Fisher M. International, multicenter randomized preclinical trials in translational stroke research: it's time to act. J Cereb Blood Flow Metab. 2012 Jun; 32(6):933-5.
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        23. Ali M, Bath P, Brady M, Davis S, Diener HC, Donnan G, Fisher M, Hacke W, Hanley DF, Luby M, Tsivgoulis G, Wahlgren N, Warach S, Lees KR. Development, expansion, and use of a stroke clinical trials resource for novel exploratory analyses. Int J Stroke. 2012 Feb; 7(2):133-8.
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        24. Fisher M, Bråtane BT. Imaging of experimental stroke models. Transl Stroke Res. 2012 Mar; 3(1):16-21.
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        25. Bråtane BT, Cui H, Cook DJ, Bouley J, Tymianski M, Fisher M. Neuroprotection by freezing ischemic penumbra evolution without cerebral blood flow augmentation with a postsynaptic density-95 protein inhibitor. Stroke. 2011 Nov; 42(11):3265-70.
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        26. Albers GW, Fisher M. Improving the accuracy of perfusion imaging in acute ischemic stroke. Ann Neurol. 2011 Sep; 70(3):347-9.
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        27. Bousser MG, Amarenco P, Chamorro A, Fisher M, Ford I, Fox KM, Hennerici MG, Mattle HP, Rothwell PM, de Cordoüe A, Fratacci MD. Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial. Lancet. 2011 Jun 11; 377(9782):2013-22.
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        28. Shuaib A, Bornstein NM, Diener HC, Dillon W, Fisher M, Hammer MD, Molina CA, Rutledge JN, Saver JL, Schellinger PD, Shownkeen H. Partial aortic occlusion for cerebral perfusion augmentation: safety and efficacy of NeuroFlo in Acute Ischemic Stroke trial. Stroke. 2011 Jun; 42(6):1680-90.
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        29. Walvick RP, Bråtane BT, Henninger N, Sicard KM, Bouley J, Yu Z, Lo E, Wang X, Fisher M. Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy. Stroke. 2011 Apr; 42(4):1110-5.
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        30. Fisher M, Loscalzo J. The perils of combination antithrombotic therapy and potential resolutions. Stroke. 2011 Feb; 42(2):278-81.
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        31. Fisher M. New approaches to neuroprotective drug development. Stroke. 2011 Jan; 42(1 Suppl):S24-7.
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        32. Morris JG, Singh S, Fisher M. Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good? Stroke. 2010 Dec; 41(12):2985-90.
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        33. Schäbitz WR, Laage R, Vogt G, Koch W, Kollmar R, Schwab S, Schneider D, Hamann GF, Rosenkranz M, Veltkamp R, Fiebach JB, Hacke W, Grotta JC, Fisher M, Schneider A. AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke. Stroke. 2010 Nov; 41(11):2545-51.
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        34. Henninger N, Kumar R, Fisher M. Acute ischemic stroke therapy. Expert Rev Cardiovasc Ther. 2010 Oct; 8(10):1389-98.
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        35. Zhou X, Sun Y, Mazzanti M, Henninger N, Mansour J, Fisher M, Albert M. MRI of stroke using hyperpolarized 129Xe. NMR Biomed. 2011 Feb; 24(2):170-5.
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        36. Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, Fisher M, Brainin M, Buchan AM, Lo EH, Skolnick BE, Furie KL, Hankey GJ, Kivipelto M, Morris J, Rothwell PM, Sacco RL, Smith SC, Wang Y, Bryer A, Ford GA, Iadecola C, Martins SC, Saver J, Skvortsova V, Bayley M, Bednar MM, Duncan P, Enney L, Finklestein S, Jones TA, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg MP, Heiss WD, Saarelma O, Schwamm LH, Shinohara Y, Trivedi B, Wahlgren N, Wong LK, Hakim A, Norrving B, Prudhomme S, Bornstein NM, Davis SM, Goldstein LB, Leys D, Tuomilehto J. Stroke: working toward a prioritized world agenda. Int J Stroke. 2010 Aug; 5(4):238-56.
