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    Robert T Woodland PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMicrobiology and Physiological Systems
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-2465
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentImmunology and Virology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMolecular Genetics and Microbiology

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentCenter for AIDS Research

        Overview 
        Narrative

        Academic Background

        Ph. D. (1974) University of Pennsylvania

        Regulation of B Cell Survival Control of Virus Expression by Lymphocyte Activators

        Photo: Robert 
T. Woodland Our laboratory is determining the soluble and cell associated ligands that maintain virgin B lymphocytes in the long-lived lumphocyte pool. In particular, we are interested in the transcriptional and post translational regulation of pro-apoptotic and anti-apoptotic proteins that control B cell homeostasis and B cell survival during stress. For these experiments we are comparing B cells from normal mice to those from mice with an X-chromosome linked immunodeficiency, as this mutation significantly reduces peripheral B cell survival. Other studies in the laboratory focus on the mechanism by which a virus infection is controlled in lymphocytes by lymphocyte activators. We have shown that virus transcription, protein translation, assembly and release of infectious particles are all processes regulated by lymphocyte activators acting on resting infected cells. We are using these observations to develope new modalities to control both acute and chronic virus infections.



        Rotation Projects

        Rotation Projects

        1. Aged mice have severely diminished numbers of naïve B cells and mount poor responses to "new antigens" despite the fact that B cell lymphogenesis continues for the life of the animal. We hypothesize this may be due to dysregulation of HP. We would like to determine if HP of immature B cells is impaired and/or if inhibition of HP by peripheral B cells is more active in aged mice. These studies require lymphocyte transfers between young and aged mice and the analysis of developmentally regulated antigens by flow cytometry.


        2. To attempt to suppress innate immune responses by using adenovirus to transfer genes encoding dominant-negative regulators of critical signal pathways. These studies will use cells from hCAR mice as targets and in vitro assays for proliferation and cytokine secretion to determine the effect of gene transfers.


