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    John Mark Madison MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-6938
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentMicrobiology and Physiological Systems

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMasters in Clinical Investigation

        Overview 
        Narrative

        Scientific interests

        • Calcium signaling in airway smooth muscle cells.
        • Adrenergic signaling in airway smooth muscle cells
        • Lung imaging

        Research activities

        Calcium signaling in airway smooth muscle cells. Contraction of airway smooth muscle, an important cause of airway obstruction in asthma, is initiated by the rapid release of calcium ions from calcium stores of the sarcoplasmic reticulum. Using calcium dyes and laser-based imaging of single cells, our recent work has focused on the observation that interleukin-4 (IL-4) releases calcium from the sarcoplasmic reticulum. We aim to understand the mechanisms underlying this effect of IL-4 on calcium signaling and the functional consequences this has on cell contractility.

        Other Titles

        Division Chief, Pulmonary, Allergy and Critical Care Medicine
        Medical Director, Pulmonary Diagnostic Laboratories

        Education

        Medical School: Harvard Medical School, 1975-79
        Medical Residency:Washington University, Barnes Hospital, 1979-82
        Pulmonary Fellowship: UCSF, 1982-85

        Bibliography




        Bibliographic 
        selected publications
        List All   |   Timeline
        1. McCarthy C, O'Rourke NC, Madison JM. Integrating advanced practice providers into medical critical care teams. Chest. 2013 Mar; 143(3):847-50.
          View in: PubMed
        2. Pbert L, Madison JM, Druker S, Olendzki N, Magner R, Reed G, Allison J, Carmody J. Effect of mindfulness training on asthma quality of life and lung function: a randomised controlled trial. Thorax. 2012 Sep; 67(9):769-76.
          View in: PubMed
        3. Madison JM, Irwin RS. Cough: a worldwide problem. Otolaryngol Clin North Am. 2010 Feb; 43(1):1-13, vii.
          View in: PubMed
        4. Nunes FP, Bishop T, Prasad ML, Madison JM, Kim DY. Laryngeal candidiasis mimicking malignancy. Laryngoscope. 2008 Nov; 118(11):1957-9.
          View in: PubMed
        5. Martin G, O'Connell RJ, Pietrzykowski AZ, Treistman SN, Ethier MF, Madison JM. Interleukin-4 activates large-conductance, calcium-activated potassium (BKCa) channels in human airway smooth muscle cells. Exp Physiol. 2008 Jul; 93(7):908-18.
          View in: PubMed
        6. Madison JM. Hypersensitivity pneumonitis: clinical perspectives. Arch Pathol Lab Med. 2008 Feb; 132(2):195-8.
          View in: PubMed
        7. Ethier MF, Madison JM. Adenosine A1 receptors mediate mobilization of calcium in human bronchial smooth muscle cells. Am J Respir Cell Mol Biol. 2006 Oct; 35(4):496-502.
          View in: PubMed
        8. Ethier MF, Madison JM. IL-4 inhibits calcium transients in bovine trachealis cells by a ryanodine receptor-dependent mechanism. FASEB J. 2006 Jan; 20(1):154-6.
          View in: PubMed
        9. Madison JM, Irwin RS. Chronic cough in adults with interstitial lung disease. Curr Opin Pulm Med. 2005 Sep; 11(5):412-6.
          View in: PubMed
        10. Smyrnios NA, Schaefer OP, Collins RM, Madison JM. Applicability of prediction rules in patients with community-acquired pneumonia requiring intensive care: a pilot study. J Intensive Care Med. 2005 Jul-Aug; 20(4):226-32.
          View in: PubMed
        11. Ethier MF, Cappelluti E, Madison JM. Mechanisms of interleukin-4 effects on calcium signaling in airway smooth muscle cells. J Pharmacol Exp Ther. 2005 Apr; 313(1):127-33.
          View in: PubMed
