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    Julie A Jonassen PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMicrobiology and Physiological Systems
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-5808
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentNeuroscience

        Overview 
        Narrative

        Academic Background

        B.S. University of Michigan, 1974;
        Ph.D. University of Michigan, 1980.

        Julie

        Regulation of the Growth, Differentiation and Death of Epithelial Cells.

        Research in our laboratory focuses on regulation of the growth, differentiation and death of epithelial cells. The goal of our current studies is to define mechanisms by which a variety of growth factors, free radicals and hormones mediate signal transduction and gene expression in human and animal renal epithelial cells. Particular emphasis is placed on elucidating the roles played by free radicals in mediating both proliferation and death of renal epithelial cells in kidney disease. I am also actively involved in research in medical education, participating in the development, implementation and assessment of new and innovative medical curricula.



        Rotation Projects

        Potential Rotation Projects

        Project #1: Analysis of gene expression in kidney stone disease. Student will be involved in isolating kidney RNA from patients with kidney stone disease and using DNA microarray to achieve expression profiling in normal and diseased kidney.



        Bibliographic 
        selected publications
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        1. Keady BT, Samtani R, Tobita K, Tsuchya M, San Agustin JT, Follit JA, Jonassen JA, Subramanian R, Lo CW, Pazour GJ. IFT25 Links the Signal-Dependent Movement of Hedgehog Components to Intraflagellar Transport. Dev Cell. 2012 May 15; 22(5):940-51.
          View in: PubMed
        2. Jonassen JA, Sanagustin J, Baker SP, Pazour GJ. Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle Misorientation. J Am Soc Nephrol. 2012 Jan 26.
          View in: PubMed
        3. Follit JA, San Agustin JT, Xu F, Jonassen JA, Samtani R, Lo CW, Pazour GJ. The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex. PLoS Genet. 2008 Dec; 4(12):e1000315.
          View in: PubMed
        4. Jonassen JA, San Agustin J, Follit JA, Pazour GJ. Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol. 2008 Nov 3; 183(3):377-84.
          View in: PubMed
        5. Jonassen JA, Kohjimoto Y, Scheid CR, Schmidt M. Oxalate toxicity in renal cells. Urol Res. 2005 Nov; 33(5):329-39.
          View in: PubMed
        6. Cao LC, Honeyman TW, Cooney R, Kennington L, Scheid CR, Jonassen JA. Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity. Kidney Int. 2004 Nov; 66(5):1890-900.
          View in: PubMed
        7. Jonassen JA, Cao LC, Honeyman T, Scheid CR. Intracellular events in the initiation of calcium oxalate stones. Nephron Exp Nephrol. 2004; 98(2):e61-4.
          View in: PubMed
        8. Scheid CR, Cao LC, Honeyman T, Jonassen JA. How elevated oxalate can promote kidney stone disease: changes at the surface and in the cytosol of renal cells that promote crystal adherence and growth. Front Biosci. 2004 Jan 1; 9:797-808.
          View in: PubMed
        9. Ferrara E, Pugnaire MP, Jonassen JA, O'Dell K, Clay M, Hatem D, Carlin M. Sexual health innovations in undergraduate medical education. Int J Impot Res. 2003 Oct; 15 Suppl 5:S46-50.
          View in: PubMed
        10. Jonassen JA, Mazor KM. Identification of physician and patient attributes that influence the likelihood of screening for intimate partner violence. Acad Med. 2003 Oct; 78(10 Suppl):S20-3.
          View in: PubMed
        11. Jonassen JA, Cao LC, Honeyman T, Scheid CR. Mechanisms mediating oxalate-induced alterations in renal cell functions. Crit Rev Eukaryot Gene Expr. 2003; 13(1):55-72.
          View in: PubMed
        12. Matthews J, Kadish W, Barrett SV, Mazor K, Field D, Jonassen J. The impact of a brief interclerkship about substance abuse on medical students' skills. Acad Med. 2002 May; 77(5):419-26.
          View in: PubMed
        13. Clay M, Jonassen J, Nemitz A. A one-day interclerkship on end-of-life care. Acad Med. 2001 May; 76(5):517-8.
          View in: PubMed
        14. Jonassen JA, Mazor K, Sefton L. Identification of factors that influence the likelihood of screening for domestic violence by medical students and residents. Acad Med. 2001 May; 76(5):529.
          View in: PubMed
