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    Steven Reppert MD

    TitleDistinguished Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentNeurobiology
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB
    Worcester MA 01605
    Phone508-856-6148
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentNeuroscience

        Overview 
        Narrative

        Biography

        B.S., University of Nebraska1973
        M.D. with Distinction, University of Nebraska1973
        M.S., Harvard University (Honorary)1993
        Pediatric Residency, Mass General Hosp /Harvard Medical School1973-1976
        Post-Doctoral Fellow, NIH1976-1979
        Charles King Trust Research Fellow1979-1981
        Instructor to Associate Professor, Harvard Medical School1979-1993
        Basil O'Connor Early Scholar Award1981-1984
        Director, Laboratory of Developmental Chronobiology, Mass General Hospital1983-2001
        Established Investigatorship of American Heart Association1986-1991
        Member, American Association for Clinical Investigation1987-
        E. Mead Johnson Award for Outstanding Research1991
        NIH-NICHD MERIT Award1992-2002
        Professor, Harvard Medical School1993-2001
        Chair, Gordon Conference on Pineal Cell Biology1998
        Higgins Family Professor of Neuroscience, UMass Med2001-
        Professor & Chair, Dept Neurobiology, UMass Med2001-
        President, Society for Research on Biological Rhythms2002-2004
        Fellow, American Association for the Advancement of Science2011-
        G.J. Mendel Medal from the Czech Academy of Sciences2012
        Doctor honoris causa (honorary doctorate) U of South Bohemia2013

        Steve New Pic as of Aug 20 2009Molecular Neuroethology

        In an integrated set of studies, our laboratory is using anatomical, cellular, molecular, electrophysiological, genetic and behavioral approaches to more fully understand the biological basis of monarch butterfly (Danaus plexippus) migration, with a focus on the butterfly's navigational abilities and its ancestral circadian clock. For details see theReppert Lab link



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Guerra PA, Reppert SM. Coldness triggers northward flight in remigrant monarch butterflies. Curr Biol. 2013 Mar 4; 23(5):419-23.
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        2. Heinze S, Florman J, Asokaraj S, El Jundi B, Reppert SM. Anatomical basis of sun compass navigation II: The neuronal composition of the central complex of the monarch butterfly. J Comp Neurol. 2013 Feb 1; 521(2):267-98.
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        3. Zhan S, Reppert SM. MonarchBase: the monarch butterfly genome database. Nucleic Acids Res. 2013 Jan 1; 41(D1):D758-63.
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        4. Merlin C, Beaver LE, Taylor OR, Wolfe SA, Reppert SM. Efficient targeted mutagenesis in the monarch butterfly using zinc-finger nucleases. Genome Res. 2013 Jan; 23(1):159-68.
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        5. Guerra PA, Merlin C, Gegear RJ, Reppert SM. Discordant timing between antennae disrupts sun compass orientation in migratory monarch butterflies. Nat Commun. 2012; 3:958.
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        6. Heinze S, Reppert SM. Anatomical basis of sun compass navigation I: The general layout of the monarch butterfly brain. J Comp Neurol. 2012 Jun 1; 520(8):1599-628.
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        7. Reppert S, Boross I, Koslowski M, Türeci O, Koch S, Lehr HA, Finotto S. A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer. Nat Commun. 2011; 2:600.
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        8. Merlin C, Heinze S, Reppert SM. Unraveling navigational strategies in migratory insects. Curr Opin Neurobiol. 2012 Apr; 22(2):353-61.
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        9. Zhan S, Merlin C, Boore JL, Reppert SM. The monarch butterfly genome yields insights into long-distance migration. Cell. 2011 Nov 23; 147(5):1171-85.
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        10. Foley LE, Gegear RJ, Reppert SM. Human cryptochrome exhibits light-dependent magnetosensitivity. Nat Commun. 2011; 2:356.
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        11. Heinze S, Reppert SM. Sun compass integration of skylight cues in migratory monarch butterflies. Neuron. 2011 Jan 27; 69(2):345-58.
