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    Last Name
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    Thomas W Smith MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPathology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-2331
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentNeurology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentNeuroscience

        Overview 
        Narrative

        Academic Background:

        1972MD, Weill Medical College of Cornell University
        1972-1973 Resident (PGY1), Anatomic Pathology, New York Hospital-CornellMedical Center, New York, NY
        1973-1976 Resident, Neuropathology, Peter Bent Brigham Hospital, Boston, MA
        1977-1978 Resident, Anatomic Pathology, Peter Bent Brigham Hospital, Boston, MA

        Clinical Activities

        My clinical activities specifically focus on diagnostic neuropathology and neuromuscular pathology. I am responsible for all clinical neuropathology services at UMMHC and its affiliated hospitals. I also serve as a consultant neuropathologist for a number of hospitals in Central, Western and Southeastern Massachusetts and for the Western Massachusetts Office of the Chief Medical Examiner. I am the medical director of diagnostic electron microscopy for UMMHC hospitals.

        Teaching

        I have a strong interest in and major commitment to undergraduate and graduate medical education. My undergraduate educational activities include co-directorships of the Mind, Brain, and Behavior (MBB2) and Biology of Disease (BoD) courses for the 2nd year medical students as well as being the General Pathology block coordinator in the BoD course. I am an active lecturer and laboratory instructor in both of these courses and in the 1st year Histology and MBB1 (Neuroscience) courses. I am an active member of a number of medical school committees and working groups, including Chair of the Second Year Curriculum Committee, and am an active participant in the ongoing curriculum revision effort in the medical school. My graduate medical educational activities primarily involve teaching Neurology and Pathology residents rotating through the neuropathology service.

        Research Interests

        My research/scholarly interests have focused on clinically-related topics and include retrospective studies using archival case material and prospective clinico-pathological projects. I have also served as neuropathology consultant for individual investigators and several program projects in other UMMS departments. Recent interests have included forensic neuropathology and CNS neoplasia.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Smith T, Gurudevan S, Cheng V, Trento A, Derobertis M, Thomson L, Friedman J, Hayes S, Siegel RJ, Berman DS. Assessment of the morphological features of degenerative mitral valve disease using 64-slice multi detector computed tomography. J Cardiovasc Comput Tomogr. 2012 Nov; 6(6):415-21.
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        2. Cachia D, Alderson L, Smith T, Yunus S. Widely metastatic meningioma. Arch Neurol. 2012 Oct; 69(10):1372-3.
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        3. Tisdell J, Smith TW, Muehlschlegel S. Multiple septic brain emboli in infectious endocarditis. Arch Neurol. 2012 Sep 1; 69(9):1206-7.
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        4. Armstrong EJ, Kwa AT, Bhat A, Romick B, Smith T, Rogers JH. Intracardiac echocardiography to guide percutaneous closure of atrial baffle defects. J Invasive Cardiol. 2012 Sep; 24(9):473-6.
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        5. Cataltepe O, Arikan MC, Ghelfi E, Karaaslan C, Ozsurekci Y, Dresser K, Li Y, Smith TW, Cataltepe S. Fatty acid binding protein 4 is expressed in distinct endothelial and non-endothelial cell populations in glioblastoma. Neuropathol Appl Neurobiol. 2012 Aug; 38(5):400-10.
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        6. Smith T, McGinty P, Bommer W, Low RI, Lim S, Fail P, Rogers JH. Prevalence and echocardiographic features of iatrogenic atrial septal defect after catheter-based mitral valve repair with the mitraclip system. Catheter Cardiovasc Interv. 2012 Oct 1; 80(4):678-85.
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        7. Javed U, Smith TW, Rogers JH. Percutaneous repair of anterior mitral leaflet perforation. J Invasive Cardiol. 2012 Mar; 24(3):134-7.
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        8. Shmilovich H, Cheng VY, Rajani R, Dey D, Tamarappoo BK, Nakazato R, Smith TW, Otaki Y, Nakanishi R, Gransar H, Paz W, Pimentel RT, Hayes SW, Friedman JD, Thomson LE, Berman DS. Relation of diagonal ear lobe crease to the presence, extent, and severity of coronary artery disease determined by coronary computed tomography angiography. Am J Cardiol. 2012 May 1; 109(9):1283-7.
