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    Last Name
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    Thomas W Smith MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPathology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-2331
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentNeurology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentNeuroscience

        Overview 
        Narrative

        Academic Background:

        1972MD, Weill Medical College of Cornell University
        1972-1973 Resident (PGY1), Anatomic Pathology, New York Hospital-CornellMedical Center, New York, NY
        1973-1976 Resident, Neuropathology, Peter Bent Brigham Hospital, Boston, MA
        1977-1978 Resident, Anatomic Pathology, Peter Bent Brigham Hospital, Boston, MA

        Clinical Activities

        My clinical activities specifically focus on diagnostic neuropathology and neuromuscular pathology. I am responsible for all clinical neuropathology services at UMMHC and its affiliated hospitals. I also serve as a consultant neuropathologist for a number of hospitals in Central, Western and Southeastern Massachusetts and for the Western Massachusetts Office of the Chief Medical Examiner. I am the medical director of diagnostic electron microscopy for UMMHC hospitals.

        Teaching

        I have a strong interest in and major commitment to undergraduate and graduate medical education. My undergraduate educational activities include co-directorships of the Mind, Brain, and Behavior (MBB2) and Biology of Disease (BoD) courses for the 2nd year medical students as well as being the General Pathology block coordinator in the BoD course. I am an active lecturer and laboratory instructor in both of these courses and in the 1st year Histology and MBB1 (Neuroscience) courses. I am an active member of a number of medical school committees and working groups, including Chair of the Second Year Curriculum Committee, and am an active participant in the ongoing curriculum revision effort in the medical school. My graduate medical educational activities primarily involve teaching Neurology and Pathology residents rotating through the neuropathology service.

        Research Interests

        My research/scholarly interests have focused on clinically-related topics and include retrospective studies using archival case material and prospective clinico-pathological projects. I have also served as neuropathology consultant for individual investigators and several program projects in other UMMS departments. Recent interests have included forensic neuropathology and CNS neoplasia.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Rogers JH, Smith T. Iatrogenic Atrial Septal Defect After MitraClip Therapy. JACC Cardiovasc Interv. 2015 Aug 17; 8(9):1270-1.
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        2. Cataltepe S, Arikan MC, Liang X, Smith TW, Cataltepe O. Fatty acid binding protein 4 expression in cerebral vascular malformations: implications for vascular remodelling. Neuropathol Appl Neurobiol. 2015 Aug; 41(5):646-56.
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        3. Wirth D, Smith TW, Moser R, Yaroslavsky AN. Demeclocycline as a contrast agent for detecting brain neoplasms using confocal microscopy. Phys Med Biol. 2015 Apr 7; 60(7):3003-11.
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        4. Quinn C, Salameh JS, Smith T, Souayah N. Necrotizing myopathies: an update. J Clin Neuromuscul Dis. 2015 Mar; 16(3):131-40.
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        5. Singh GD, Smith TW, Rogers JH. Multi-MitraClip therapy for severe degenerative mitral regurgitation: "Anchor" technique for extremely flail segments. Catheter Cardiovasc Interv. 2015 Aug; 86(2):339-46.
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        6. Kuhn BT, Javed U, Armstrong EJ, Singh GD, Smith TW, Whitcomb CJ, Allen RP, Rogers JH. Balloon dilation atrial septostomy for advanced pulmonary hypertension in patients on prostanoid therapy. Catheter Cardiovasc Interv. 2015 May; 85(6):1066-72.
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        7. Cachia D, Smith T, Paydarfar D, Pomorska G. A case of early-onset rapidly progressive dementia. JAMA Neurol. 2014 Nov 1; 71(11):1445-9.
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        8. Shmilovich H, Cheng VY, Nakazato R, Smith TW, Otaki Y, Nakanishi R, Paz W, Pimentel RT, Berman DS, Rajani R. Incremental value of diagonal earlobe crease to the diamond-forrester classification in estimating the probability of significant coronary artery disease determined by computed tomographic angiography. Am J Cardiol. 2014 Dec 1; 114(11):1670-5.
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        9. Tang Y, Dundamadappa SK, Thangasamy S, Flood T, Moser R, Smith T, Cauley K, Takhtani D. Correlation of apparent diffusion coefficient with Ki-67 proliferation index in grading meningioma. AJR Am J Roentgenol. 2014 Jun; 202(6):1303-8.
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        10. Botser IB, Jackson TJ, Smith TW, Leonard JP, Stake CE, Domb BG. Open surgical dislocation versus arthroscopic treatment of femoroacetabular impingement. Am J Orthop (Belle Mead NJ). 2014 May; 43(5):209-14.
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        11. Yang C, Wang H, Qiao T, Yang B, Aliaga L, Qiu L, Tan W, Salameh J, McKenna-Yasek DM, Smith T, Peng L, Moore MJ, Brown RH, Cai H, Xu Z. Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):E1121-9.
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        12. Jensen G, Smith T, Flores M. Repair of a duplicate mitral valve in a patient with ascending aortic aneurysm and bicuspid aortic valve. Ann Thorac Surg. 2014 Mar; 97(3):e67-9.
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        13. Smith TW, Bommer WJ. Multimodality imaging in transcatheter aortic valve replacement. Rev Cardiovasc Med. 2014; 15(2):75-85.