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        12. Reppert SM, Gegear RJ, Merlin C. Navigational mechanisms of migrating monarch butterflies. Trends Neurosci. 2010 Sep; 33(9):399-406.
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        13. Gegear RJ, Foley LE, Casselman A, Reppert SM. Animal cryptochromes mediate magnetoreception by an unconventional photochemical mechanism. Nature. 2010 Feb 11; 463(7282):804-7.
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        14. Merlin C, Gegear RJ, Reppert SM. Antennal circadian clocks coordinate sun compass orientation in migratory monarch butterflies. Science. 2009 Sep 25; 325(5948):1700-4.
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        15. Etchegaray JP, Machida KK, Noton E, Constance CM, Dallmann R, Di Napoli MN, DeBruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009 Jul; 29(14):3853-66.
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        16. Zhu H, Gegear RJ, Casselman A, Kanginakudru S, Reppert SM. Defining behavioral and molecular differences between summer and migratory monarch butterflies. BMC Biol. 2009; 7:14.
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        17. Gegear RJ, Casselman A, Waddell S, Reppert SM. Cryptochrome mediates light-dependent magnetosensitivity in Drosophila. Nature. 2008 Aug 21; 454(7207):1014-8.
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        18. Zhu H, Casselman A, Reppert SM. Chasing migration genes: a brain expressed sequence tag resource for summer and migratory monarch butterflies (Danaus plexippus). PLoS One. 2008; 3(1):e1345.
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        19. Zhu H, Sauman I, Yuan Q, Casselman A, Emery-Le M, Emery P, Reppert SM. Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation. PLoS Biol. 2008 Jan; 6(1):e4.
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        20. DeBruyne JP, Weaver DR, Reppert SM. Peripheral circadian oscillators require CLOCK. Curr Biol. 2007 Jul 17; 17(14):R538-9.
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        21. Song SH, Oztürk N, Denaro TR, Arat NO, Kao YT, Zhu H, Zhong D, Reppert SM, Sancar A. Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly. J Biol Chem. 2007 Jun 15; 282(24):17608-12.
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        22. DeBruyne JP, Weaver DR, Reppert SM. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci. 2007 May; 10(5):543-5.
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        23. Yuan Q, Metterville D, Briscoe AD, Reppert SM. Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocks. Mol Biol Evol. 2007 Apr; 24(4):948-55.
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        24. Reppert SM. The ancestral circadian clock of monarch butterflies: role in time-compensated sun compass orientation. Cold Spring Harb Symp Quant Biol. 2007; 72:113-8.
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        25. Etchegaray JP, Yang X, DeBruyne JP, Peters AH, Weaver DR, Jenuwein T, Reppert SM. The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28; 281(30):21209-15.
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        26. Debruyne JP, Noton E, Lambert CM, Maywood ES, Weaver DR, Reppert SM. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron. 2006 May 4; 50(3):465-77.
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        27. Reppert SM. A colorful model of the circadian clock. Cell. 2006 Jan 27; 124(2):233-6.
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        28. Zhu H, Yuan Q, Briscoe AD, Froy O, Casselman A, Reppert SM. The two CRYs of the butterfly. Curr Biol. 2005 Dec 6; 15(23):R953-4.
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        29. Sauman I, Briscoe AD, Zhu H, Shi D, Froy O, Stalleicken J, Yuan Q, Casselman A, Reppert SM. Connecting the navigational clock to sun compass input in monarch butterfly brain. Neuron. 2005 May 5; 46(3):457-67.
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        30. Emery P, Reppert SM. A rhythmic Ror. Neuron. 2004 Aug 19; 43(4):443-6.
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        31. Reppert SM, Zhu H, White RH. Polarized light helps monarch butterflies navigate. Curr Biol. 2004 Jan 20; 14(2):155-8.
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        32. Lee C, Weaver DR, Reppert SM. Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004 Jan; 24(2):584-94.
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        33. Chang DC, McWatters HG, Williams JA, Gotter AL, Levine JD, Reppert SM. Constructing a feedback loop with circadian clock molecules from the silkmoth, Antheraea pernyi. J Biol Chem. 2003 Oct 3; 278(40):38149-58.
