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    Paulo J Oliveira MD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-3121
        Bibliographic 
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        1. Santos-Alves E, Marques-Aleixo I, Coxito P, Balça MM, Rizo-Roca D, Rocha-Rodrigues S, Martins S, Torrella JR, Oliveira PJ, Moreno AJ, Magalhães J, Ascensão A. Exercise mitigates diclofenac-induced liver mitochondrial dysfunction. Eur J Clin Invest. 2014 Jul; 44(7):668-77.
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        2. Gonçalves IO, Passos E, Rocha-Rodrigues S, Diogo CV, Torrella JR, Rizo D, Viscor G, Santos-Alves E, Marques-Aleixo I, Oliveira PJ, Ascensão A, Magalhães J. Physical exercise prevents and mitigates non-alcoholic steatohepatitis-induced liver mitochondrial structural and bioenergetics impairments. Mitochondrion. 2014 Mar; 15:40-51.
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        3. Braga SS, Marques J, Heister E, Diogo CV, Oliveira PJ, Paz FA, Santos TM, Marques MP. Carriers for metal complexes on tumour cells: the effect of cyclodextrins vs CNTs on the model guest phenanthroline-5,6-dione trithiacyclononane ruthenium(II) chloride. Biometals. 2014 Jun; 27(3):507-25.
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        4. Oliveira PJ, Perkins EL, Holy J. Vital imaging of multicellular spheroids. Methods Mol Biol. 2014; 1075:227-41.
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        5. Monteiro JP, Morais CM, Oliveira PJ, Jurado AS. Mitochondrial Membrane Lipids in Life and Death and their Molecular Modulation by Diet: Tuning the Furnace. Curr Drug Targets. 2014; 15(8):797-810.
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        6. Boundy KE, Fraire AE, Oliveira PJ. A patient with progressive dyspnea and multiple foci of airspace consolidation. Chest. 2014 Jan 1; 145(1):167-72.
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        7. Pereira SL, Grãos M, Rodrigues AS, Anjo SI, Carvalho RA, Oliveira PJ, Arenas E, Ramalho-Santos J. Inhibition of Mitochondrial Complex III Blocks Neuronal Differentiation and Maintains Embryonic Stem Cell Pluripotency. PLoS One. 2013; 8(12):e82095.
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        8. Gomes C, Lopes ML, Oliveira PJ. Municipal solid waste shear strength parameters defined through laboratorial and in situ tests. J Air Waste Manag Assoc. 2013 Nov; 63(11):1352-68.
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        9. Shaikh AY, Oliveira PJ. Exogenous Lipoid Pneumonia (Fire-eater's Lung). Am J Med. 2014 Feb; 127(2):e3-4.
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        10. Bernardo TC, Cunha-Oliveira T, Serafim TL, Holy J, Krasutsky D, Kolomitsyna O, Krasutsky P, Moreno AM, Oliveira PJ. Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition. Bioorg Med Chem. 2013 Dec 1; 21(23):7239-49.
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        11. Burgeiro A, Mollinedo F, Oliveira PJ. Ipilimumab and vemurafenib: two different routes for targeting melanoma. Curr Cancer Drug Targets. 2013 Oct; 13(8):879-94.
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        12. Gonçalves IO, Oliveira PJ, Ascensão A, Magalhães J. Exercise as a therapeutic tool to prevent mitochondrial degeneration in nonalcoholic steatohepatitis. Eur J Clin Invest. 2013 Nov; 43(11):1184-94.
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        13. Valente AX, Oliveira PJ, Khaiboullina SF, Palotás A, Rizvanov AA. Biological insight, high-throughput datasets and the nature of neuro-degenerative disorders. Curr Drug Metab. 2013 Sep; 14(7):814-8.
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        14. Branco AF, Sampaio SF, Wieckowski MR, Sardão VA, Oliveira PJ. Mitochondrial disruption occurs downstream from ß-adrenergic overactivation by isoproterenol in differentiated, but not undifferentiated H9c2 cardiomyoblasts: differential activation of stress and survival pathways. Int J Biochem Cell Biol. 2013 Nov; 45(11):2379-91.
