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    Richard T Ellison III MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-3158
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentMicrobiology and Physiological Systems

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentClinical Population Health Research

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMolecular Genetics and Microbiology

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentCenter for AIDS Research

        Overview 
        Narrative

        Background

        Education:

        • B.A., University of Virginia, 1973
        • M.D., Hahnemann Medical College, 1977

        Post-Graduate Training:

        • Internal Medicine Residency, Rhode Island Hospital, Providence, RI, 1977-80
        • Chief Medical Resident, Veterans Administration Medical Center, Providence, RI, 1980-81
        • Infectious Disease Fellowship, University of Colorado, Denver, CO, 1981-83

        Board Certification:

        • National Board of Medical Examiners, 1978
        • Diplomate, American Board of Internal Medicine, 1980
        • Diplomate, American Board of Internal Medicine (Infectious Diseases), 1984

        Honors and Awards:

        • Fellow, American College of Physicians
        • Western Society of Clinical Investigation
        • Fellow, Infectious Disease Society of America
        • President, Massachusetts Infectious Disease Society, 1998-2001
        • Fellow, Society for Healthcare Epidemiology of America

         

        Other Activities:

        • Deputy Editor, Journal Watch for Infectious Diseases

        Research/Clinical Interests

        Photo: Richard T Ellison IIIResearch Interests: Dr. Ellison's clinical research interests focus on the broad areas of identification and treatment of nosocomial infections, infections in the ICU setting, sepsis, and clinical care of patients with HIV disease. Recent work has been focused on the use of medical information system databases in identifying both infections and other adverse events in the inpatient setting; as well as novel approaches to preventing nosocomial infections. His laboratory research interests have been into the nature of innate antimicrobial host defense systems towards bacterial pathogens. This has involved studies of the complement system and antimicrobial proteins including lactoferrin, lysozyme, and natural antimicrobial peptides. More recent work has involved studies of a new class of antimicrobial agents active towards Gram-positive bacterial pathogens and bacterial antimicrobial resistance mechanisms.

        Clinical Interests: Dr. Ellison provides subspecialty consultative care in the field of Infectious Diseases, as well as primary medical care to individuals with HIV disease.

         