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        14. Paradas C, Akman HO, Ionete C, Lau H, Riskind PN, Jones DE, Smith TW, Hirano M, Dimauro S. Branching enzyme deficiency: expanding the clinical spectrum. JAMA Neurol. 2014 Jan; 71(1):41-7.
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        15. Cornejo KM, Hutchinson L, Cosar EF, Smith T, Tomaszewicz K, Dresser K, Deng A. Is it a primary or metastatic melanocytic neoplasm of the central nervous system?: A molecular based approach. Pathol Int. 2013 Nov; 63(11):559-64.
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        16. Tisdell J, Smith TW, Muehlschlegel S. Multiple septic brain emboli in infectious endocarditis. Arch Neurol. 2012 Sep; 69(9):1206-7.
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        17. Armstrong EJ, Kwa AT, Bhat A, Romick B, Smith T, Rogers JH. Intracardiac echocardiography to guide percutaneous closure of atrial baffle defects. J Invasive Cardiol. 2012 Sep; 24(9):473-6.
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        18. Cataltepe O, Arikan MC, Ghelfi E, Karaaslan C, Ozsurekci Y, Dresser K, Li Y, Smith TW, Cataltepe S. Fatty acid binding protein 4 is expressed in distinct endothelial and non-endothelial cell populations in glioblastoma. Neuropathol Appl Neurobiol. 2012 Aug; 38(5):400-10.
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        19. Smith T, McGinty P, Bommer W, Low RI, Lim S, Fail P, Rogers JH. Prevalence and echocardiographic features of iatrogenic atrial septal defect after catheter-based mitral valve repair with the MitraClip system. Catheter Cardiovasc Interv. 2012 Oct 1; 80(4):678-85.
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        20. Javed U, Smith TW, Rogers JH. Percutaneous repair of anterior mitral leaflet perforation. J Invasive Cardiol. 2012 Mar; 24(3):134-7.
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        21. Hao S, Smith TW, Chu PG, Liu Q, Ok CY, Woda BA, Lu D, Lin P, Wang SA, Dresser K, Rock KL, Jiang Z. The oncofetal protein IMP3: a novel molecular marker to predict aggressive meningioma. Arch Pathol Lab Med. 2011 Aug; 135(8):1032-6.
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        22. Nakazato R, Tamarappoo BK, Smith TW, Cheng VY, Dey D, Shmilovich H, Gutstein A, Gurudevan S, Hayes SW, Thomson LE, Friedman JD, Berman DS. Assessment of left ventricular regional wall motion and ejection fraction with low-radiation dose helical dual-source CT: comparison to two-dimensional echocardiography. J Cardiovasc Comput Tomogr. 2011 May-Jun; 5(3):149-57.
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        23. Tamarappoo BK, Dey D, Nakazato R, Shmilovich H, Smith T, Cheng VY, Thomson LE, Hayes SW, Friedman JD, Germano G, Slomka PJ, Berman DS. Comparison of the extent and severity of myocardial perfusion defects measured by CT coronary angiography and SPECT myocardial perfusion imaging. JACC Cardiovasc Imaging. 2010 Oct; 3(10):1010-9.
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        24. Cataltepe O, Liptzin D, Jolley L, Smith TW. Diffuse villous hyperplasia of the choroid plexus and its surgical management. J Neurosurg Pediatr. 2010 May; 5(5):518-22.
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        25. Burrows AM, Smith TW, Hall WR, Pilitsis JG. Neurological picture. Ascending paralysis from malignant leptomeningeal melanomatosis. J Neurol Neurosurg Psychiatry. 2010 Apr; 81(4):449-50.
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        26. Rogers JH, Smith TW. Eliminating right-to-left shunt with patent foramen ovale closure: not as simple as it seems. JACC Cardiovasc Interv. 2009 Jun; 2(6):568-9.
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        27. Cataltepe O, Marshall P, Smith TW. Dysembryoplastic neuroepithelial tumor located in pericallosal and intraventricular area in a child. Case report. J Neurosurg Pediatr. 2009 Jun; 3(6):456-60.
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        28. Jaster JH, Ottaviani G, Matturri L, Lavezzi AM, Zamecnik J, Smith TW. Sudden unexpected death related to medullary brain lesions. Am J Forensic Med Pathol. 2008 Dec; 29(4):371-4.
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        29. Jaster JH, Ottaviani G, Zamecnik J, Smith TW. Reversible posterior leukoencephalopathy syndrome. Arch Neurol. 2008 Aug; 65(8):1135-6; author reply 1136.
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        30. Mahmud E, Smith TW, Palakodeti V, Zaidi O, Ang L, Mitchell CR, Zafar N, Bromberg-Marin G, Keramati S, Tsimikas S. Renal frame count and renal blush grade: quantitative measures that predict the success of renal stenting in hypertensive patients with renal artery stenosis. JACC Cardiovasc Interv. 2008 Jun; 1(3):286-92.
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        31. Haleem K, Lippa CF, Smith TW, Kowa H, Wu J, Iwatsubo T. Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins. Am J Alzheimers Dis Other Demen. 2007 Apr-May; 22(2):137-44.
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        32. Lengner CJ, Steinman HA, Gagnon J, Smith TW, Henderson JE, Kream BE, Stein GS, Lian JB, Jones SN. Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol. 2006 Mar 13; 172(6):909-21.
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        33. Daou MC, Smith TW, Litofsky NS, Hsieh CC, Ross AH. Doublecortin is preferentially expressed in invasive human brain tumors. Acta Neuropathol. 2005 Nov; 110(5):472-80.