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        34. Froy O, Gotter AL, Casselman AL, Reppert SM. Illuminating the circadian clock in monarch butterfly migration. Science. 2003 May 23; 300(5623):1303-5.
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        35. Chang DC, Reppert SM. A novel C-terminal domain of drosophila PERIOD inhibits dCLOCK:CYCLE-mediated transcription. Curr Biol. 2003 Apr 29; 13(9):758-62.
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        36. Jin X, von Gall C, Pieschl RL, Gribkoff VK, Stehle JH, Reppert SM, Weaver DR. Targeted disruption of the mouse Mel(1b) melatonin receptor. Mol Cell Biol. 2003 Feb; 23(3):1054-60.
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        37. Etchegaray JP, Lee C, Wade PA, Reppert SM. Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature. 2003 Jan 9; 421(6919):177-82.
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        38. Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002 Aug 29; 418(6901):935-41.
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        39. Travnickova-Bendova Z, Cermakian N, Reppert SM, Sassone-Corsi P. Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7728-33.
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        40. Froy O, Chang DC, Reppert SM. Redox potential: differential roles in dCRY and mCRY1 functions. Curr Biol. 2002 Jan 22; 12(2):147-52.
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        41. Lee C, Etchegaray JP, Cagampang FR, Loudon AS, Reppert SM. Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 2001 Dec 28; 107(7):855-67.
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        42. Gotter AL, Reppert SM. Analysis of human Per4. Brain Res Mol Brain Res. 2001 Aug 15; 92(1-2):19-26.
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        43. Bae K, Jin X, Maywood ES, Hastings MH, Reppert SM, Weaver DR. Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron. 2001 May; 30(2):525-36.
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        44. Chang DC, Reppert SM. The circadian clocks of mice and men. Neuron. 2001 Mar; 29(3):555-8.
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        45. Clayton JD, Kyriacou CP, Reppert SM. Keeping time with the human genome. Nature. 2001 Feb 15; 409(6822):829-31.
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        46. Reppert SM, Weaver DR. Molecular analysis of mammalian circadian rhythms. Annu Rev Physiol. 2001; 63:647-76.
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        47. Reppert SM, Weaver DR. Comparing clockworks: mouse versus fly. J Biol Rhythms. 2000 Oct; 15(5):357-64.
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        48. Shearman LP, Jin X, Lee C, Reppert SM, Weaver DR. Targeted disruption of the mPer3 gene: subtle effects on circadian clock function. Mol Cell Biol. 2000 Sep; 20(17):6269-75.
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        49. Reppert SM. Cellular and molecular basis of circadian timing in mammals. Semin Perinatol. 2000 Aug; 24(4):243-6.
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        50. Gotter AL, Manganaro T, Weaver DR, Kolakowski LF, Possidente B, Sriram S, MacLaughlin DT, Reppert SM. A time-less function for mouse timeless. Nat Neurosci. 2000 Aug; 3(8):755-6.
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        51. Shearman LP, Sriram S, Weaver DR, Maywood ES, Chaves I, Zheng B, Kume K, Lee CC, van der Horst GT, Hastings MH, Reppert SM. Interacting molecular loops in the mammalian circadian clock. Science. 2000 May 12; 288(5468):1013-9.
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        52. Ripperger JA, Shearman LP, Reppert SM, Schibler U. CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Genes Dev. 2000 Mar 15; 14(6):679-89.
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        53. Gubitz AK, Reppert SM. Chimeric and point-mutated receptors reveal that a single glycine residue in transmembrane domain 6 is critical for high affinity melatonin binding. Endocrinology. 2000 Mar; 141(3):1236-44.
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        54. Field MD, Maywood ES, O'Brien JA, Weaver DR, Reppert SM, Hastings MH. Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms. Neuron. 2000 Feb; 25(2):437-47.
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        55. Liu C, Reppert SM. GABA synchronizes clock cells within the suprachiasmatic circadian clock. Neuron. 2000 Jan; 25(1):123-8.
