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    Chyke A Doubeni MD, MPH

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentFamily Medicine and Community Health
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-334-7772
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentQuantitative Health Sciences

        Overview 
        Narrative
        Chyke 2011 photo

        Education

        MD (MBBS), College of Medicine, University of Lagos, Nigeria (1987)
        FRCS, Royal College of Surgeons of England, UK (1993)
        MPH, University of Massachusetts, Amherst, MA (2004)

        Affiliations

        2003 - Member, North America Primary Care Research Group
        2004 - Member, American Academy of Family Physicians
        2009 - Member, American College of Preventive Medicine
        1998 - Diplomate, American Board of Family Medicine
        2010 - Diplomate, American Board of Preventive Medicine

        Scholarly Activity

        Current research projects:

        COLOFIT: Optimizing Colonoscopy & Fecal Immunochemical Tests for Community-Based Screening
        (NIH/NCI, U54, PROSPR) 09/1/2011-08/31/2016 Role: co-PI (subcontract)
        This project establishes a PROSPR Research Center aimed at maximizing the benefits and minimizing the harms of screening with colonoscopy or FIT in community settings. The project will also work with Cancer Intervention and Surveillance Modeling Network (CISNET) to examine the benefits, harms and comparative effectiveness of the two tests and assess risk-based screening strategies as well as the likely relative impact of remediating preventable failures in the CRC screening process.

        Effectiveness of Screening Colonoscopy in Reducing Deaths from Colorectal Cancer
        (NIH/NCI, RO1) 09/1/2010 - 03/30/2015 Role: co-PI
        The three-site study will estimate the effectiveness of screening colonoscopy in reducing death from colorectal cancer (CRC) among average-risk adults, particularly in the right colon

        SEARCH: Cancer Screening Effectiveness and Research in Community-based Healthcare
        (NIH/NCI, RC2)09/1/09 - 08/31/2012 Role: co-PI
        The goal of this study is to develop scientific and methodological capacity for cancer screening comparative effectiveness research in a community-based setting using administrative and clinical databases and medical records data. The long-term goal is to generate and disseminate findings about high priority comparative effectiveness research topics for patients, clinicians, policy makers, payers and public health practitioners. The project is supported by a national Advisory Board of scientists and policy makers on cancer screening and in collaboration with the Cancer Intervention and Surveillance Modeling Network (CISNET)

        Understanding Racial and Ethnic Differences in Survival from Colorectal Cancer
        (NIH/NCI, KO1) 09/10/07 - 8/31/2012 Role: co-PI
        The goal of this 5-year career development research award is to investigate underlying causes of racial and ethnic differences in CRC survival.

        Minority supplement to Effectiveness of Screening Colonoscopy in Reducing Death from Colorectal Cancer.
        06/1/2011-03/31/2013 Role: PI
        This is a training award for a minority investigator (Dr. Rosalie Torres Stone) from the NCI Center to Reduce Cancer Health Disparities.

        Completed research projects:

        ARRA Administrative Supplement to KO1 - Understanding Racial & Ethnic Differences in Survival from Colorectal Cancer
        09/25/2009 - 09/24/2011 Role: PI

        Improving the Process of Cancer Screening for Low Income Diverse Populations
        09/2007-09/2010 Role: Project Leader
        This project assessed barriers and facilitators in the process of CRC screening, and complete diagnostic evaluation of abnormal screening for low income patients receiving care at community health centers. This pilot project was funded under the auspices of the MassCONECT project.

        Socioeconomic Diversity in Integrated Healthcare Delivery Systems
        04/2008-05/2009 Role: Project Leader
        This pilot project assessed the area-level socioeconomic and racial structure of enrollees of participating integrated health delivery systems and compared the use of preventive health care services according to levels of neighborhood SES.

        How Do Perceived Availability and Knowledge of Commercial Sources of Tobacco Contribute to Tobacco Use?06/2006-05/2007 Role:PI
        This project assessed whether perceived availability, and/or merchant non-compliance with tobacco ordinances are risk factors for susceptibility, initiation, or regular tobacco use among adolescents. Studies conducted under this project demonstrated that smoking and the development of addiction are two reinforcing processes.

        Research supplement for under-represented minorities
        04/2004 -02/2007 Role: Project Leader
        Studies conducted under the auspices of this funding reported on the utilization patterns of cancer early detection services among women following diagnosis of incident breast cancer or cervical neoplasm.

        Peripheral Arterial Disease in the Managed Care Setting
        01/2002-07/2004 Role: Project Leader
        This project, conducted as part of my MPH thesis, assessed the feasibility of screening for peripheral arterial disease in the managed care setting by assessing the yield from screening a high-risk population with no pre-existing cardiovascular disease.