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        37. El Khoury R, Fisher M, Savitz SI. Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke. Stroke. 2010 Sep; 41(9):2038-43.
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        38. Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, Fisher M, Brainin M, Buchan AM, Lo EH, Skolnick BE, Furie KL, Hankey GJ, Kivipelto M, Morris J, Rothwell PM, Sacco RL, Smith SC, Wang Y, Bryer A, Ford GA, Iadecola C, Martins SC, Saver J, Skvortsova V, Bayley M, Bednar MM, Duncan P, Enney L, Finklestein S, Jones TA, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg MP, Heiss WD, Saarelma O, Schwamm LH, Shinohara Y, Trivedi B, Wahlgren N, Wong LK, Hakim A, Norrving B, Prudhomme S, Bornstein NM, Davis SM, Goldstein LB, Leys D, Tuomilehto J. Stroke: working toward a prioritized world agenda. Stroke. 2010 Jun; 41(6):1084-99.
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        39. Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, Fisher M, Brainin M, Buchan AM, Lo EH, Skolnick BE, Furie KL, Hankey GJ, Kivipelto M, Morris J, Rothwell PM, Sacco RL, Smith SC, Wang Y, Bryer A, Ford GA, Iadecola C, Martins SC, Saver J, Skvortsova V, Bayley M, Bednar MM, Duncan P, Enney L, Finklestein S, Jones TA, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg MP, Heiss WD, Saarelma O, Schwamm LH, Shinohara Y, Trivedi B, Wahlgren N, Wong LK, Hakim A, Norrving B, Prudhomme S, Bornstein NM, Davis SM, Goldstein LB, Leys D, Tuomilehto J. Stroke: working toward a prioritized world agenda. Cerebrovasc Dis. 2010; 30(2):127-47.
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        40. Fisher M. Introduction to advances in stroke 2009. Stroke. 2010 Feb; 41(2):e62.
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        41. Sicard KM, Fisher M. Animal models of focal brain ischemia. Exp Transl Stroke Med. 2009; 1:7.
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        42. Bråtane BT, Walvick RP, Corot C, Lancelot E, Fisher M. Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASL. J Cereb Blood Flow Metab. 2010 Feb; 30(2):336-42.
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        43. Bråtane BT, Bouley J, Schneider A, Bastan B, Henninger N, Fisher M. Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat. Stroke. 2009 Sep; 40(9):3102-6.
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        44. Henninger N, Chowdhury N, Fisher M, Moonis M. Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke. Cerebrovasc Dis. 2009; 27 Suppl 4:9-14.
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        45. Morris JG, Duffis EJ, Fisher M. Cardiac workup of ischemic stroke: can we improve our diagnostic yield? Stroke. 2009 Aug; 40(8):2893-8.
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        46. Saver JL, Albers GW, Dunn B, Johnston KC, Fisher M. Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials. Stroke. 2009 Jul; 40(7):2594-600.
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        47. Bråtane BT, Bastan B, Fisher M, Bouley J, Henninger N. Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps. Brain Res. 2009 Jul 7; 1279:182-8.
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        48. Fisher M, Hachinski V. European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy. Stroke. 2009 Jun; 40(6):2262-3.
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        49. Fisher M. Does the combination of warfarin and aspirin have a place in secondary stroke prevention? No. Stroke. 2009 May; 40(5):1944-5.
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        50. Sicard KM, Fisher M. Emerging drugs for acute ischemic stroke. Expert Opin Emerg Drugs. 2009 Mar; 14(1):33-42.
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        51. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke. 2009 Jun; 40(6):2244-50.