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        15. Monteiro JP, Silva AM, Jurado AS, Oliveira PJ. Rapeseed oil-rich diet alters in vitro menadione and nimesulide hepatic mitochondrial toxicity. Food Chem Toxicol. 2013 Oct; 60:479-87.
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        16. Ascensão A, Martins MJ, Santos-Alves E, Gonçalves IO, Portincasa P, Oliveira PJ, Magalhães J. Modulation of hepatic redox status and mitochondrial metabolism by exercise: Therapeutic strategy for liver diseases. Mitochondrion. 2013 Nov; 13(6):862-70.
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        17. Rocha-Rodrigues S, Santos-Alves E, Coxito PM, Marques-Aleixo I, Passos E, Guimarães JT, Martins MJ, Oliveira PJ, Magalhães J, Ascensão A. Combined effects of aging and in vitro non-steroid anti-inflammatory drugs on kidney and liver mitochondrial physiology. Life Sci. 2013 Sep 3; 93(8):329-37.
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        18. Monteiro JP, Oliveira PJ, Jurado AS. Mitochondrial membrane lipid remodeling in pathophysiology: A new target for diet and therapeutic interventions. Prog Lipid Res. 2013 Oct; 52(4):513-28.
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        19. Pereira SP, Pereira GC, Pereira CV, Carvalho FS, Cordeiro MH, Mota PC, Ramalho-Santos J, Moreno AJ, Oliveira PJ. Dioxin-induced acute cardiac mitochondrial oxidative damage and increased activity of ATP-sensitive potassium channels in Wistar rats. Environ Pollut. 2013 Sep; 180:281-90.
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        20. Grattagliano I, Diogo CV, Mastrodonato M, de Bari O, Persichella M, Wang DQ, Liquori A, Ferri D, Carratù MR, Oliveira PJ, Portincasa P. A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes. World J Gastroenterol. 2013 May 28; 19(20):3007-17.
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        21. Loureiro R, Mesquita KA, Oliveira PJ, Vega-Naredo I. Mitochondria in cancer stem cells: a target for therapy. Recent Pat Endocr Metab Immune Drug Discov. 2013 May; 7(2):102-14.
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        22. Monteiro JP, Pereira CV, Silva AM, Maciel E, Baldeiras I, Peixoto F, Domingues MR, Jurado AS, Oliveira PJ. Rapeseed oil-rich diet alters hepatic mitochondrial membrane lipid composition and disrupts bioenergetics. Arch Toxicol. 2013 Dec; 87(12):2151-63.
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        23. Monteiro JP, Martins AF, Nunes C, Morais CM, Lúcio M, Reis S, Pinheiro TJ, Geraldes CF, Oliveira PJ, Jurado AS. A biophysical approach to menadione membrane interactions: relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects. Biochim Biophys Acta. 2013 Aug; 1828(8):1899-908.
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        24. Magalhães J, Fraga M, Lumini-Oliveira J, Gonçalves I, Costa M, Ferreira R, Oliveira PJ, Ascensão A. Eccentric exercise transiently affects mice skeletal muscle mitochondrial function. Appl Physiol Nutr Metab. 2013 Apr; 38(4):401-9.
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        25. Burgeiro A, Bento AC, Gajate C, Oliveira PJ, Mollinedo F. Rapid human melanoma cell death induced by sanguinarine through oxidative stress. Eur J Pharmacol. 2013 Apr 5; 705(1-3):109-18.
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        26. Carvalho FS, Burgeiro A, Garcia R, Moreno AJ, Carvalho RA, Oliveira PJ. Doxorubicin-induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy. Med Res Rev. 2014 Jan; 34(1):106-35.
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        27. Branco AF, Sampaio SF, Moreira AC, Holy J, Wallace KB, Baldeiras I, Oliveira PJ, Sardão VA. Differentiation-dependent doxorubicin toxicity on H9c2 cardiomyoblasts. Cardiovasc Toxicol. 2012 Dec; 12(4):326-40.
