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    Stephen N Jones PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentCell and Developmental Biology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-7500
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentCancer Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCancer Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCell Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

        Overview 
        Narrative

        CDB Department Website

        Jones Lab Website

        Academic Background

        Ph.D., 1988, Vanderbilt University School of Medicine

        Signaling Pathways in Development and Tumor Suppression

        Failure to properly regulate cell differentiation and proliferation can lead to aberrant development and/or tumorigenesis. Our laboratory generates genetically modified mice to investigate the regulatory pathways that govern normal cell growth and development, and to examine how alteration of these pathways can lead to cancer. We are presently focusing on mechanisms that regulate the expression and function of tumor suppressor proteins.

        Regulation of the p53 tumor suppressor by MDM proteins

        The MDM2 and MDMX oncogenes are amplified and overexpressed in a wide variety of human cancers. Our previous research has demonstrated that the MDM oncoproteins complex with the p53 tumor suppressor protein and inhibit p53 functions during mouse embryogenesis. In addition to negatively regulating the p53 tumor suppressor, we have also identified p53-independent roles for Mdm2 and MdmX in governing cell proliferation and tumorigenesis. We have also explored the effects of post-translational modifications to p53 and MDM proteins to gain insight into the regulation of p53 stability and transcriptional activation. Collectively, our work has established that MDM proteins are the major regulators of the p53 tumor suppressor in normal cell growth and in development, and that alterations in MDM-p53 signaling is a common mechanistic feature in cancer. In addition, we have determined that dysregulation of p53 activity can lead to accelerated aging phenotypes in mice, linking Mdm2-p53 signaling in tumor suppression with the regulation of aging. Work to further dissect the roles of MDM proteins in regulating p53 activity in response to DNA damage and oncogene activation using knock-in mouse models is ongoing.

        Non-canonical Wnt signaling in development and cancer

        Wnt5a is a member of the WNT family of secreted glycoproteins that function as paracrine or autocrine signals to regulate growth control and tissue patterning. We have generated several Wnt5a mouse models to investigate the role of Wnt5a in development, and have determined that Wnt5a is required for proper gastrulation and organogenesis. In addition, we have identified a role for Wnt5a in regulation of B-cell proliferation and in suppressesing B-cell lymphomas and myeloid tumorigenesis in mice and humans. We have recently generated Wnt5a-conditional mice, and will continue to explore the role of non-canonical Wnt5a signaling in tumor suppression and in inhibiting the canonical Wnt/B-catenin signaling pathway.

        Epigenetic regulation of tumor suppressor functions

        Our lab has generated various other mouse models to explore epigenetic regulation of mouse development and tumorigenesis. We have documented a role of SWI/SNF chromatin remodeling in tumor suppression by deleting the Snf5 gene in mice, and revealed a functional interaction between the Snf5 and Rb tumor suppressors in cell growth and pituitary cancer. In addition, we have also recently examined the role of ING chromatin modifiers in cancer. Our studies have determined that Ing1, a member of the mSin3/HDAC complex, suppresses spontaneous follicular B-cell tumors and collaborates with p53 to prevent diffuse large B cell lymphomas. In contrast, mice deleted for Ing4 (a subunit of the HB01 HAT complex) fail to form tumors, but display defects in innate immunity due to altered NF-kB signaling. Thus ING proteins can function as tumor suppressors and/or alter inflammation in mice. Analysis of the link between inflammation and cancer in these models is ongoing. Lastly, we have also generated Dicer-conditional mice to explore the role of miRNA in the epigenetic regulation of cell growth. Loss of Dicer and miRNA biogenesis activates the p19ARF and p53 tumor suppressors and induces senescence in primary cells during development. Although ablation of Dicer can inhibit the differentiation of various cell types, deletion of Dicer in skin epithelium does not inhibit skin formation, but results in loss of fur. Interestingly, co-deletion of p53 in skin can delay the loss of fur in this model, and mice co-deleted for both p53 and Dicer develop aggressive squamous cell carcinomas. These ongoing studies indicate that miRNAs function to prevent the accumulation of DNA damage in skin epithelium and to suppress skin cancer in mice. The role of miRNAs in activating p53 functions in skin epithelium and identification of the individual miRNA molecules involved in regulating skin cancer is presently being explored.