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        34. Salajegheh M, Rudnicki A, Smith TW. Expression of urokinase-type plasminogen activator receptor (uPAR) in primary central nervous system neoplasms. Appl Immunohistochem Mol Morphol. 2005 Jun; 13(2):184-9.
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        35. Jaster JH, Smith TW. Demyelination in the brain as a paraneoplastic disorder. Br J Radiol. 2004 Oct; 77(922):899.
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        36. Jang T, Litofsky NS, Smith TW, Ross AH, Recht LD. Aberrant nestin expression during ethylnitrosourea-(ENU)-induced neurocarcinogenesis. Neurobiol Dis. 2004 Apr; 15(3):544-52.
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        37. Rosales MY, Smith TW, Safran M. Hemorrhagic Rathke's cleft cyst presenting as diplopia. Endocr Pract. 2004 Mar-Apr; 10(2):129-34.
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        38. Jones S, Phillips N, Ali F, Fernandes JA, Flowers MJ, Smith TW. Triplane fractures of the distal tibia requiring open reduction and internal fixation. Pre-operative planning using computed tomography. Injury. 2003 May; 34(4):293-8.
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        39. Lin Y, Smith TW, Alexandridis P. Adsorption of a polymeric siloxane surfactant on carbon black particles dispersed in mixtures of water with polar organic solvents. J Colloid Interface Sci. 2002 Nov 1; 255(1):1-9.
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        40. Sweeney MA, Smith TW, Croucher M, Langner A, Miri M, Klymachyov A, Kaplan S, Tshudy D. Colloidal particles derived from a complex of phosphotungstic Acid and ethoxylated surfactants. J Colloid Interface Sci. 2002 Sep 1; 253(1):53-61.
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        41. Moore BE, Somers NP, Smith TW. Methotrexate-related nonnecrotizing multifocal axonopathy detected by beta-amyloid precursor protein immunohistochemistry. Arch Pathol Lab Med. 2002 Jan; 126(1):79-81.
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        42. Jaster JH, Fitzek S, Fitzek C, Smith TW, Becske T. Myocardial injury after hemorrhage into the lateral medulla oblongata. Neurology. 2001 Sep 25; 57(6):1145.
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        43. Guidi CJ, Sands AT, Zambrowicz BP, Turner TK, Demers DA, Webster W, Smith TW, Imbalzano AN, Jones SN. Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice. Mol Cell Biol. 2001 May; 21(10):3598-603.
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        44. Jaster JH, Smith TW, Gleckman AM, Currier RD, Bebin J. A medullary syndrome characterized by wild arm ataxia. Neurology. 2000 Jul 25; 55(2):321.
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        45. Gleckman AM, Jiang Z, Liu Y, Smith TW. Neuronal and glial DNA fragmentation in Pick's disease. Acta Neuropathol. 1999 Jul; 98(1):55-61.
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        46. Epstein LM, Smith TW. Initial experience with a steerable intracardiac echocardiographic catheter. J Invasive Cardiol. 1999 May; 11(5):322-6.
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        47. Gleckman AM, Bell MD, Evans RJ, Smith TW. Diffuse axonal injury in infants with nonaccidental craniocerebral trauma: enhanced detection by beta-amyloid precursor protein immunohistochemical staining. Arch Pathol Lab Med. 1999 Feb; 123(2):146-51.
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        48. Lippa CF, Smith TW, Perry E. Dementia with Lewy bodies: choline acetyltransferase parallels nucleus basalis pathology. J Neural Transm. 1999; 106(5-6):525-35.
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        49. Kotecha N, George MJ, Smith TW, Corvi F, Litofsky NS. Enhancing progressive multifocal leukoencephalopathy: an indicator of improved immune status? Am J Med. 1998 Dec; 105(6):541-3.
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        50. Gleckman AM, Smith TW. Sudden unexpected death from primary posterior fossa tumors. Am J Forensic Med Pathol. 1998 Dec; 19(4):303-8.
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        51. Litofsky NS, Pihan G, Corvi F, Smith TW. Intracranial leiomyosarcoma: a neuro-oncological consequence of acquired immunodeficiency syndrome. J Neurooncol. 1998 Nov; 40(2):179-83.
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        52. Litofsky NS, Smith TW, Megerian CA. Merkel cell carcinoma of the external auditory canal invading the intracranial compartment. Am J Otolaryngol. 1998 Sep-Oct; 19(5):330-4.
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        53. O'Sullivan KL, Pap SA, Megerian CA, Li Y, Sheffler LR, Smith TW, Lawrence WT. Improved axon diameter and myelin sheath thickness in facial nerve cable grafts wrapped in temporoparietal fascial flaps. Ann Plast Surg. 1998 May; 40(5):478-85.
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        54. Joe EK, Schussheim AE, Longrois D, Mäki T, Kelly RA, Smith TW, Balligand JL. Regulation of cardiac myocyte contractile function by inducible nitric oxide synthase (iNOS): mechanisms of contractile depression by nitric oxide. J Mol Cell Cardiol. 1998 Feb; 30(2):303-15.
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        55. Lippa CF, Johnson R, Smith TW. The medial temporal lobe in dementia with Lewy bodies: a comparative study with Alzheimer's disease. Ann Neurol. 1998 Jan; 43(1):102-6.