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        28. Burgeiro A, Pereira CV, Carvalho FS, Pereira GC, Mollinedo F, Oliveira PJ. Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition. Mitochondrion. 2013 Jan; 13(1):25-35.
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        29. Marques-Aleixo I, Oliveira PJ, Moreira PI, Magalhães J, Ascensão A. Physical exercise as a possible strategy for brain protection: evidence from mitochondrial-mediated mechanisms. Prog Neurobiol. 2012 Nov; 99(2):149-62.
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        30. Choumessi AT, Loureiro R, Silva AM, Moreira AC, Pieme AC, Tazoacha A, Oliveira PJ, Penlap VB. Toxicity evaluation of some traditional African spices on breast cancer cells and isolated rat hepatic mitochondria. Food Chem Toxicol. 2012 Nov; 50(11):4199-208.
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        31. Pereira CV, Oliveira PJ, Will Y, Nadanaciva S. Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms. Toxicol Appl Pharmacol. 2012 Oct 15; 264(2):167-81.
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        32. Alves MG, Oliveira PF, Martins FO, Oliveira PJ, Carvalho RA. Gender-dependent metabolic remodeling during heart preservation in cardioplegic celsior and histidine buffer solution. J Cardiovasc Pharmacol. 2012 Aug; 60(2):227-33.
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        33. Lebiedzinska M, Karkucinska-Wieckowska A, Wojtala A, Suski JM, Szabadkai G, Wilczynski G, Wlodarczyk J, Diogo CV, Oliveira PJ, Tauber J, Ježek P, Pronicki M, Duszynski J, Pinton P, Wieckowski MR. Disrupted ATP synthase activity and mitochondrial hyperpolarisation-dependent oxidative stress is associated with p66Shc phosphorylation in fibroblasts of NARP patients. Int J Biochem Cell Biol. 2013 Jan; 45(1):141-50.
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        34. Diogo CV, Suski JM, Lebiedzinska M, Karkucinska-Wieckowska A, Wojtala A, Pronicki M, Duszynski J, Pinton P, Portincasa P, Oliveira PJ, Wieckowski MR. Cardiac mitochondrial dysfunction during hyperglycemia--the role of oxidative stress and p66Shc signaling. Int J Biochem Cell Biol. 2013 Jan; 45(1):114-22.
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        35. Pereira GC, Pereira SP, Pereira CV, Lumini JA, Magalhães J, Ascensão A, Santos MS, Moreno AJ, Oliveira PJ. Mitochondrionopathy phenotype in doxorubicin-treated Wistar rats depends on treatment protocol and is cardiac-specific. PLoS One. 2012; 7(6):e38867.
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        36. Valente AX, das Neves RP, Oliveira PJ. Epigenetic engineering to reverse the Parkinson's expression state. Parkinsonism Relat Disord. 2012 Jul; 18(6):717-21.
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        37. Barbosa IA, Machado NG, Skildum AJ, Scott PM, Oliveira PJ. Mitochondrial remodeling in cancer metabolism and survival: potential for new therapies. Biochim Biophys Acta. 2012 Aug; 1826(1):238-54.
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        38. Grattagliano I, de Bari O, Bernardo TC, Oliveira PJ, Wang DQ, Portincasa P. Role of mitochondria in nonalcoholic fatty liver disease--from origin to propagation. Clin Biochem. 2012 Jun; 45(9):610-8.
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        39. Alves MG, Oliveira PF, Martins FO, Oliveira PJ, Carvalho RA. Gender-dependent metabolic remodeling during heart preservation in cardioplegic celsior and histidine buffer solution. J Cardiovasc Pharmacol. 2012 Feb; 59(2):151-7.
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        40. Oliveira PJ, Carvalho RA, Portincasa P, Bonfrate L, Sardao VA. Fatty Acid Oxidation and Cardiovascular Risk during Menopause: A Mitochondrial Connection? J Lipids. 2012; 2012:365798.