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        56. Zylka MJ, Reppert SM. Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches. Brain Res Mol Brain Res. 1999 Dec 10; 74(1-2):175-81.
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        57. Gotter AL, Levine JD, Reppert SM. Sex-linked period genes in the silkmoth, Antheraea pernyi: implications for circadian clock regulation and the evolution of sex chromosomes. Neuron. 1999 Dec; 24(4):953-65.
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        58. Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell. 1999 Jul 23; 98(2):193-205.
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        59. Hastings MH, Field MD, Maywood ES, Weaver DR, Reppert SM. Differential regulation of mPER1 and mTIM proteins in the mouse suprachiasmatic nuclei: new insights into a core clock mechanism. J Neurosci. 1999 Jun 15; 19(12):RC11.
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        60. Shearman LP, Zylka MJ, Reppert SM, Weaver DR. Expression of basic helix-loop-helix/PAS genes in the mouse suprachiasmatic nucleus. Neuroscience. 1999 Mar; 89(2):387-97.
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        61. Gubitz AK, Reppert SM. Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50). Genomics. 1999 Jan 15; 55(2):248-51.
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        62. Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ, Reppert SM. A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell. 1999 Jan 8; 96(1):57-68.
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        63. Zylka MJ, Shearman LP, Levine JD, Jin X, Weaver DR, Reppert SM. Molecular analysis of mammalian timeless. Neuron. 1998 Nov; 21(5):1115-22.
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        64. Reppert SM. A clockwork explosion! Neuron. 1998 Jul; 21(1):1-4.
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        65. Zylka MJ, Shearman LP, Weaver DR, Reppert SM. Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. Neuron. 1998 Jun; 20(6):1103-10.
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        66. Sauman I, Reppert SM. Brain control of embryonic circadian rhythms in the silkmoth Antheraea pernyi. Neuron. 1998 Apr; 20(4):741-8.
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        67. Liu C, Weaver DR, Strogatz SH, Reppert SM. Cellular construction of a circadian clock: period determination in the suprachiasmatic nuclei. Cell. 1997 Dec 12; 91(6):855-60.
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        68. Reppert SM. Melatonin receptors: molecular biology of a new family of G protein-coupled receptors. J Biol Rhythms. 1997 Dec; 12(6):528-31.
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        69. Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. 1997 Dec; 19(6):1261-9.
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        70. Liu C, Weaver DR, Jin X, Shearman LP, Pieschl RL, Gribkoff VK, Reppert SM. Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron. 1997 Jul; 19(1):91-102.
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        71. Reppert SM, Weaver DR. Forward genetic approach strikes gold: cloning of a mammalian clock gene. Cell. 1997 May 16; 89(4):487-90.
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        72. Godson C, Reppert SM. The Mel1a melatonin receptor is coupled to parallel signal transduction pathways. Endocrinology. 1997 Jan; 138(1):397-404.
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        73. Weaver DR, Reppert SM. The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei. Neuroreport. 1996 Dec 20; 8(1):109-12.
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        74. Sauman I, Tsai T, Roca AL, Reppert SM. Period protein is necessary for circadian control of egg hatching behavior in the silkmoth Antheraea pernyi. Neuron. 1996 Nov; 17(5):901-9.
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        75. Sauman I, Reppert SM. Circadian clock neurons in the silkmoth Antheraea pernyi: novel mechanisms of Period protein regulation. Neuron. 1996 Nov; 17(5):889-900.
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        76. Weaver DR, Liu C, Reppert SM. Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters. Mol Endocrinol. 1996 Nov; 10(11):1478-87.
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        77. Sauman I, Reppert SM. Molecular characterization of prothoracicotropic hormone (PTTH) from the giant silkmoth Antheraea pernyi: developmental appearance of PTTH-expressing cells and relationship to circadian clock cells in central brain. Dev Biol. 1996 Sep 15; 178(2):418-29.
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        78. Roca AL, Godson C, Weaver DR, Reppert SM. Structure, characterization, and expression of the gene encoding the mouse Mel1a melatonin receptor. Endocrinology. 1996 Aug; 137(8):3469-77.