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        9. Hao S, Smith TW, Chu PG, Liu Q, Ok CY, Woda BA, Lu D, Lin P, Wang SA, Dresser K, Rock KL, Jiang Z. The Oncofetal Protein IMP3: A Novel Molecular Marker to Predict Aggressive Meningioma. Arch Pathol Lab Med. 2011 Aug; 135(8):1032-6.
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        10. Curd E, Pollinger J, Toffelmier E, Smith T. Rapid influenza A detection and quantitation in birds using a one-step real-time reverse transcriptase PCR and High Resolution Melting. J Virol Methods. 2011 Sep; 176(1-2):125-30.
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        11. McGinty PM, Smith TW, Rogers JH. Transseptal left heart catheterization and the incidence of persistent iatrogenic atrial septal defects. J Interv Cardiol. 2011 Jun; 24(3):254-63.
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        12. Botser IB, Smith TW, Nasser R, Domb BG. Open surgical dislocation versus arthroscopy for femoroacetabular impingement: a comparison of clinical outcomes. Arthroscopy. 2011 Feb; 27(2):270-8.
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        13. Nakazato R, Tamarappoo BK, Smith TW, Cheng VY, Dey D, Shmilovich H, Gutstein A, Gurudevan S, Hayes SW, Thomson LE, Friedman JD, Berman DS. Assessment of left ventricular regional wall motion and ejection fraction with low-radiation dose helical dual-source CT: Comparison to two-dimensional echocardiography. J Cardiovasc Comput Tomogr. 2011 May-Jun; 5(3):149-57.
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        14. Tamarappoo BK, Dey D, Nakazato R, Shmilovich H, Smith T, Cheng VY, Thomson LE, Hayes SW, Friedman JD, Germano G, Slomka PJ, Berman DS. Comparison of the extent and severity of myocardial perfusion defects measured by CT coronary angiography and SPECT myocardial perfusion imaging. JACC Cardiovasc Imaging. 2010 Oct; 3(10):1010-9.
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        15. Sheng Z, Li L, Zhu LJ, Smith TW, Demers A, Ross AH, Moser RP, Green MR. A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications. Nat Med. 2010 Jun; 16(6):671-7.
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        16. Cataltepe O, Liptzin D, Jolley L, Smith TW. Diffuse villous hyperplasia of the choroid plexus and its surgical management. J Neurosurg Pediatr. 2010 May; 5(5):518-22.
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        17. Kheradmand A, Smith T. Dural metastatic adenocarcinoma mimicking meningioma. Neurology. 2010 Apr 27; 74(17):1396.
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        18. Burrows AM, Smith TW, Hall WR, Pilitsis JG. Neurological picture. Ascending paralysis from malignant leptomeningeal melanomatosis. J Neurol Neurosurg Psychiatry. 2010 Apr; 81(4):449-50.
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        19. Cataltepe O, Marshall P, Smith TW. Dysembryoplastic neuroepithelial tumor located in pericallosal and intraventricular area in a child. Case report. J Neurosurg Pediatr. 2009 Jun; 3(6):456-60.
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        20. Rogers JH, Smith TW. Eliminating right-to-left shunt with patent foramen ovale closure: not as simple as it seems. JACC Cardiovasc Interv. 2009 Jun; 2(6):568-9.
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        21. Jaster JH, Ottaviani G, Matturri L, Lavezzi AM, Zamecnik J, Smith TW. Sudden unexpected death related to medullary brain lesions. Am J Forensic Med Pathol. 2008 Dec; 29(4):371-4.
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        22. Jaster JH, Ottaviani G, Zamecnik J, Smith TW. Reversible posterior leukoencephalopathy syndrome. Arch Neurol. 2008 Aug; 65(8):1135-6; author reply 1136.
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        23. Mahmud E, Smith TW, Palakodeti V, Zaidi O, Ang L, Mitchell CR, Zafar N, Bromberg-Marin G, Keramati S, Tsimikas S. Renal frame count and renal blush grade: quantitative measures that predict the success of renal stenting in hypertensive patients with renal artery stenosis. JACC Cardiovasc Interv. 2008 Jun; 1(3):286-92.
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        24. Haleem K, Lippa CF, Smith TW, Kowa H, Wu J, Iwatsubo T. Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins. Am J Alzheimers Dis Other Demen. 2007 Apr-May; 22(2):137-44.
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        25. Brodsky JR, Smith TW, Litofsky S, Lee DJ. Lipoma of the cerebellopontine angle. Am J Otolaryngol. 2006 Jul-Aug; 27(4):271-4.