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        41. Pereira CV, Nadanaciva S, Oliveira PJ, Will Y. The contribution of oxidative stress to drug-induced organ toxicity and its detection in vitro and in vivo. Expert Opin Drug Metab Toxicol. 2012 Feb; 8(2):219-37.
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        42. Silva AM, Oliveira PJ. Evaluation of respiration with clark type electrode in isolated mitochondria and permeabilized animal cells. Methods Mol Biol. 2012; 810:7-24.
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        43. Alves MG, Machado NG, Sardão VA, Carvalho RA, Oliveira PJ. Anti-apoptotic protection afforded by cardioplegic celsior and histidine buffer solutions to hearts subjected to ischemia and ischemia/reperfusion. J Cell Biochem. 2011 Dec; 112(12):3872-81.
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        44. Branco AF, Pereira SL, Moreira AC, Holy J, Sardão VA, Oliveira PJ. Isoproterenol cytotoxicity is dependent on the differentiation state of the cardiomyoblast H9c2 cell line. Cardiovasc Toxicol. 2011 Sep; 11(3):191-203.
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        45. Cuenca-Lopez MD, Karachitos A, Massarotto L, Oliveira PJ, Aguirre N, Galindo MF, Kmita H, Jordán J. Minocycline exerts uncoupling and inhibiting effects on mitochondrial respiration through adenine nucleotide translocase inhibition. Pharmacol Res. 2012 Jan; 65(1):120-8.
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        46. Pereira CV, Lebiedzinska M, Wieckowski MR, Oliveira PJ. Regulation and protection of mitochondrial physiology by sirtuins. Mitochondrion. 2012 Jan; 12(1):66-76.
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        47. Vega-Naredo I, Caballero B, Sierra V, García-Macia M, de Gonzalo-Calvo D, Oliveira PJ, Rodríguez-Colunga MJ, Coto-Montes A. Melatonin modulates autophagy through a redox-mediated action in female Syrian hamster Harderian gland controlling cell types and gland activity. J Pineal Res. 2012 Jan; 52(1):80-92.
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        48. Burgeiro A, Gajate C, Dakir el H, Villa-Pulgarín JA, Oliveira PJ, Mollinedo F. Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells. Anticancer Drugs. 2011 Jul; 22(6):507-18.
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        49. Diogo CV, Machado NG, Barbosa IA, Serafim TL, Burgeiro A, Oliveira PJ. Berberine as a promising safe anti-cancer agent - is there a role for mitochondria? Curr Drug Targets. 2011 Jun; 12(6):850-9.
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        50. Ascensão A, Lumini-Oliveira J, Oliveira PJ, Magalhães J. Mitochondria as a target for exercise-induced cardioprotection. Curr Drug Targets. 2011 Jun; 12(6):860-71.
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        51. Oliveira PJ. Mitochondria as a drug target in health and disease. Curr Drug Targets. 2011 Jun; 12(6):761.
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        52. Ascensão A, Oliveira PJ, Magalhães J. Exercise as a beneficial adjunct therapy during Doxorubicin treatment--role of mitochondria in cardioprotection. Int J Cardiol. 2012 Apr 5; 156(1):4-10.
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        53. Grattagliano I, Russmann S, Diogo C, Bonfrate L, Oliveira PJ, Wang DQ, Portincasa P. Mitochondria in chronic liver disease. Curr Drug Targets. 2011 Jun; 12(6):879-93.
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        54. Pereira SL, Ramalho-Santos J, Branco AF, Sardão VA, Oliveira PJ, Carvalho RA. Metabolic remodeling during H9c2 myoblast differentiation: relevance for in vitro toxicity studies. Cardiovasc Toxicol. 2011 Jun; 11(2):180-90.
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        55. Suski J, Lebiedzinska M, Machado NG, Oliveira PJ, Pinton P, Duszynski J, Wieckowski MR. Mitochondrial tolerance to drugs and toxic agents in ageing and disease. Curr Drug Targets. 2011 Jun; 12(6):827-49.