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        52. Zivin JA, Albers GW, Bornstein N, Chippendale T, Dahlof B, Devlin T, Fisher M, Hacke W, Holt W, Ilic S, Kasner S, Lew R, Nash M, Perez J, Rymer M, Schellinger P, Schneider D, Schwab S, Veltkamp R, Walker M, Streeter J. Effectiveness and safety of transcranial laser therapy for acute ischemic stroke. Stroke. 2009 Apr; 40(4):1359-64.
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        53. Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, van der Worp HB, Traystman RJ, Minematsu K, Donnan GA, Howells DW. Reprint: Good laboratory practice: preventing introduction of bias at the bench. Int J Stroke. 2009 Feb; 4(1):3-5.
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        54. Reinecke H, Brand E, Mesters R, Schäbitz WR, Fisher M, Pavenstädt H, Breithardt G. Dilemmas in the management of atrial fibrillation in chronic kidney disease. J Am Soc Nephrol. 2009 Apr; 20(4):705-11.
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        55. Philip M, Benatar M, Fisher M, Savitz SI. Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials. Stroke. 2009 Feb; 40(2):577-81.
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        56. Henninger N, Bouley J, Bråtane BT, Bastan B, Shea M, Fisher M. Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke. Exp Neurol. 2009 Feb; 215(2):290-7.
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        57. Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, Buchan A, van der Worp HB, Traystman RJ, Minematsu K, Donnan GA, Howells DW. Reprint: Good laboratory practice: preventing introduction of bias at the bench. J Cereb Blood Flow Metab. 2009 Feb; 29(2):221-3.
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        58. Henninger N, Bratane BT, Bastan B, Bouley J, Fisher M. Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model. J Cereb Blood Flow Metab. 2009 Jan; 29(1):119-29.
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        59. Fisher M, Bastan B. Treating acute ischemic stroke. Curr Opin Drug Discov Devel. 2008 Sep; 11(5):626-32.
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        60. Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, van der Worp HB, Traystman R, Minematsu K, Donnan GA, Howells DW. Good laboratory practice: preventing introduction of bias at the bench. Stroke. 2009 Mar; 40(3):e50-2.
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        61. Savitz SI, Benatar M, Saver JL, Fisher M. Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices. Cerebrovasc Dis. 2008; 26(2):156-62.
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        62. Fisher M. Stroke and TIA: epidemiology, risk factors, and the need for early intervention. Am J Manag Care. 2008 Jun; 14(6 Suppl 2):S204-11.
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        63. Donnan GA, Fisher M, Macleod M, Davis SM. Stroke. Lancet. 2008 May 10; 371(9624):1612-23.
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        64. Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S. Acute stroke imaging research roadmap. AJNR Am J Neuroradiol. 2008 May; 29(5):e23-30.
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        65. Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S. Acute stroke imaging research roadmap. Stroke. 2008 May; 39(5):1621-8.
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        66. Fisher M, Folland E. Acute ischemic coronary artery disease and ischemic stroke: similarities and differences. Am J Ther. 2008 Mar-Apr; 15(2):137-49.
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        67. Fisher M. Advances in Stroke 2007: introduction. Stroke. 2008 Feb; 39(2):250-1.
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        68. Langley B, D'Annibale MA, Suh K, Ayoub I, Tolhurst A, Bastan B, Yang L, Ko B, Fisher M, Cho S, Beal MF, Ratan RR. Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection. J Neurosci. 2008 Jan 2; 28(1):163-76.
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        69. Savitz SI, Fisher M. NXY-059 for the treatment of stroke. N Engl J Med. 2007 Nov 22; 357(21):2198; author reply 2198-9.
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        70. Fisher M, Hess DC, Lees K. Issues pertaining to the critiques of the SAINT-I Trial. Stroke. 2007 Nov; 38(11):e126-7; author reply e128.
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        71. Henninger N, Sicard KM, Li Z, Kulkarni P, Dützmann S, Urbanek C, Schwab S, Fisher M. Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat. Crit Care Med. 2007 Nov; 35(11):2607-14.