        15. Cao LC, Jonassen J, Honeyman TW, Scheid C. Oxalate-induced redistribution of phosphatidylserine in renal epithelial cells: implications for kidney stone disease. Am J Nephrol. 2001 Jan-Feb; 21(1):69-77.
          View in: PubMed
        16. Kohjimoto Y, Honeyman TW, Jonassen J, Gravel K, Kennington L, Scheid CR. Phospholipase A2 mediates immediate early genes in cultured renal epithelial cells: possible role of lysophospholipid. Kidney Int. 2000 Aug; 58(2):638-46.
          View in: PubMed
        17. Cao LC, Honeyman T, Jonassen J, Scheid C. Oxalate-induced ceramide accumulation in Madin-Darby canine kidney and LLC-PK1 cells. Kidney Int. 2000 Jun; 57(6):2403-11.
          View in: PubMed
        18. Miller C, Kennington L, Cooney R, Kohjimoto Y, Cao LC, Honeyman T, Pullman J, Jonassen J, Scheid C. Oxalate toxicity in renal epithelial cells: characteristics of apoptosis and necrosis. Toxicol Appl Pharmacol. 2000 Jan 15; 162(2):132-41.
          View in: PubMed
        19. Scheid C, Honeyman T, Kohjimoto Y, Cao LC, Jonassen J. Oxalate-induced changes in renal epithelial cell function: role in stone disease. Mol Urol. 2000; 4(4):371-82.
          View in: PubMed
        20. Jonassen JA, Cooney R, Kennington L, Gravel K, Honeyman T, Scheid CR. Oxalate-induced changes in the viability and growth of human renal epithelial cells. J Am Soc Nephrol. 1999 Nov; 10 Suppl 14:S446-51.
          View in: PubMed
        21. Jonassen JA, Pugnaire MP, Mazor K, Regan MB, Jacobson EW, Gammon W, Doepel DG, Cohen AJ. The effect of a domestic violence interclerkship on the knowledge, attitudes, and skills of third-year medical students. Acad Med. 1999 Jul; 74(7):821-8.
          View in: PubMed
        22. Jonassen JA, Cardasis CA, Clay MA. Integrating clinical ethical concepts and patient-centered problem solving into the basic science curriculum. Acad Med. 1997 May; 72(5):426-7.
          View in: PubMed
        23. Jonassen JA, Doepel DG, Pugnaire MP. An interclerkship course on domestic abuse. Acad Med. 1997 May; 72(5):422-3.
          View in: PubMed
        24. Koul H, Kennington L, Honeyman T, Jonassen J, Menon M, Scheid C. Activation of c-myc gene mediates the mitogenic effects of oxalate in LLC-PK1 cells, a line of renal epithelial cells. Kidney Int. 1996 Nov; 50(5):1525-30.
          View in: PubMed
        25. Miller K, Cardasis C, Jonassen J. Integrating women's health issues into the first-year curriculum. Acad Med. 1996 May; 71(5):543-4.
          View in: PubMed
        26. Jonassen JA, Burwick TN, Pugnaire MP. An interdisciplinary course on domestic and family violence. Acad Med. 1996 May; 71(5):548.
          View in: PubMed
        27. Scheid C, Koul H, Hill WA, Luber-Narod J, Jonassen J, Honeyman T, Kennington L, Kohli R, Hodapp J, Ayvazian P, Menon M. Oxalate toxicity in LLC-PK1 cells, a line of renal epithelial cells. J Urol. 1996 Mar; 155(3):1112-6.
          View in: PubMed
        28. Scheid C, Koul H, Hill WA, Luber-Narod J, Kennington L, Honeyman T, Jonassen J, Menon M. Oxalate toxicity in LLC-PK1 cells: role of free radicals. Kidney Int. 1996 Feb; 49(2):413-9.
          View in: PubMed
        29. Scheid CR, Koul HK, Kennington L, Hill WA, Luber-Narod J, Jonassen J, Honeyman T, Menon M. Oxalate-induced damage to renal tubular cells. Scanning Microsc. 1995; 9(4):1097-105; discussion 1105-7.
          View in: PubMed
        30. Bittman EL, Jonassen JA, Hegarty CM. Photoperiodic regulation of pulsatile luteinizing hormone secretion and adenohypophyseal gene expression in female golden hamsters. Biol Reprod. 1992 Jul; 47(1):66-71.
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        31. Jonassen JA, Mullikin-Kilpatrick D, Hoogasian J, Benoit SE, Leeman SE. Regulation of adenohypophyseal messenger RNAs in female rats by age, hypothyroidism, estradiol and neonatal androgenization. Mol Cell Endocrinol. 1992 Mar; 84(1-2):55-64.
          View in: PubMed
        32. Jonassen JA, Baker SP, McNeilly AS. Long-term hyperprolactinaemia reduces basal but not androgen-stimulated oestradiol production in small antral follicles of the rat ovary. J Endocrinol. 1991 Jun; 129(3):357-62.
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        33. Jonassen JA, Leeman SE. Developmental and hormonal regulation of the sex difference in preprotachykinin gene expression in rat anterior pituitaries. Ann N Y Acad Sci. 1991; 632:1-9.
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        34. Hegarty CM, Jonassen JA, Bittman EL. Pituitary hormone gene expression in male golden hamsters: interactions between photoperiod and testosterone. J Neuroendocrinol. 1990 Oct 1; 2(5):567-73.