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        56. Han X, Kobzik L, Zhao YY, Opel DJ, Liu WD, Kelly RA, Smith TW. Nitric oxide regulation of atrioventricular node excitability. Can J Cardiol. 1997 Dec; 13(12):1191-201.
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        57. Kupatt C, Weber C, Wolf DA, Becker BF, Smith TW, Kelly RA. Nitric oxide attenuates reoxygenation-induced ICAM-1 expression in coronary microvascular endothelium: role of NFkappaB. J Mol Cell Cardiol. 1997 Oct; 29(10):2599-609.
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        58. Aird WC, Edelberg JM, Weiler-Guettler H, Simmons WW, Smith TW, Rosenberg RD. Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment. J Cell Biol. 1997 Sep 8; 138(5):1117-24.
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        59. Feron O, Smith TW, Michel T, Kelly RA. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem. 1997 Jul 11; 272(28):17744-8.
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        60. Silver B, McAvoy K, Mikesell S, Smith TW. Fulminating encephalopathy with perivenular demyelination and vacuolar myelopathy as the initial presentation of human immunodeficiency virus infection. Arch Neurol. 1997 May; 54(5):647-50.
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        61. Lippa CF, Pulaski-Salo D, Dickson DW, Smith TW. Alzheimer's disease, Lewy body disease and aging: a comparative study of the perforant pathway. J Neurol Sci. 1997 Apr 15; 147(2):161-6.
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        62. Lippa CF, Smith TW, Saunders AM, Hulette C, Pulaski-Salo D, Roses AD. Apolipoprotein E-epsilon 2 and Alzheimer's disease: genotype influences pathologic phenotype. Neurology. 1997 Feb; 48(2):515-9.
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        63. Fischer TA, Ungureanu-Longrois D, Singh K, de Zengotita J, DeUgarte D, Alali A, Gadbut AP, Lee MA, Balligand JL, Kifor I, Smith TW, Kelly RA. Regulation of bFGF expression and ANG II secretion in cardiac myocytes and microvascular endothelial cells. Am J Physiol. 1997 Feb; 272(2 Pt 2):H958-68.
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        64. Kaye DM, Wiviott SD, Kobzik L, Kelly RA, Smith TW. S-nitrosothiols inhibit neuronal norepinephrine transport. Am J Physiol. 1997 Feb; 272(2 Pt 2):H875-83.
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        65. Balligand JL, Kelly RA, Smith TW. Cardiac endothelium and tissue growth. Prog Cardiovasc Dis. 1997 Jan-Feb; 39(4):351-60.
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        66. Smith TW, Balligand JL, Kaye DM, Wiviott SD, Simmons WW, Han X, Michel T, Singh K, Kelly RA. The role of the NO pathway in the control of cardiac function. J Card Fail. 1996 Dec; 2(4 Suppl):S141-7.
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        67. Keaney JF, Hare JM, Balligand JL, Loscalzo J, Smith TW, Colucci WS. Inhibition of nitric oxide synthase augments myocardial contractile responses to beta-adrenergic stimulation. Am J Physiol. 1996 Dec; 271(6 Pt 2):H2646-52.
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        68. Vodovotz Y, Lucia MS, Flanders KC, Chesler L, Xie QW, Smith TW, Weidner J, Mumford R, Webber R, Nathan C, Roberts AB, Lippa CF, Sporn MB. Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease. J Exp Med. 1996 Oct 1; 184(4):1425-33.
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        69. Simmons WW, Ungureanu-Longrois D, Smith GK, Smith TW, Kelly RA. Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport. J Biol Chem. 1996 Sep 27; 271(39):23928-37.
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        70. Huang MH, Friend DS, Sunday ME, Singh K, Haley K, Austen KF, Kelly RA, Smith TW. An intrinsic adrenergic system in mammalian heart. J Clin Invest. 1996 Sep 15; 98(6):1298-1303.
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        71. Feron O, Belhassen L, Kobzik L, Smith TW, Kelly RA, Michel T. Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells. J Biol Chem. 1996 Sep 13; 271(37):22810-4.
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        72. Kaye DM, Kelly RA, Smith TW. Cytokines and cardiac hypertrophy: roles of angiotensin II and basic fibroblast growth factor. Clin Exp Pharmacol Physiol. 1996 Sep; 23 Suppl 3:S136-41.
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        73. Kelly RA, Balligand JL, Smith TW. Nitric oxide and cardiac function. Circ Res. 1996 Sep; 79(3):363-80.
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        74. Han X, Kobzik L, Balligand JL, Kelly RA, Smith TW. Nitric oxide synthase (NOS3)-mediated cholinergic modulation of Ca2+ current in adult rabbit atrioventricular nodal cells. Circ Res. 1996 Jun; 78(6):998-1008.
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        75. Kelly RA, Smith TW. Nitric oxide and nitrovasodilators: similarities, differences, and interactions. Am J Cardiol. 1996 May 30; 77(13):2C-7C.
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        76. Gross WL, Bak MI, Ingwall JS, Arstall MA, Smith TW, Balligand JL, Kelly RA. Nitric oxide inhibits creatine kinase and regulates rat heart contractile reserve. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5604-9.
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        77. Belhassen L, Kelly RA, Smith TW, Balligand JL. Nitric oxide synthase (NOS3) and contractile responsiveness to adrenergic and cholinergic agonists in the heart. Regulation of NOS3 transcription in vitro and in vivo by cyclic adenosine monophosphate in rat cardiac myocytes. J Clin Invest. 1996 Apr 15; 97(8):1908-15.
