John Mark Madison MD
|Institution||University of Massachusetts Medical School|
|Address||University of Massachusetts Medical School|
55 Lake Avenue North
Worcester MA 01655
|Institution||UMMS - School of Medicine|
|Department||Microbiology and Physiological Systems|
|Institution||UMMS - Graduate School of Biomedical Sciences|
|Department||Masters in Clinical Investigation|
Calcium signaling in airway smooth muscle cells. Contraction of airway smooth muscle, an important cause of airway obstruction in asthma, is initiated by the rapid release of calcium ions from calcium stores of the sarcoplasmic reticulum. Using calcium dyes and laser-based imaging of single cells, our recent work has focused on the observation that interleukin-4 (IL-4) releases calcium from the sarcoplasmic reticulum. We aim to understand the mechanisms underlying this effect of IL-4 on calcium signaling and the functional consequences this has on cell contractility.
Division Chief, Pulmonary, Allergy and Critical Care Medicine
Medical Director, Pulmonary Diagnostic Laboratories
Medical School: Harvard Medical School, 1975-79
Medical Residency:Washington University, Barnes Hospital, 1979-82
Pulmonary Fellowship: UCSF, 1982-85
For assistance with using Profiles, please refer to the online tutorials
or contact UMMS Help Desk
or call 508-856-8643.
Click the "See All" links for more information and interactive visualizations!
People who are also in this person's primary department.