         

         

         

         

         

         

         

         

         

         

         

         

         

         

         

         

         

         

         

         

         

         

        Figures

        Jones Figure 1

        Regulation of the p53 tumor suppressor by MDM proteins

        MdmX deletion increases multi-polar mitosis resulting in rapid chromosomal loss in p53-null cells

         

        Jones Figure 2

        Non-canonical Wnt signaling in development and cancer

        Wnt5a loss reduces cell proliferation during development in structures emanating from the main body axis

         

        Jones Figure 3

        Epigenetic regulation of tumor suppressor functions

        Deletion of Dicer in skin inhibits fur growth and suppresses squamous cell carcinoma formation in mice co-ablated for p53



        Rotation Projects

        Potential Rotation Projects

        We are presently generating Mdm2 and MdmX-knockin mice in order to investigate the roles of cAbl-induced phosphorylation in p53 stability and function. This rotation will provide training in ES cell gene targeting, in analysis of cell genotypes, and in mouse modeling.

        Another rotation project involves the generation of MdmX-mutant transgenes to explore the role of MdmX in chromosomal segregation in mammary carcinogenesis in mice. This rotation will provide training in cloning, in Southern analysis, and in the generation of transgenic mice.

        We have recently generated Wnt5a-conditional mice. Analysis of the effects of Wnt5a deletion on hematopoiesis, in cancer, and in regulating the canonical Wnt/B-catenin signaling pathway will be undertaken. This rotation will provide training in mouse handling, in genotyping, and in cell sorting and FACS analysis.

