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    Last Name

    Jun R Huh PhD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB-313
    Worcester MA 01605
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentImmunology and Microbiology Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program



        Jun R. Huh received his Ph.D. from California Institute of Technology, Pasadena. Subsequently he joined Dr. Dan Littman's laboratory at NYU school of medicine for his post-doctoral work. In 2013, he joined the faculty as an Assistant Professor of Medicine.

        Research Information

        Our research focuses on the identification of chemical and genetic tools to regulate pro-inflammatory immune cells in murine disease models such as intestinal bowel diseases, and the pursuit of bacterial metabolites regulating host immune responses. We are also interested in studying epigenetic regulatory mechanisms as well as the mechanisms through which immune cells modulate neural development.


        The Huh lab website

        Rotation Projects
        Please email to if you are interested in rotations.

        Post Docs

        I am currently recruiting a post-doctoral fellowwith experience in immunology, microbiology, molecular biology or a relateddiscipline. Please email to if you are interested.

        selected publications
        List All   |   Timeline
        1. Sellars M, Huh JR, Day K, Issuree PD, Galan C, Gobeil S, Absher D, Green MR, Littman DR. Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages. Nat Immunol. 2015 Jul; 16(7):746-54.
          View in: PubMed
        2. Longman RS, Diehl GE, Victorio DA, Huh JR, Galan C, Miraldi ER, Swaminath A, Bonneau R, Scherl EJ, Littman DR. CX3CR1? mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med. 2014 Jul 28; 211(8):1571-83.
          View in: PubMed
        3. Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP, Johnson RL, Huang W, Littman DR. Identification of Potent and Selective Diphenylpropanamide ROR? Inhibitors. ACS Med Chem Lett. 2013 Jan 10; 4(1):79-84.
          View in: PubMed
        4. Huh JR, Littman DR. Small molecule inhibitors of ROR?t: targeting Th17 cells and other applications. Eur J Immunol. 2012 Sep; 42(9):2232-7.
          View in: PubMed
        5. Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka RR, Chow J, Manel N, Ciofani M, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, Rastinejad F, Littman DR. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing ROR?t activity. Nature. 2011 Apr 28; 472(7344):486-90.
          View in: PubMed
        6. Huh JR, Foe I, Muro I, Chen CH, Seol JH, Yoo SJ, Guo M, Park JM, Hay BA. The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers. J Biol Chem. 2007 Jan 19; 282(3):2056-68.
          View in: PubMed
        7. Muro I, Berry DL, Huh JR, Chen CH, Huang H, Yoo SJ, Guo M, Baehrecke EH, Hay BA. The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. Development. 2006 Sep; 133(17):3305-15.
          View in: PubMed
        8. Clark IE, Dodson MW, Jiang C, Cao JH, Huh JR, Seol JH, Yoo SJ, Hay BA, Guo M. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature. 2006 Jun 29; 441(7097):1162-6.
          View in: PubMed
        9. Yan N, Huh JR, Schirf V, Demeler B, Hay BA, Shi Y. Structure and activation mechanism of the Drosophila initiator caspase Dronc. J Biol Chem. 2006 Mar 31; 281(13):8667-74.
          View in: PubMed
        10. Hay BA, Huh JR, Guo M. The genetics of cell death: approaches, insights and opportunities in Drosophila. Nat Rev Genet. 2004 Dec; 5(12):911-22.
          View in: PubMed
        11. Huh JR, Guo M, Hay BA. Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role. Curr Biol. 2004 Jul 27; 14(14):1262-6.
          View in: PubMed
        12. Huh JR, Vernooy SY, Yu H, Yan N, Shi Y, Guo M, Hay BA. Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol. 2004 Jan; 2(1):E15.
          View in: PubMed
        13. Chai J, Yan N, Huh JR, Wu JW, Li W, Hay BA, Shi Y. Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. Nat Struct Biol. 2003 Nov; 10(11):892-8.
          View in: PubMed
        14. Olson MR, Holley CL, Yoo SJ, Huh JR, Hay BA, Kornbluth S. Reaper is regulated by IAP-mediated ubiquitination. J Biol Chem. 2003 Feb 7; 278(6):4028-34.
          View in: PubMed
        15. Huh JR, Hay BA. Apoptosis: sculpture of a fly's head. Nature. 2002 Aug 29; 418(6901):926-8.
          View in: PubMed
        16. Yoo SJ, Huh JR, Muro I, Yu H, Wang L, Wang SL, Feldman RM, Clem RJ, Müller HA, Hay BA. Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms. Nat Cell Biol. 2002 Jun; 4(6):416-24.
          View in: PubMed
        17. Dorstyn L, Read S, Cakouros D, Huh JR, Hay BA, Kumar S. The role of cytochrome c in caspase activation in Drosophila melanogaster cells. J Cell Biol. 2002 Mar 18; 156(6):1089-98.
          View in: PubMed
        18. Cao Y, Kang HL, Xu X, Wang M, Dho SH, Huh JR, Lee BJ, Kalush F, Bocskai D, Ding Y, Tesmer JG, Lee J, Moon E, Jurecic V, Baldini A, Weier HU, Doggett NA, Simon MI, Adams MD, Kim UJ. A 12-Mb complete coverage BAC contig map in human chromosome 16p13.1-p11.2. Genome Res. 1999 Aug; 9(8):763-74.
          View in: PubMed
        19. Huh JR, Park JM, Kim M, Carlson BA, Hatfield DL, Lee BJ. Recruitment of TBP or TFIIB to a promoter proximal position leads to stimulation of RNA polymerase II transcription without activator proteins both in vivo and in vitro. Biochem Biophys Res Commun. 1999 Mar 5; 256(1):45-51.
          View in: PubMed
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