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        79. Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF. Cloning of a melatonin-related receptor from human pituitary. FEBS Lett. 1996 May 20; 386(2-3):219-24.
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        80. Reppert SM, Weaver DR, Godson C. Melatonin receptors step into the light: cloning and classification of subtypes. Trends Pharmacol Sci. 1996 Mar; 17(3):100-2.
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        81. Welsh DK, Reppert SM. Gap junctions couple astrocytes but not neurons in dissociated cultures of rat suprachiasmatic nucleus. Brain Res. 1996 Jan 8; 706(1):30-6.
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        82. Reppert SM, Weaver DR. Melatonin madness. Cell. 1995 Dec 29; 83(7):1059-62.
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        83. Reppert SM, Weaver DR, Cassone VM, Godson C, Kolakowski LF. Melatonin receptors are for the birds: molecular analysis of two receptor subtypes differentially expressed in chick brain. Neuron. 1995 Nov; 15(5):1003-15.
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        84. Reppert SM, Sauman I. period and timeless tango: a dance of two clock genes. Neuron. 1995 Nov; 15(5):983-6.
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        85. Weaver DR, Reppert SM. Definition of the developmental transition from dopaminergic to photic regulation of c-fos gene expression in the rat suprachiasmatic nucleus. Brain Res Mol Brain Res. 1995 Oct; 33(1):136-48.
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        86. Reppert SM, Godson C, Mahle CD, Weaver DR, Slaugenhaupt SA, Gusella JF. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8734-8.
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        87. Levine JD, Sauman I, Imbalzano M, Reppert SM, Jackson FR. Period protein from the giant silkmoth Antheraea pernyi functions as a circadian clock element in Drosophila melanogaster. Neuron. 1995 Jul; 15(1):147-57.
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        88. Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM. Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). Genomics. 1995 May 20; 27(2):355-7.
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        89. Weaver DR, Roca AL, Reppert SM. c-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulation. Brain Res Dev Brain Res. 1995 Apr 18; 85(2):293-7.
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        90. Welsh DK, Logothetis DE, Meister M, Reppert SM. Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms. Neuron. 1995 Apr; 14(4):697-706.
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        91. Reppert SM. Interaction between the circadian clocks of mother and fetus. Ciba Found Symp. 1995; 183:198-207; discussion 207-11.
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        92. Reppert SM, Weaver DR, Ebisawa T. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron. 1994 Nov; 13(5):1177-85.
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        93. Reppert SM, Tsai T, Roca AL, Sauman I. Cloning of a structural and functional homolog of the circadian clock gene period from the giant silkmoth Antheraea pernyi. Neuron. 1994 Nov; 13(5):1167-76.
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        94. Viswanathan N, Weaver DR, Reppert SM, Davis FC. Entrainment of the fetal hamster circadian pacemaker by prenatal injections of the dopamine agonist SKF 38393. J Neurosci. 1994 Sep; 14(9):5393-8.
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        95. Ebisawa T, Karne S, Lerner MR, Reppert SM. Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):6133-7.
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        96. Linden J, Taylor HE, Robeva AS, Tucker AL, Stehle JH, Rivkees SA, Fink JS, Reppert SM. Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution. Mol Pharmacol. 1993 Sep; 44(3):524-32.
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        97. Roca AL, Weaver DR, Reppert SM. Serotonin receptor gene expression in the rat suprachiasmatic nuclei. Brain Res. 1993 Apr 9; 608(1):159-65.
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        98. Weaver DR, Stehle JH, Stopa EG, Reppert SM. Melatonin receptors in human hypothalamus and pituitary: implications for circadian and reproductive responses to melatonin. J Clin Endocrinol Metab. 1993 Feb; 76(2):295-301.
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        99. Rivkees SA, Weaver DR, Reppert SM. Circadian and developmental regulation of Oct-2 gene expression in the suprachiasmatic nuclei. Brain Res. 1992 Dec 11; 598(1-2):332-6.
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        100. Weaver DR, Reppert SM. Adenosine receptor gene expression in rat kidney. Am J Physiol. 1992 Dec; 263(6 Pt 2):F991-5.