        HRSA - Title III Ryan White grant
        2000-2001 Role: Program/Medical Director
        This grant supported a program that provided accessible coordinated care to persons living with HIV/AIDS through a collaboration with the Division of Infectious Diseases at East Carolina University School of Medicine.

        Biography

        Chyke Doubeni, MD, MPH, associate professor of family medicine & community health, is a clinical epidemiologist, and board-certified in both preventive medicine & family medicine. Currently, he is a co-Principal Investigator of three large, multi-site research projects, which focus on the comparative effectiveness of colorectal cancer screening tests and on improving the process of screening for colorectal cancer in community settings.

        Dr. Doubeni has also conducted studies to understand the complex social, biological and health-care related issues that contribute to disparities in mortality from colorectal cancer. In October 2011, Dr. Doubeni received a 2010 Presidential Early Career Award for Scientists and Engineers (PECASE) in recognition of innovative research, mentoring and community work. This award is bestowed each year upon "...outstanding scientists and engineers who are beginning their independent research careers, show exceptional potential for leadership, and have demonstrated a commitment to community service and the advancement of science, technology, engineering and math education".*

        * http://www.whitehouse.gov/blog/2011/10/17/president-obama-meets-nations-cutting-edge-researchers



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Corley DA, Levin TR, Doubeni CA. Adenoma detection rate and risk of colorectal cancer and death. N Engl J Med. 2014 Jun 26; 370(26):2541.
          View in: PubMed
        2. Tiro JA, Kamineni A, Levin TR, Zheng Y, Schottinger JS, Rutter CM, Corley DA, Skinner CS, Chubak J, Doubeni CA, Halm EA, Gupta S, Wernli KJ, Klabunde C. The Colorectal Cancer Screening Process in Community Settings: A Conceptual Model for the Population-Based Research Optimizing Screening through Personalized Regimens Consortium. Cancer Epidemiol Biomarkers Prev. 2014 Jul; 23(7):1147-58.
          View in: PubMed
        3. Corley DA, Jensen CD, Marks AR, Zhao WK, Lee JK, Doubeni CA, Zauber AG, de Boer J, Fireman BH, Schottinger JE, Quinn VP, Ghai NR, Levin TR, Quesenberry CP. Adenoma detection rate and risk of colorectal cancer and death. N Engl J Med. 2014 Apr 3; 370(14):1298-306.
          View in: PubMed
        4. Gupta S, Sussman DA, Doubeni CA, Anderson DS, Day L, Deshpande AR, Joseph Elmunzer B, Laiyemo AO, Mendez J, Somsouk M, Allison J, Bhuket T, Geng Z, Green BB, Itzkowitz SH, Martinez ME. Challenges and possible solutions to colorectal cancer screening for the underserved. J Natl Cancer Inst. 2014 Apr 1; 106(4):dju032.
          View in: PubMed
        5. Fassil H, Adams KF, Weinmann S, Doria-Rose VP, Johnson E, Williams AE, Corley DA, Doubeni CA. Approaches for classifying the indications for colonoscopy using detailed clinical data. BMC Cancer. 2014; 14(1):95.
          View in: PubMed
        6. Eldridge RC, Doubeni CA, Fletcher RH, Zauber AG, Corley DA, Doria-Rose VP, Goodman M. Uncontrolled confounding in studies of screening effectiveness: an example of colonoscopy. J Med Screen. 2013; 20(4):198-207.
          View in: PubMed
        7. Chubak J, Rutter CM, Kamineni A, Johnson EA, Stout NK, Weiss NS, Doria-Rose VP, Doubeni CA, Buist DS. Measurement in comparative effectiveness research. Am J Prev Med. 2013 May; 44(5):513-9.
          View in: PubMed
        8. Laiyemo AO, Doubeni C, Pinsky PF, Doria-Rose VP, Marcus PM, Schoen RE, Lanza E, Cross AJ. Factors associated with the risk of adenoma recurrence in distal and proximal colon. Digestion. 2013; 87(3):141-6.
          View in: PubMed
        9. Doubeni CA, Weinmann S, Adams K, Kamineni A, Buist DS, Ash AS, Rutter CM, Doria-Rose VP, Corley DA, Greenlee RT, Chubak J, Williams A, Kroll-Desrosiers AR, Johnson E, Webster J, Richert-Boe K, Levin TR, Fletcher RH, Weiss NS. Screening colonoscopy and risk for incident late-stage colorectal cancer diagnosis in average-risk adults: a nested case-control study. Ann Intern Med. 2013 Mar 5; 158(5 Pt 1):312-20.