        Bibliographic 
        selected publications
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        1. Manuell ME, Co MD, Ellison RT. Pandemic influenza: implications for preparation and delivery of critical care services. J Intensive Care Med. 2011 Nov; 26(6):347-67.
          View in: PubMed
        2. Wang D, Rundensteiner E, Ellison RT III, Wang H. Active Complex Event Processing infrastructure: Monitoring and reacting to event streams. Data Engineering Workshops (ICDEW), IEEE. 2011; 249-254.
        3. Yu C, Baker S, Morse LJ, Gardiner J, Meehan M, Esposito A, Roberto R, Ellison RT. Clinical and laboratory findings in individuals with acute norovirus disease. Arch Intern Med. 2007 Sep 24; 167(17):1903-5.
          View in: PubMed
        4. Zivna I, Bergin D, Casavant J, Fontecchio S, Nelson S, Kelley A, Mathis S, Melvin Z, Erlichman R, Ellison RT. Impact of Bordetella pertussis exposures on a Massachusetts tertiary care medical system. Infect Control Hosp Epidemiol. 2007 Jun; 28(6):708-12.
          View in: PubMed
        5. Ellison RT. Review: probiotics are effective for prevention of antibiotic-associated diarrhea and treatment of Clostridium difficile disease. ACP J Club. 2006 Sep-Oct; 145(2):46.
          View in: PubMed
        6. Daly JS, Giehl TJ, Brown NC, Zhi C, Wright GE, Ellison RT. In vitro antimicrobial activities of novel anilinouracils which selectively inhibit DNA polymerase III of gram-positive bacteria. Antimicrob Agents Chemother. 2000 Aug; 44(8):2217-21.
          View in: PubMed
        7. Sharkey ME, Teo I, Greenough T, Sharova N, Luzuriaga K, Sullivan JL, Bucy RP, Kostrikis LG, Haase A, Veryard C, Davaro RE, Cheeseman SH, Daly JS, Bova C, Ellison RT, Mady B, Lai KK, Moyle G, Nelson M, Gazzard B, Shaunak S, Stevenson M. Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy. Nat Med. 2000 Jan; 6(1):76-81.
          View in: PubMed
        8. Ellison RT. Steroid therapy for late septic shock. Crit Care Med. 1999 Jul; 27(7):1402.
          View in: PubMed
        9. Riester KA, Peduzzi P, Holford TR, Ellison RT, Donta ST. Statistical evaluation of the role of Helicobacter pylori in stress gastritis: applications of splines and bootstrapping to the logistic model. J Clin Epidemiol. 1997 Nov; 50(11):1273-9.
          View in: PubMed
        10. Ellison RT, Perez-Perez G, Welsh CH, Blaser MJ, Riester KA, Cross AS, Donta ST, Peduzzi P. Risk factors for upper gastrointestinal bleeding in intensive care unit patients: role of helicobacter pylori. Federal Hyperimmune Immunoglobulin Therapy Study Group. Crit Care Med. 1996 Dec; 24(12):1974-81.
          View in: PubMed
        11. Donta ST, Peduzzi P, Cross AS, Sadoff J, Haakenson C, Cryz SJ, Kauffman C, Bradley S, Gafford G, Elliston D, Beam TR, John JF, Ribner B, Cantey R, Welsh CH, Ellison RT, Young EJ, Hamill RJ, Leaf H, Schein RM, Mulligan M, Johnson C, Abrutyn E, Griffiss JM, Slagle D, et al. Immunoprophylaxis against klebsiella and pseudomonas aeruginosa infections. The Federal Hyperimmune Immunoglobulin Trial Study Group. J Infect Dis. 1996 Sep; 174(3):537-43.
          View in: PubMed
        12. Davaro RE, Cheeseman SH, Keroack MA, Ellison RT. The significance of isolated antibody to hepatitis B core antigen seropositivity in patients infected with human immunodeficiency virus. Clin Infect Dis. 1996 Jul; 23(1):189-90.
          View in: PubMed
        13. Cheeseman SH, Davaro RE, Ellison RT. Hepatitis B vaccination and plasma HIV-1 RNA. N Engl J Med. 1996 May 9; 334(19):1272.
          View in: PubMed
        14. Bessesen MT, Miller LA, Cohn DL, Bartlett S, Ellison RT. Administration of pyrimethamine/sulfadoxine for prevention of Pneumocystis carinii pneumonia in patients with AIDS. Clin Infect Dis. 1995 Mar; 20(3):730-1.
          View in: PubMed
        15. Ellison RT. The effects of lactoferrin on gram-negative bacteria. Adv Exp Med Biol. 1994; 357:71-90.
          View in: PubMed
        16. Yamauchi K, Tomita M, Giehl TJ, Ellison RT. Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment. Infect Immun. 1993 Feb; 61(2):719-28.
          View in: PubMed
        17. MacKenzie TD, Ellison RT, Mostow SR. Sunlight and cholera. Lancet. 1992 Aug 8; 340(8815):367.
          View in: PubMed
        18. Marr JJ, Baum KF, Chapman AD, Douglas JM, Ellison RT, Marman GW, Perlman D, Riley HE, Sintek CD, Woltemath DA. Development of an antimicrobial formulary for a university teaching hospital system. Am J Hosp Pharm. 1992 Jun; 49(6):1481-4.
          View in: PubMed
        19. Ellison RT, Giehl TJ. Killing of gram-negative bacteria by lactoferrin and lysozyme. J Clin Invest. 1991 Oct; 88(4):1080-91.
          View in: PubMed
        20. Pei ZH, Ellison RT, Blaser MJ. Identification, purification, and characterization of major antigenic proteins of Campylobacter jejuni. J Biol Chem. 1991 Sep 5; 266(25):16363-9.
          View in: PubMed