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        26. Forman MS, Mackenzie IR, Cairns NJ, Swanson E, Boyer PJ, Drachman DA, Jhaveri BS, Karlawish JH, Pestronk A, Smith TW, Tu PH, Watts GD, Markesbery WR, Smith CD, Kimonis VE. Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations. J Neuropathol Exp Neurol. 2006 Jun; 65(6):571-81.
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        27. Lengner CJ, Steinman HA, Gagnon J, Smith TW, Henderson JE, Kream BE, Stein GS, Lian JB, Jones SN. Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol. 2006 Mar 13; 172(6):909-21.
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        28. Jaster JH, Zamecnik J, Bartos A, Smith TW. Demyelination in the brain as a paraneoplastic disorder: candidates include some cases of multiple sclerosis. Neuroepidemiology. 2005; 25(4):212.
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        29. Daou MC, Smith TW, Litofsky NS, Hsieh CC, Ross AH. Doublecortin is preferentially expressed in invasive human brain tumors. Acta Neuropathol. 2005 Nov; 110(5):472-80.
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        30. Salajegheh M, Rudnicki A, Smith TW. Expression of urokinase-type plasminogen activator receptor (uPAR) in primary central nervous system neoplasms. Appl Immunohistochem Mol Morphol. 2005 Jun; 13(2):184-9.
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        31. Jaster JH, Zamecnik J, Bartos A, Dohan FC, Smith TW. Unexpected sudden death caused by medullary brain lesions involves all age groups and may include 'sudden infant death syndrome' as a subset. Acta Neuropathol. 2005 May; 109(5):552-3.
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        32. Jaster JH, Smith TW. Demyelination in the brain as a paraneoplastic disorder. Br J Radiol. 2004 Oct; 77(922):899.
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        33. Jang T, Litofsky NS, Smith TW, Ross AH, Recht LD. Aberrant nestin expression during ethylnitrosourea-(ENU)-induced neurocarcinogenesis. Neurobiol Dis. 2004 Apr; 15(3):544-52.
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        34. Rosales MY, Smith TW, Safran M. Hemorrhagic Rathke's cleft cyst presenting as diplopia. Endocr Pract. 2004 Mar-Apr; 10(2):129-34.
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        35. Jaster JH, Niell HB, Dohan FC, Smith TW. Demyelination in the brain as a paraneoplastic disorder: candidates include some cases of leukemia and non-Hodgkin's lymphoma. Ann Hematol. 2003 Nov; 82(11):714-5.
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        36. Jones S, Phillips N, Ali F, Fernandes JA, Flowers MJ, Smith TW. Triplane fractures of the distal tibia requiring open reduction and internal fixation. Pre-operative planning using computed tomography. Injury. 2003 May; 34(4):293-8.
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        37. Jaster JH, Niell HB, Dohan FC, Smith TW. Therapy-related acute myeloblastic leukemia after mitoxantrone treatment in a patient with MS. Neurology. 2003 Apr 22; 60(8):1399-400; author reply 1400.
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        38. Lin Y, Smith TW, Alexandridis P. Adsorption of a polymeric siloxane surfactant on carbon black particles dispersed in mixtures of water with polar organic solvents. J Colloid Interface Sci. 2002 Nov 1; 255(1):1-9.
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        39. Sweeney MA, Smith TW, Croucher M, Langner A, Miri M, Klymachyov A, Kaplan S, Tshudy D. Colloidal particles derived from a complex of phosphotungstic Acid and ethoxylated surfactants. J Colloid Interface Sci. 2002 Sep 1; 253(1):53-61.
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        40. Moore BE, Somers NP, Smith TW. Methotrexate-related nonnecrotizing multifocal axonopathy detected by beta-amyloid precursor protein immunohistochemistry. Arch Pathol Lab Med. 2002 Jan; 126(1):79-81.
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        41. Kumar A, Jones S, Bickerstaff DR, Smith TW. Functional evaluation of the modified Elmslie-Trillat procedure for patello-femoral dysfunction. Knee. 2001 Dec; 8(4):287-92.
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        42. Jaster JH, Fitzek S, Fitzek C, Smith TW, Becske T. Myocardial injury after hemorrhage into the lateral medulla oblongata. Neurology. 2001 Sep 25; 57(6):1145.