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        72. Savitz SI, Lew R, Bluhmki E, Hacke W, Fisher M. Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials. Stroke. 2007 Dec; 38(12):3205-12.
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        73. Henninger N, Fisher M. Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke. Stroke. 2007 Oct; 38(10):2779-86.
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        74. Tatlisumak T, Rantanen K, Fisher M. Stroke prevention: a challenging but rewarding task. Curr Drug Targets. 2007 Jul; 8(7):784-5.
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        75. Savitz SI, Fisher M. Prophylactic neuroprotection. Curr Drug Targets. 2007 Jul; 8(7):846-9.
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        76. Savitz SI, Fisher M. Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials. Ann Neurol. 2007 May; 61(5):396-402.
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        77. Lampl Y, Zivin JA, Fisher M, Lew R, Welin L, Dahlof B, Borenstein P, Andersson B, Perez J, Caparo C, Ilic S, Oron U. Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1). Stroke. 2007 Jun; 38(6):1843-9.
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        78. Ali M, Bath PM, Curram J, Davis SM, Diener HC, Donnan GA, Fisher M, Gregson BA, Grotta J, Hacke W, Hennerici MG, Hommel M, Kaste M, Marler JR, Sacco RL, Teal P, Wahlgren NG, Warach S, Weir CJ, Lees KR. The Virtual International Stroke Trials Archive. Stroke. 2007 Jun; 38(6):1905-10.
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        79. Henninger N, Sicard KM, Fisher M. Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats. J Cereb Blood Flow Metab. 2007 Oct; 27(10):1756-63.
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        80. Bardutzky J, Shen Q, Henninger N, Schwab S, Duong TQ, Fisher M. Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging. Stroke. 2007 Apr; 38(4):1336-44.
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        81. Henninger N, Bouley J, Nelligan JM, Sicard KM, Fisher M. Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2007 Sep; 27(9):1632-42.
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        82. Fisher M, Hanley DF, Howard G, Jauch EC, Warach S. Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes. Stroke. 2007 Feb; 38(2):245-8.
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        83. Fisher M, Henninger N. Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials. Curr Neurol Neurosci Rep. 2007 Jan; 7(1):35-41.
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        84. Bouley J, Fisher M, Henninger N. Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging. Neurosci Lett. 2007 Feb 2; 412(3):185-90.
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        85. Fisher M. Is penumbral imaging useful for extending the treatment window for intravenous tissue plasminogen activator? Ann Neurol. 2006 Nov; 60(5):499-501.
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        86. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats. Stroke. 2006 Oct; 37(10):2593-600.
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        87. Fisher M. NXY-059 for acute ischemic stroke: the promise of neuroprotection is finally realized? Stroke. 2006 Oct; 37(10):2651-2.
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        88. Fisher M, Lees K, Papadakis M, Buchan AM. NXY-059: brain or vessel protection. Stroke. 2006 Aug; 37(8):2189-90.
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        89. Fisher M. Does neuroprotection with NXY-059 improve patient outcome after acute ischemic stroke? Nat Clin Pract Cardiovasc Med. 2006 Jun; 3(6):302-3.
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        90. Fisher M. The ischemic penumbra: a new opportunity for neuroprotection. Cerebrovasc Dis. 2006; 21 Suppl 2:64-70.
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        91. Fisher M, Cheung K, Howard G, Warach S. New pathways for evaluating potential acute stroke therapies. Int J Stroke. 2006 May; 1(2):52-8.
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        92. Padma V, Fisher M, Moonis M. Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke. Expert Rev Cardiovasc Ther. 2006 May; 4(3):405-15.
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        93. Henninger N, Sicard KM, Schmidt KF, Bardutzky J, Fisher M. Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging. Stroke. 2006 May; 37(5):1283-7.
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        94. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2006 Nov; 26(11):1451-62.