        21. Holdcroft CJ, Ellison RT. Trimethoprim-sulfamethoxazole reaction simulating Pneumocystis carinii pneumonia. AIDS. 1991 Aug; 5(8):1029.
          View in: PubMed
        22. Ehni WF, Reller LB, Ellison RT. Bacteremia in granulocytopenic patients in a tertiary-care general hospital. Rev Infect Dis. 1991 Jul-Aug; 13(4):613-9.
          View in: PubMed
        23. Bessesen MT, Luo QA, Rotbart HA, Blaser MJ, Ellison RT. Detection of Listeria monocytogenes by using the polymerase chain reaction. Appl Environ Microbiol. 1990 Sep; 56(9):2930-2.
          View in: PubMed
        24. Ellison RT, LaForce FM, Giehl TJ, Boose DS, Dunn BE. Lactoferrin and transferrin damage of the gram-negative outer membrane is modulated by Ca2+ and Mg2+. J Gen Microbiol. 1990 Jul; 136(7):1437-46.
          View in: PubMed
        25. Ellison RT, Luo Q, Reller LB. Enhancement of the activity of cefotaxime by iron-binding proteins. J Antimicrob Chemother. 1990 Mar; 25(3):479-81.
          View in: PubMed
        26. Ellison RT, Horsburgh CR, Curd J. Complement levels in patients with hepatic dysfunction. Dig Dis Sci. 1990 Feb; 35(2):231-5.
          View in: PubMed
        27. Cover TL, Dunn BE, Ellison RT, Blaser MJ. Vibrio cholerae wound infection acquired in Colorado. J Infect Dis. 1989 Dec; 160(6):1083.
          View in: PubMed
        28. Ellison RT, Giehl TJ, LaForce FM. Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin. Infect Immun. 1988 Nov; 56(11):2774-81.
          View in: PubMed
        29. Pei Z, Ellison RT, Lewis RV, Blaser MJ. Purification and characterization of a family of high molecular weight surface-array proteins from Campylobacter fetus. J Biol Chem. 1988 May 5; 263(13):6416-20.
          View in: PubMed
        30. Ellison RT, Giehl TJ. Pulmonary secretions accelerate the metabolic rate of Escherichia coli. Microb Pathog. 1988 Jan; 4(1):15-20.
          View in: PubMed
        31. Ellison RT. Colorado tick fever or ehrlichiosis. JAMA. 1987 Oct 2; 258(13):1731-2.
          View in: PubMed
        32. Ehni WF, Ellison RT. Spontaneous Candida albicans meningitis in a patient with the acquired immune deficiency syndrome. Am J Med. 1987 Oct; 83(4):806-7.
          View in: PubMed
        33. Ellison RT, Curd JG, Kohler PF, Reller LB, Judson FN. Underlying complement deficiency in patients with disseminated gonococcal infection. Sex Transm Dis. 1987 Oct-Dec; 14(4):201-4.
          View in: PubMed
        34. Ellison RT, McGregor JA. Recurrent postcoital lower-extremity streptococcal erythroderma in women. Streptococcal-sex syndrome. JAMA. 1987 Jun 19; 257(23):3260-2.
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        35. LaForce FM, Boose DS, Ellison RT. Effect of aerosolized Escherichia coli and Staphylococcus aureus on iron and iron-binding proteins in lung lavage fluid. J Infect Dis. 1986 Dec; 154(6):959-65.
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        36. Ellison RT, Mason SR, Kohler PF, Curd JG, Reller LB. Meningococcemia and acquired complement deficiency. Association in patients with hepatic failure. Arch Intern Med. 1986 Aug; 146(8):1539-40.
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        37. Ellison RT, Reller LB. Differentiating pyogenic arthritis from spontaneous hemarthrosis in patients with hemophilia. West J Med. 1986 Jan; 144(1):42-5.
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        38. Cooper ER, Ellison RT, Smith GS, Blaser MJ, Reller LB, Paisley JW. Rifampin-resistant meningococcal disease in a contact patient given prophylactic rifampin. J Pediatr. 1986 Jan; 108(1):93-6.
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        39. Ellison RT, Boose D, LaForce FM. Isolation of an antibacterial peptide from human lung lavage fluid. J Infect Dis. 1985 Jun; 151(6):1123-9.
          View in: PubMed
        40. Blaser MJ, Ellison RT. Rapid nighttime evacuation of a veterans hospital. J Emerg Med. 1985; 3(5):387-94.
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        41. Ellison RT, Mostow SR. Pyogenic meningitis manifesting during therapy for Aeromonas hydrophila sepsis. Arch Intern Med. 1984 Oct; 144(10):2078-9.
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        42. Ellison RT, Judson FN, Peterson LC, Cohn DL, Ehret JM. Oral rifampin and trimethoprim/sulfamethoxazole therapy in asymptomatic carriers of methicillin-resistant Staphylococcus aureus infections. West J Med. 1984 May; 140(5):735-40.
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        43. Ellison RT, Kohler PF, Curd JG, Judson FN, Reller LB. Prevalence of congenital or acquired complement deficiency in patients with sporadic meningocococcal disease. N Engl J Med. 1983 Apr 21; 308(16):913-6.
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        44. Ellison RT, Corrao WM, Fox MJ, Braman SS. Spontaneous mediastinal hemorrhage in patients on chronic hemodialysis. Ann Intern Med. 1981 Dec; 95(6):704-6.
          View in: PubMed
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