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        101. Rivkees SA, Reppert SM. RFL9 encodes an A2b-adenosine receptor. Mol Endocrinol. 1992 Oct; 6(10):1598-604.
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        102. Weaver DR, Rivkees SA, Reppert SM. D1-dopamine receptors activate c-fos expression in the fetal suprachiasmatic nuclei. Proc Natl Acad Sci U S A. 1992 Oct 1; 89(19):9201-4.
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        103. Fink JS, Weaver DR, Rivkees SA, Peterfreund RA, Pollack AE, Adler EM, Reppert SM. Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum. Brain Res Mol Brain Res. 1992 Jul; 14(3):186-95.
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        104. Reppert SM, Weaver DR, Stehle JH, Rivkees SA, Grabbe S, Granstein RD. Molecular cloning of a G protein-coupled receptor that is highly expressed in lymphocytes and proliferative areas of developing brain. Mol Cell Neurosci. 1992 Jun; 3(3):206-14.
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        105. Stehle JH, Rivkees SA, Lee JJ, Weaver DR, Deeds JD, Reppert SM. Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype. Mol Endocrinol. 1992 Mar; 6(3):384-93.
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        106. Rivkees SA, Reppert SM. Perinatal development of day-night rhythms in humans. Horm Res. 1992; 37 Suppl 3:99-104.
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        107. Reppert SM. Pre-natal development of a hypothalamic biological clock. Prog Brain Res. 1992; 93:119-31; discussion 132.
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        108. Rivkees SA, Reppert SM. Appearance of melatonin receptors during embryonic life in Siberian hamsters (Phodopus sungorous). Brain Res. 1991 Dec 24; 568(1-2):345-9.
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        109. Reppert SM, Weaver DR, Stehle JH, Rivkees SA. Molecular cloning and characterization of a rat A1-adenosine receptor that is widely expressed in brain and spinal cord. Mol Endocrinol. 1991 Aug; 5(8):1037-48.
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        110. Carlson LL, Weaver DR, Reppert SM. Melatonin receptors and signal transduction during development in Siberian hamsters (Phodopus sungorus). Brain Res Dev Brain Res. 1991 Mar 18; 59(1):83-8.
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        111. Weaver DR, Provencio I, Carlson LL, Reppert SM. Melatonin receptors and signal transduction in photorefractory Siberian hamsters (Phodopus sungorus). Endocrinology. 1991 Feb; 128(2):1086-92.
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        112. Weaver DR, Reppert SM. Melatonin receptors are present in the ferret pars tuberalis and pars distalis, but not in brain. Endocrinology. 1990 Nov; 127(5):2607-9.
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        113. Rivkees SA, Conron RW, Reppert SM. Solubilization and purification of melatonin receptors from lizard brain. Endocrinology. 1990 Sep; 127(3):1206-14.
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        114. Rivkees SA, Reppert SM. Entrainment of circadian phase in developing gray short-tailed opossums: mother vs. environment. Am J Physiol. 1990 Sep; 259(3 Pt 1):E384-8.
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        115. Nadakavukaren JJ, Welsh DK, Reppert SM. Aluminum fluoride reveals a phosphoinositide system within the suprachiasmatic region of rat hypothalamus. Brain Res. 1990 Jan 22; 507(2):181-8.
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        116. Weaver DR, Carlson LL, Reppert SM. Melatonin receptors and signal transduction in melatonin-sensitive and melatonin-insensitive populations of white-footed mice (Peromyscus leucopus). Brain Res. 1990 Jan 8; 506(2):353-7.
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        117. Carlson LL, Weaver DR, Reppert SM. Melatonin signal transduction in hamster brain: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein. Endocrinology. 1989 Nov; 125(5):2670-6.
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        118. Weaver DR, Rivkees SA, Reppert SM. Localization and characterization of melatonin receptors in rodent brain by in vitro autoradiography. J Neurosci. 1989 Jul; 9(7):2581-90.