        Mice co-deleted for both p53 and Dicer in skin epithelium develop aggressive squamous cell carcinomas. These ongoing studies suggest that miRNAs function in the skin to prevent the accumulation of DNA damage. The role of miRNAs in activating p53 functions in skin epithelium and in suppressing cancer is presently being explored. This rotation will provide training in mouse handling and genotyping, in tumor histology, in miRNA analysis, and in culturing tumor cells.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Lyle S, Hoover K, Colpan C, Zhu Z, Matijasevic Z, Jones SN. Dicer Cooperates with p53 to Suppress DNA Damage and Skin Carcinogenesis in Mice. PLoS One. 2014; 9(6):e100920.
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        2. Shin J, Wallingford MC, Gallant J, Marcho C, Jiao B, Byron M, Bossenz M, Lawrence JB, Jones SN, Mager J, Bach I. RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast. Nature. 2014 Jul 3; 511(7507):86-9.
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        3. Miloslavski R, Cohen E, Avraham A, Iluz Y, Hayouka Z, Kasir J, Mudhasani R, Jones SN, Cybulski N, Rüegg MA, Larsson O, Gandin V, Rajakumar A, Topisirovic I, Meyuhas O. Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. J Mol Cell Biol. 2014 Jun; 6(3):255-66.
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        4. Wan G, Zhang X, Langley RR, Liu Y, Hu X, Han C, Peng G, Ellis LM, Jones SN, Lu X. DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway. Cell Rep. 2013 Jun 27; 3(6):2100-12.
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        5. van der Deen M, Taipaleenmäki H, Zhang Y, Teplyuk NM, Gupta A, Cinghu S, Shogren K, Maran A, Yaszemski MJ, Ling L, Cool SM, Leong DT, Dierkes C, Zustin J, Salto-Tellez M, Ito Y, Bae SC, Zielenska M, Squire JA, Lian JB, Stein JL, Zambetti GP, Jones SN, Galindo M, Hesse E, Stein GS, van Wijnen AJ. MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. J Biol Chem. 2013 Jul 19; 288(29):21307-19.
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        6. Ramkumar C, Cui H, Kong Y, Jones SN, Gerstein RM, Zhang H. Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1. Nat Commun. 2013; 4:2598.
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        7. Yoon Y, Cowley DO, Gallant J, Jones SN, Van Dyke T, Rivera-Pérez JA. Conditional Aurora A deficiency differentially affects early mouse embryo patterning. Dev Biol. 2012 Nov 1; 371(1):77-85.
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        8. Gannon HS, Woda BA, Jones SN. ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice. Cancer Cell. 2012 May 15; 21(5):668-79.
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        9. Ramkumar C, Kong Y, Cui H, Hao S, Jones SN, Gerstein RM, Zhang H. Smurf2 regulates the senescence response and suppresses tumorigenesis in mice. Cancer Res. 2012 Jun 1; 72(11):2714-9.
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        10. Edelstein LC, Luna EJ, Gibson IB, Bray M, Jin Y, Kondkar A, Nagalla S, Hadjout-Rabi N, Smith TC, Covarrubias D, Jones SN, Ahmad F, Stolla M, Kong X, Fang Z, Bergmeier W, Shaw C, Leal SM, Bray PF. Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress. Circulation. 2012 Jun 5; 125(22):2762-71.
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        11. Gannon HS, Jones SN. Using Mouse Models to Explore MDM-p53 Signaling in Development, Cell Growth, and Tumorigenesis. Genes Cancer. 2012 Mar; 3(3-4):209-18.
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        12. Bianchetta MJ, Lam TT, Jones SN, Morabito MA. Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons. J Neurosci. 2011 Aug 17; 31(33):12029-35.
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        13. Liu JC, Lengner CJ, Gaur T, Lou Y, Hussain S, Jones MD, Borodic B, Colby JL, Steinman HA, van Wijnen AJ, Stein JL, Jones SN, Stein GS, Lian JB. Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation. J Biol Chem. 2011 Aug 26; 286(34):30057-70.
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        14. Liu LJ, Xie R, Hussain S, Lian JB, Rivera-Perez J, Jones SN, Stein JL, Stein GS, van Wijnen AJ. Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development. Gene. 2011 Sep 1; 483(1-2):1-10.
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        15. Mudhasani R, Puri V, Hoover K, Czech MP, Imbalzano AN, Jones SN. Dicer is required for the formation of white but not brown adipose tissue. J Cell Physiol. 2011 May; 226(5):1399-406.
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        16. Gannon HS, Donehower LA, Lyle S, Jones SN. Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin. Dev Biol. 2011 May 1; 353(1):1-9.
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        17. Regeling A, Armata HL, Gallant J, Jones SN, Sluss HK. Mice defective in p53 nuclear localization signal 1 exhibit exencephaly. Transgenic Res. 2011 Aug; 20(4):899-912.
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        18. Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi-Ishigaki N, Zhu X, Jiao B, Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB, Bach I. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature. 2010 Oct 21; 467(7318):977-81.
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        19. Mason EF, Zhao Y, Goraksha-Hicks P, Coloff JL, Gannon H, Jones SN, Rathmell JC. Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. Cancer Res. 2010 Oct 15; 70(20):8066-76.
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        20. Mudhasani R, Imbalzano AN, Jones SN. An essential role for Dicer in adipocyte differentiation. J Cell Biochem. 2010 Jul 1; 110(4):812-6.
