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    David Paydarfar MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentNeurology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-1658
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMillennium MD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentNeuroscience

        Overview 
        Narrative

        My research is devoted to understanding the neural control of autonomic functions. Specific areas of interest are the genesis of respiratory rhythm, the coordination of breathing and swallowing, and the maintenance of circulation during upright posture. The major goal is to understand how normal control mechanisms break down and lead to certain common disease states: central apnea, neurogenic aspiration, and neurally mediated syncope.

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        Bibliographic 
        selected publications
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        1. Kheradmand A, Fisher M, Paydarfar D. Ischemic Stroke in Evolution: Predictive Value of Perfusion Computed Tomography. J Stroke Cerebrovasc Dis. 2013 Aug 15.
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        2. Williamson JR, Bliss DW, Paydarfar D. Forecasting respiratory collapse: Theory and practice for averting life-threatening infant apneas. Respir Physiol Neurobiol. 2013 Nov 1; 189(2):223-31.
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        3. Indic P, Paydarfar D, Barbieri R. Point process modeling of interbreath interval: a new approach for the assessment of instability of breathing in neonates. IEEE Trans Biomed Eng. 2013 Oct; 60(10):2858-66.
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        4. Clay JR, Forger DB, Paydarfar D. Ionic mechanism underlying optimal stimuli for neuronal excitation: role of na(+) channel inactivation. PLoS One. 2012; 7(9):e45983.
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        5. Gaspari RJ, Paydarfar D. Respiratory recovery following organophosphate poisoning in a rat model is suppressed by isolated hypoxia at the point of apnea. Toxicology. 2012 Dec 16; 302(2-3):242-7.
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        6. Paydarfar D. Protecting the airway during swallowing: What is the role for afferent surveillance? Head Neck. 2011 Oct; 33 Suppl 1:S26-9.
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        7. McFarland DH, Paydarfar D. Proceedings of the Integrative Neural Systems Underlying Vital Aerodigestive Tract Functions Conference, June 17-19, 2010: Work group summary and call to action. Head Neck. 2011 Oct; 33 Suppl 1:S54-7.
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        8. Indic P, Paydarfar D, Barbieri R. A point process model of respiratory dynamics in early physiological development. Conf Proc IEEE Eng Med Biol Soc. 2011 Aug; 2011:3804-7.
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        9. Forger DB, Paydarfar D, Clay JR. Optimal stimulus shapes for neuronal excitation. PLoS Comput Biol. 2011 Jul; 7(7):e1002089.
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        10. Paydarfar D, Schwartz WJ. A piece of my mind. Dear provider. JAMA. 2011 May 25; 305(20):2046-7.
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        11. Indic P, Bloch-Salisbury E, Bednarek F, Brown EN, Paydarfar D, Barbieri R. Assessment of cardio-respiratory interactions in preterm infants by bivariate autoregressive modeling and surrogate data analysis. Early Hum Dev. 2011 Jul; 87(7):477-87.
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        12. Gaspari RJ, Paydarfar D. Dichlorvos-induced central apnea: Effects of selective brainstem exposure in the rat. Neurotoxicology. 2011 Mar; 32(2):206-14.
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        13. Bloch-Salisbury E, Hall MH, Sharma P, Boyd T, Bednarek F, Paydarfar D. Heritability of apnea of prematurity: a retrospective twin study. Pediatrics. 2010 Oct; 126(4):e779-87.
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        14. Marcus CL, Smith RJ, Mankarious LA, Arens R, Mitchell GS, Elluru RG, Forte V, Goudy S, Jabs EW, Kane AA, Katz E, Paydarfar D, Pereira K, Reeves RH, Richtsmeier JT, Ruiz RL, Thach BT, Tunkel DE, Whitsett JA, Wootton D, Blaisdell CJ. Developmental aspects of the upper airway: report from an NHLBI Workshop, March 5-6, 2009. Proc Am Thorac Soc. 2009 Sep 15; 6(6):513-20.
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        15. Bloch-Salisbury E, Indic P, Bednarek F, Paydarfar D. Stabilizing immature breathing patterns of preterm infants using stochastic mechanosensory stimulation. J Appl Physiol. 2009 Oct; 107(4):1017-27.
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        16. Adams L, Lansing RW, O'Donnell CR, Paydarfar D, Banzett RB. No evidence for reduction in dyspnea following lesions of the right insula. Am J Respir Crit Care Med. 2009 Apr 1; 179(7):623; author reply 623-4.
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        17. Gaspari RJ, Paydarfar D. Respiratory failure induced by acute organophosphate poisoning in rats: effects of vagotomy. Neurotoxicology. 2009 Mar; 30(2):298-304.
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        18. Clay JR, Paydarfar D, Forger DB. A simple modification of the Hodgkin and Huxley equations explains type 3 excitability in squid giant axons. J R Soc Interface. 2008 Dec 6; 5(29):1421-8.
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        19. Indic P, Salisbury E, Paydarfar D, Brown E, Barbieri R. Interaction between Heart Rate Variability and Respiration in Preterm Infants. Comput Cardiol. 2008 Sep; 35:57-60.