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        95. Henninger N, Sicard KM, Bouley J, Fisher M, Stagliano NE. The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia. Neurosci Lett. 2006 May 8; 398(3):300-5.
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        96. Fisher M. Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist. Arch Neurol. 2006 Jan; 63(1):20-4.
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        97. Henninger N, Fisher M. Normobaric hyperoxia - a promising approach to expand the time window for acute stroke treatment. Cerebrovasc Dis. 2006; 21(1-2):134-6.
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        98. Warach S, Kaufman D, Chiu D, Devlin T, Luby M, Rashid A, Clayton L, Kaste M, Lees KR, Sacco R, Fisher M. Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy. Cerebrovasc Dis. 2006; 21(1-2):106-11.
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        99. Fisher M. Developing and implementing future stroke therapies: the potential of telemedicine. Ann Neurol. 2005 Nov; 58(5):666-71.
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        100. Shen Q, Ren H, Cheng H, Fisher M, Duong TQ. Functional, perfusion and diffusion MRI of acute focal ischemic brain injury. J Cereb Blood Flow Metab. 2005 Oct; 25(10):1265-79.
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        101. Shen Q, Ren H, Fisher M, Duong TQ. Statistical prediction of tissue fate in acute ischemic brain injury. J Cereb Blood Flow Metab. 2005 Oct; 25(10):1336-45.
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        102. Fisher M, Tatlisumak T. Use of animal models has not contributed to development of acute stroke therapies: con. Stroke. 2005 Oct; 36(10):2324-5.
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        103. Bardutzky J, Meng X, Bouley J, Duong TQ, Ratan R, Fisher M. Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model. J Cereb Blood Flow Metab. 2005 Aug; 25(8):968-77.
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        104. Bardutzky J, Shen Q, Henninger N, Bouley J, Duong TQ, Fisher M. Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging. Stroke. 2005 Sep; 36(9):2000-5.
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        105. Fisher M, Albers GW, Donnan GA, Furlan AJ, Grotta JC, Kidwell CS, Sacco RL, Wechsler LR. Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable. Stroke. 2005 Aug; 36(8):1808-13.
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        106. Bardutzky J, Shen Q, Bouley J, Sotak CH, Duong TQ, Fisher M. Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution. Brain Res. 2005 May 10; 1043(1-2):155-62.
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        107. Moonis M, Kane K, Schwiderski U, Sandage BW, Fisher M. HMG-CoA reductase inhibitors improve acute ischemic stroke outcome. Stroke. 2005 Jun; 36(6):1298-300.
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        108. Henning EC, Meng X, Fisher M, Sotak CH. Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging. Magn Reson Med. 2005 Apr; 53(4):851-7.
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        109. Padma V, Fisher M, Moonis M. Thrombolytic therapy for acute ischemic stroke: 3 h and beyond. Expert Rev Neurother. 2005 Mar; 5(2):223-33.
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        110. Furlan AJ, Fisher M. Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke. Stroke. 2005 Feb; 36(2):398-9.
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        111. Davalos A, Fisher M. Emerging therapies for cerebrovascular disorders. Stroke. 2005 Feb; 36(2):208-10.
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        112. Ren H, Shen Q, Bardutzky J, Fisher M, Duong TQ. Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model. Magn Reson Med. 2004 Dec; 52(6):1328-35.
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        113. Padma V, Fisher M, Moonis M. Antihypertensive medications for risk reduction of first and recurrent ischemic stroke. Expert Rev Cardiovasc Ther. 2004 Nov; 2(6):867-76.
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        114. Fisher M, Davalos A. The MATCH study results in the context of secondary stroke prevention. Stroke. 2004 Nov; 35(11):2609.
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        115. Gerriets T, Stolz E, Walberer M, Müller C, Rottger C, Kluge A, Kaps M, Fisher M, Bachmann G. Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography. Stroke. 2004 Oct; 35(10):2372-7.
