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    John L Sullivan MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPediatrics
    AddressUniversity of Massachusetts Medical School
    373 Plantation Street
    Worcester MA 01605
    Phone508-856-1638
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentMicrobiology and Physiological Systems

      InstitutionUMMS - School of Medicine
      DepartmentPathology

      InstitutionUMMS - School of Medicine
      DepartmentProgram in Molecular Medicine

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentClinical Population Health Research

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentImmunology and Virology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMasters in Clinical Investigation

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMolecular Genetics and Microbiology

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentCenter for AIDS Research

        Overview 
        Narrative

        Academic Background

        John L. Sullivan received his BS from LeMoyne College in 1968 and his MD from SUNY Upstate Medical School, Syracuse, in 1972. From 1973 to 1975, he served as a staff associate in the Division of Virology at the NIH Bureau of Biologics in Bethesda, Maryland. He completed his pediatric training and clinical immunology at the University of Washington. In 1978, he joined the Department of Pediatrics at the University of Massachusetts Medical School. In 1984 the American Heart Association awarded him an Established Investigatorship. Dr. Sullivan served on the Immunological Sciences Study Section 1982-1986 and was a Charter Member of AIDS and Related Research Study Section (1990-92) of the NIH.

        Epstein-Barr Virus [EBV] and Human Immunodeficiency Virus [HIV]

        John L. Sullivan, MDResearch in this laboratory is aimed at understandingthe pathogenesis of chronic infection with Epstein-Barr Virus [EBV] and Human Immunodeficiency Virus [HIV]. Studies of EBV are focused on the nature of the immune response which controls but does not eradicate viral replication and the nature of the immune defect which results in the X-linked lymphoproliferative syndrome. Studies of HIV are focused on the elucidation and characterization of HIV gene mutations which result in infections associated with long term control of viral replication and/or lack of disease progression.

        Experimental therapeutic and preventative vaccine approaches are also being studied. These include combination antiretroviral agents to interrupt viral replication and recombinant vector or live attenuated vaccines to prevent HIV-1 infection. Of particular interest is the development of therapeutics and vaccine regimens which can be used in the developing world to interrupt maternal to child transmission.



