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    Thomas W Honeyman PhD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMicrobiology and Physiological Systems
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-2407
        Overview 
        Narrative

        Academic Background

        B.A., Colgate University, 1967;
        Ph.D., Harvard Medical School, 1974.

        The Transduction of Hormonal Neurotransmitter Signals

        Photo: Thomas W. Honeyman

        The biochemical and physiological events involved in the transductionof hormonal neurotransmitter signals. Intracellular signalling pathwaysin the control of Ca2+, H+ and Na+ in smoothmuscle. Application of computer-aided image analysis to the study of thepathogenesis of cancer.

        Historical Figure

        Historical Figure

        Original kymograph used to record blood pressure. Described by Carl Ludwig, 1847.



        Rotation Projects

        Potential Rotation Projects

        Project #1: The dynamics of caspase-3 activation during oxalate-induced toxicity in kidney epithelial cells. A fluorescent energy transfer probe will be introduced into cells by transient and stable transfection and used to monitor activation of caspase-3 (a key proteolytic enzyme involved in cell death) in individual cells.

        Project #2: The dynamics of activation of cytosolic phospholipase A2 in kidney and bone cells. Fusion constructs of phospholipase A2 - green fluorescent protein will be made and to produce transient and stable transfected cells. These cells will then be used to follow the dynamics of intracellular movement of the enzyme in response to oxalate in kidney cells and Vitamin D in bone cells.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Olson ML, Kargacin ME, Honeyman TW, Ward CA, Kargacin GJ. Effects of phytoestrogens on sarcoplasmic/endoplasmic reticulum calcium ATPase 2a and Ca2+ uptake into cardiac sarcoplasmic reticulum. J Pharmacol Exp Ther. 2006 Feb; 316(2):628-35.
          View in: PubMed
        2. Cao LC, Honeyman TW, Cooney R, Kennington L, Scheid CR, Jonassen JA. Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity. Kidney Int. 2004 Nov; 66(5):1890-900.
          View in: PubMed
        3. Jonassen JA, Cao LC, Honeyman T, Scheid CR. Intracellular events in the initiation of calcium oxalate stones. Nephron Exp Nephrol. 2004; 98(2):e61-4.
          View in: PubMed
        4. Scheid CR, Cao LC, Honeyman T, Jonassen JA. How elevated oxalate can promote kidney stone disease: changes at the surface and in the cytosol of renal cells that promote crystal adherence and growth. Front Biosci. 2004 Jan 1; 9:797-808.
          View in: PubMed
        5. Jonassen JA, Cao LC, Honeyman T, Scheid CR. Mechanisms mediating oxalate-induced alterations in renal cell functions. Crit Rev Eukaryot Gene Expr. 2003; 13(1):55-72.
          View in: PubMed
        6. Cao LC, Jonassen J, Honeyman TW, Scheid C. Oxalate-induced redistribution of phosphatidylserine in renal epithelial cells: implications for kidney stone disease. Am J Nephrol. 2001 Jan-Feb; 21(1):69-77.
          View in: PubMed
        7. Kohjimoto Y, Honeyman TW, Jonassen J, Gravel K, Kennington L, Scheid CR. Phospholipase A2 mediates immediate early genes in cultured renal epithelial cells: possible role of lysophospholipid. Kidney Int. 2000 Aug; 58(2):638-46.
          View in: PubMed
        8. Kohjimoto Y, Kennington L, Scheid CR, Honeyman TW. Role of phospholipase A2 in the cytotoxic effects of oxalate in cultured renal epithelial cells. Kidney Int. 1999 Oct; 56(4):1432-41.
          View in: PubMed
        9. Norton GR, Woodiwiss AJ, McGinn RJ, Lorbar M, Chung ES, Honeyman TW, Fenton RA, Dobson JG, Meyer TE. Adenosine A1 receptor-mediated antiadrenergic effects are modulated by A2a receptor activation in rat heart. Am J Physiol. 1999 Feb; 276(2 Pt 2):H341-9.