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        116. Shen Q, Ren H, Fisher M, Bouley J, Duong TQ. Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data. J Cereb Blood Flow Metab. 2004 Aug; 24(8):887-97.
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        117. Duong TQ, Fisher M. Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke. Curr Atheroscler Rep. 2004 Jul; 6(4):267-73.
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        118. Kazemi M, Silva MD, Li F, Fisher M, Sotak CH. Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats. Magn Reson Imaging. 2004 Jun; 22(5):653-9.
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        119. Mayzel-Oreg O, Omae T, Kazemi M, Li F, Fisher M, Cohen Y, Sotak CH. Microsphere-induced embolic stroke: an MRI study. Magn Reson Med. 2004 Jun; 51(6):1232-8.
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        120. Shen Q, Fisher M, Sotak CH, Duong TQ. Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging. J Cereb Blood Flow Metab. 2004 Mar; 24(3):280-90.
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        121. Meng X, Fisher M, Shen Q, Sotak CH, Duong TQ. Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia. Ann Neurol. 2004 Feb; 55(2):207-12.
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        122. Gerriets T, Stolz E, Walberer M, Müller C, Kluge A, Kaps M, Fisher M, Bachmann G. Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats. Brain Res Brain Res Protoc. 2004 Feb; 12(3):137-43.
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        123. Fisher M, Davalos A. Emerging therapies for cerebrovascular disorders. Stroke. 2004 Feb; 35(2):367-9.
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        124. Fisher M. The ischemic penumbra: identification, evolution and treatment concepts. Cerebrovasc Dis. 2004; 17 Suppl 1:1-6.
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        125. Shen Q, Meng X, Fisher M, Sotak CH, Duong TQ. Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging. J Cereb Blood Flow Metab. 2003 Dec; 23(12):1479-88.
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        126. Moonis M, Fisher M. Antiplatelet treatment for secondary prevention of acute ischemic stroke and transient ischemic attacks: mechanisms, choices and possible emerging patterns of use. Expert Rev Cardiovasc Ther. 2003 Nov; 1(4):611-5.
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        127. Fisher M. Stem cell transplantation for stroke: does it work, and if so, how? Stroke. 2003 Aug; 34(8):2083.
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        128. Fisher M. Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3. Stroke. 2003 Jun; 34(6):1539-46.
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        129. Shashoua VE, Adams DS, Boyer-Boiteau A, Cornell-Bell A, Li F, Fisher M. Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia. Brain Res. 2003 Feb 14; 963(1-2):214-23.
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        130. Fisher M, Brott TG. Emerging therapies for acute ischemic stroke: new therapies on trial. Stroke. 2003 Feb; 34(2):359-61.
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        131. Gerriets T, Li F, Silva MD, Meng X, Brevard M, Sotak CH, Fisher M. The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats. J Neurosci Methods. 2003 Jan 30; 122(2):201-11.
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        132. Fisher M. Ongoing trials and future directions for acute ischemic stroke treatment. Adv Neurol. 2003; 92:401-8.
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        133. Fisher M, Ratan R. New perspectives on developing acute stroke therapy. Ann Neurol. 2003 Jan; 53(1):10-20.
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        134. Fisher M. Reversal of diffusion abnormalities after ischemic stroke: adding difficulty and complexity to the conundrum of acute stroke imaging. Ann Neurol. 2002 Dec; 52(6):695-6.
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        135. Silva MD, Omae T, Helmer KG, Li F, Fisher M, Sotak CH. Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain. Magn Reson Med. 2002 Nov; 48(5):826-37.
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        136. Moonis M, Fisher M. Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke. Stroke. 2002 Jul; 33(7):1927-33.
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        137. Li F, Liu KF, Silva MD, Meng X, Gerriets T, Helmer KG, Fenstermacher JD, Sotak CH, Fisher M. Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats. AJNR Am J Neuroradiol. 2002 Feb; 23(2):180-8.
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