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        43. Kothare SV, Sotrel A, Duchowny M, Jayakar P, Marshall PC, Smith TW. Absence of hippocampal sclerosis in children with multiple daily seizures since infancy. J Child Neurol. 2001 Aug; 16(8):562-4.
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        44. Guidi CJ, Sands AT, Zambrowicz BP, Turner TK, Demers DA, Webster W, Smith TW, Imbalzano AN, Jones SN. Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice. Mol Cell Biol. 2001 May; 21(10):3598-603.
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        45. Jaster JH, Smith TW, Gleckman AM, Currier RD, Bebin J. A medullary syndrome characterized by wild arm ataxia. Neurology. 2000 Jul 25; 55(2):321.
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        46. McDermott SS, McDermott PF, Skare J, Glantz M, Smith TW, Litofsky NS, Recht LD. Positive CSF HSV PCR in patients with GBM: a note of caution. Neurology. 2000 Feb 8; 54(3):746-9.
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        47. Gleckman AM, Evans RJ, Bell MD, Smith TW. Optic nerve damage in shaken baby syndrome: detection by beta-amyloid precursor protein immunohistochemistry. Arch Pathol Lab Med. 2000 Feb; 124(2):251-6.
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        48. Lippa CF, Ozawa K, Mann DM, Ishii K, Smith TW, Arawaka S, Mori H. Deposition of beta-amyloid subtypes 40 and 42 differentiates dementia with Lewy bodies from Alzheimer disease. Arch Neurol. 1999 Sep; 56(9):1111-8.
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        49. Selvaraj N, Chad DA, Smith TW, Weinberg DH, Weaver JP. Myasthenic crisis after resection of an isolated metastatic thymoma of the cervical spine. J Clin Neuromuscul Dis. 1999 Sep; 1(1):11-3.
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        50. Gleckman AM, Jiang Z, Liu Y, Smith TW. Neuronal and glial DNA fragmentation in Pick's disease. Acta Neuropathol. 1999 Jul; 98(1):55-61.
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        51. Epstein LM, Smith TW. Initial experience with a steerable intracardiac echocardiographic catheter. J Invasive Cardiol. 1999 May; 11(5):322-6.
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        52. Gleckman AM, Bell MD, Evans RJ, Smith TW. Diffuse axonal injury in infants with nonaccidental craniocerebral trauma: enhanced detection by beta-amyloid precursor protein immunohistochemical staining. Arch Pathol Lab Med. 1999 Feb; 123(2):146-51.
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        53. Lippa CF, Smith TW, Perry E. Dementia with Lewy bodies: choline acetyltransferase parallels nucleus basalis pathology. J Neural Transm. 1999; 106(5-6):525-35.
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        54. Kotecha N, George MJ, Smith TW, Corvi F, Litofsky NS. Enhancing progressive multifocal leukoencephalopathy: an indicator of improved immune status? Am J Med. 1998 Dec; 105(6):541-3.
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        55. Gleckman AM, Smith TW. Sudden unexpected death from primary posterior fossa tumors. Am J Forensic Med Pathol. 1998 Dec; 19(4):303-8.
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        56. Litofsky NS, Mix TC, Baker SP, Recht LD, Smith TW. Ki-67 (clone MIB-1) proliferation index in recurrent glial neoplasms: no prognostic significance. Surg Neurol. 1998 Dec; 50(6):579-85.
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        57. Litofsky NS, Pihan G, Corvi F, Smith TW. Intracranial leiomyosarcoma: a neuro-oncological consequence of acquired immunodeficiency syndrome. J Neurooncol. 1998 Nov; 40(2):179-83.
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        58. Litofsky NS, Smith TW, Megerian CA. Merkel cell carcinoma of the external auditory canal invading the intracranial compartment. Am J Otolaryngol. 1998 Sep-Oct; 19(5):330-4.
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        59. Jaster JH, Smith TW. Arrhythmia mechanism of unexpected sudden death following lateral medullary infarction. Tenn Med. 1998 Jul; 91(7):284.
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        60. O'Sullivan KL, Pap SA, Megerian CA, Li Y, Sheffler LR, Smith TW, Lawrence WT. Improved axon diameter and myelin sheath thickness in facial nerve cable grafts wrapped in temporoparietal fascial flaps. Ann Plast Surg. 1998 May; 40(5):478-85.
