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    Chad E Darling MD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentEmergency Medicine
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-421-1400
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMasters in Clinical Investigation

        Bibliographic 
        selected publications
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        1. Darling CE, Fisher KA, McManus DD, Coles AH, Spencer FA, Gore JM, Goldberg RJ. Survival after hospital discharge for ST-segment elevation and non-ST-segment elevation acute myocardial infarction: a population-based study. Clin Epidemiol. 2013; 5:229-36.
          View in: PubMed
        2. Joffe SW, Webster K, McManus DD, Kiernan MS, Lessard D, Yarzebski J, Darling C, Gore JM, Goldberg RJ. Improved survival after heart failure: a community-based perspective. J Am Heart Assoc. 2013; 2(3):e000053.
          View in: PubMed
        3. Darling C, Saczynski JS, McManus DD, Lessard D, Spencer FA, Goldberg RJ. Delayed hospital presentation in acute decompensated heart failure: Clinical and patient reported factors. Heart Lung. 2013 Jul-Aug; 42(4):281-6.
          View in: PubMed
        4. Darling CE, Smith CS, Sun JE, Klaucke CG, Lerner J, Cyr J, Paige PG, Paige P, Bird SB. Cost reductions associated with a quality improvement initiative for patients with ST-elevation myocardial infarction. Jt Comm J Qual Patient Saf. 2013 Jan; 39(1):16-21.
          View in: PubMed
        5. Coles AH, Fisher KA, Darling C, McManus D, Maitas O, Yarzebski J, Gore JM, Lessard D, Goldberg RJ. Recent trends in post-discharge mortality among patients with an initial acute myocardial infarction. Am J Cardiol. 2012 Oct 15; 110(8):1073-7.
          View in: PubMed
        6. Kiefer CR, Stock RE, Flanagan SS, Darling CE, Smith CS, Snyder LM. Early verification of myocardial ischemia with a novel biomarker of acute tissue damage: C-reactive protein fractional forms. Clin Chim Acta. 2012 Oct 9; 413(19-20):1536-41.
          View in: PubMed
        7. Goldberg RJ, Lamusta J, Darling C, Dewolf M, Saczynski JS, Lessard D, Ward J, Gore JM. Community trends in the use and characteristics of persons with acute myocardial infarction who are transported by emergency medical services. Heart Lung. 2012 Jul; 41(4):323-31.
          View in: PubMed
        8. Park D, McManus D, Darling C, Goldberg JH, Gore JM, Lessard D, Goldberg RJ. Recent trends in the characteristics and prognosis of patients hospitalized with acute heart failure. Clin Epidemiol. 2011; 3:295-303.
          View in: PubMed
        9. Weibrecht K, Dayno M, Darling C, Bird SB. Liver aminotransferases are elevated with rhabdomyolysis in the absence of significant liver injury. J Med Toxicol. 2010 Sep; 6(3):294-300.
          View in: PubMed
        10. Weisberg S, Fitch J, Towner D, Darling CE. Transporting without infusions: effect on door-to-needle time for acute coronary syndrome patients. Prehosp Emerg Care. 2010 Apr 6; 14(2):159-63.
          View in: PubMed
        11. Saczynski JS, Darling CE, Spencer FA, Lessard D, Gore JM, Goldberg RJ. Clinical features, treatment practices, and hospital and long-term outcomes of older patients hospitalized with decompensated heart failure: The Worcester Heart Failure Study. J Am Geriatr Soc. 2009 Sep; 57(9):1587-94.
          View in: PubMed
        12. Goldberg RJ, Darling C, Joseph B, Saczynski J, Chinali M, Lessard D, Pezzella S, Spencer FA. Epidemiology of decompensated heart failure in a single community in the northeastern United States. Am J Cardiol. 2009 Aug 1; 104(3):377-82.
          View in: PubMed
        13. Darling CE, Michelson AD, Volturo GA, Przyklenk K. Platelet reactivity and the identification of acute coronary syndromes in the emergency department. J Thromb Thrombolysis. 2009 Jul; 28(1):31-7.
          View in: PubMed
        14. Przyklenk K, Maynard M, Darling CE, Whittaker P. Aging mouse hearts are refractory to infarct size reduction with post-conditioning. J Am Coll Cardiol. 2008 Apr 8; 51(14):1393-8.
          View in: PubMed
        15. Darling CE, Solari PB, Smith CS, Furman MI, Przyklenk K. 'Postconditioning' the human heart: multiple balloon inflations during primary angioplasty may confer cardioprotection. Basic Res Cardiol. 2007 May; 102(3):274-8.
          View in: PubMed
        16. Darling CE, Jiang R, Maynard M, Whittaker P, Vinten-Johansen J, Przyklenk K. Postconditioning via stuttering reperfusion limits myocardial infarct size in rabbit hearts: role of ERK1/2. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1618-26.
          View in: PubMed
        17. Przyklenk K, Maynard M, Darling CE, Whittaker P. Pretreatment with D-myo-inositol trisphosphate reduces infarct size in rabbit hearts: role of inositol trisphosphate receptors and gap junctions in triggering protection. J Pharmacol Exp Ther. 2005 Sep; 314(3):1386-92.
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        18. Dickson EW, Whittaker P, Darling CE, Hirsch DJ, Blehar DJ, Przyklenk K. Brief apnea induces myocardial ischemic tolerance by an opioid-insensitive mechanism. Cardiovasc Pathol. 2004 Jul-Aug; 13(4):225-9.
          View in: PubMed
        19. Przyklenk K, Darling CE, Dickson EW, Whittaker P. Cardioprotection 'outside the box'--the evolving paradigm of remote preconditioning. Basic Res Cardiol. 2003 May; 98(3):149-57.
          View in: PubMed
        20. Dickson EW, Tubbs RJ, Porcaro WA, Lee WJ, Blehar DJ, Carraway RE, Darling CE, Przyklenk K. Myocardial preconditioning factors evoke mesenteric ischemic tolerance via opioid receptors and K(ATP) channels. Am J Physiol Heart Circ Physiol. 2002 Jul; 283(1):H22-8.
          View in: PubMed
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