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        21. Arrate MP, Vincent T, Odvody J, Kar R, Jones SN, Eischen CM. MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival. Cancer Res. 2010 Jul 15; 70(14):6083-92.
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        22. Coles AH, Gannon H, Cerny A, Kurt-Jones E, Jones SN. Inhibitor of growth-4 promotes IkappaB promoter activation to suppress NF-kappaB signaling and innate immunity. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11423-8.
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        23. Mallappa C, Nasipak BT, Etheridge L, Androphy EJ, Jones SN, Sagerström CG, Ohkawa Y, Imbalzano AN. Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function. Mol Cell Biol. 2010 Jul; 30(13):3176-86.
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        24. Sluss HK, Gannon H, Coles AH, Shen Q, Eischen CM, Jones SN. Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis. Mol Cancer Res. 2010 Feb; 8(2):216-22.
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        25. Gaur T, Hussain S, Mudhasani R, Parulkar I, Colby JL, Frederick D, Kream BE, van Wijnen AJ, Stein JL, Stein GS, Jones SN, Lian JB. Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse. Dev Biol. 2010 Apr 1; 340(1):10-21.
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        26. Dowdy CR, Xie R, Frederick D, Hussain S, Zaidi SK, Vradii D, Javed A, Li X, Jones SN, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation. Hum Mol Genet. 2010 Mar 15; 19(6):1048-57.
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        27. Zhang X, Lin L, Guo H, Yang J, Jones SN, Jochemsen A, Lu X. Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response. Cancer Res. 2009 Oct 15; 69(20):7960-8.
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        28. Xie R, Medina R, Zhang Y, Hussain S, Colby J, Ghule P, Sundararajan S, Keeler M, Liu LJ, van der Deen M, Mitra P, Lian JB, Rivera-Perez JA, Jones SN, Stein JL, van Wijnen AJ, Stein GS. The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12359-64.
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        29. Coles AH, Jones SN. The ING gene family in the regulation of cell growth and tumorigenesis. J Cell Physiol. 2009 Jan; 218(1):45-57.
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        30. Lou Y, Javed A, Hussain S, Colby J, Frederick D, Pratap J, Xie R, Gaur T, van Wijnen AJ, Jones SN, Stein GS, Lian JB, Stein JL. A Runx2 threshold for the cleidocranial dysplasia phenotype. Hum Mol Genet. 2009 Feb 1; 18(3):556-68.
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        31. Chang L, Zhou B, Hu S, Guo R, Liu X, Jones SN, Yen Y. ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18519-24.
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        32. Low HP, Gréco B, Tanahashi Y, Gallant J, Jones SN, Billings-Gagliardi S, Recht LD, Schwartz WJ. Embryonic stem cell rescue of tremor and ataxia in myelin-deficient shiverer mice. J Neurol Sci. 2009 Jan 15; 276(1-2):133-7.
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        33. Coles AH, Marfella CG, Imbalzano AN, Steinman HA, Garlick DS, Gerstein RM, Jones SN. p37Ing1b regulates B-cell proliferation and cooperates with p53 to suppress diffuse large B-cell lymphomagenesis. Cancer Res. 2008 Nov 1; 68(21):8705-14.
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        34. Matijasevic Z, Krzywicka-Racka A, Sluder G, Jones SN. MdmX regulates transformation and chromosomal stability in p53-deficient cells. Cell Cycle. 2008 Oct; 7(19):2967-73.
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        35. Mudhasani R, Zhu Z, Hutvagner G, Eischen CM, Lyle S, Hall LL, Lawrence JB, Imbalzano AN, Jones SN. Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol. 2008 Jun 30; 181(7):1055-63.
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        36. Delaunay A, Bromberg KD, Hayashi Y, Mirabella M, Burch D, Kirkwood B, Serra C, Malicdan MC, Mizisin AP, Morosetti R, Broccolini A, Guo LT, Jones SN, Lira SA, Puri PL, Shelton GD, Ronai Z. The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis. PLoS One. 2008; 3(2):e1609.
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        37. Liang H, Coles AH, Zhu Z, Zayas J, Jurecic R, Kang J, Jones SN. Noncanonical Wnt signaling promotes apoptosis in thymocyte development. J Exp Med. 2007 Dec 24; 204(13):3077-84.
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        38. Matijasevic Z, Steinman HA, Hoover K, Jones SN. MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice. Mol Cell Biol. 2008 Feb; 28(4):1265-73.
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        39. Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA. The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell. 2007 Oct; 12(4):342-54.
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        40. Wang P, Lushnikova T, Odvody J, Greiner TC, Jones SN, Eischen CM. Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells. Oncogene. 2008 Mar 6; 27(11):1590-8.
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        41. Coles AH, Liang H, Zhu Z, Marfella CG, Kang J, Imbalzano AN, Jones SN. Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis. Cancer Res. 2007 Mar 1; 67(5):2054-61.
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        42. Marfella CG, Ohkawa Y, Coles AH, Garlick DS, Jones SN, Imbalzano AN. Mutation of the SNF2 family member Chd2 affects mouse development and survival. J Cell Physiol. 2006 Oct; 209(1):162-71.