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        61. Lippa CF, Johnson R, Smith TW. The medial temporal lobe in dementia with Lewy bodies: a comparative study with Alzheimer's disease. Ann Neurol. 1998 Jan; 43(1):102-6.
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        62. Aird WC, Edelberg JM, Weiler-Guettler H, Simmons WW, Smith TW, Rosenberg RD. Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment. J Cell Biol. 1997 Sep 8; 138(5):1117-24.
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        63. Hung TY, Litofsky NS, Smith TW, Megerian CA. Ganglionic hamartoma of the intracanalicular acoustic nerve causing sensorineural hearing loss. Am J Otol. 1997 Jul; 18(4):498-500.
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        64. Stemmer-Rachamimov AO, Horgan MA, Taratuto AL, Munoz DG, Smith TW, Frosch MP, Louis DN. Meningioangiomatosis is associated with neurofibromatosis 2 but not with somatic alterations of the NF2 gene. J Neuropathol Exp Neurol. 1997 May; 56(5):485-9.
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        65. Silver B, McAvoy K, Mikesell S, Smith TW. Fulminating encephalopathy with perivenular demyelination and vacuolar myelopathy as the initial presentation of human immunodeficiency virus infection. Arch Neurol. 1997 May; 54(5):647-50.
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        66. Lippa CF, Pulaski-Salo D, Dickson DW, Smith TW. Alzheimer's disease, Lewy body disease and aging: a comparative study of the perforant pathway. J Neurol Sci. 1997 Apr 15; 147(2):161-6.
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        67. Lippa CF, Smith TW, Saunders AM, Hulette C, Pulaski-Salo D, Roses AD. Apolipoprotein E-epsilon 2 and Alzheimer's disease: genotype influences pathologic phenotype. Neurology. 1997 Feb; 48(2):515-9.
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        68. Vodovotz Y, Lucia MS, Flanders KC, Chesler L, Xie QW, Smith TW, Weidner J, Mumford R, Webber R, Nathan C, Roberts AB, Lippa CF, Sporn MB. Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease. J Exp Med. 1996 Oct 1; 184(4):1425-33.
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        69. Moonis M, Smith TW. Meningeal gliomatosis presenting as multiple cerebral infarcts: a case report. Neurology. 1996 Jun; 46(6):1760-2.
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        70. Kelly RA, Smith TW. Nitric oxide and nitrovasodilators: similarities, differences, and interactions. Am J Cardiol. 1996 May 30; 77(13):2C-7C.
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        71. Simmons WW, Closs EI, Cunningham JM, Smith TW, Kelly RA. Cytokines and insulin induce cationic amino acid transporter (CAT) expression in cardiac myocytes. Regulation of L-arginine transport and no production by CAT-1, CAT-2A, and CAT-2B. J Biol Chem. 1996 May 17; 271(20):11694-702.
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        72. Lippa CF, Saunders AM, Smith TW, Swearer JM, Drachman DA, Ghetti B, Nee L, Pulaski-Salo D, Dickson D, Robitaille Y, Bergeron C, Crain B, Benson MD, Farlow M, Hyman BT, George-Hyslop SP, Roses AD, Pollen DA. Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway. Neurology. 1996 Feb; 46(2):406-12.
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        73. North KN, Miller G, Iannaccone ST, Clemens PR, Chad DA, Bella I, Smith TW, Beggs AH, Specht LA. Cognitive dysfunction as the major presenting feature of Becker's muscular dystrophy. Neurology. 1996 Feb; 46(2):461-5.
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        74. Savarese DM, Gordon J, Smith TW, Litofsky NS, Licho R, Ragland R, Recht L. Cerebral demyelination syndrome in a patient treated with 5-fluorouracil and levamisole. The use of thallium SPECT imaging to assist in noninvasive diagnosis--a case report. Cancer. 1996 Jan 15; 77(2):387-94.
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        75. McCann EL, Smith TW, Chad DA, Sargent J. Severe cranial nerve involvement in longstanding demyelinating polyneuropathy: a clinicopathologic correlation. Acta Neuropathol. 1996; 91(3):309-12.
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        76. Krishna M, Smith TW, Recht LD. Expression of bcl-2 in reactive and neoplastic astrocytes: lack of correlation with presence or degree of malignancy. J Neurosurg. 1995 Dec; 83(6):1017-22.
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        77. Lippa CF, Smith TW, Flanders KC. Transforming growth factor-beta: neuronal and glial expression in CNS degenerative diseases. Neurodegeneration. 1995 Dec; 4(4):425-32.