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        78. Kaye DM, Wiviott SD, Balligand JL, Simmons WW, Smith TW, Kelly RA. Frequency-dependent activation of a constitutive nitric oxide synthase and regulation of contractile function in adult rat ventricular myocytes. Circ Res. 1996 Feb; 78(2):217-24.
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        79. Lippa CF, Saunders AM, Smith TW, Swearer JM, Drachman DA, Ghetti B, Nee L, Pulaski-Salo D, Dickson D, Robitaille Y, Bergeron C, Crain B, Benson MD, Farlow M, Hyman BT, George-Hyslop SP, Roses AD, Pollen DA. Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway. Neurology. 1996 Feb; 46(2):406-12.
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        80. Kaye D, Pimental D, Prasad S, Mäki T, Berger HJ, McNeil PL, Smith TW, Kelly RA. Role of transiently altered sarcolemmal membrane permeability and basic fibroblast growth factor release in the hypertrophic response of adult rat ventricular myocytes to increased mechanical activity in vitro. J Clin Invest. 1996 Jan 15; 97(2):281-91.
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        81. Singh K, Balligand JL, Fischer TA, Smith TW, Kelly RA. Regulation of cytokine-inducible nitric oxide synthase in cardiac myocytes and microvascular endothelial cells. Role of extracellular signal-regulated kinases 1 and 2 (ERK1/ERK2) and STAT1 alpha. J Biol Chem. 1996 Jan 12; 271(2):1111-7.
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        82. Kaye DM, Kelly RA, Smith TW. Cytokines and cardiac hypertrophy: roles of angiotensin II and basic fibroblast growth factor. Clin Exp Pharmacol Physiol Suppl. 1996; 3:S136-41.
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        83. McCann EL, Smith TW, Chad DA, Sargent J. Severe cranial nerve involvement in longstanding demyelinating polyneuropathy: a clinicopathologic correlation. Acta Neuropathol. 1996; 91(3):309-12.
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        84. Krishna M, Smith TW, Recht LD. Expression of bcl-2 in reactive and neoplastic astrocytes: lack of correlation with presence or degree of malignancy. J Neurosurg. 1995 Dec; 83(6):1017-22.
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        85. Lippa CF, Smith TW, Flanders KC. Transforming growth factor-beta: neuronal and glial expression in CNS degenerative diseases. Neurodegeneration. 1995 Dec; 4(4):425-32.
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        86. Singh K, Balligand JL, Fischer TA, Smith TW, Kelly RA. Glucocorticoids increase osteopontin expression in cardiac myocytes and microvascular endothelial cells. Role in regulation of inducible nitric oxide synthase. J Biol Chem. 1995 Nov 24; 270(47):28471-8.
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        87. Ungureanu-Longrois D, Balligand JL, Simmons WW, Okada I, Kobzik L, Lowenstein CJ, Kunkel SL, Michel T, Kelly RA, Smith TW. Induction of nitric oxide synthase activity by cytokines in ventricular myocytes is necessary but not sufficient to decrease contractile responsiveness to beta-adrenergic agonists. Circ Res. 1995 Sep; 77(3):494-502.
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        88. Ungureanu-Longrois D, Balligand JL, Okada I, Simmons WW, Kobzik L, Lowenstein CJ, Kunkel SL, Michel T, Kelly RA, Smith TW. Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture. Circ Res. 1995 Sep; 77(3):486-93.
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        89. Lippa CF, Smith TW, Nee L, Robitaille Y, Crain B, Dickson D, Pulaski-Salo D, Pollen DA. Familial Alzheimer's disease and cortical Lewy bodies: is there a genetic susceptibility factor? Dementia. 1995 Jul-Aug; 6(4):191-4.
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        90. Balligand JL, Kobzik L, Han X, Kaye DM, Belhassen L, O'Hara DS, Kelly RA, Smith TW, Michel T. Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J Biol Chem. 1995 Jun 16; 270(24):14582-6.
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        91. Smith TW, Lippa CF. Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders. J Neuropathol Exp Neurol. 1995 May; 54(3):297-303.
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        92. Lau KY, Ragland RL, Weaver JP, Smith TW, Knorr JR, Weyreuther M. Epidural mass related to calvarial aneurysmal bone cyst: computed tomographic and magnetic resonance demonstration. J Neuroimaging. 1995 Apr; 5(2):128-30.
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        93. Balligand JL, Ungureanu-Longrois D, Simmons WW, Kobzik L, Lowenstein CJ, Lamas S, Kelly RA, Smith TW, Michel T. Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1 beta and IFN-gamma. Am J Physiol. 1995 Mar; 268(3 Pt 2):H1293-303.
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        94. Ungureanu-Longrois D, Balligand JL, Kelly RA, Smith TW. Myocardial contractile dysfunction in the systemic inflammatory response syndrome: role of a cytokine-inducible nitric oxide synthase in cardiac myocytes. J Mol Cell Cardiol. 1995 Jan; 27(1):155-67.
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        95. Tenreiro-Picon OR, Kamath SV, Knorr JR, Ragland RL, Smith TW, Lau KY. Desmoplastic infantile ganglioglioma: CT and MRI features. Pediatr Radiol. 1995; 25(7):540-3.