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        20. Indic P, Schwartz WJ, Paydarfar D. Design principles for phase-splitting behaviour of coupled cellular oscillators: clues from hamsters with 'split' circadian rhythms. J R Soc Interface. 2008 Aug 6; 5(25):873-83.
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        21. Gaspari RJ, Paydarfar D. Pathophysiology of respiratory failure following acute dichlorvos poisoning in a rodent model. Neurotoxicology. 2007 May; 28(3):664-71.
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        22. Paydarfar D, Forger DB, Clay JR. Noisy inputs and the induction of on-off switching behavior in a neuronal pacemaker. J Neurophysiol. 2006 Dec; 96(6):3338-48.
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        23. Forger DB, Paydarfar D. Starting, stopping, and resetting biological oscillators: in search of optimum perturbations. J Theor Biol. 2004 Oct 21; 230(4):521-32.
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        24. Jafari S, Prince RA, Kim DY, Paydarfar D. Sensory regulation of swallowing and airway protection: a role for the internal superior laryngeal nerve in humans. J Physiol. 2003 Jul 1; 550(Pt 1):287-304.
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        25. Binks AP, Paydarfar D, Schachter SC, Guz A, Banzett RB. High strength stimulation of the vagus nerve in awake humans: a lack of cardiorespiratory effects. Respir Physiol. 2001 Sep; 127(2-3):125-33.
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        26. Paydarfar D, Schwartz WJ. An algorithm for discovery. Science. 2001 Apr 6; 292(5514):13.
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        27. Paydarfar D, Krieger D, Dib N, Blair RH, Pastore JO, Stetz JJ, Symes JF. In vivo magnetic resonance imaging and surgical histopathology of intracardiac masses: distinct features of subacute thrombi. Cardiology. 2001; 95(1):40-7.
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        28. Banzett RB, Guz A, Paydarfar D, Shea SA, Schachter SC, Lansing RW. Cardiorespiratory variables and sensation during stimulation of the left vagus in patients with epilepsy. Epilepsy Res. 1999 May; 35(1):1-11.
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        29. Paydarfar D, Eldridge FL, Paydarfar JA. Phase resetting of the respiratory oscillator by carotid sinus nerve stimulation in cats. J Physiol. 1998 Jan 15; 506 ( Pt 2):515-28.
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        30. Paydarfar D, Buerkel DM. Sporadic apnea: paradoxical transformation to eupnea by perturbations that inhibit inspiration. Med Hypotheses. 1997 Jul; 49(1):19-26.
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        31. Paydarfar D, de la Monte SM. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12-1997. A 50-year-old woman with multiple sclerosis and an enlarging frontal-lobe mass. N Engl J Med. 1997 Apr 17; 336(16):1163-71.
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        32. Paydarfar D, Buerkel DM. Dysrhythmias of the respiratory oscillator. Chaos. 1995 Mar; 5(1):18-29.
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        33. Paydarfar D, Gilbert RJ, Poppel CS, Nassab PF. Respiratory phase resetting and airflow changes induced by swallowing in humans. J Physiol. 1995 Feb 15; 483 ( Pt 1):273-88.
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        34. Shea SA, Andres LP, Paydarfar D, Banzett RB, Shannon DC. Effect of mental activity on breathing in congenital central hypoventilation syndrome. Respir Physiol. 1993 Dec; 94(3):251-63.
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        35. Paydarfar D, Eldridge FL, Wagner PG, Dowell RT. Neural respiratory responses to cortically induced seizures in cats. Respir Physiol. 1992 Aug; 89(2):225-37.
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        36. Paydarfar D, Eldridge FL, Scott SC, Dowell RT, Wagner PG. Respiratory responses to focal and generalized seizures in cats. Am J Physiol. 1991 May; 260(5 Pt 2):R934-40.
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        37. Harris AK, Pryer NK, Paydarfar D. Effects of electric fields on fibroblast contractility and cytoskeleton. J Exp Zool. 1990 Feb; 253(2):163-76.
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        38. Gominak S, Cros D, Paydarfar D. Herpes simplex labialis and trigeminal neuropathy. Neurology. 1990 Jan; 40(1):151-2.
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        39. Eldridge FL, Paydarfar D, Wagner PG, Dowell RT. Phase resetting of respiratory rhythm: effect of changing respiratory "drive". Am J Physiol. 1989 Aug; 257(2 Pt 2):R271-7.
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        40. Eldridge FL, Paydarfar D. Desynchronized respiratory rhythms and their interactions in cats with split brain stems. J Physiol. 1989 Mar; 410:513-32.
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        41. Eldridge FL, Paydarfar D, Scott SC, Dowell RT. Role of endogenous adenosine in recurrent generalized seizures. Exp Neurol. 1989 Feb; 103(2):179-85.
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        42. Eldridge FL, Kiley JP, Paydarfar D. Dynamics of medullary hydrogen ion and respiratory responses to square-wave change of arterial carbon dioxide in cats. J Physiol. 1987 Apr; 385:627-42.
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        43. Paydarfar D, Eldridge FL. Phase resetting and dysrhythmic responses of the respiratory oscillator. Am J Physiol. 1987 Jan; 252(1 Pt 2):R55-62.
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        44. Paydarfar D, Eldridge FL, Kiley JP. Resetting of mammalian respiratory rhythm: existence of a phase singularity. Am J Physiol. 1986 Apr; 250(4 Pt 2):R721-7.
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