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        56. Monteiro JP, Martins AF, Lúcio M, Reis S, Pinheiro TJ, Geraldes CF, Oliveira PJ, Jurado AS. Nimesulide interaction with membrane model systems: are membrane physical effects involved in nimesulide mitochondrial toxicity? Toxicol In Vitro. 2011 Sep; 25(6):1215-23.
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        57. Monteiro JP, Martins AF, Lúcio M, Reis S, Geraldes CF, Oliveira PJ, Jurado AS. Interaction of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) with lipid membrane systems: a biophysical approach with relevance to mitochondrial uncoupling. J Bioenerg Biomembr. 2011 Jun; 43(3):287-98.
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        58. Serafim TL, Carvalho FS, Marques MP, Calheiros R, Silva T, Garrido J, Milhazes N, Borges F, Roleira F, Silva ET, Holy J, Oliveira PJ. Lipophilic caffeic and ferulic acid derivatives presenting cytotoxicity against human breast cancer cells. Chem Res Toxicol. 2011 May 16; 24(5):763-74.
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        59. Alves MG, Oliveira PJ, Carvalho RA. Substrate selection in hearts subjected to ischemia/reperfusion: role of cardioplegic solutions and gender. NMR Biomed. 2011 Nov; 24(9):1029-37.
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        60. Pereira GC, Silva AM, Diogo CV, Carvalho FS, Monteiro P, Oliveira PJ. Drug-induced cardiac mitochondrial toxicity and protection: from doxorubicin to carvedilol. Curr Pharm Des. 2011; 17(20):2113-29.
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        61. Ascensão A, Lumini-Oliveira J, Machado NG, Ferreira RM, Gonçalves IO, Moreira AC, Marques F, Sardão VA, Oliveira PJ, Magalhães J. Acute exercise protects against calcium-induced cardiac mitochondrial permeability transition pore opening in doxorubicin-treated rats. Clin Sci (Lond). 2011 Jan; 120(1):37-49.
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        62. Alves MG, Soares AF, Carvalho RA, Oliveira PJ. Sodium hydrosulfide improves the protective potential of the cardioplegic histidine buffer solution. Eur J Pharmacol. 2011 Mar 1; 654(1):60-7.
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        63. Mota PC, Cordeiro M, Pereira SP, Oliveira PJ, Moreno AJ, Ramalho-Santos J. Differential effects of p,p'-DDE on testis and liver mitochondria: implications for reproductive toxicology. Reprod Toxicol. 2011 Jan; 31(1):80-5.
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        64. Moreira PI, Custódio JB, Nunes E, Oliveira PJ, Moreno A, Seiça R, Oliveira CR, Santos MS. Mitochondria from distinct tissues are differently affected by 17ß-estradiol and tamoxifen. J Steroid Biochem Mol Biol. 2011 Jan; 123(1-2):8-16.
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        65. Machado NG, Baldeiras I, Pereira GC, Pereira SP, Oliveira PJ. Sub-chronic administration of doxorubicin to Wistar rats results in oxidative stress and unaltered apoptotic signaling in the lung. Chem Biol Interact. 2010 Dec 5; 188(3):478-86.
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        66. Lumini-Oliveira J, Magalhães J, Pereira CV, Moreira AC, Oliveira PJ, Ascensão A. Endurance training reverts heart mitochondrial dysfunction, permeability transition and apoptotic signaling in long-term severe hyperglycemia. Mitochondrion. 2011 Jan; 11(1):54-63.
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        67. Holy J, Kolomitsyna O, Krasutsky D, Oliveira PJ, Perkins E, Krasutsky PA. Dimethylaminopyridine derivatives of lupane triterpenoids are potent disruptors of mitochondrial structure and function. Bioorg Med Chem. 2010 Aug 15; 18(16):6080-8.
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        68. Lumini-Oliveira J, Ascensão A, Pereira CV, Magalhães S, Marques F, Oliveira PJ, Magalhães J. Long-term hyperglycaemia decreases gastrocnemius susceptibility to permeability transition. Eur J Clin Invest. 2010 Apr; 40(4):319-29.