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        119. Rivkees SA, Cassone VM, Weaver DR, Reppert SM. Melatonin receptors in chick brain: characterization and localization. Endocrinology. 1989 Jul; 125(1):363-8.
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        120. Rivkees SA, Carlson LL, Reppert SM. Guanine nucleotide-binding protein regulation of melatonin receptors in lizard brain. Proc Natl Acad Sci U S A. 1989 May; 86(10):3882-6.
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        121. Weaver DR, Reppert SM. Direct in utero perception of light by the mammalian fetus. Brain Res Dev Brain Res. 1989 May 1; 47(1):151-5.
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        122. Weaver DR, Reppert SM. Periodic feeding of SCN-lesioned pregnant rats entrains the fetal biological clock. Brain Res Dev Brain Res. 1989 Apr 1; 46(2):291-6.
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        123. Rivkees SA, Chaar MR, Hanley DF, Maxwell M, Reppert SM, Uhl GR. Localization and regulation of vasopressin mRNA in human neurons. Synapse. 1989; 3(3):246-54.
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        124. Rivkees SA, Fox CA, Jacobson CD, Reppert SM. Anatomic and functional development of the suprachiasmatic nuclei in the gray short-tailed opossum. J Neurosci. 1988 Nov; 8(11):4269-76.
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        125. Reppert SM, Weaver DR, Rivkees SA, Stopa EG. Putative melatonin receptors in a human biological clock. Science. 1988 Oct 7; 242(4875):78-81.
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        126. Reppert SM, Uhl GR. The vasopressin gene is expressed prior to regulation in the supraoptic nuclei of fetal rats. Brain Res. 1988 Jul 26; 456(2):392-6.
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        127. Rivkees SA, Hall DA, Weaver DR, Reppert SM. Djungarian hamsters exhibit reproductive responses to changes in daylength at extreme photoperiods. Endocrinology. 1988 Jun; 122(6):2634-8.
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        128. Weaver DR, Namboodiri MA, Reppert SM. Iodinated melatonin mimics melatonin action and reveals discrete binding sites in fetal brain. FEBS Lett. 1988 Feb 8; 228(1):123-7.
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        129. Reppert SM, Weaver DR, Rivkees SA. Maternal communication of circadian phase to the developing mammal. Psychoneuroendocrinology. 1988; 13(1-2):63-78.
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        130. Weaver DR, Keohan JT, Reppert SM. Definition of a prenatal sensitive period for maternal-fetal communication of day length. Am J Physiol. 1987 Dec; 253(6 Pt 1):E701-4.
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        131. Weaver DR, Reppert SM. Maternal-fetal communication of circadian phase in a precocious rodent, the spiny mouse. Am J Physiol. 1987 Oct; 253(4 Pt 1):E401-9.
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        132. Gillette MU, Reppert SM. The hypothalamic suprachiasmatic nuclei: circadian patterns of vasopressin secretion and neuronal activity in vitro. Brain Res Bull. 1987 Jul; 19(1):135-9.
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        133. Reppert SM, Uhl GR. Vasopressin messenger ribonucleic acid in supraoptic and suprachiasmatic nuclei: appearance and circadian regulation during development. Endocrinology. 1987 Jun; 120(6):2483-7.
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        134. Jacques SL, Weaver DR, Reppert SM. Penetration of light into the uterus of pregnant animals. Photochem Photobiol. 1987 May; 45(5):637-41.
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        135. Reppert SM, Henshaw D, Schwartz WJ, Weaver DR. The circadian-gated timing of birth in rats: disruption by maternal SCN lesions or by removal of the fetal brain. Brain Res. 1987 Feb 17; 403(2):398-402.
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        136. Weaver DR, Reppert SM. Maternal melatonin communicates daylength to the fetus in Djungarian hamsters. Endocrinology. 1986 Dec; 119(6):2861-3.
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        137. Reppert SM, Schwartz WJ. Maternal endocrine extirpations do not abolish maternal coordination of the fetal circadian clock. Endocrinology. 1986 Oct; 119(4):1763-7.
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        138. Reppert SM, Schwartz WJ. Maternal suprachiasmatic nuclei are necessary for maternal coordination of the developing circadian system. J Neurosci. 1986 Sep; 6(9):2724-9.