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        78. Flanders KC, Lippa CF, Smith TW, Pollen DA, Sporn MB. Altered expression of transforming growth factor-beta in Alzheimer's disease. Neurology. 1995 Aug; 45(8):1561-9.
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        79. Lippa CF, Smith TW, Nee L, Robitaille Y, Crain B, Dickson D, Pulaski-Salo D, Pollen DA. Familial Alzheimer's disease and cortical Lewy bodies: is there a genetic susceptibility factor? Dementia. 1995 Jul-Aug; 6(4):191-4.
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        80. Smith TW, Lippa CF. Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders. J Neuropathol Exp Neurol. 1995 May; 54(3):297-303.
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        81. Lau KY, Ragland RL, Weaver JP, Smith TW, Knorr JR, Weyreuther M. Epidural mass related to calvarial aneurysmal bone cyst: computed tomographic and magnetic resonance demonstration. J Neuroimaging. 1995 Apr; 5(2):128-30.
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        82. Kamath SV, Tenreiro-Picon OR, Ragland RL, Smith TW, Weaver JP, Knorr JR. Brain metastases from primary lung malignant fibrous histiocytoma: a case report. J Neuroimaging. 1995 Apr; 5(2):133-4.
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        83. Lippa CF, Smith TW, Saunders AM, Crook R, Pulaski-Salo D, Davies P, Hardy J, Roses AD, Dickson D. Apolipoprotein E genotype and Lewy body disease. Neurology. 1995 Jan; 45(1):97-103.
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        84. Tenreiro-Picon OR, Kamath SV, Knorr JR, Ragland RL, Smith TW, Lau KY. Desmoplastic infantile ganglioglioma: CT and MRI features. Pediatr Radiol. 1995; 25(7):540-3.
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        85. Lacomis D, Chad DA, Smith TW. Proximal weakness as the primary manifestation of myotonic dystrophy in older adults. Muscle Nerve. 1994 Jun; 17(6):687-8.
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        86. Gultekin SH, Smith TW. Diffuse axonal injury in craniocerebral trauma. A comparative histologic and immunohistochemical study. Arch Pathol Lab Med. 1994 Feb; 118(2):168-71.
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        87. Lippa CF, Smith TW, Swearer JM. Alzheimer's disease and Lewy body disease: a comparative clinicopathological study. Ann Neurol. 1994 Jan; 35(1):81-8.
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        88. Tonkonogy JM, Smith TW, Barreira PJ. Obsessive-compulsive disorders in Pick's disease. J Neuropsychiatry Clin Neurosci. 1994; 6(2):176-80.
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        89. Smith TW, Nikulasson S, De Girolami U, De Gennaro LJ. Immunohistochemistry of synapsin I and synaptophysin in human nervous system and neuroendocrine tumors. Applications in diagnostic neuro-oncology. Clin Neuropathol. 1993 Nov-Dec; 12(6):335-42.
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        90. Lippa CF, Hamos JE, Smith TW, Pulaski-Salo D, Drachman DA. Vascular amyloid deposition in Alzheimer's disease. Neither necessary nor sufficient for the local formation of plaques or tangles. Arch Neurol. 1993 Oct; 50(10):1088-92.
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        91. Michel T, Smith TW. Nitric oxide synthases and cardiovascular signaling. Am J Cardiol. 1993 Sep 9; 72(8):33C-38C.
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        92. Lacomis D, Chad DA, Smith TW. Myopathy in the elderly: evaluation of the histopathologic spectrum and the accuracy of clinical diagnosis. Neurology. 1993 Apr; 43(4):825-8.
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        93. Lacomis D, Smith TW, Chad DA. Acute myopathy and neuropathy in status asthmaticus: case report and literature review. Muscle Nerve. 1993 Jan; 16(1):84-90.
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        94. Lippa CF, Pearson D, Smith TW. Cortical tubers demonstrate reduced immunoreactivity for synapsin I. Acta Neuropathol. 1993; 85(4):449-51.
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        95. Lippa CF, Smith TW. The indusium griseum in Alzheimer's disease: an immunocytochemical study. J Neurol Sci. 1992 Aug; 111(1):39-45.
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        96. Smith TW, De Girolami U, Hickey WF. Neuropathology of immunosuppression. Brain Pathol. 1992 Jul; 2(3):183-94.