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        96. Hare JM, Keaney JF, Balligand JL, Loscalzo J, Smith TW, Colucci WS. Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs. J Clin Invest. 1995 Jan; 95(1):360-6.
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        97. Gruver EJ, Toupin D, Smith TW, Marsh JD. Acadesine improves tolerance to ischemic injury in rat cardiac myocytes. J Mol Cell Cardiol. 1994 Sep; 26(9):1187-95.
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        98. Sen L, Smith TW. T-type Ca2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts. Circ Res. 1994 Jul; 75(1):149-55.
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        99. Lacomis D, Chad DA, Smith TW. Proximal weakness as the primary manifestation of myotonic dystrophy in older adults. Muscle Nerve. 1994 Jun; 17(6):687-8.
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        100. Springhorn JP, Singh K, Kelly RA, Smith TW. Posttranscriptional regulation of Id1 activity in cardiac muscle. Alternative splicing of novel Id1 transcript permits homodimerization. J Biol Chem. 1994 Feb 18; 269(7):5132-6.
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        101. Gultekin SH, Smith TW. Diffuse axonal injury in craniocerebral trauma. A comparative histologic and immunohistochemical study. Arch Pathol Lab Med. 1994 Feb; 118(2):168-71.
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        102. Kelly RA, Smith TW. Endogenous cardiac glycosides. Adv Pharmacol. 1994; 25:263-88.
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        103. Berger HJ, Prasad SK, Davidoff AJ, Pimental D, Ellingsen O, Marsh JD, Smith TW, Kelly RA. Continual electric field stimulation preserves contractile function of adult ventricular myocytes in primary culture. Am J Physiol. 1994 Jan; 266(1 Pt 2):H341-9.
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        104. Tonkonogy JM, Smith TW, Barreira PJ. Obsessive-compulsive disorders in Pick's disease. J Neuropsychiatry Clin Neurosci. 1994; 6(2):176-80.
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        105. Matoba Y, Colucci WS, Fields BN, Smith TW. The reovirus M1 gene determines the relative capacity of growth of reovirus in cultured bovine aortic endothelial cells. J Clin Invest. 1993 Dec; 92(6):2883-8.
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        106. Smith TW, Nikulasson S, De Girolami U, De Gennaro LJ. Immunohistochemistry of synapsin I and synaptophysin in human nervous system and neuroendocrine tumors. Applications in diagnostic neuro-oncology. Clin Neuropathol. 1993 Nov-Dec; 12(6):335-42.
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        107. Lippa CF, Hamos JE, Smith TW, Pulaski-Salo D, Drachman DA. Vascular amyloid deposition in Alzheimer's disease. Neither necessary nor sufficient for the local formation of plaques or tangles. Arch Neurol. 1993 Oct; 50(10):1088-92.
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        108. Kelly RA, Smith TW. Digoxin in heart failure: implications of recent trials. J Am Coll Cardiol. 1993 Oct; 22(4 Suppl A):107A-112A.
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        109. Ellingsen O, Davidoff AJ, Prasad SK, Berger HJ, Springhorn JP, Marsh JD, Kelly RA, Smith TW. Adult rat ventricular myocytes cultured in defined medium: phenotype and electromechanical function. Am J Physiol. 1993 Aug; 265(2 Pt 2):H747-54.
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        110. Berger HJ, Taratuska A, Smith TW, Halperin JA. Activated complement directly modifies the performance of isolated heart muscle cells from guinea pig and rat. Am J Physiol. 1993 Jul; 265(1 Pt 2):H267-72.
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        111. Nishida M, Springhorn JP, Kelly RA, Smith TW. Cell-cell signaling between adult rat ventricular myocytes and cardiac microvascular endothelial cells in heterotypic primary culture. J Clin Invest. 1993 May; 91(5):1934-41.
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        112. Balligand JL, Ungureanu D, Kelly RA, Kobzik L, Pimental D, Michel T, Smith TW. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. J Clin Invest. 1993 May; 91(5):2314-9.
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        113. Nishida M, Carley WW, Gerritsen ME, Ellingsen O, Kelly RA, Smith TW. Isolation and characterization of human and rat cardiac microvascular endothelial cells. Am J Physiol. 1993 Feb; 264(2 Pt 2):H639-52.
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        114. Lippa CF, Pearson D, Smith TW. Cortical tubers demonstrate reduced immunoreactivity for synapsin I. Acta Neuropathol. 1993; 85(4):449-51.
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        115. Sen L, Bialecki RA, Smith E, Smith TW, Colucci WS. Cholesterol increases the L-type voltage-sensitive calcium channel current in arterial smooth muscle cells. Circ Res. 1992 Oct; 71(4):1008-14.
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        116. Borzak S, Reers M, Arruda J, Sharma VK, Sheu SS, Smith TW, Marsh JD. Na+ efflux mechanisms in ventricular myocytes: measurement of [Na+]i with Na(+)-binding benzofuran isophthalate. Am J Physiol. 1992 Sep; 263(3 Pt 2):H866-74.
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        117. Lippa CF, Smith TW. The indusium griseum in Alzheimer's disease: an immunocytochemical study. J Neurol Sci. 1992 Aug; 111(1):39-45.
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        118. Smith TW, De Girolami U, Hickey WF. Neuropathology of immunosuppression. Brain Pathol. 1992 Jul; 2(3):183-94.
