Richard A Tuft PhD
|Title||Research Associate Professor|
|Institution||University of Massachusetts Medical School|
|Department||Microbiology and Physiological Systems|
|Address||University of Massachusetts Medical School|
373 Plantation Street
Worcester MA 01605
|Institution||UMMS - Graduate School of Biomedical Sciences|
|Department||Biochemistry and Molecular Pharmacology|
1963, B.S., Pennsylvania State University
1966, M.S.E.E., Massachusetts Institute of Technology
1972, Ph.D., Worcester Polytechnic Institute
Development of New Optical/Electronic Microscopes
My current research interest is the development of newoptical/electronic microscopes, and their application to the problems ofimaging rapid changes in the concentration of intracellular ions andmolecules. A microscope incorporating fast piezoelectric focusing (at 1micrometer per millisecond), a low-noise high-quantum-efficiency solidstate CCD camera, and ultraviolet and visible laser illumination iscurrently being used to study intracellular [Ca2+] near the plasma membrane of smooth muscle cells,the role of Ca2+ and other secondmessengers in the chemotaxis of white blood cells, and [Ca2+] dynamics in secretory cells.
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