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        43. Fan L, Jones SN, Padden C, Shen Q, Newburger PE. Nuclease sensitive element binding protein 1 gene disruption results in early embryonic lethality. J Cell Biochem. 2006 Sep 1; 99(1):140-5.
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        44. Guidi CJ, Mudhasani R, Hoover K, Koff A, Leav I, Imbalzano AN, Jones SN. Functional interaction of the retinoblastoma and Ini1/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis. Cancer Res. 2006 Aug 15; 66(16):8076-82.
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        45. Lengner CJ, Steinman HA, Gagnon J, Smith TW, Henderson JE, Kream BE, Stein GS, Lian JB, Jones SN. Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol. 2006 Mar 13; 172(6):909-21.
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        46. Frese KK, Latorre IJ, Chung SH, Caruana G, Bernstein A, Jones SN, Donehower LA, Justice MJ, Garner CC, Javier RT. Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor. EMBO J. 2006 Mar 22; 25(6):1406-17.
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        47. Steinman HA, Hoover KM, Keeler ML, Sands AT, Jones SN. Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development. Oncogene. 2005 Nov 24; 24(53):7935-40.
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        48. Asher DR, Cerny AM, Weiler SR, Horner JW, Keeler ML, Neptune MA, Jones SN, Bronson RT, Depinho RA, Finberg RW. Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development. Genesis. 2005 Jun; 42(2):77-85.
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        49. Repik A, Pincus SE, Ghiran I, Nicholson-Weller A, Asher DR, Cerny AM, Casey LS, Jones SM, Jones SN, Mohamed N, Klickstein LB, Spitalny G, Finberg RW. A transgenic mouse model for studying the clearance of blood-borne pathogens via human complement receptor 1 (CR1). Clin Exp Immunol. 2005 May; 140(2):230-40.
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        50. Imbalzano AN, Jones SN. Snf5 tumor suppressor couples chromatin remodeling, checkpoint control, and chromosomal stability. Cancer Cell. 2005 Apr; 7(4):294-5.
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        51. Liang H, Atkins H, Abdel-Fattah R, Jones SN, Lunec J. Genomic organisation of the human MDM2 oncogene and relationship to its alternatively spliced mRNAs. Gene. 2004 Sep 1; 338(2):217-23.
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        52. Doan DN, Veal TM, Yan Z, Wang W, Jones SN, Imbalzano AN. Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymes. Oncogene. 2004 Apr 22; 23(19):3462-73.
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        53. Rogoff HA, Pickering MT, Frame FM, Debatis ME, Sanchez Y, Jones S, Kowalik TF. Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol Cell Biol. 2004 Apr; 24(7):2968-77.
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        54. Cha KB, Douglas KR, Potok MA, Liang H, Jones SN, Camper SA. WNT5A signaling affects pituitary gland shape. Mech Dev. 2004 Feb; 121(2):183-94.
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        55. Sluss HK, Armata H, Gallant J, Jones SN. Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol Cell Biol. 2004 Feb; 24(3):976-84.
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        56. Steinman HA, Sluss HK, Sands AT, Pihan G, Jones SN. Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth. Oncogene. 2004 Jan 8; 23(1):303-6.
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        57. Gréco B, Low HP, Johnson EC, Salmonsen RA, Gallant J, Jones SN, Ross AH, Recht LD. Differentiation prevents assessment of neural stem cell pluripotency after blastocyst injection. Stem Cells. 2004; 22(4):600-8.
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        58. Guidi CJ, Veal TM, Jones SN, Imbalzano AN. Transcriptional compensation for loss of an allele of the Ini1 tumor suppressor. J Biol Chem. 2004 Feb 6; 279(6):4180-5.
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        59. Steinman HA, Burstein E, Lengner C, Gosselin J, Pihan G, Duckett CS, Jones SN. An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis. J Biol Chem. 2004 Feb 6; 279(6):4877-86.
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        60. Liang H, Chen Q, Coles AH, Anderson SJ, Pihan G, Bradley A, Gerstein R, Jurecic R, Jones SN. Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell. 2003 Nov; 4(5):349-60.
          View in: PubMed
        61. Moore L, Venkatachalam S, Vogel H, Watt JC, Wu CL, Steinman H, Jones SN, Donehower LA. Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis. Oncogene. 2003 Oct 30; 22(49):7831-7.
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        62. Houghtaling S, Timmers C, Noll M, Finegold MJ, Jones SN, Meyn MS, Grompe M. Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev. 2003 Aug 15; 17(16):2021-35.
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        63. Kennedy NJ, Sluss HK, Jones SN, Bar-Sagi D, Flavell RA, Davis RJ. Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes Dev. 2003 Mar 1; 17(5):629-37.
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        64. Sluss HK, Jones SN. Analysing p53 tumour suppressor functions in mice. Expert Opin Ther Targets. 2003 Feb; 7(1):89-99.
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        65. Jones SN, Donehower LA. Functional analysis of tumor suppressor genes in mice. Methods Mol Biol. 2003; 223:283-314.
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        66. Schonhoff CM, Daou MC, Jones SN, Schiffer CA, Ross AH. Nitric oxide-mediated inhibition of Hdm2-p53 binding. Biochemistry. 2002 Nov 19; 41(46):13570-4.