        12. Madison JM. Migration of airway smooth muscle cells. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):8-11.
          View in: PubMed
        13. Madison JM, Irwin RS. Pharmacotherapy of chronic cough in adults. Expert Opin Pharmacother. 2003 Jul; 4(7):1039-48.
          View in: PubMed
        14. Ethier MF, Madison JM. LY294002, but not wortmannin, increases intracellular calcium and inhibits calcium transients in bovine and human airway smooth muscle cells. Cell Calcium. 2002 Jul; 32(1):31-8.
          View in: PubMed
        15. Irwin RS, Madison JM. The persistently troublesome cough. Am J Respir Crit Care Med. 2002 Jun 1; 165(11):1469-74.
          View in: PubMed
        16. Irwin RS, Madison JM. Diagnosis and treatment of chronic cough due to gastro-esophageal reflux disease and postnasal drip syndrome. Pulm Pharmacol Ther. 2002; 15(3):261-6.
          View in: PubMed
        17. Madison JM, Ethier MF. Interleukin-4 rapidly inhibits calcium transients in response to carbachol in bovine airway smooth muscle cells. Am J Respir Cell Mol Biol. 2001 Aug; 25(2):239-44.
          View in: PubMed
        18. Ethier MF, Yamaguchi H, Madison JM. Effects of cyclopiazonic acid on cytosolic calcium in bovine airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2001 Jul; 281(1):L126-33.
          View in: PubMed
        19. Mitra P, De A, Ethier MF, Mimori K, Kodys K, Shibuta K, Mori M, Madison JM, Miller-Graziano C, Barnard GF. Loss of chemokine SDF-1alpha-mediated CXCR4 signalling and receptor internalization in human hepatoma cell line HepG2. Cell Signal. 2001 May; 13(5):311-9.
          View in: PubMed
        20. Irwin RS, Madison JM. Symptom research on chronic cough: a historical perspective. Ann Intern Med. 2001 May 1; 134(9 Pt 2):809-14.
          View in: PubMed
        21. Irwin RS, Madison JM. The diagnosis and treatment of cough. N Engl J Med. 2000 Dec 7; 343(23):1715-21.
          View in: PubMed
        22. Ethier MF, Dextradeur T, Schaefer OP, Madison JM. Effects of salmeterol on muscarinic inhibition of adenylyl cyclase in bovine trachealis cells. Life Sci. 2000 Oct 20; 67(22):2753-8.
          View in: PubMed
        23. Irwin RS, Madison JM, Fraire AE. The cough reflex and its relation to gastroesophageal reflux. Am J Med. 2000 Mar 6; 108 Suppl 4a:73S-78S.
          View in: PubMed
        24. Irwin RS, Madison JM. Anatomical diagnostic protocol in evaluating chronic cough with specific reference to gastroesophageal reflux disease. Am J Med. 2000 Mar 6; 108 Suppl 4a:126S-130S.
          View in: PubMed
        25. Madison JM, Ethier MF, Yamaguchi H. Refilling of caffeine-sensitive intracellular calcium stores in bovine airway smooth muscle cells. Am J Physiol. 1998 Nov; 275(5 Pt 1):L852-60.
          View in: PubMed
        26. Madison JM, Irwin RS. Chronic obstructive pulmonary disease. Lancet. 1998 Aug 8; 352(9126):467-73.
          View in: PubMed
        27. Ethier MF, Schaefer OP, Samant N, Yamaguchi H, Madison JM. Muscarinic receptor reserve for inhibition of cAMP accumulation in bovine trachealis cells. Am J Physiol. 1996 Feb; 270(2 Pt 1):L199-207.
          View in: PubMed
        28. Madison JM, Yamaguchi H. Muscarinic inhibition of adenylyl cyclase regulates intracellular calcium in single airway smooth muscle cells. Am J Physiol. 1996 Feb; 270(2 Pt 1):L208-14.
          View in: PubMed
        29. Schaefer OP, Ethier MF, Madison JM. Muscarinic regulation of cyclic AMP in bovine trachealis cells. Am J Respir Cell Mol Biol. 1995 Aug; 13(2):217-26.
          View in: PubMed
        30. Yamaguchi H, Kajita J, Madison JM. Isoproterenol increases peripheral [Ca2+]i and decreases inner [Ca2+]i in single airway smooth muscle cells. Am J Physiol. 1995 Mar; 268(3 Pt 1):C771-9.
          View in: PubMed
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