        Bibliographic 
        selected publications
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        1. Schmidt MR, McGinnes LW, Kenward SA, Willems KN, Woodland RT, Morrison TG. Long-Term and Memory Immune Responses in Mice against Newcastle Disease Virus-Like Particles Containing Respiratory Syncytial Virus Glycoprotein Ectodomains. J Virol. 2012 Nov; 86(21):11654-62.
          View in: PubMed
        2. Castro I, Wright JA, Damdinsuren B, Hoek KL, Carlesso G, Shinners NP, Gerstein RM, Woodland RT, Sen R, Khan WN. B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and NF-kappaB2. J Immunol. 2009 Jun 15; 182(12):7729-37.
          View in: PubMed
        3. Schmidt MR, Appel MC, Giassi LJ, Greiner DL, Shultz LD, Woodland RT. Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice. PLoS One. 2008; 3(9):e3192.
          View in: PubMed
        4. Giassi LJ, Pearson T, Shultz LD, Laning J, Biber K, Kraus M, Woda BA, Schmidt MR, Woodland RT, Rossini AA, Greiner DL. Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice. Exp Biol Med (Maywood). 2008 Aug; 233(8):997-1012.
          View in: PubMed
        5. King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol. 2008 Mar; 126(3):303-14.
          View in: PubMed
        6. Woodland RT, Fox CJ, Schmidt MR, Hammerman PS, Opferman JT, Korsmeyer SJ, Hilbert DM, Thompson CB. Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood. 2008 Jan 15; 111(2):750-60.
          View in: PubMed
        7. Shinners NP, Carlesso G, Castro I, Hoek KL, Corn RA, Woodland RT, Woodland RL, Scott ML, Wang D, Khan WN. Bruton's tyrosine kinase mediates NF-kappa B activation and B cell survival by B cell-activating factor receptor of the TNF-R family. J Immunol. 2007 Sep 15; 179(6):3872-80.
          View in: PubMed
        8. Woodland RT, Schmidt MR, Thompson CB. BLyS and B cell homeostasis. Semin Immunol. 2006 Oct; 18(5):318-26.
          View in: PubMed
        9. Schrader CE, Linehan EK, Mochegova SN, Woodland RT, Stavnezer J. Inducible DNA breaks in Ig S regions are dependent on AID and UNG. J Exp Med. 2005 Aug 15; 202(4):561-8.
          View in: PubMed
        10. Woodland RT, Schmidt MR. Homeostatic proliferation of B cells. Semin Immunol. 2005 Jun; 17(3):209-17.
          View in: PubMed
        11. Alugupalli KR, Leong JM, Woodland RT, Muramatsu M, Honjo T, Gerstein RM. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity. 2004 Sep; 21(3):379-90.
          View in: PubMed
        12. Alugupalli KR, Gerstein RM, Chen J, Szomolanyi-Tsuda E, Woodland RT, Leong JM. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol. 2003 Apr 1; 170(7):3819-27.
          View in: PubMed
        13. Cabatingan MS, Schmidt MR, Sen R, Woodland RT. Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit. J Immunol. 2002 Dec 15; 169(12):6795-805.
          View in: PubMed
        14. Tumang JR, Negm RS, Solt LA, Schneider TJ, Colarusso TP, Hastings WD, Woodland RT, Rothstein TL. BCR engagement induces Fas resistance in primary B cells in the absence of functional Bruton's tyrosine kinase. J Immunol. 2002 Mar 15; 168(6):2712-9.
          View in: PubMed
        15. Cancro MP, Sah AP, Levy SL, Allman DM, Schmidt MR, Woodland RT. xid mice reveal the interplay of homeostasis and Bruton's tyrosine kinase-mediated selection at multiple stages of B cell development. Int Immunol. 2001 Dec; 13(12):1501-14.
          View in: PubMed
        16. Szomolanyi-Tsuda E, Brien JD, Dorgan JE, Garcea RL, Woodland RT, Welsh RM. Antiviral T-cell-independent type 2 antibody responses induced in vivo in the absence of T and NK cells. Virology. 2001 Feb 15; 280(2):160-8.
          View in: PubMed
        17. Schmidt MR, Piekos B, Cabatingan MS, Woodland RT. Expression of a human coxsackie/adenovirus receptor transgene permits adenovirus infection of primary lymphocytes. J Immunol. 2000 Oct 1; 165(7):4112-9.
          View in: PubMed
        18. Cancro MP, Sah AP, Levy SL, Allman DM, Constantinescu D, Schmidt MR, Woodland RT. B cell production and turnover in CBA/Ca, CBA/N and CBA/N-bcl-2 transgenic mice: xid-mediated failure among pre B cells is unaltered by bcl-2 overexpression. Curr Top Microbiol Immunol. 2000; 252:31-8.
          View in: PubMed
        19. Woodland RT, Schmidt MR, Korsmeyer SJ, Gravel KA. Regulation of B cell survival in xid mice by the proto-oncogene bcl-2. J Immunol. 1996 Mar 15; 156(6):2143-54.
          View in: PubMed
        20. Woodland RT, Schmidt MR, Riggs JE, Korsmeyer SJ, Lussier AM, Gravel KA. Radiation-induced apoptosis is differentially regulated in primary B cells from normal mice and mice with the CBA/N X-linked immunodeficiency. J Immunol. 1995 Oct 1; 155(7):3453-63.
          View in: PubMed
        21. Schmidt MR, Gravel KA, Woodland RT. Progression of a vesicular stomatitis virus infection in primary lymphocytes is restricted at multiple levels during B cell activation. J Immunol. 1995 Sep 1; 155(5):2533-44.
          View in: PubMed
        22. Prior L, Pierson S, Woodland RT, Riggs J. Rapid restoration of B-cell function in XID mice by intravenous transfer of peritoneal cavity B cells. Immunology. 1994 Oct; 83(2):180-3.
          View in: PubMed
        23. Schmidt MR, Woodland RT. Virus-lymphocyte interactions: inductive signals necessary to render B lymphocytes susceptible to vesicular stomatitis virus infection. J Virol. 1990 Jul; 64(7):3289-96.
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        24. Riggs JE, Lussier AM, Lee SK, Appel MC, Woodland RT. Differential radiosensitivity among B cell subpopulations. J Immunol. 1988 Sep 15; 141(6):1799-807.
          View in: PubMed
        25. Lee SK, Woodland RT. Selective effect of irradiation on responses to thymus-independent antigen. J Immunol. 1985 Feb; 134(2):761-4.
          View in: PubMed
        26. Woodland RT, Huber BT. Selective activation by thymus-dependent antigens of distinct B cell subpopulations expressing a major cross-reactive idiotype. J Immunol. 1984 Oct; 133(4):1801-10.
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        27. Woodland RT. Antibody-mediated inhibition of effector B and T cell function. Surv Immunol Res. 1984; 3(2-3):111-4.
          View in: PubMed
        28. Woodland RT, Zimmerman DM, Schrater AF. Anti-hapten antibody in primary immune antiserum can specifically inhibit antibody-secreting cells. J Immunol. 1982 Nov; 129(5):2009-15.
          View in: PubMed
        29. Woodland RT, Cantor H. V(H) gene products allow specific communication among immunologic cell sets. Contemp Top Immunobiol. 1980; 11:227-44.
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        30. Woodland R, Cantor H. Idiotype-specific T helper cells are required to induce idiotype-positive B memory cells to secrete antibody. Eur J Immunol. 1978 Aug; 8(8):600-6.
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        31. Luderer AA, Maurer PH, Woodland RT. Genetic control of the immune response in rats to the known sequential polypeptide (Tyr-Glu-Ala-Gly)n. I. Antibody responses. J Immunol. 1976 Oct; 117(4):1079-84.
          View in: PubMed
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