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        97. Kelly RA, Smith TW. Recognition and management of digitalis toxicity. Am J Cardiol. 1992 Jun 4; 69(18):108G-118G; disc. 118G-119G.
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        98. Gelber ND, Ragland RL, Knorr JR, Smith TW, Stone BB. Intracranial metastatic adenoid cystic carcinoma: presumed hematogenous spread from a primary tumor in the parotid gland. AJR Am J Roentgenol. 1992 May; 158(5):1163-4.
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        99. Recht LD, Lew R, Smith TW. Suspected low-grade glioma: is deferring treatment safe? Ann Neurol. 1992 Apr; 31(4):431-6.
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        100. Lacomis D, Smith TW, Long RR. Angiotropic lymphoma (intravascular large cell lymphoma) presenting with cauda equina syndrome. Clin Neurol Neurosurg. 1992; 94(4):311-5.
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        101. Smith TW, Lippa CF, de Girolami U. Immunocytochemical study of ballooned neurons in cortical degeneration with neuronal achromasia. Clin Neuropathol. 1992 Jan-Feb; 11(1):28-35.
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        102. Knorr JR, Ragland RL, Smith TW, Davidson RI, Keller JD. Squamous carcinoma arising in a cerebellopontine angle epidermoid: CT and MR findings. AJNR Am J Neuroradiol. 1991 Nov-Dec; 12(6):1182-4.
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        103. Lippa CF, Cohen R, Smith TW, Drachman DA. Primary progressive aphasia with focal neuronal achromasia. Neurology. 1991 Jun; 41(6):882-6.
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        104. Strongwater SL, Woda BA, Yood RA, Rybak ME, Sargent J, DeGirolami U, Smith TW, Varnis C, Allen S, Murphy K, et al. Eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. Analysis of four patients and implications for differential diagnosis and pathogenesis. Arch Intern Med. 1990 Oct; 150(10):2178-86.
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        105. Chad DA, Smith TW, Blumenfeld A, Fairchild PG, DeGirolami U. Human immunodeficiency virus (HIV)-associated myopathy: immunocytochemical identification of an HIV antigen (gp 41) in muscle macrophages. Ann Neurol. 1990 Oct; 28(4):579-82.
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        106. Lippa CF, Smith TW, DeGirolami U. Lobar atrophy with pontine neuronal chromatolysis ("ballooned" neurons). Hum Pathol. 1990 Oct; 21(10):1076-9.
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        107. Lippa CF, Smith TW, Fontneau N. Corticonigral degeneration with neuronal achromasia. A clinicopathologic study of two cases. J Neurol Sci. 1990 Sep; 98(2-3):301-10.
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        108. Lippa CF, Smith TW, Degirolami U, Drachman DA. The indusium griseum: is it involved in Alzheimer's disease? Neurobiol Aging. 1990 Sep-Oct; 11(5):551-4.
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        109. Smith TW, DeGirolami U, Hénin D, Bolgert F, Hauw JJ. Human immunodeficiency virus (HIV) leukoencephalopathy and the microcirculation. J Neuropathol Exp Neurol. 1990 Jul; 49(4):357-70.
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        110. De Girolami U, Smith TW, Hénin D, Hauw JJ. Neuropathology of the acquired immunodeficiency syndrome. Arch Pathol Lab Med. 1990 Jul; 114(7):643-55.
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        111. Recht L, Torres CO, Smith TW, Raso V, Griffin TW. Transferrin receptor in normal and neoplastic brain tissue: implications for brain-tumor immunotherapy. J Neurosurg. 1990 Jun; 72(6):941-5.
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        112. Anwer UE, Smith TW, DeGirolami U, Wilkinson HA. Medulloblastoma with cartilaginous differentiation. Arch Pathol Lab Med. 1989 Jan; 113(1):84-8.
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        113. Deymeer F, Smith TW, DeGirolami U, Drachman DA. Thalamic dementia and motor neuron disease. Neurology. 1989 Jan; 39(1):58-61.
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        114. Anwer UE, Smith TW, DeGirolami U, Abroms IF, Whitlock JA. Unusual thalamic inclusions in an infant with progressive neurologic dysfunction and blindness. Clin Neuropathol. 1988 Sep-Oct; 7(5):259-65.
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        115. Lippa CF, Smith TW. Chromatolytic neurons in Werdnig-Hoffmann disease contain phosphorylated neurofilaments. Acta Neuropathol. 1988; 77(1):91-4.