          View in: PubMed
        10. Laiyemo AO, Doubeni C, Brim H, Ashktorab H, Schoen RE, Gupta S, Charabaty A, Lanza E, Smoot DT, Platz E, Cross AJ. Short- and long-term risk of colorectal adenoma recurrence among whites and blacks. Gastrointest Endosc. 2013 Mar; 77(3):447-54.
          View in: PubMed
        11. Corley DA, Jensen CD, Marks AR, Zhao WK, de Boer J, Levin TR, Doubeni C, Fireman BH, Quesenberry CP. Variation of adenoma prevalence by age, sex, race, and colon location in a large population: implications for screening and quality programs. Clin Gastroenterol Hepatol. 2013 Feb; 11(2):172-80.
          View in: PubMed
        12. Doubeni CA, Major JM, Laiyemo AO, Schootman M, Zauber AG, Hollenbeck AR, Sinha R, Allison J. Contribution of behavioral risk factors and obesity to socioeconomic differences in colorectal cancer incidence. J Natl Cancer Inst. 2012 Sep 19; 104(18):1353-62.
          View in: PubMed
        13. Laiyemo AO, Doubeni C, Badurdeen DS, Murphy G, Marcus PM, Schoen RE, Lanza E, Smoot DT, Cross AJ. Obesity, weight change, and risk of adenoma recurrence: a prospective trial. Endoscopy. 2012 Sep; 44(9):813-8.
          View in: PubMed
        14. Major JM, Norman Oliver M, Doubeni CA, Hollenbeck AR, Graubard BI, Sinha R. Socioeconomic status, healthcare density, and risk of prostate cancer among African American and Caucasian men in a large prospective study. Cancer Causes Control. 2012 Jul; 23(7):1185-91.
          View in: PubMed
        15. Doubeni CA, Jambaulikar GD, Fouayzi H, Robinson SB, Gunter MJ, Field TS, Roblin DW, Fletcher RH. Neighborhood socioeconomic status and use of colonoscopy in an insured population--a retrospective cohort study. PLoS One. 2012; 7(5):e36392.
          View in: PubMed
        16. Higgins AY, Doubeni AR, Phillips KL, Laiyemo AO, Briesacher B, Tjia J, Doubeni CA. Self-reported colorectal cancer screening of Medicare beneficiaries in family medicine vs. internal medicine practices in the United States: a cross-sectional study. BMC Gastroenterol. 2012; 12:23.
          View in: PubMed
        17. Briesacher BA, Tjia J, Doubeni CA, Chen Y, Rao SR. Methodological issues in using multiple years of the medicare current beneficiary survey. Medicare Medicaid Res Rev. 2012; 2(1).
          View in: PubMed
        18. Doubeni CA, Laiyemo AO, Major JM, Schootman M, Lian M, Park Y, Graubard BI, Hollenbeck AR, Sinha R. Socioeconomic status and the risk of colorectal cancer: an analysis of more than a half million adults in the National Institutes of Health-AARP Diet and Health Study. Cancer. 2012 Jul 15; 118(14):3636-44.
          View in: PubMed
        19. Doubeni CA, Schootman M, Major JM, Stone RA, Laiyemo AO, Park Y, Lian M, Messer L, Graubard BI, Sinha R, Hollenbeck AR, Schatzkin A. Health status, neighborhood socioeconomic context, and premature mortality in the United States: The National Institutes of Health-AARP Diet and Health Study. Am J Public Health. 2012 Apr; 102(4):680-8.
          View in: PubMed
        20. Laiyemo AO, Doubeni C, Pinsky PF, Doria-Rose VP, Sanderson AK, Bresalier R, Weissfeld J, Schoen RE, Marcus PM, Prorok PC, Berg CD. Factors associated with inadequate colorectal cancer screening with flexible sigmoidoscopy. Cancer Epidemiol. 2012 Aug; 36(4):395-9.
          View in: PubMed
        21. Major JM, Cross AJ, Doubeni CA, Park Y, Lian M, Hollenbeck AR, Schatzkin A, Graubard BI, Sinha R. Socioeconomic deprivation impact on meat intake and mortality: NIH-AARP Diet and Health Study. Cancer Causes Control. 2011 Dec; 22(12):1699-707.
          View in: PubMed
        22. Lian M, Schootman M, Doubeni CA, Park Y, Major JM, Stone RA, Laiyemo AO, Hollenbeck AR, Graubard BI, Schatzkin A. Geographic variation in colorectal cancer survival and the role of small-area socioeconomic deprivation: a multilevel survival analysis of the NIH-AARP Diet and Health Study Cohort. Am J Epidemiol. 2011 Oct 1; 174(7):828-38.
          View in: PubMed