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        67. Rogoff HA, Pickering MT, Debatis ME, Jones S, Kowalik TF. E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis. Mol Cell Biol. 2002 Aug; 22(15):5308-18.
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        68. Li L, Liu F, Salmonsen RA, Turner TK, Litofsky NS, Di Cristofano A, Pandolfi PP, Jones SN, Recht LD, Ross AH. PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation. Mol Cell Neurosci. 2002 May; 20(1):21-9.
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        69. Luong MX, van der Meijden CM, Xing D, Hesselton R, Monuki ES, Jones SN, Lian JB, Stein JL, Stein GS, Neufeld EJ, van Wijnen AJ. Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility. Mol Cell Biol. 2002 Mar; 22(5):1424-37.
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        70. Steinman HA, Jones SN. Generation of an Mdm2 conditional allele in mice. Genesis. 2002 Feb; 32(2):142-4.
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        71. Whitmarsh AJ, Kuan CY, Kennedy NJ, Kelkar N, Haydar TF, Mordes JP, Appel M, Rossini AA, Jones SN, Flavell RA, Rakic P, Davis RJ. Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev. 2001 Sep 15; 15(18):2421-32.
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        72. Choi JY, Pratap J, Javed A, Zaidi SK, Xing L, Balint E, Dalamangas S, Boyce B, van Wijnen AJ, Lian JB, Stein JL, Jones SN, Stein GS. Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8650-5.
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        73. Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, Davis RJ. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev. 2001 Jun 1; 15(11):1419-26.
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        74. Guidi CJ, Sands AT, Zambrowicz BP, Turner TK, Demers DA, Webster W, Smith TW, Imbalzano AN, Jones SN. Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice. Mol Cell Biol. 2001 May; 21(10):3598-603.
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        75. Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, Davis RJ. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science. 2000 May 5; 288(5467):870-4.
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        76. Jones SN, Hancock AR, Vogel H, Donehower LA, Bradley A. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15608-12.
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        77. Fuchs SY, Adler V, Buschmann T, Yin Z, Wu X, Jones SN, Ronai Z. JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes Dev. 1998 Sep 1; 12(17):2658-63.
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        78. Venkatachalam S, Shi YP, Jones SN, Vogel H, Bradley A, Pinkel D, Donehower LA. Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J. 1998 Aug 17; 17(16):4657-67.
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        79. Kubbutat MH, Jones SN, Vousden KH. Regulation of p53 stability by Mdm2. Nature. 1997 May 15; 387(6630):299-303.
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        80. Jones SN, Sands AT, Hancock AR, Vogel H, Donehower LA, Linke SP, Wahl GM, Bradley A. The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14106-11.
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        81. Jones SN, Ansari-Lari MA, Hancock AR, Jones WJ, Gibbs RA, Donehower LA, Bradley A. Genomic organization of the mouse double minute 2 gene. Gene. 1996 Oct 10; 175(1-2):209-13.
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        82. Ansari-Lari MA, Jones SN, Timms KM, Gibbs RA. Improved ligation-anchored PCR strategy for identification of 5' ends of transcripts. Biotechniques. 1996 Jul; 21(1):34-6, 38.
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        83. Jones SN, Roe AE, Donehower LA, Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature. 1995 Nov 9; 378(6553):206-8.
          View in: PubMed
        84. Cogan JD, Jones SN, Hall RK, Tibbetts C. Functional diversity of E1A gene autoregulation among human adenoviruses. J Virol. 1992 Jun; 66(6):3833-45.
          View in: PubMed
        85. Grompe M, Jones SN, Loulseged H, Caskey CT. Retroviral-mediated gene transfer of human ornithine transcarbamylase into primary hepatocytes of spf and spf-ash mice. Hum Gene Ther. 1992 Feb; 3(1):35-44.
          View in: PubMed
        86. Gelb BD, Adams V, Jones SN, Griffin LD, MacGregor GR, McCabe ER. Targeting of hexokinase 1 to liver and hepatoma mitochondria. Proc Natl Acad Sci U S A. 1992 Jan 1; 89(1):202-6.
          View in: PubMed
        87. Jones SN, Jones PG, Ibarguen H, Caskey CT, Craigen WJ. Induction of the Cyp1a-1 dioxin-responsive enhancer in transgenic mice. Nucleic Acids Res. 1991 Dec 11; 19(23):6547-51.
          View in: PubMed
        88. Grompe M, Mitani K, Lee CC, Jones SN, Caskey CT. Gene therapy in man and mice: adenosine deaminase deficiency, ornithine transcarbamylase deficiency, and Duchenne muscular dystrophy. Adv Exp Med Biol. 1991; 309B:51-6.
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        89. Grompe M, Jones SN, Caskey CT. Molecular detection and correction of ornithine transcarbamylase deficiency. Trends Genet. 1990 Oct; 6(10):335-9.
          View in: PubMed
        90. Jones SN, Grompe M, Munir MI, Veres G, Craigen WJ, Caskey CT. Ectopic correction of ornithine transcarbamylase deficiency in sparse fur mice. J Biol Chem. 1990 Aug 25; 265(24):14684-90.
          View in: PubMed
        91. Jones SN, Tibbetts C. Upstream DNA sequences determine different autoregulatory responses of the adenovirus types 5 and 3 E1A promoters. J Virol. 1989 Apr; 63(4):1833-8.
          View in: PubMed
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