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        69. Silva JP, Sardão VA, Coutinho OP, Oliveira PJ, Olveira PJ. Nitrogen compounds prevent h9c2 myoblast oxidative stress-induced mitochondrial dysfunction and cell death. Cardiovasc Toxicol. 2010 Mar; 10(1):51-65.
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        70. Oliveira P, Castro NM, Muniz AL, Tanajura D, Brandão JC, Porto AF, Carvalho EM. Prevalence of erectile dysfunction in HTLV-1-infected patients and its association with overactive bladder. Urology. 2010 May; 75(5):1100-3.
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        71. Machado NG, Alves MG, Carvalho RA, Oliveira PJ. Mitochondrial involvement in cardiac apoptosis during ischemia and reperfusion: can we close the box? Cardiovasc Toxicol. 2009 Dec; 9(4):211-27.
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        72. Alves MG, Oliveira PJ, Carvalho RA. Mitochondrial preservation in Celsior versus histidine buffer solution during cardiac ischemia and reperfusion. Cardiovasc Toxicol. 2009 Dec; 9(4):185-93.
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        73. Carvalho C, Santos RX, Cardoso S, Correia S, Oliveira PJ, Santos MS, Moreira PI. Doxorubicin: the good, the bad and the ugly effect. Curr Med Chem. 2009; 16(25):3267-85.
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        74. Pereira SP, Pereira GC, Moreno AJ, Oliveira PJ. Can drug safety be predicted and animal experiments reduced by using isolated mitochondrial fractions? Altern Lab Anim. 2009 Sep; 37(4):355-65.
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        75. Lumini-Oliveira J, Magalhães J, Pereira CV, Aleixo I, Oliveira PJ, Ascensão A. Endurance training improves gastrocnemius mitochondrial function despite increased susceptibility to permeability transition. Mitochondrion. 2009 Nov; 9(6):454-62.
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        76. Silva BA, Oliveira PJ, Cristóvão A, Dias AC, Malva JO. Biapigenin modulates the activity of the adenine nucleotide translocator in isolated rat brain mitochondria. Neurotox Res. 2010 Jan; 17(1):75-90.
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        77. Diogo CV, Félix L, Vilela S, Burgeiro A, Barbosa IA, Carvalho MJ, Oliveira PJ, Peixoto FP. Mitochondrial toxicity of the phyotochemicals daphnetoxin and daphnoretin--relevance for possible anti-cancer application. Toxicol In Vitro. 2009 Aug; 23(5):772-9.
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        78. Mota P, Amaral S, Martins L, de Lourdes Pereira M, Oliveira PJ, Ramalho-Santos J. Mitochondrial bioenergetics of testicular cells from the domestic cat (Felis catus)-a model for endangered species. Reprod Toxicol. 2009 Apr; 27(2):111-6.
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        79. Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB. Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts. Cancer Chemother Pharmacol. 2009 Sep; 64(4):811-27.
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        80. Pereira CV, Moreira AC, Pereira SP, Machado NG, Carvalho FS, Sardão VA, Oliveira PJ. Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety? Curr Drug Saf. 2009 Jan; 4(1):34-54.
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        81. Amaral S, Mota PC, Lacerda B, Alves M, Pereira Mde L, Oliveira PJ, Ramalho-Santos J. Testicular mitochondrial alterations in untreated streptozotocin-induced diabetic rats. Mitochondrion. 2009 Feb; 9(1):41-50.
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        82. Amaral S, Mota P, Rodrigues AS, Martins L, Oliveira PJ, Ramalho-Santos J. Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak. FEBS Lett. 2008 Dec 24; 582(30):4191-6.
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        83. Tavares RS, Martins FC, Oliveira PJ, Ramalho-Santos J, Peixoto FP. Parabens in male infertility-is there a mitochondrial connection? Reprod Toxicol. 2009 Jan; 27(1):1-7.
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        84. Cardoso S, Santos RX, Carvalho C, Correia S, Pereira GC, Pereira SS, Oliveira PJ, Santos MS, Proença T, Moreira PI. Doxorubicin increases the susceptibility of brain mitochondria to Ca(2+)-induced permeability transition and oxidative damage. Free Radic Biol Med. 2008 Nov 15; 45(10):1395-402.
