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    Jeanmarie Houghton MD, PhD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB
    Worcester MA 01605
    Phone508-856-6441
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentCancer Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCancer Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMillennium MD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMolecular Genetics and Microbiology

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentMolecular Genetics and Microbiology

        Overview 
        Narrative

        Academic Background

        Education:
        B. A., Rutgers University, New Brunswick, NJ
        MD,UMDNJ-New Jersey Medical School, Newark, NJ
        PhD, UMDNJ-Graduate School of Biological Sciences, Newark, NJ

        Post-Graduate Training:
        UMDNJ-University Hospital, Newark, New Jersey
        Internal Medicine Residency

        UMDNJ-University Hospital, Newark, New Jersey
        Chief Medical Resident

        UMDNJ-University Hospital, Newark, New Jersey
        Gastroenterology Fellowship

        Research Interests:


        Host immune response to Helicobacter pylori infection, immune modulation of gastric cell signaling and growth regulation in response to Helicobacter infection.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Maykel J, Liu JH, Li H, Shultz LD, Greiner DL, Houghton J. NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : A Model for Stromal Cell-Tumor Cell Interaction for Human Colon Cancer. Dig Dis Sci. 2014 Jun; 59(6):1169-79.
          View in: PubMed
        2. Stoicov C, Li H, Liu JH, Houghton J. Mesenchymal stem cells utilize CXCR4-SDF-1 signaling for acute, but not chronic, trafficking to gastric mucosal inflammation. Dig Dis Sci. 2013 Sep; 58(9):2466-77.
          View in: PubMed
        3. Houghton JM. Helicobacter species methods and protocols. Introduction. Methods Mol Biol. 2012; 921:1-5.
          View in: PubMed
        4. Moore N, Houghton J, Lyle S. Slow-cycling therapy-resistant cancer cells. Stem Cells Dev. 2012 Jul 1; 21(10):1822-30.
          View in: PubMed
        5. Hutchinson L, Stenstrom B, Chen D, Piperdi B, Levey S, Lyle S, Wang TC, Houghton J. Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant. Stem Cells Dev. 2011 Jan; 20(1):11-7.
          View in: PubMed
        6. Houghton J, Li H, Fan X, Liu Y, Liu JH, Rao VP, Poutahidis T, Taylor CL, Jackson EA, Hewes C, Lyle S, Cerny A, Bowen G, Cerny J, Moore N, Kurt-Jones EA, Erdman SE. Mutations in bone marrow-derived stromal stem cells unmask latent malignancy. Stem Cells Dev. 2010 Aug; 19(8):1153-66.
          View in: PubMed
        7. Martin J, Donnelly JM, Houghton J, Zavros Y. The role of sonic hedgehog reemergence during gastric cancer. Dig Dis Sci. 2010 Jun; 55(6):1516-24.
          View in: PubMed
        8. Cerny J, Trneny M, Slavickova A, Pytlik R, Salkova J, Valkova V, Liu Q, Houghton J, Klener P. Rituximab based therapy followed by autologous stem cell transplantation leads to superior outcome and high rates of PCR negativity in patients with indolent B-cell lymphoproliferative disorders. Hematology. 2009 Aug; 14(4):187-97.
          View in: PubMed
        9. Stoicov C, Fan X, Liu JH, Bowen G, Whary M, Kurt-Jones E, Houghton J. T-bet knockout prevents Helicobacter felis-induced gastric cancer. J Immunol. 2009 Jul 1; 183(1):642-9.
          View in: PubMed
        10. Li H, Fan X, Stoicov C, Liu JH, Zubair S, Tsai E, Ste Marie R, Wang TC, Lyle S, Kurt-Jones E, Houghton J. Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver. Gastroenterology. 2009 Sep; 137(3):934-44, 944.e1-4.
          View in: PubMed
        11. Stoicov C, Saffari R, Houghton J. Green tea inhibits Helicobacter growth in vivo and in vitro. Int J Antimicrob Agents. 2009 May; 33(5):473-8.
          View in: PubMed
        12. Rogers AB, Houghton J. Helicobacter-based mouse models of digestive system carcinogenesis. Methods Mol Biol. 2009; 511:267-95.
          View in: PubMed
        13. Li H, Fan X, Kovi RC, Jo Y, Moquin B, Konz R, Stoicov C, Kurt-Jones E, Grossman SR, Lyle S, Rogers AB, Montrose M, Houghton J. Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice. Cancer Res. 2007 Nov 15; 67(22):10889-98.
          View in: PubMed
        14. Li H, Cai X, Fan X, Moquin B, Stoicov C, Houghton J. Fas Ag-FasL coupling leads to ERK1/2-mediated proliferation of gastric mucosal cells. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G263-75.
          View in: PubMed
        15. Correa P, Houghton J. Carcinogenesis of Helicobacter pylori. Gastroenterology. 2007 Aug; 133(2):659-72.