        Rotation Projects

        Potential Rotation Projects

        Contact Dr. Sullivan for more project details.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Wang S, Kishko M, Wan S, Wang Y, Brewster F, Gray GE, Violari A, Sullivan JL, Somasundaran M, Luzuriaga K, Lu S. Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates. Hum Vaccin Immunother. 2012 Nov 1; 8(11):1638-47.
          View in: PubMed
        2. Kishko M, Somasundaran M, Brewster F, Sullivan JL, Clapham PR, Luzuriaga K. Genotypic and functional properties of early infant HIV-1 envelopes. Retrovirology. 2011; 8:67.
          View in: PubMed
        3. Clute SC, Naumov YN, Watkin LB, Aslan N, Sullivan JL, Thorley-Lawson DA, Luzuriaga K, Welsh RM, Puzone R, Celada F, Selin LK. Broad cross-reactive TCR repertoires recognizing dissimilar epstein-barr and influenza A virus epitopes. J Immunol. 2010 Dec 1; 185(11):6753-64.
          View in: PubMed
        4. Luzuriaga K, Sullivan JL. Infectious mononucleosis. N Engl J Med. 2010 May 27; 362(21):1993-2000.
          View in: PubMed
        5. Mehta N, Trzmielina S, Nonyane BA, Eliot MN, Lin R, Foulkes AS, McNeal K, Ammann A, Eulalievyolo V, Sullivan JL, Luzuriaga K, Somasundaran M. Low-cost HIV-1 diagnosis and quantification in dried blood spots by real time PCR. PLoS One. 2009; 4(6):e5819.
          View in: PubMed
        6. Greenough TC, Cunningham CK, Muresan P, McManus M, Persaud D, Fenton T, Barker P, Gaur A, Panicali D, Sullivan JL, Luzuriaga K. Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy. Vaccine. 2008 Dec 9; 26(52):6883-93.
          View in: PubMed
        7. Newell ML, Huang S, Fiore S, Thorne C, Mandelbrot L, Sullivan JL, Maupin R, Delke I, Watts DH, Gelber RD, Cunningham CK. Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA. BMC Infect Dis. 2007; 7:60.
          View in: PubMed
        8. Clute SC, Watkin LB, Cornberg M, Naumov YN, Sullivan JL, Luzuriaga K, Welsh RM, Selin LK. Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis. J Clin Invest. 2005 Dec; 115(12):3602-12.
          View in: PubMed
        9. Greenough TC, Carville A, Coderre J, Somasundaran M, Sullivan JL, Luzuriaga K, Mansfield K. Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus. Am J Pathol. 2005 Aug; 167(2):455-63.
          View in: PubMed
        10. Farrow MA, Somasundaran M, Zhang C, Gabuzda D, Sullivan JL, Greenough TC. Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuation. AIDS Res Hum Retroviruses. 2005 Jun; 21(6):565-74.
          View in: PubMed
        11. Greenough TC, Babcock GJ, Roberts A, Hernandez HJ, Thomas WD, Coccia JA, Graziano RF, Srinivasan M, Lowy I, Finberg RW, Subbarao K, Vogel L, Somasundaran M, Luzuriaga K, Sullivan JL, Ambrosino DM. Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice. J Infect Dis. 2005 Feb 15; 191(4):507-14.
          View in: PubMed
        12. Luzuriaga K, Sullivan JL. Prevention of mother-to-child transmission of HIV infection. Clin Infect Dis. 2005 Feb 1; 40(3):466-7.
          View in: PubMed
        13. Cunningham CK, Balasubramanian R, Delke I, Maupin R, Mofenson L, Dorenbaum A, Sullivan JL, Gonzalez-Garcia A, Thorpe E, Rathore M, Gelber RD. The impact of race/ethnicity on mother-to-child HIV transmission in the United States in Pediatric AIDS Clinical Trials Group Protocol 316. J Acquir Immune Defic Syndr. 2004 Jul 1; 36(3):800-7.
          View in: PubMed
        14. Luzuriaga K, McManus M, Mofenson L, Britto P, Graham B, Sullivan JL. A trial of three antiretroviral regimens in HIV-1-infected children. N Engl J Med. 2004 Jun 10; 350(24):2471-80.
          View in: PubMed
        15. Sullivan JL. Prevention of mother-to-child transmission of HIV--what next? J Acquir Immune Defic Syndr. 2003 Sep; 34 Suppl 1:S67-72.
          View in: PubMed
        16. Mirochnick M, Dorenbaum A, Blanchard S, Cunningham CK, Gelber RD, Mofenson L, Culnane M, Sullivan JL. Predose infant nevirapine concentration with the two-dose intrapartum neonatal nevirapine regimen: association with timing of maternal intrapartum nevirapine dose. J Acquir Immune Defic Syndr. 2003 Jun 1; 33(2):153-6.
          View in: PubMed
        17. Grant RM, Kuritzkes DR, Johnson VA, Mellors JW, Sullivan JL, Swanstrom R, D'Aquila RT, Van Gorder M, Holodniy M, Lloyd Jr RM, Reid C, Morgan GF, Winslow DL. Accuracy of the TRUGENE HIV-1 genotyping kit. J Clin Microbiol. 2003 Apr; 41(4):1586-93.
          View in: PubMed
        18. Precopio ML, Sullivan JL, Willard C, Somasundaran M, Luzuriaga K. Differential kinetics and specificity of EBV-specific CD4+ and CD8+ T cells during primary infection. J Immunol. 2003 Mar 1; 170(5):2590-8.
          View in: PubMed
        19. Moodley D, Moodley J, Coovadia H, Gray G, McIntyre J, Hofmyer J, Nikodem C, Hall D, Gigliotti M, Robinson P, Boshoff L, Sullivan JL. A multicenter randomized controlled trial of nevirapine versus a combination of zidovudine and lamivudine to reduce intrapartum and early postpartum mother-to-child transmission of human immunodeficiency virus type 1. J Infect Dis. 2003 Mar 1; 187(5):725-35.
          View in: PubMed
        20. Mirochnick M, Dorenbaum A, Holland D, Cunningham-Schrader B, Cunningham C, Gelber R, Mofenson L, Culnane M, Connor J, Sullivan JL. Concentrations of protease inhibitors in cord blood after in utero exposure. Pediatr Infect Dis J. 2002 Sep; 21(9):835-8.
          View in: PubMed
        21. Dorenbaum A, Cunningham CK, Gelber RD, Culnane M, Mofenson L, Britto P, Rekacewicz C, Newell ML, Delfraissy JF, Cunningham-Schrader B, Mirochnick M, Sullivan JL. Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trial. JAMA. 2002 Jul 10; 288(2):189-98.
          View in: PubMed
        22. Cunningham CK, Chaix ML, Rekacewicz C, Britto P, Rouzioux C, Gelber RD, Dorenbaum A, Delfraissy JF, Bazin B, Mofenson L, Sullivan JL. Development of resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 316. J Infect Dis. 2002 Jul 15; 186(2):181-8.
          View in: PubMed
        23. Haran JP, Greenough TC, Luzuriaga K, Sullivan JL, Flanigan T, Somasundaran M. Enhanced culture method for detection of replication-competent virus in peripheral blood mononuclear cells of HIV type 1-infected individuals. AIDS Res Hum Retroviruses. 2002 May 20; 18(8):577-83.
          View in: PubMed
        24. Catalina MD, Sullivan JL, Brody RM, Luzuriaga K. Phenotypic and functional heterogeneity of EBV epitope-specific CD8+ T cells. J Immunol. 2002 Apr 15; 168(8):4184-91.
          View in: PubMed
        25. Luzuriaga K, Sullivan JL. Pediatric HIV-1 infection: advances and remaining challenges. AIDS Rev. 2002 Jan-Mar; 4(1):21-6.
          View in: PubMed
        26. Sullivan JL. The abnormal gene in X-linked lymphoproliferative syndrome. Curr Opin Immunol. 1999 Aug; 11(4):431-4.
          View in: PubMed
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