          View in: PubMed
        10. Ellstrom DR, Honeyman TW, Scheid CR. Role of blood pressure in regulating Na+/H+ exchange in vascular smooth muscle. Am J Hypertens. 1994 Apr; 7(4 Pt 1):340-5.
          View in: PubMed
        11. Ellstrom DR, Foster CD, Honeyman TW, Scheid CR. Regulation of Na+/H+ exchange in mesenteric arteries from spontaneously hypertensive rats. Am J Hypertens. 1993 Jan; 6(1):21-7.
          View in: PubMed
        12. Foster CD, Honeyman TW, Scheid CR. Alterations in Na(+)-H+ exchange in mesenteric arteries from spontaneously hypertensive rats. Am J Physiol. 1992 Jun; 262(6 Pt 2):H1657-62.
          View in: PubMed
        13. Foster CD, Hill WA, Honeyman TW, Scheid CR. Characterization of Na(+)-H+ exchange in segments of rat mesenteric artery. Am J Physiol. 1992 Jun; 262(6 Pt 2):H1651-6.
          View in: PubMed
        14. Quinn DA, Honeyman TW, Joseph PM, Thompson BT, Hales CA, Scheid CR. Contribution of Na+/H+ exchange to pH regulation in pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 1991 Dec; 5(6):586-91.
          View in: PubMed
        15. Park CS, Honeyman TW, Ha SK, Choi HK, Chung CL, Hong CD. Mechanisms of ionophore-induced stimulation of renin secretion with special reference to a chemiosmotic hypothesis. J Pharmacol Exp Ther. 1991 Oct; 259(1):211-8.
          View in: PubMed
        16. Doh PS, Lee CJ, Hwang PM, Cho KW, Honeyman TW, Park CS. Role of membrane sulfhydryl groups in stimulation of renin secretion by sulfhydryl reagents. Kidney Int. 1991 May; 39(5):867-73.
          View in: PubMed
        17. Goodman HM, Gorin E, Schwartz Y, Tai LR, Chipkin SR, Honeyman TW, Frick GP, Yamaguchi H. Cellular effects of growth hormone on adipocytes. Chin J Physiol. 1991; 34(1):27-44.
          View in: PubMed
        18. Cooney RA, Honeyman TW, Scheid CR. Contribution of Na(+)-dependent and ATP-dependent Ca2+ transport to smooth muscle calcium homeostasis. Ann N Y Acad Sci. 1991; 639:558-60.
          View in: PubMed
        19. Lucchesi PA, Scheid CR, Romano FD, Kargacin ME, Mullikin-Kilpatrick D, Yamaguchi H, Honeyman TW. Ligand binding and G protein coupling of muscarinic receptors in airway smooth muscle. Am J Physiol. 1990 Apr; 258(4 Pt 1):C730-8.
          View in: PubMed
        20. Lee DY, Cho KW, Lee JS, Honeyman TW, Park CS. Stimulation of renin secretion by non-diuretic sulfhydryl reagents. Kidney Int. 1989 Mar; 35(3):812-6.
          View in: PubMed
        21. Lucchesi PA, Romano FD, Scheid CR, Yamaguchi H, Honeyman TW. Interaction of agonists and selective antagonists with gastric smooth muscle muscarinic receptors. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jan-Feb; 339(1-2):145-51.
          View in: PubMed
        22. Kargacin ME, Scheid CR, Honeyman TW. Continuous monitoring of Ca2+ uptake in membrane vesicles with fura-2. Am J Physiol. 1988 Nov; 255(5 Pt 1):C694-8.
          View in: PubMed
        23. Lucchesi PA, Cooney RA, Mangsen-Baker C, Honeyman TW, Scheid CR. Assessment of transport capacity of plasmalemmal Ca2+ pump in smooth muscle. Am J Physiol. 1988 Aug; 255(2 Pt 1):C226-36.
          View in: PubMed
        24. Kargacin ME, Bassell G, Ryan PJ, Honeyman TW. Separation and analysis of fluorescent derivatives of myo-inositol and myo-inositol 2-phosphate by high-performance liquid chromatography. J Chromatogr. 1987 May 1; 393(3):454-8.
          View in: PubMed
        25. Honeyman TW, Strohsnitter W, Scheid CR, Schimmel RJ. Phosphatidic acid and phosphatidylinositol labelling in adipose tissue. Relationship to the metabolic effects of insulin and insulin-like agents. Biochem J. 1983 May 15; 212(2):489-98.
          View in: PubMed
        26. Scheid CR, Honeyman TW, Fay FS. Mechanism of beta-adrenergic relaxation of smooth muscle. Nature. 1979 Jan 4; 277(5691):32-6.
          View in: PubMed
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