        23. Laiyemo AO, Doubeni C, Sanderson AK, Pinsky PF, Badurdeen DS, Doria-Rose VP, Marcus PM, Schoen RE, Lanza E, Schatzkin A, Cross AJ. Likelihood of missed and recurrent adenomas in the proximal versus the distal colon. Gastrointest Endosc. 2011 Aug; 74(2):253-61.
          View in: PubMed
        24. Major JM, Doubeni CA, Freedman ND, Park Y, Lian M, Hollenbeck AR, Schatzkin A, Graubard BI, Sinha R. Neighborhood socioeconomic deprivation and mortality: NIH-AARP diet and health study. PLoS One. 2010; 5(11):e15538.
          View in: PubMed
        25. Doubeni CA, Laiyemo AO, Young AC, Klabunde CN, Reed G, Field TS, Fletcher RH. Primary care, economic barriers to health care, and use of colorectal cancer screening tests among Medicare enrollees over time. Ann Fam Med. 2010 Jul-Aug; 8(4):299-307.
          View in: PubMed
        26. Doubeni CA, Reed G, Difranza JR. Early course of nicotine dependence in adolescent smokers. Pediatrics. 2010 Jun; 125(6):1127-33.
          View in: PubMed
        27. Laiyemo AO, Doubeni C, Pinsky PF, Doria-Rose VP, Bresalier R, Lamerato LE, Crawford ED, Kvale P, Fouad M, Hickey T, Riley T, Weissfeld J, Schoen RE, Marcus PM, Prorok PC, Berg CD. Race and colorectal cancer disparities: health-care utilization vs different cancer susceptibilities. J Natl Cancer Inst. 2010 Apr 21; 102(8):538-46.
          View in: PubMed
        28. Doubeni CA, Laiyemo AO, Klabunde CN, Young AC, Field TS, Fletcher RH. Racial and ethnic trends of colorectal cancer screening among Medicare enrollees. Am J Prev Med. 2010 Feb; 38(2):184-91.
          View in: PubMed
        29. Doubeni CA, Laiyemo AO, Reed G, Field TS, Fletcher RH. Socioeconomic and racial patterns of colorectal cancer screening among Medicare enrollees in 2000 to 2005. Cancer Epidemiol Biomarkers Prev. 2009 Aug; 18(8):2170-5.
          View in: PubMed
        30. Doubeni CA, Li W, Fouayzi H, DiFranza JR. Perceived accessibility of cigarettes among youth: a prospective cohort study. Am J Prev Med. 2009 Mar; 36(3):239-42.
          View in: PubMed
        31. Doubeni CA, Li W, Fouayzi H, Difranza JR. Perceived accessibility as a predictor of youth smoking. Ann Fam Med. 2008 Jul-Aug; 6(4):323-30.
          View in: PubMed
        32. Field TS, Doubeni C, Fox MP, Buist DS, Wei F, Geiger AM, Quinn VP, Lash TL, Prout MN, Yood MU, Frost FJ, Silliman RA. Under utilization of surveillance mammography among older breast cancer survivors. J Gen Intern Med. 2008 Feb; 23(2):158-63.
          View in: PubMed
        33. Doubeni CA, Field TS, Buist DS, Korner EJ, Bigelow C, Lamerato L, Herrinton L, Quinn VP, Hart G, Hornbrook MC, Gurwitz JH, Wagner EH. Racial differences in tumor stage and survival for colorectal cancer in an insured population. Cancer. 2007 Feb 1; 109(3):612-20.
          View in: PubMed
        34. Spencer FA, Lessard D, Doubeni C, Yarzebski J, Gore JM, Goldberg RJ. Treatment practices and outcomes of patients with established peripheral arterial disease hospitalized with acute myocardial infarction in a community setting. Am Heart J. 2007 Jan; 153(1):140-6.
          View in: PubMed
        35. Doubeni C, Bigelow C, Lessard D, Spencer F, Yarzebski J, Gore J, Gurwitz J, Goldberg R. Trends and outcomes associated with angiotensin-converting enzyme inhibitors. Am J Med. 2006 Jul; 119(7):616.e9-16.
          View in: PubMed
        36. Doubeni CA, Field TS, Ulcickas Yood M, Rolnick SJ, Quessenberry CP, Fouayzi H, Gurwitz JH, Wei F. Patterns and predictors of mammography utilization among breast cancer survivors. Cancer. 2006 Jun 1; 106(11):2482-8.
          View in: PubMed
        37. Doubeni CA, Yood RA, Emani S, Gurwitz JH. Identifying unrecognized peripheral arterial disease among asymptomatic patients in the primary care setting. Angiology. 2006 Mar-Apr; 57(2):171-80.
          View in: PubMed
        38. Field TS, Buist DS, Doubeni C, Enger S, Fouayzi H, Hart G, Korner EJ, Lamerato L, Bachman DJ, Ellis J, Herrinton L, Hornbrook MC, Krajenta R, Liu L, Yao J. Disparities and survival among breast cancer patients. J Natl Cancer Inst Monogr. 2005; (35):88-95.
          View in: PubMed
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