Thomas W Honeyman PhD
|Institution||University of Massachusetts Medical School|
|Department||Microbiology and Physiological Systems|
|Address||University of Massachusetts Medical School|
55 Lake Avenue North
Worcester MA 01655
B.A., Colgate University, 1967;
Ph.D., Harvard Medical School, 1974.
The Transduction of Hormonal Neurotransmitter Signals
The biochemical and physiological events involved in the transductionof hormonal neurotransmitter signals. Intracellular signalling pathwaysin the control of Ca2+, H+ and Na+ in smoothmuscle. Application of computer-aided image analysis to the study of thepathogenesis of cancer.
Original kymograph used to record blood pressure. Described by Carl Ludwig, 1847.
Potential Rotation Projects
Project #1: The dynamics of caspase-3 activation during oxalate-induced toxicity in kidney epithelial cells. A fluorescent energy transfer probe will be introduced into cells by transient and stable transfection and used to monitor activation of caspase-3 (a key proteolytic enzyme involved in cell death) in individual cells.
Project #2: The dynamics of activation of cytosolic phospholipase A2 in kidney and bone cells. Fusion constructs of phospholipase A2 - green fluorescent protein will be made and to produce transient and stable transfected cells. These cells will then be used to follow the dynamics of intracellular movement of the enzyme in response to oxalate in kidney cells and Vitamin D in bone cells.
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