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        35. Bittman EL, Hegarty CM, Layden MQ, Jonassen JA. Influences of photoperiod on sexual behaviour, neuroendocrine steroid receptors and adenohypophysial hormone secretion and gene expression in female golden hamsters. J Mol Endocrinol. 1990 Aug; 5(1):15-25.
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        36. Stopa EG, Minamitani N, Jonassen JA, King JC, Wolfe H, Mobtaker H, Albers HE. Localization of vasoactive intestinal peptide and peptide histidine isoleucine immunoreactivity and mRNA within the rat suprachiasmatic nucleus. Brain Res. 1988 Dec; 464(4):319-25.
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        37. Salton SR, Blum M, Jonassen JA, Clayton RN, Roberts JL. Stimulation of pituitary luteinizing hormone secretion by gonadotropin-releasing hormone is not coupled to beta-luteinizing hormone gene transcription. Mol Endocrinol. 1988 Nov; 2(11):1033-42.
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        38. Jonassen JA, Mullikin-Kilpatrick D, McAdam A, Leeman SE. Thyroid hormone status regulates preprotachykinin-A gene expression in male rat anterior pituitary. Endocrinology. 1987 Oct; 121(4):1555-61.
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        39. Eberwine JH, Jonassen JA, Evinger MJ, Roberts JL. Complex transcriptional regulation by glucocorticoids and corticotropin-releasing hormone of proopiomelanocortin gene expression in rat pituitary cultures. DNA. 1987 Oct; 6(5):483-92.
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        40. McNeilly AS, Jonassen JA, Rhind SM. Reduced ovarian follicular development as a consequence of low body condition in ewes. Acta Endocrinol (Copenh). 1987 May; 115(1):75-83.
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        41. McNeilly AS, Jonassen JA, Fraser HM. Suppression of follicular development after chronic LHRH immunoneutralization in the ewe. J Reprod Fertil. 1986 Jan; 76(1):481-90.
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        42. Jonassen JA, McNeilly AS. Prolactin effects on basal and gonadotrophin-stimulated progesterone accumulation by PMSG-primed mouse ovaries in vitro. Acta Endocrinol (Copenh). 1985 Dec; 110(4):553-7.
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        43. Popkin R, Fraser HM, Jonassen J. Stimulation of androstenedione and progesterone release by LHRH and LHRH agonist from isolated rat preovulatory follicles. Mol Cell Endocrinol. 1983 Feb; 29(2):169-79.
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        44. McNeilly AS, Glasier A, Jonassen J, Howie PW. Evidence for direct inhibition of ovarian function by prolactin. J Reprod Fertil. 1982 Jul; 65(2):559-69.
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        45. Jonassen JA, Bose K, Richards JS. Enhancement and desensitization of hormone-responsive adenylate cyclase in granulosa cells of preantral and antral ovarian follicles: effects of estradiol and follicle-stimulating hormone. Endocrinology. 1982 Jul; 111(1):74-9.
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        46. Campbell KL, Bagavandoss P, Byrne MD, Jonassen JA, Landefeld TD, Quasney MW, Sanders MM, Midgley AR. Differential processing of the two subunits of human choriogonadotropin by granulosa cells. II. In vivo studies. Endocrinology. 1981 Dec; 109(6):1858-71.
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        47. Richards JS, Jonassen JA, Kersey K. Evidence that changes in tonic luteinizing hormone secretion determine the growth of preovulatory follicles in the rat. Endocrinology. 1980 Sep; 107(3):641-8.
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        48. Jonassen JA, Richards JS. Granulosa cell desensitization: effects of gonadotropin on antral and preantral follicles. Endocrinology. 1980 Jun; 106(6):1786-94.
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        49. Richards JS, Jonassen JA, Rolfes AI, Kersey K, Reichert LE. Adenosine 3',5'-monophosphate, luteinizing hormone receptor, and progesterone during granulosa cell differentiation: effects of estradiol and follicle-stimulating hormone. Endocrinology. 1979 Mar; 104(3):765-73.
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        50. Richards JS, Uilenbroek JT, Jonassen JA. Follicular growth in the rat: a reevaluation of the roles of FSH and LH. Adv Exp Med Biol. 1979; 112:11-26.
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