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        116. Smith TW, Anwer U, DeGirolami U, Drachman DA. Vacuolar change in Alzheimer's disease. Arch Neurol. 1987 Dec; 44(12):1225-8.
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        117. Ansell J, Badon S, Woda BA, Smith TW. Diabetes insipidus associated with dysplastic pancytopenia. Am J Med. 1987 Jul; 83(1):189.
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        118. Rudnicki S, Chad DA, Drachman DA, Smith TW, Anwer UE, Levitan N. Motor neuron disease and paraproteinemia. Neurology. 1987 Feb; 37(2):335-7.
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        119. Chad DA, Smith TW, DeGirolami U, Hammer K. Perineuritis and ulcerative colitis. Neurology. 1986 Oct; 36(10):1377-9.
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        120. Lippa CF, Chad DA, Smith TW, Kaplan MH, Hammer K. Neuropathy associated with cryoglobulinemia. Muscle Nerve. 1986 Sep; 9(7):626-31.
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        121. Specht CS, Pinto-Lord C, Smith TW, DeGirolami U, Suran E, Marshall PC, Davidson RI. Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. Neurosurgery. 1986 Aug; 19(2):278-81.
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        122. Pinto-Lord MC, Abroms IF, Smith TW. Hyperdense cerebral lesion in childhood tuberous sclerosis: computed tomographic demonstration and neuropathologic analysis. Pediatr Neurol. 1986 Jul-Aug; 2(4):245-8.
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        123. Griffin TW, Smith TW, Levy BS, Recht LD. Synchronous occurrence of glioblastoma multiforme in a husband and wife. J Neurooncol. 1986; 4(1):75-8.
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        124. Badon SJ, Ansell J, Smith TW, Coslovsky R, Gill L, Woda BA. Diabetes insipidus caused by extramedullary hematopoiesis. Am J Clin Pathol. 1985 Apr; 83(4):509-12.
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        125. Lamas GA, Koller LR, Antman EM, Smith TW. Electrocardiogram by Einthoven 63 years earlier. Am J Cardiol. 1984 Nov 1; 54(8):1163-5.
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        126. Warner NJ, Leahey EB, Hougen TJ, Bigger JT, Smith TW. Tissue digoxin concentrations during the quinidine-digoxin interaction. Am J Cardiol. 1983 Jun; 51(10):1717-21.
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        127. Smith TW, Bhawan J, Keller RB, DeGirolami U. Charcot-Marie-Tooth disease associated with hypertrophic neuropathy: a neuropathologic study of two cases. J Neuropathol Exp Neurol. 1980 Jul; 39(4):420-40.
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        128. Wynne J, Malacoff RF, Benotti JR, Curfman GD, Grossman W, Holman BL, Smith TW, Braunwald E. Oral amrinone in refractory congestive heart failure. Am J Cardiol. 1980 Jun; 45(6):1245-9.
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        129. Ochs HR, Greenblatt DJ, Woo E, Smith TW. Reduced quinidine clearance in elderly persons. Am J Cardiol. 1978 Sep; 42(3):481-5.
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        130. Lloyd BL, Greenblatt DJ, Allen MD, Harmatz JS, Smith TW. Pharmacokinetics and bioavailability of digoxin capsules, solution and tablets after single and multiple doses. Am J Cardiol. 1978 Jul; 42(1):129-36.
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        131. Ochs HR, Greenblatt DJ, Woo E, Franke K, Pfeifer HJ, Smith TW. Single and multiple dose pharmacokinetics of oral quinidine sulfate and gluconate. Am J Cardiol. 1978 Apr; 41(4):770-7.
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        132. Beller GA, Smith TW, Hood WB. Effects of ischemia and coronary reperfusion on myocardial digoxin uptake. Am J Cardiol. 1975 Dec; 36(7):902-7.
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        133. Smith TW, Tyler HR, Schoene WC. Atypical astrocytes and Rosenthal fibers in a case of amyotrophic lateral sclerosis associated with a cerebral glioblastoma multiforme. Acta Neuropathol. 1975; 31(1):29-34.
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        134. Beller GA, Hood WB, Smith TW, Abelmann WH, Wacker WE. Correlation of serum magnesium levels and cardiac digitalis intoxication. Am J Cardiol. 1974 Feb; 33(2):225-9.
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