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        119. Eid H, Larson DM, Springhorn JP, Attawia MA, Nayak RC, Smith TW, Kelly RA. Role of epicardial mesothelial cells in the modification of phenotype and function of adult rat ventricular myocytes in primary coculture. Circ Res. 1992 Jul; 71(1):40-50.
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        120. Kelly RA, Smith TW. Use and misuse of digitalis blood levels. Heart Dis Stroke. 1992 May-Jun; 1(3):117-22.
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        121. Gelber ND, Ragland RL, Knorr JR, Smith TW, Stone BB. Intracranial metastatic adenoid cystic carcinoma: presumed hematogenous spread from a primary tumor in the parotid gland. AJR Am J Roentgenol. 1992 May; 158(5):1163-4.
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        122. Recht LD, Lew R, Smith TW. Suspected low-grade glioma: is deferring treatment safe? Ann Neurol. 1992 Apr; 31(4):431-6.
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        123. Ogawa S, Barnett JV, Sen L, Galper JB, Smith TW, Marsh JD. Direct contact between sympathetic neurons and rat cardiac myocytes in vitro increases expression of functional calcium channels. J Clin Invest. 1992 Apr; 89(4):1085-93.
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        124. Lacomis D, Smith TW, Long RR. Angiotropic lymphoma (intravascular large cell lymphoma) presenting with cauda equina syndrome. Clin Neurol Neurosurg. 1992; 94(4):311-5.
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        125. Smith TW, Lippa CF, de Girolami U. Immunocytochemical study of ballooned neurons in cortical degeneration with neuronal achromasia. Clin Neuropathol. 1992 Jan-Feb; 11(1):28-35.
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        126. Knorr JR, Ragland RL, Smith TW, Davidson RI, Keller JD. Squamous carcinoma arising in a cerebellopontine angle epidermoid: CT and MR findings. AJNR Am J Neuroradiol. 1991 Nov-Dec; 12(6):1182-4.
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        127. Lippa CF, Cohen R, Smith TW, Drachman DA. Primary progressive aphasia with focal neuronal achromasia. Neurology. 1991 Jun; 41(6):882-6.
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        128. Esumi K, Nishida M, Shaw D, Smith TW, Marsh JD. NADH measurements in adult rat myocytes during simulated ischemia. Am J Physiol. 1991 Jun; 260(6 Pt 2):H1743-52.
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        129. Matoba Y, Sherry B, Fields BN, Smith TW. Identification of the viral genes responsible for growth of strains of reovirus in cultured mouse heart cells. J Clin Invest. 1991 May; 87(5):1628-33.
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        130. Smith TW. Review of clinical experience with digoxin immune Fab (ovine). Am J Emerg Med. 1991 Mar; 9(2 Suppl 1):1-6; discussion 33-4.
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        131. Krämer BK, Smith TW, Kelly RA. Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na(+)-H+ exchanger. Circ Res. 1991 Jan; 68(1):269-79.
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        132. Sen LY, O'Neill M, Marsh JD, Smith TW. Myocyte structure, function, and calcium kinetics in the cardiomyopathic hamster heart. Am J Physiol. 1990 Nov; 259(5 Pt 2):H1533-43.
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        133. Sen L, Liang BT, Colucci WS, Smith TW. Enhanced alpha 1-adrenergic responsiveness in cardiomyopathic hamster cardiac myocytes. Relation to the expression of pertussis toxin-sensitive G protein and alpha 1-adrenergic receptors. Circ Res. 1990 Nov; 67(5):1182-92.
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        134. Kelly RA, Eid H, Krämer BK, O'Neill M, Liang BT, Reers M, Smith TW. Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway. J Clin Invest. 1990 Oct; 86(4):1164-71.
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        135. Strongwater SL, Woda BA, Yood RA, Rybak ME, Sargent J, DeGirolami U, Smith TW, Varnis C, Allen S, Murphy K, et al. Eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. Analysis of four patients and implications for differential diagnosis and pathogenesis. Arch Intern Med. 1990 Oct; 150(10):2178-86.
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        136. Chad DA, Smith TW, Blumenfeld A, Fairchild PG, DeGirolami U. Human immunodeficiency virus (HIV)-associated myopathy: immunocytochemical identification of an HIV antigen (gp 41) in muscle macrophages. Ann Neurol. 1990 Oct; 28(4):579-82.
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        137. Lippa CF, Smith TW, DeGirolami U. Lobar atrophy with pontine neuronal chromatolysis ("ballooned" neurons). Hum Pathol. 1990 Oct; 21(10):1076-9.
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        138. Lippa CF, Smith TW, Degirolami U, Drachman DA. The indusium griseum: is it involved in Alzheimer's disease? Neurobiol Aging. 1990 Sep-Oct; 11(5):551-4.
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        139. Ikeda U, Briggs GM, Allen PD, Sen L, Medford RM, Smith TW. Properties of adult rat ventricular cells in long-term culture. Cardioscience. 1990 Sep; 1(3):225-33.
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        140. Smith TW, DeGirolami U, Hénin D, Bolgert F, Hauw JJ. Human immunodeficiency virus (HIV) leukoencephalopathy and the microcirculation. J Neuropathol Exp Neurol. 1990 Jul; 49(4):357-70.
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        141. De Girolami U, Smith TW, Hénin D, Hauw JJ. Neuropathology of the acquired immunodeficiency syndrome. Arch Pathol Lab Med. 1990 Jul; 114(7):643-55.