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        139. Uhl GR, Reppert SM. Suprachiasmatic nucleus vasopressin messenger RNA: circadian variation in normal and Brattleboro rats. Science. 1986 Apr 18; 232(4748):390-3.
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        140. Duncan MJ, Banister MJ, Reppert SM. Developmental appearance of light-dark entrainment in the rat. Brain Res. 1986 Mar 26; 369(1-2):326-30.
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        141. Schwartz WJ, Reppert SM. Neural regulation of the circadian vasopressin rhythm in cerebrospinal fluid: a pre-eminent role for the suprachiasmatic nuclei. J Neurosci. 1985 Oct; 5(10):2771-8.
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        142. Reppert SM. Maternal entrainment of the developing circadian system. Ann N Y Acad Sci. 1985; 453:162-9.
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        143. Reppert SM, Duncan MJ, Goldman BD. Photic influences on the developing mammal. Ciba Found Symp. 1985; 117:116-28.
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        144. Reppert SM, Coleman RJ, Heath HW, Swedlow JR. Pineal N-acetyltransferase activity in 10-day-old rats: a paradigm for studying the developing circadian system. Endocrinology. 1984 Sep; 115(3):918-25.
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        145. Reppert SM, Perlow MJ, Artman HG, Ungerleider LG, Fisher DA, Klein DC. The circadian rhythm of oxytocin in primate cerebrospinal fluid: effects of destruction of the suprachiasmatic nuclei. Brain Res. 1984 Jul 30; 307(1-2):384-7.
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        146. Reppert SM, Schwartz WJ. The suprachiasmatic nuclei of the fetal rat: characterization of a functional circadian clock using 14C-labeled deoxyglucose. J Neurosci. 1984 Jul; 4(7):1677-82.
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        147. Reppert SM, Schwartz WJ. Functional activity of the suprachiasmatic nuclei in the fetal primate. Neurosci Lett. 1984 May 4; 46(2):145-9.
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        148. Schwartz WJ, Reppert SM, Eagan SM, Moore-Ede MC. In vivo metabolic activity of the suprachiasmatic nuclei: a comparative study. Brain Res. 1983 Sep 5; 274(1):184-7.
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        149. Reppert SM, Schwartz WJ. Maternal coordination of the fetal biological clock in utero. Science. 1983 May 27; 220(4600):969-71.
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        150. Schwartz WJ, Coleman RJ, Reppert SM. A daily vasopressin rhythm in rat cerebrospinal fluid. Brain Res. 1983 Mar 14; 263(1):105-12.
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        151. Reppert SM, Coleman RJ, Heath HW, Keutmann HT. Circadian properties of vasopressin and melatonin rhythms in cat cerebrospinal fluid. Am J Physiol. 1982 Dec; 243(6):E489-98.
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        152. Artman HG, Reppert SM, Perlow MJ, Swaminathan S, Oddie TH, Fisher DA. Characterization of the daily oxytocin rhythm in primate cerebrospinal fluid. J Neurosci. 1982 May; 2(5):598-603.
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        153. Reppert SM, Perlow MJ, Tamarkin L, Orloff D, Klein DC. The effects of environmental lighting on the daily melatonin rhythm in primate cerebrospinal fluid. Brain Res. 1981 Nov 2; 223(2):313-23.
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        154. Millard WJ, Reppert SM, Sagar SM, Martin JB. Light-dark entrainment of the growth hormone ultradian rhythm in the rat is mediated by the arcuate nucleus. Endocrinology. 1981 Jun; 108(6):2394-6.
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        155. Perlow MJ, Reppert SM, Boyar RM, Klein DC. Daily rhythms in cortisol and melatonin in primate cerebrospinal fluid. Effects of constant light and dark. Neuroendocrinology. 1981 Apr; 32(4):193-6.
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        156. Tamarkin L, Reppert SM, Klein DC. Regulation of pineal melatonin in the Syrian hamster. Endocrinology. 1979 Feb; 104(2):385-9.
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