          View in: PubMed
        16. Li H, Fan X, Houghton J. Tumor microenvironment: the role of the tumor stroma in cancer. J Cell Biochem. 2007 Jul 1; 101(4):805-15.
          View in: PubMed
        17. Houghton J. Bone-marrow-derived cells and cancer--an opportunity for improved therapy. Nat Clin Pract Oncol. 2007 Jan; 4(1):2-3.
          View in: PubMed
        18. Kurt-Jones EA, Cao L, Sandor F, Rogers AB, Whary MT, Nambiar PR, Cerny A, Bowen G, Yan J, Takaishi S, Chi AL, Reed G, Houghton J, Fox JG, Wang TC. Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses. Infect Immun. 2007 Jan; 75(1):471-80.
          View in: PubMed
        19. Cui G, Takaishi S, Ai W, Betz KS, Florholmen J, Koh TJ, Houghton J, Pritchard DM, Wang TC. Gastrin-induced apoptosis contributes to carcinogenesis in the stomach. Lab Invest. 2006 Oct; 86(10):1037-51.
          View in: PubMed
        20. Houghton J, Morozov A, Smirnova I, Wang TC. Stem cells and cancer. Semin Cancer Biol. 2007 Jun; 17(3):191-203.
          View in: PubMed
        21. Li HC, Stoicov C, Rogers AB, Houghton J. Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers. World J Gastroenterol. 2006 Jan 21; 12(3):363-71.
          View in: PubMed
        22. Stoicov C, Li H, Carlson J, Houghton J. Bone marrow cells as the origin of stomach cancer. Future Oncol. 2005 Dec; 1(6):851-62.
          View in: PubMed
        23. Cai X, Stoicov C, Li H, Carlson J, Whary M, Fox JG, Houghton J. Overcoming Fas-mediated apoptosis accelerates Helicobacter-induced gastric cancer in mice. Cancer Res. 2005 Dec 1; 65(23):10912-20.
          View in: PubMed
        24. Stoicov C, Cai X, Li H, Klucevsek K, Carlson J, Saffari R, Houghton J. Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation. Infect Immun. 2005 Oct; 73(10):6311-21.
          View in: PubMed
        25. Cai X, Carlson J, Stoicov C, Li H, Wang TC, Houghton J. Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology. 2005 Jun; 128(7):1937-52.
          View in: PubMed
        26. Takaishi S, Cui G, Frederick DM, Carlson JE, Houghton J, Varro A, Dockray GJ, Ge Z, Whary MT, Rogers AB, Fox JG, Wang TC. Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer. Gastroenterology. 2005 Jun; 128(7):1965-83.
          View in: PubMed
        27. Houghton J, Wang TC. Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology. 2005 May; 128(6):1567-78.
          View in: PubMed
        28. Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TC. Gastric cancer originating from bone marrow-derived cells. Science. 2004 Nov 26; 306(5701):1568-71.
          View in: PubMed
        29. Mandell L, Moran AP, Cocchiarella A, Houghton J, Taylor N, Fox JG, Wang TC, Kurt-Jones EA. Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun. 2004 Nov; 72(11):6446-54.
          View in: PubMed
        30. Stoicov C, Saffari R, Cai X, Hasyagar C, Houghton J. Molecular biology of gastric cancer: Helicobacter infection and gastric adenocarcinoma: bacterial and host factors responsible for altered growth signaling. Gene. 2004 Oct 27; 341:1-17.
          View in: PubMed
        31. Stoicov C, Whary M, Rogers AB, Lee FS, Klucevsek K, Li H, Cai X, Saffari R, Ge Z, Khan IA, Combe C, Luster A, Fox JG, Houghton J. Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections. J Immunol. 2004 Sep 1; 173(5):3329-36.
          View in: PubMed
        32. Koh TJ, Field JK, Varro A, Liloglou T, Fielding P, Cui G, Houghton J, Dockray GJ, Wang TC. Glycine-extended gastrin promotes the growth of lung cancer. Cancer Res. 2004 Jan 1; 64(1):196-201.
          View in: PubMed
        33. Li H, Stoicov C, Cai X, Wang TC, Houghton J. Helicobacter and gastric cancer disease mechanisms: host response and disease susceptibility. Curr Gastroenterol Rep. 2003 Dec; 5(6):459-67.
          View in: PubMed
        34. Zivny J, Wang TC, Yantiss R, Kim KH, Houghton J. Role of therapy or monitoring in preventing progression to gastric cancer. J Clin Gastroenterol. 2003 May-Jun; 36(5 Suppl):S50-60; discussion S61-2.
          View in: PubMed
        35. Houghton J, Fox JG, Wang TC. Gastric cancer: laboratory bench to clinic. J Gastroenterol Hepatol. 2002 Apr; 17(4):495-502.
          View in: PubMed
        36. Houghton J, Ramamoorthy R, Pandya H, Dhirmalani R, Kim KH. Human plasma is directly bacteriocidal against Helicobacter pylori in vitro, potentially explaining the decreased detection of Helicobacter pylori during acute upper GI bleeding. Gastrointest Endosc. 2002 Jan; 55(1):11-6.
          View in: PubMed
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