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        85. Serafim TL, Matos JA, Sardão VA, Pereira GC, Branco AF, Pereira SL, Parke D, Perkins EL, Moreno AJ, Holy J, Oliveira PJ. Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells--nuclear vs. mitochondrial effects. Biochem Pharmacol. 2008 Dec 1; 76(11):1459-75.
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        86. Pereira CV, Machado NG, Oliveira PJ. Mechanisms of berberine (natural yellow 18)-induced mitochondrial dysfunction: interaction with the adenine nucleotide translocator. Toxicol Sci. 2008 Oct; 105(2):408-17.
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        87. Silva B, Oliveira PJ, Dias A, Malva JO. Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insults. Neurotox Res. 2008 May-Jun; 13(3-4):265-79.
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        88. Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB. Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets. Cell Biol Toxicol. 2009 Jun; 25(3):227-43.
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        89. Sardão VA, Pereira SL, Oliveira PJ. Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury. Expert Opin Drug Saf. 2008 Mar; 7(2):129-46.
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        90. Amaral S, Oliveira PJ, Ramalho-Santos J. Diabetes and the impairment of reproductive function: possible role of mitochondria and reactive oxygen species. Curr Diabetes Rev. 2008 Feb; 4(1):46-54.
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        91. Lumini JA, Magalhães J, Oliveira PJ, Ascensão A. Beneficial effects of exercise on muscle mitochondrial function in diabetes mellitus. Sports Med. 2008; 38(9):735-50.
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        92. Magalhães J, Ferreira R, Neuparth MJ, Oliveira PJ, Marques F, Ascensão A. Vitamin E prevents hypobaric hypoxia-induced mitochondrial dysfunction in skeletal muscle. Clin Sci (Lond). 2007 Dec; 113(12):459-66.
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        93. O'Brien TM, Oliveira PJ, Wallace KB. Inhibition of the adenine nucleotide translocator by N-acetyl perfluorooctane sulfonamides in vitro. Toxicol Appl Pharmacol. 2008 Mar 1; 227(2):184-95.
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        94. Tamagnini P, Leitão E, Oliveira P, Ferreira D, Pinto F, Harris DJ, Heidorn T, Lindblad P. Cyanobacterial hydrogenases: diversity, regulation and applications. FEMS Microbiol Rev. 2007 Nov; 31(6):692-720.
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        95. Pereira GC, Branco AF, Matos JA, Pereira SL, Parke D, Perkins EL, Serafim TL, Sardão VA, Santos MS, Moreno AJ, Holy J, Oliveira PJ. Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions. J Pharmacol Exp Ther. 2007 Nov; 323(2):636-49.
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        96. Oliveira PJ, Asner GP, Knapp DE, Almeyda A, Galván-Gildemeister R, Keene S, Raybin RF, Smith RC. Land-use allocation protects the Peruvian Amazon. Science. 2007 Aug 31; 317(5842):1233-6.
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        97. Serafim TL, Oliveira PJ, Sardao VA, Perkins E, Parke D, Holy J. Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line. Cancer Chemother Pharmacol. 2008 May; 61(6):1007-18.
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        98. Ferreira D, Leitão E, Sjöholm J, Oliveira P, Lindblad P, Moradas-Ferreira P, Tamagnini P. Transcription and regulation of the hydrogenase(s) accessory genes, hypFCDEAB, in the cyanobacterium Lyngbya majuscula CCAP 1446/4. Arch Microbiol. 2007 Dec; 188(6):609-17.
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        99. Castro NM, Rodrigues W, Freitas DM, Muniz A, Oliveira P, Carvalho EM. Urinary symptoms associated with human T-cell lymphotropic virus type I infection: evidence of urinary manifestations in large group of HTLV-I carriers. Urology. 2007 May; 69(5):813-8.
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        100. Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB. Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide--characterization of morphological features of cell death. BMC Cell Biol. 2007; 8:11.
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