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        142. Recht L, Torres CO, Smith TW, Raso V, Griffin TW. Transferrin receptor in normal and neoplastic brain tissue: implications for brain-tumor immunotherapy. J Neurosurg. 1990 Jun; 72(6):941-5.
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        143. Antman EM, Wenger TL, Butler VP, Haber E, Smith TW. Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Final report of a multicenter study. Circulation. 1990 Jun; 81(6):1744-52.
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        144. Cole PL, Beamer AD, McGowan N, Cantillon CO, Benfell K, Kelly RA, Hartley LH, Smith TW, Antman EM. Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent. Circulation. 1990 Apr; 81(4):1260-70.
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        145. Kelly RA, Smith TW. The search for the endogenous digitalis: an alternative hypothesis. Am J Physiol. 1989 May; 256(5 Pt 1):C937-50.
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        146. Reers M, Kelly RA, Smith TW. Calcium and proton activities in rat cardiac mitochondria. Effect of matrix environment on behaviour of fluorescent probes. Biochem J. 1989 Jan 1; 257(1):131-42.
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        147. Antman EM, Smith TW. Current concepts in the use of digitalis. Adv Intern Med. 1989; 34:425-54.
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        148. Anwer UE, Smith TW, DeGirolami U, Wilkinson HA. Medulloblastoma with cartilaginous differentiation. Arch Pathol Lab Med. 1989 Jan; 113(1):84-8.
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        149. Deymeer F, Smith TW, DeGirolami U, Drachman DA. Thalamic dementia and motor neuron disease. Neurology. 1989 Jan; 39(1):58-61.
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        150. Marsh JD, Dionne MA, Chiu M, Smith TW. A dihydropyridine calcium channel blocker with phosphodiesterase inhibitory activity: effects on cultured vascular smooth muscle and cultured heart cells. J Mol Cell Cardiol. 1988 Dec; 20(12):1141-50.
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        151. Haigh LS, Leatherman GF, O'Hara DS, Smith TW, Galper JB. Effects of low density lipoproteins and mevinolin on cholesterol content and muscarinic cholinergic responsiveness in cultured chick atrial cells. Regulation of levels of muscarinic receptors and guanine nucleotide regulatory proteins. J Biol Chem. 1988 Oct 25; 263(30):15608-18.
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        152. Murphy JG, Smith TW, Marsh JD. Mechanisms of reoxygenation-induced calcium overload in cultured chick embryo heart cells. Am J Physiol. 1988 Jun; 254(6 Pt 2):H1133-41.
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        153. Nabel EG, Berk BC, Brock TA, Smith TW. Na+-Ca2+ exchange in cultured vascular smooth muscle cells. Circ Res. 1988 Mar; 62(3):486-93.
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        154. Lippa CF, Smith TW. Chromatolytic neurons in Werdnig-Hoffmann disease contain phosphorylated neurofilaments. Acta Neuropathol. 1988; 77(1):91-4.
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        155. Smith TW, Anwer U, DeGirolami U, Drachman DA. Vacuolar change in Alzheimer's disease. Arch Neurol. 1987 Dec; 44(12):1225-8.
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        156. Antman EM, Arnold JM, Friedman PL, Smith TW. Pharmacokinetic drug interactions between digoxin and antiarrhythmic agents and calcium channel blocking agents: an appraisal of study methodology. Cardiovasc Drugs Ther. 1987 Aug; 1(2):183-9.
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        157. Specht CS, Pinto-Lord C, Smith TW, DeGirolami U, Suran E, Marshall PC, Davidson RI. Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. Neurosurgery. 1986 Aug; 19(2):278-81.
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        158. Pinto-Lord MC, Abroms IF, Smith TW. Hyperdense cerebral lesion in childhood tuberous sclerosis: computed tomographic demonstration and neuropathologic analysis. Pediatr Neurol. 1986 Jul-Aug; 2(4):245-8.
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        159. Griffin TW, Smith TW, Levy BS, Recht LD. Synchronous occurrence of glioblastoma multiforme in a husband and wife. J Neurooncol. 1986; 4(1):75-8.
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        160. Badon SJ, Ansell J, Smith TW, Coslovsky R, Gill L, Woda BA. Diabetes insipidus caused by extramedullary hematopoiesis. Am J Clin Pathol. 1985 Apr; 83(4):509-12.
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        161. Lamas GA, Koller LR, Antman EM, Smith TW. Electrocardiogram by Einthoven 63 years earlier. Am J Cardiol. 1984 Nov 1; 54(8):1163-5.
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        162. Warner NJ, Leahey EB, Hougen TJ, Bigger JT, Smith TW. Tissue digoxin concentrations during the quinidine-digoxin interaction. Am J Cardiol. 1983 Jun; 51(10):1717-21.
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        163. Ochs HR, Greenblatt DJ, Woo E, Smith TW. Reduced quinidine clearance in elderly persons. Am J Cardiol. 1978 Sep; 42(3):481-5.
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        164. Lloyd BL, Greenblatt DJ, Allen MD, Harmatz JS, Smith TW. Pharmacokinetics and bioavailability of digoxin capsules, solution and tablets after single and multiple doses. Am J Cardiol. 1978 Jul; 42(1):129-36.
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        165. Beller GA, Smith TW, Hood WB. Effects of ischemia and coronary reperfusion on myocardial digoxin uptake. Am J Cardiol. 1975 Dec; 36(7):902-7.
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